Hepatocellular Carcinoma

• CLINICAL_TRIALS trial_result · 2025-11-19
  Clinical Trial Update: High Dose-Rate Brachytherapy for the Treatment of Both Primary and Secondary Unresectable Liver Malignancies [NA]

  A clinical trial is evaluating high dose-rate brachytherapy for unresectable primary and metastatic liver malignancies. The study is current…

• CLINICAL_TRIALS trial_result · 2025-11-18
  Clinical Trial Update: Predicting Survival After Surgical Resection for the Entire Spectrum of Anatomically Resectable HCC

  This completed clinical trial investigates predictive factors for survival after surgical resection across the full spectrum of anatomically…

• CLINICAL_TRIALS trial_result · 2025-11-17
  Clinical Trial Update: A Study to Evaluate Camrelizumab Plus Rivoceranib (Apatinib) Versus Camrelizumab as Adjuvant Therapy in Patients With Hepatocellular Carcinoma (HCC) at High Risk of Recurrence After Curative Resection or Ablation [Phase 2]

  Phase 2 trial evaluating camrelizumab plus rivoceranib versus camrelizumab as adjuvant therapy for hepatocellular carcinoma at high risk of …

• CLINICAL_TRIALS trial_result · 2025-11-17
  Clinical Trial Update: Testing Immunotherapy for Patients With Liver Cancer and Moderately Altered Liver Functions [Phase 2]

  Phase 2 clinical trial testing an immunotherapy for hepatocellular carcinoma in patients with moderately altered liver function has complete…

• CLINICAL_TRIALS trial_result · 2025-11-17
  Clinical Trial Update: A Study of SOT101 in Combination With Pembrolizumab to Evaluate the Efficacy and Safety in Patients With Selected Advanced Solid Tumors [Phase 2]

  Phase 2 study evaluating SOT101 in combination with pembrolizumab in selected advanced solid tumors was terminated; results have been posted…

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• CLINICAL_TRIALS trial_result · 2025-11-17
  Clinical Trial Update: Streamlined Resin Y90 Radiation Segmentectomy for Small HCC

  Clinical trial update describing a streamlined yttrium-90 resin microsphere radiation segmentectomy approach for small hepatocellular carcin…

• CLINICAL_TRIALS trial_result · 2025-11-12
  Clinical Trial Update: A Study of Cobolimab Plus Dostarlimab in Pediatric and Young Adult Participants With Cancer [Phase 1, Phase 2]

  This document details an ongoing Phase 1/2 clinical trial evaluating cobolimab in combination with dostarlimab in pediatric and young adult …

• CLINICAL_TRIALS trial_result · 2025-11-10
  Clinical Trial Update: Study of CHS-388 (Formerly Known as SRF388) in Patients With Advanced Solid Tumors [Phase 1]

  This is a completed Phase 1 clinical trial update evaluating CHS-388 (formerly SRF388) in patients with advanced solid tumors, including cle…

• CLINICAL_TRIALS trial_result · 2025-11-04
  Clinical Trial Update: Cytokine Armored GPC3 Specific Chimeric Antigen Receptor Expressing T-cells in Adults With Solid Tumors [Phase 1]

  Phase 1 trial evaluating cytokine-armored GPC3-targeted CAR-T cells in adults with solid tumors, including hepatocellular carcinoma; the stu…

• CLINICAL_TRIALS trial_result · 2025-10-31
  Clinical Trial Update: 68Ga-PSMA-Dual-Contrast PET/MRI or PET/CT for Early Detection of Liver Cancer [Phase 2]

  Phase 2 trial assessing 68Ga-PSMA dual-contrast PET imaging for early detection of hepatocellular carcinoma; the study has completed.

• CLINICAL_TRIALS trial_result · 2025-10-30
  Clinical Trial Update: A Phase II Study of Intra-arterial Chemotherapy With Cisplatin and Mitomycin-C in Patients With Hepatocellular Carcinoma [Phase 2]

  A Phase II trial evaluating intra-arterial chemotherapy with cisplatin and mitomycin-C in hepatocellular carcinoma has completed, with resul…

• CLINICAL_TRIALS trial_result · 2025-10-29
  Clinical Trial Update: Futibatinib and Pembrolizumab for Treatment of Advanced or Metastatic FGF19 Positive BCLC Stage A, B, or C Liver Cancer [Phase 2]

  Phase 2 trial results for futibatinib plus pembrolizumab in advanced hepatocellular carcinoma (BCLC A-C and metastatic) have been completed …

