Hepatocellular Carcinoma

• CLINICAL_TRIALS trial_result · 2025-12-26
  Clinical Trial Update: Study of LVGN3616 and LVGN6051±LVGN7409 in Combination With Nab-Paclitaxel or Bevacizumab and Cyclophosphamide in Metastatic Solid Tumors [Phase 1]

  Phase 1 trial evaluating LVGN3616 and LVGN6051±LVGN7409 with nab-paclitaxel or bevacizumab and cyclophosphamide in various metastatic solid …

• CLINICAL_TRIALS trial_result · 2025-12-24
  Clinical Trial Update: An Immuno-therapy Study to Evaluate the Effectiveness, Safety and Tolerability of Nivolumab or Nivolumab in Combination With Other Agents in Patients With Advanced Liver Cancer [Phase 1, Phase 2]

  An update on Phase 1/2 trials evaluating nivolumab, alone or in combination with other agents, for advanced hepatocellular carcinoma, with t…

• CLINICAL_TRIALS trial_result · 2025-12-23
  Clinical Trial Update: Long-Term Survival With Lenvatinib-Based Therapy in Unresectable Liver Cancer

  This clinical trial update reports long-term survival outcomes for patients with unresectable hepatocellular carcinoma treated with a lenvat…

• CLINICAL_TRIALS trial_result · 2025-12-18
  Clinical Trial Update: Feasibility and Efficacy of Perioperative Nivolumab With or Without Relatlimab for Patients With Potentially Resectable Hepatocellular Carcinoma (HCC) [Phase 1]

  Phase 1 clinical trial update evaluating perioperative nivolumab with or without relatlimab in patients with potentially resectable hepatoce…

• CLINICAL_TRIALS trial_result · 2025-12-18
  Clinical Trial Update: Biliary Anastomosis Using Surgical Loupe Versus Microscope in Living Donor Liver Transplantation [NA]

  This clinical trial compared biliary anastomosis using a surgical loupe versus a microscope in living donor liver transplantation. The study…

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• CLINICAL_TRIALS trial_result · 2025-12-18
  Clinical Trial Update: Study of ADI-PEG 20 Versus Placebo in Subjects With High Arginine Level and Unresectable Hepatocellular Carcinoma [Phase 3]

  Phase 3 trial evaluating ADI-PEG 20 versus placebo in patients with high arginine levels and unresectable hepatocellular carcinoma is curren…

• CLINICAL_TRIALS trial_result · 2025-12-18
  Clinical Trial Update: Immune Cells as a New Biomarker of Response in Patients Treated by Immunotherapy for Advanced Hepatocellular Carcinoma

  A clinical trial update reports that immune cell biomarkers may predict responses to immunotherapy in advanced hepatocellular carcinoma; the…

• CLINICAL_TRIALS trial_result · 2025-12-18
  Clinical Trial Update: A Study of MT-303 in Adults With Advanced or Metastatic GPC3-Expressing Cancers, Including HCC [Phase 1]

  A Phase 1 study of MT-303 in adults with advanced or metastatic GPC3-expressing cancers, including hepatocellular carcinoma, is currently re…

• CLINICAL_TRIALS trial_result · 2025-12-18
  Clinical Trial Update: Neoadjuvant HAIC of TACE Plus Donafenib in BCLC B Stage HCC: a Multi-center Randomized Controlled Trial. [Phase 2, Phase 3]

  A multi-center randomized Phase 2/3 trial evaluating neoadjuvant hepatic arterial infusion chemotherapy with transarterial chemoembolization…

• CLINICAL_TRIALS trial_result · 2025-12-16
  Clinical Trial Update: The Efficacy of Sequential Treatment With Bevacizumab Combined With Atezolizumab in Advanced Liver Cancer With MASLD [Phase 2, Phase 3]

  A phase 2/3 clinical trial is evaluating sequential bevacizumab and atezolizumab in advanced hepatocellular carcinoma associated with MASLD;…

• CLINICAL_TRIALS trial_result · 2025-12-12
  Clinical Trial Update: Organ-specific Responses to Atezolizumab Plus Bevacizumab in Advanced HCC

  The trial evaluated organ-specific responses to the combination of atezolizumab and bevacizumab in advanced hepatocellular carcinoma; result…

• CLINICAL_TRIALS trial_result · 2025-12-11
  Clinical Trial Update: Evaluating Length of Treatment With PD-1/PD-L1 Inhibitor in Advanced Solid Tumors [Phase 3]

  Phase 3 trial evaluating the duration of PD-1/PD-L1 inhibitor therapy in advanced solid tumors; the study has completed.

