Hepatocellular Carcinoma

• CLINICAL_TRIALS research · 2026-04-01
  Clinical Trial Update: BITS-TO-HCC Study: HAIC+Iparomlimab/Tuvonralimab + Bevacizumab + SBRT for BCLC-C HCC With PVTT and/or Oligometastases [Phase 2]

  Phase 2 clinical trial (BITS-TO-HCC) in recruiting evaluating hepatic arterial infusion chemotherapy plus iparomlimab and tuvonralimab with …

• CLINICAL_TRIALS research · 2026-04-01
  Clinical Trial Update: Ph II Study of Enfortumab Vedotin in Patients With Advanced or Metastatic CRC or HCC [Phase 2]

  Ongoing phase 2 trial evaluating enfortumab vedotin in advanced or metastatic colorectal cancer and hepatocellular carcinoma; study is curre…

• CLINICAL_TRIALS research · 2026-04-01
  Clinical Trial Update: Tislelizumab Monotherapy or Combined With Lenvatinib as Neoadjuvant Therapy for Resectable Hepatocellular Carcinoma. [Phase 2]

  Phase 2 trial evaluating tislelizumab alone or with lenvatinib as neoadjuvant therapy for resectable hepatocellular carcinoma has completed.…

• CLINICAL_TRIALS research · 2026-03-31
  Clinical Trial Update: Ipilimumab and Nivolumab With SBRT in Locally Advanced Hepatocellular Cancer [Phase 1]

  Phase 1 trial updating the combo of ipilimumab and nivolumab with SBRT for locally advanced hepatocellular carcinoma; study status is not ye…

• CLINICAL_TRIALS research · 2026-03-31
  Clinical Trial Update: Large Language Models Assist in Tumor MDT [NA]

  A clinical trial is recruiting to test the use of large language models to assist multidisciplinary tumor board discussions across multiple …

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• CLINICAL_TRIALS research · 2026-03-31
  Clinical Trial Update: A Study to Evaluate ALN-BCAT in Patients With Hepatocellular Carcinoma [Phase 1]

  A Phase 1 clinical trial evaluating ALN-BCAT in patients with hepatocellular carcinoma (advanced or metastatic) is currently recruiting.

• CLINICAL_TRIALS research · 2026-03-30
  Clinical Trial Update: Efficacy and Safety Comparison Between Intensified Therapy and Conversion Therapy For Advanced HCC After Failure of First-line [Phase 2]

  This document provides a status update on a Phase 2 clinical trial comparing intensified therapy versus conversion therapy for advanced hepa…

• CLINICAL_TRIALS research · 2026-03-30
  Clinical Trial Update: Stereotactic Body Radiation Therapy (SBRT) Efficiency and Toxicity in Liver Cancer [NA]

  This clinical trial update reports on the use of stereotactic body radiation therapy (SBRT) for liver cancer and liver metastases, focusing …

• CLINICAL_TRIALS research · 2026-03-30
  Clinical Trial Update: HAI or IV of Adebrelimab, Combined With Bevacizumab and HAI of FOLFOX for Advanced Unresectable Hepatocellular Carcinoma [Phase 2]

  Phase 2 trial evaluating Adebrelimab in combination with Bevacizumab and hepatic artery infusion of FOLFOX for advanced unresectable hepatoc…

• CLINICAL_TRIALS research · 2026-03-30
  Clinical Trial Update: Volatile Organic Compounds for the Assessment of Liver Disease

  A completed clinical trial evaluating volatile organic compounds for the assessment of liver disease.

• CLINICAL_TRIALS research · 2026-03-30
  Clinical Trial Update: Dual-Target GPC3/B7-H3 CAR-NK Cells for Advanced HCC [Phase 1, Phase 2]

  This clinical trial update describes a Phase 1/Phase 2 study evaluating dual-target GPC3/B7-H3 CAR-NK cells for advanced hepatocellular carc…

• CLINICAL_TRIALS research · 2026-03-27
  Clinical Trial Update: TACE or Ablation Combined With Sintilimab and Ipilimumab N01 as Neoadjuvant Therapy for Resectable Hepatocellular Carcinoma With Intermediate-High Recurrence Risk [Phase 2]

  A Phase 2 trial evaluating neoadjuvant therapy consisting of TACE or ablation plus Sintilimab and Ipilimumab for resectable hepatocellular c…

• CLINICAL_TRIALS research · 2026-03-27
  Clinical Trial Update: A Study to Evaluate the Tolerability, Safety, and PK of AST-201 in Patients With GPC3-positive Advanced Solid Tumors [Phase 1]