• CLINICAL_TRIALS trial_result · 2025-10-29
  Clinical Trial Update: Sulfur Colloid SPECT/CT in Measuring Liver Function in Patients With Primary or Metastatic Liver Cancer Undergoing Radiation Therapy or Surgery [NA]

  This trial update reports that the sulfur colloid SPECT/CT liver-function study in patients with hepatocellular carcinoma or intrahepatic ch…

• CLINICAL_TRIALS trial_result · 2025-10-24
  Clinical Trial Update: A Study of E7386 in Combination With Pembrolizumab in Previously Treated Participants With Selected Solid Tumors [Phase 1, Phase 2]

  Results from a Phase 1/2 study of E7386 in combination with pembrolizumab in previously treated solid tumors (melanoma, hepatocellular carci…

• CLINICAL_TRIALS trial_result · 2025-10-23
  Clinical Trial Update: Immunotherapy for Advanced Liver Cancer [Phase 2, Phase 3]

  A Phase 2/Phase 3 immunotherapy trial for hepatocellular carcinoma has been suspended.

• CLINICAL_TRIALS trial_result · 2025-10-23
  Clinical Trial Update: Pressure Enabled Delivery of SD-101 With Checkpoint Blockade for Primary Liver Tumors [Phase 1, Phase 2]

  A Phase 1/2 trial evaluating pressure-enabled delivery of SD-101 in combination with checkpoint blockade for primary liver tumors has been t…

• CLINICAL_TRIALS trial_result · 2025-10-22
  Clinical Trial Update: A Study of HFB301001 in Adult Patients With Advanced Solid Tumors [Phase 1]

  The Phase 1 trial of HFB301001 in adults with advanced solid tumors has been terminated.

• CLINICAL_TRIALS trial_result · 2025-10-21
  Clinical Trial Update: An Open-Label Safety and Tolerability Study of INCB062079 in Subjects With Advanced Hepatocellular Carcinoma and Other Malignancies [Phase 1]

  Open-label Phase 1 safety and tolerability study of INCB062079 in patients with advanced hepatocellular carcinoma and other malignancies; st…

• CLINICAL_TRIALS trial_result · 2025-10-20
  Clinical Trial Update: Therasphere® and Systemic Therapy for Patients With Hepatocellular Carcinoma That is High-risk [Phase 2]

  Phase 2 clinical trial evaluating TheraSphere in combination with systemic therapy for high-risk hepatocellular carcinoma is currently suspe…

• CLINICAL_TRIALS trial_result · 2025-10-16
  Clinical Trial Update: Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of INCB099318 in Participants With Advanced Solid Tumors [Phase 1]

  Phase 1 clinical trial of INCB099318 in participants with advanced solid tumors has been terminated. The update reports safety, tolerability…

• CLINICAL_TRIALS trial_result · 2025-10-16
  Clinical Trial Update: Nivolumab Combined With BMS-986253 in HCC Patients [Phase 2]

  A Phase 2 study evaluating nivolumab in combination with BMS-986253 for hepatocellular carcinoma has been terminated, with results posted.

• CLINICAL_TRIALS trial_result · 2025-10-16
  Clinical Trial Update: Taxoprexin® Treatment for Advanced Primary Cancers of the Liver, Gallbladder or Biliary Tract [Phase 2]

  Phase 2 trial of Taxoprexin for advanced primary cancers of the liver, gallbladder, or biliary tract was terminated.

• CLINICAL_TRIALS trial_result · 2025-10-15
  Clinical Trial Update: ALTUS: Performance of a Multi- Target Hepatocellular Carcinoma (HCC) Test in Subjects With Increased Risk

  Exact Sciences is reporting on the performance of a multi-target hepatocellular carcinoma test in individuals at increased risk. The clinica…

• CLINICAL_TRIALS trial_result · 2025-10-14
  Clinical Trial Update: A Study of Tislelizumab Versus Sorafenib in Participants With Unresectable Hepatocellular Carcinoma (HCC) [Phase 3]

  Phase 3 trial comparing tislelizumab to sorafenib for unresectable hepatocellular carcinoma has completed and posted results on 2025-10-14.

• CLINICAL_TRIALS trial_result · 2025-10-14
  Clinical Trial Update: A Study of MGC018 in Combination With MGD019 in Participants With Advanced Solid Tumors [Phase 1]

  This Phase 1 trial update reports on the combination of MGC018 and MGD019 in participants with advanced solid tumors, including castration-r…