• CLINICAL_TRIALS trial_result · 2025-12-11
  Clinical Trial Update: Study of Cabozantinib in Combination With Atezolizumab Versus Sorafenib in Participants With Advanced Hepatocellular Carcinoma (HCC) Who Have Not Received Previous Systemic Anticancer Therapy [Phase 3]

  A Phase 3 study comparing cabozantinib in combination with atezolizumab versus sorafenib as first-line therapy for advanced hepatocellular c…

• CLINICAL_TRIALS trial_result · 2025-12-11
  Clinical Trial Update: HAIC vs. TACE Combined With ICIs and TKIs in Intermediate-to-Advanced HCC: A Multicenter Study on Liver Injury and Survival

  A completed multicenter study in hepatocellular carcinoma compared hepatic artery infusion chemotherapy (HAIC) to transarterial chemoemboliz…

• CLINICAL_TRIALS trial_result · 2025-12-11
  Clinical Trial Update: A Study of Nofazinlimab (CS1003) in Subjects With Advanced Hepatocellular Carcinoma [Phase 3]

  Clinical trial update for Nofazinlimab (CS1003) in advanced hepatocellular carcinoma; the Phase 3 study is currently active but not recruiti…

• CLINICAL_TRIALS trial_result · 2025-12-11
  Clinical Trial Update: Radiotherapy Combined With QL1706 and Bevacizumab for Unresectable Non-metastatic Hepatocellular Carcinoma [Phase 2]

  A Phase 2 trial is evaluating radiotherapy in combination with QL1706 and bevacizumab for unresectable non-metastatic hepatocellular carcino…

• CLINICAL_TRIALS trial_result · 2025-12-11
  Clinical Trial Update: A Prospective Observational Study on Efficacy of TARE for Early Stage HCC

  A prospective observational study evaluating the efficacy of transarterial radioembolization (TARE) with Yttrium-90 microspheres for early-s…

• CLINICAL_TRIALS trial_result · 2025-12-11
  Clinical Trial Update: A Study Evaluating The Efficacy and Safety of Neoadjuvant Immunotherapy Combinations in Patients With Surgically Resectable Hepatocellular Carcinoma [Phase 1, Phase 2]

  Hoffmann-La Roche sponsored a Phase 1/2 trial evaluating neoadjuvant immunotherapy combinations in patients with surgically resectable hepat…

• CLINICAL_TRIALS trial_result · 2025-12-05
  Clinical Trial Update: BOXR1030 T Cells in Subjects With Advanced GPC3-Positive Solid Tumors [Phase 1, Phase 2]

  Clinical trial update for BOXR1030 T Cells shows a Phase 1/2 study in GPC3-positive solid tumors, including hepatocellular carcinoma and add…

• CLINICAL_TRIALS trial_result · 2025-12-03
  Clinical Trial Update: A Phase I Clinical Study of Recombinant Humanized Anti-BTLA Monoclonal Antibody (JS004) Injection Combined With Toripalimab Injection in Patients With Advanced Solid Tumors [Phase 1]

  A Phase I trial of JS004, a recombinant humanized anti-BTLA monoclonal antibody, in combination with toripalimab for advanced solid tumors h…

• CLINICAL_TRIALS trial_result · 2025-12-01
  Clinical Trial Update: Cabozantinib toLERANCE Study in HepatoCellular Carcinoma (CLERANCE) [Phase 4]

  A Phase 4 clinical trial (CLERANCE) evaluating cabozantinib in hepatocellular carcinoma has completed. The document provides no trial result…

• CLINICAL_TRIALS trial_result · 2025-11-28
  Clinical Trial Update: Study of ACC-1898 in Adult Participants With Advanced Solid Tumors [Phase 1]

  Phase 1 study update for ACC-1898 in adults with advanced solid tumors; the trial is not yet recruiting.

• CLINICAL_TRIALS trial_result · 2025-11-21
  Clinical Trial Update: A Study of Nivolumab in Participants With Hepatocellular Carcinoma Who Are at High Risk of Recurrence After Curative Hepatic Resection or Ablation [Phase 3]

  A Phase 3 trial evaluating nivolumab for preventing recurrence of hepatocellular carcinoma after curative liver resection or ablation; the s…

• CLINICAL_TRIALS trial_result · 2025-11-21
  Clinical Trial Update: Clinical Study of TQB2223 Injection Combined With AK105 Injection in the Treatment of Advanced Hepatocellular Carcinoma. [Phase 1]

  A Phase 1 clinical trial of TQB2223 in combination with AK105 for advanced hepatocellular carcinoma has been terminated.

• CLINICAL_TRIALS trial_result · 2025-11-20
  Clinical Trial Update: A Phase 2 Study of BB102 in Patients With Hepatocellular Carcinoma [Phase 2]

  A Phase 2 clinical trial evaluating BB102 for hepatocellular carcinoma is planned but not yet recruiting, sponsored by Broadenbio Ltd.