  A Phase 1 study is evaluating tolerability, safety, and pharmacokinetics of AST-201 in patients with GPC3-positive advanced solid tumors; th…

• CLINICAL_TRIALS research · 2026-03-27
  Clinical Trial Update: Intelligence System for Predicting Atezolizumab-Bevacizumab Response and Clinical Outcomes in Unresectable Hepatocellular Carcinoma

  A clinical trial update describes an intelligence system intended to predict response and outcomes to atezolizumab-bevacizumab in unresectab…

• CLINICAL_TRIALS research · 2026-03-27
  Clinical Trial Update: Sintilimab Combined With Bevacizumab Biosimilar as Adjuvant Treatment After Resection of Ruptured Hepatocellular Carcinoma (CLEAR-2) [Phase 2]

  Phase 2 trial investigating sintilimab plus a bevacizumab biosimilar as adjuvant therapy after resection of ruptured hepatocellular carcinom…

• CLINICAL_TRIALS research · 2026-03-27
  Clinical Trial Update: 18F-Fibroblast Activation Protein Inhibitor ([18F]FAPI-74) PET Imaging for Cancer Detection [Phase 2]

  Phase 2 trial assessing the imaging tracer 18F-FAPI-74 for cancer detection across multiple indications; currently recruiting.

• CLINICAL_TRIALS research · 2026-03-27
  Clinical Trial Update: TheraSphere With Durvalumab and Tremelimumab for HCC [Phase 2]

  A Phase 2 trial evaluating TheraSphere in combination with durvalumab and tremelimumab for hepatocellular carcinoma is active but not recrui…

• CLINICAL_TRIALS research · 2026-03-27
  Clinical Trial Update: Optimizing Y90 Therapy for Radiation Lobectomy

  Northwestern University sponsors a trial to optimize Y-90 radioembolization for radiation lobectomy in hepatocellular carcinoma to improve s…

• CLINICAL_TRIALS research · 2026-03-27
  Clinical Trial Update: A Clinical Study on the Safety, Tolerability and Efficacy of Neoantigen-based Personalized mRNA Therapy iNeo-Vac-R01 Plus PD-1 Inhibitor in Adjuvant Treatment of Liver Cancer Post Radical Resection [Phase 1, Phase 2]

  This document updates a Phase 1/2 clinical study evaluating iNeo-Vac-R01, a neoantigen-based personalized mRNA therapy, in combination with …

• CLINICAL_TRIALS research · 2026-03-27
  Clinical Trial Update: IIT2025-03-YANG-LIFT-HCC [Phase 2]

  Phase 2 IIT2025-03-YANG-LIFT-HCC trial for hepatocellular carcinoma is currently recruiting.

• CLINICAL_TRIALS research · 2026-03-27
  Clinical Trial Update: Regorafenib and Yttrium-90 Radioembolization for Unresectable Hepatocellular Carcinoma [Phase 2]

  This is a Phase 2 clinical trial evaluating regorafenib in combination with Yttrium-90 radioembolization for unresectable hepatocellular car…

• CLINICAL_TRIALS research · 2026-03-25
  Clinical Trial Update: A Study to Assess Adverse Events and Change in Disease Activity of Intravenously (IV) Infused ABBV-324 in Adult Participants With Hepatocellular Cancer (HCC) or Squamous-Cell Non-Small Cell Lung Cancer (LUSC) [Phase 1]

  This clinical trial update describes a Phase 1 study evaluating adverse events and changes in disease activity for intravenous ABBV-324 in a…

• CLINICAL_TRIALS research · 2026-03-25
  Clinical Trial Update: Cemiplimab +/- Fianlimab Post Y90 Radioembolization in Patients With Hepatocellular Carcinoma [Phase 1]

  A Phase 1 trial evaluating cemiplimab with or without fianlimab following Y-90 radioembolization in patients with hepatocellular carcinoma.

• CLINICAL_TRIALS research · 2026-03-25
  Clinical Trial Update: Fostrox Plus Lenvatinib vs Lenvatinib in Advanced Hepatocellular Carcinoma After First-line Immunotherapy [Phase 2]

  This is a Phase 2 trial comparing Fostrox plus lenvatinib versus lenvatinib alone in advanced hepatocellular carcinoma after failure of firs…

• CLINICAL_TRIALS research · 2026-03-25
  Clinical Trial Update: An Open-Label, Phase I Clinical Trial of Super CAR-T With GPC3-Positive Advanced Hepatocellular Carcinoma [Phase 1]

  An open-label Phase I study evaluating a Super CAR-T therapy targeting GPC3 in advanced hepatocellular carcinoma is currently recruiting.