Hepatocellular Carcinoma

• CLINICAL_TRIALS research · 2025-08-01
  Clinical Trial Update: Continuation of First-line Therapy With Radiotherapy Versus Early Switch to Second-line Therapy in Oligoprogressive HCC [Phase 3]

  This entry describes a Phase 3 trial comparing continuation of first-line radiotherapy versus early switch to second-line therapy for oligop…

• CLINICAL_TRIALS research · 2025-08-01
  Clinical Trial Update: I-FIGS Feasibility Study [NA]

  Clinical trial update indicating the completion of the I-FIGS feasibility study sponsored by University Hospital Plymouth NHS Trust. The stu…

• CLINICAL_TRIALS research · 2025-07-29
  Clinical Trial Update: A Study to Evaluate the Safety, Tolerability and Efficacy of RZ-001 in Combination With Valganciclovir (VGCV) and Atezolizumab/Bevacizumab in Subjects With Hepatocellular Carcinoma [Phase 1, Phase 2]

  Phase 1/2 clinical trial evaluating safety, tolerability and efficacy of RZ-001 in combination with valganciclovir and atezolizumab/bevacizu…

• CLINICAL_TRIALS research · 2025-07-29
  Clinical Trial Update: Curative Therapy After Atezolizumab and Bevacizumab Treatment for Unresectable Hepatocellular Carcinoma

  This clinical trial update announces recruitment for a study evaluating curative therapy after initial treatment with atezolizumab and bevac…

• CLINICAL_TRIALS research · 2025-07-28
  Clinical Trial Update: Evaluation of Efficacy and Safety of Immune Check Point Inhibitors in Hepatocellular Carcinoma Patients in Ain Shams University Hospitals

  A clinical trial update from Ain Shams University Hospitals indicates enrollment of hepatocellular carcinoma patients to evaluate the effica…

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• CLINICAL_TRIALS research · 2025-07-28
  Clinical Trial Update: Clinical Trials of the Hepatitis B Sandwich Combination Therapy for Treating Patients Infected With Hepatitis B Virus [NA]

  A clinical trial entry for a Hepatitis B 'Sandwich' combination therapy for Hepatitis B infection and hepatocellular carcinoma, with the stu…

• CLINICAL_TRIALS research · 2025-07-24
  Clinical Trial Update: Prophylactic Endoscopic Variceal Ligation in Patients With High-risk Esophageal Varices Receiving Atezo/Bev for HCC [Phase 2]

  Phase 2 clinical trial evaluating prophylactic endoscopic variceal ligation to prevent variceal bleeding in patients with high-risk esophage…

• CLINICAL_TRIALS research · 2025-07-23
  Clinical Trial Update: Perioperative Sintilimab Plus Bevacizumab Biosimilar and TACE-HAIC for HCC Patients With PVTT: A Phase-2 Clinical Trial [Phase 2]

  Phase 2 clinical trial evaluating perioperative sintilimab plus a bevacizumab biosimilar and TACE-HAIC for hepatocellular carcinoma with PVT…

• CLINICAL_TRIALS research · 2025-07-23
  Clinical Trial Update: Role of Early API in Accurately Differentiating Hepatocellular Carcinoma From Dysplastic Nodules in Cirrhotic Patients

  This clinical trial update discusses the role of an early API to differentiate hepatocellular carcinoma from dysplastic nodules in patients …

• CLINICAL_TRIALS research · 2025-07-23
  Clinical Trial Update: Acupuncture for Oxaliplatin-induced Peripheral Neuropathy in Gastro-intestinal Cancer Patients [NA]

  This clinical trial is evaluating acupuncture to address oxaliplatin-induced peripheral neuropathy in patients with gastrointestinal cancers…

• CLINICAL_TRIALS research · 2025-07-23
  Clinical Trial Update: HepQuant: Study to Assess the Role of Blood-based Biomarkers and Quantitative MR Imaging for Patients Receiving Radiation Therapy for Liver Cancer [NA]

  This clinical trial update describes the HepQuant study at Montefiore Medical Center evaluating blood-based biomarkers and quantitative MR i…

• CLINICAL_TRIALS research · 2025-07-23
  Clinical Trial Update: PSMA PET for the Staging and Management of Hepatocellular Carcinoma

  Clinical trial is recruiting to evaluate PSMA PET imaging for staging and management of hepatocellular carcinoma, sponsored by the VA Office…

• CLINICAL_TRIALS research · 2025-07-22
  Clinical Trial Update: Comparing the Combination of Trastuzumab and Regorafenib With Regorafenib Monotherapy for Advanced Hepatocellular Carcinoma After First-line Treatment [Phase 2]

  A Phase 2 clinical trial compares the combination of trastuzumab and regorafenib versus regorafenib alone for advanced hepatocellular carcin…

• CLINICAL_TRIALS research · 2025-07-22
  Clinical Trial Update: The Efficacy and Safety of First-line Treatment Combined With Immunotherapy for Advanced Hepatocellular Carcinoma: a Single Center, Real-world Study

  This real-world, single-center study assesses first-line treatment combined with immunotherapy for advanced hepatocellular carcinoma and is …

• CLINICAL_TRIALS research · 2025-07-22
  Clinical Trial Update: Predicting Immunotherapy Response and Survival of Liver Cancer Patients Using Artificial Intelligence and Radiomics (Radiology-AI-Liver)

  A clinical trial investigating artificial intelligence and radiomics to predict immunotherapy response and survival in patients with hepatoc…

• CLINICAL_TRIALS research · 2025-07-20
  Clinical Trial Update: JDB153 Combined With Penpulimab for Hepatocellular Carcinoma After Standard Treatment Failure [Phase 1, Phase 2]

  This document outlines a Phase 1/Phase 2 clinical trial evaluating JDB153 combined with Penpulimab for refractory hepatocellular carcinoma a…

• CLINICAL_TRIALS research · 2025-07-17
  Clinical Trial Update: Digital Early Warning System for Acute Lung Injury in Liver Surgery

  A ClinicalTrials.gov entry describing a study of a digital early warning system to detect acute lung injury in patients undergoing liver sur…

• CLINICAL_TRIALS research · 2025-07-16
  Clinical Trial Update: Comparing the Prognosis of Patients With HCC and PVTT Treated With Surgery Versus Locoregional Therapy. [NA]

  Clinical trial update NCT06248528 in hepatocellular carcinoma with portal vein tumor thrombosis compares surgical resection to locoregional …

• CLINICAL_TRIALS research · 2025-07-16
  Clinical Trial Update: Hepatocellular Carcinoma Imaging Using PSMA PET/CT [Phase 2]

  Phase 2 clinical trial evaluating PSMA PET/CT imaging for hepatocellular carcinoma; the study is currently active but not recruiting.

• CLINICAL_TRIALS research · 2025-07-15
  Clinical Trial Update: A Generative Model-based System for Predicting Survival and Guiding Treatment Decisions in Patients With Unresectable Hepatocellularcarcinoma Undergoing Transcatheter Arterial Chemoembolization in Combination With Immunotherapy and Targeted Therapy

  A clinical trial update describes a generative model-based system to predict survival and guide treatment decisions for patients with unrese…

• CLINICAL_TRIALS research · 2025-07-15
  Clinical Trial Update: Tauroursodeoxycholic Acid Combined With PD-1/PD-L1 Immunotherapy in Advanced Hepatocellular Carcinoma: A Prospective Study [Phase 2]

  A Phase 2 prospective trial evaluating tauroursodeoxycholic acid in combination with PD-1/PD-L1 immunotherapy for advanced hepatocellular ca…

• CLINICAL_TRIALS research · 2025-07-15
  Clinical Trial Update: Targeted Navigation in Hepatocellular Carcinoma (HCC) [NA]

  A University of Miami-sponsored clinical trial is currently recruiting to study targeted navigation approaches in hepatocellular carcinoma, …

• CLINICAL_TRIALS research · 2025-07-15
  Clinical Trial Update: The Real-world Study of AK104 Combining With TACE for Resectable Hepatocellular Carcinoma (MORNING)

  A real-world study assessing AK104 in combination with transarterial chemoembolization (TACE) for patients with resectable hepatocellular ca…

• CLINICAL_TRIALS research · 2025-07-10
  Clinical Trial Update: Liver Cancer and Immunotherapy in the Liquid Biopsy Era [NA]

  An update on an ongoing clinical trial at University Hospital, Montpellier, evaluating immunotherapy and liquid biopsy approaches for hepato…

• CLINICAL_TRIALS research · 2025-07-10
  Clinical Trial Update: Downstaging Prediction Model for HCC

  An update on a clinical trial to develop a downstaging prediction model for hepatocellular carcinoma; the study is not yet recruiting.