Hepatocellular Carcinoma
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CLINICAL_TRIALS research · 2025-10-03Clinical Trial Update: Conversion Therapy Using TACE/HAIC With Anti-Angiogenic and Immunotherapy for Initially Unresectable Hepatocellular Carcinoma Achieving Complete Response or Resectability, Followed by Surgery or Continued Systemic Treatment: A Prospective Cohort Study
This clinical trial update describes a prospective cohort study of conversion therapy for initially unresectable hepatocellular carcinoma us…
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CLINICAL_TRIALS research · 2025-10-02Clinical Trial Update: Atezolizumab Plus Bevacizumab Combined With Locoregional Therapies in Unresectable Hepatocellular Carcinoma (ISMIO-001)
This clinical trial update describes the ISMIO-001 study evaluating the combination of atezolizumab and bevacizumab with locoregional therap…
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CLINICAL_TRIALS research · 2025-10-01Clinical Trial Update: SBRT + Atezolizumab + Bevacizumab in Resectable HCC [EARLY_Phase 1]
An early-phase trial is evaluating the combination of SBRT (radiation therapy) with atezolizumab and bevacizumab in patients with resectable…
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CLINICAL_TRIALS research · 2025-10-01Clinical Trial Update: Tissue Procurement for Gastric Cancer, Gastrointestinal Stromal Tumors (GIST), Esophageal Cancer, Pancreas Cancer, Hepatocellular Cancer, Biliary Cancer, Neuroendocrine, Peritoneal Mesothelioma, Anal Cancer and Colorectal Cancer in Patients Undergoing Surgery or Biopsy
University of Chicago is recruiting for a tissue procurement study across multiple cancers in patients undergoing surgery or biopsy to colle…
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CLINICAL_TRIALS research · 2025-10-01Clinical Trial Update: A Study of SZ1003 Injection in Patients With Advanced Hepatocellular Carcinoma [EARLY_Phase 1]
SZ1003 injection is being studied in an early-phase trial for advanced hepatocellular carcinoma, with status not yet recruiting.
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CLINICAL_TRIALS research · 2025-09-30Clinical Trial Update: Neoadjuvant Atezo, Adjuvant Atezo + Beva Combined With RF Ablation of Small HCC: a Multicenter Randomized Phase II Trial [Phase 2]
A multicenter randomized Phase II trial is evaluating neoadjuvant atezolizumab and adjuvant atezolizumab plus bevacizumab with radiofrequenc…
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CLINICAL_TRIALS research · 2025-09-30Clinical Trial Update: A Prospective Study of Memantine in Patients With Cirrhosis and Liver Cancer [Phase 2, Phase 3]
A prospective Phase 2/Phase 3 clinical trial evaluating memantine in patients with cirrhosis and hepatocellular carcinoma is currently recru…
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CLINICAL_TRIALS research · 2025-09-30Clinical Trial Update: Adjuvant IP-001 Treatment for HCC Patients Following Surgical Resection and Ablation or Ablation Alone [Phase 2]
Phase 2 clinical trial investigating adjuvant IP-001 following surgical resection and ablation (or ablation alone) for hepatocellular carcin…
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CLINICAL_TRIALS research · 2025-09-29Clinical Trial Update: Neoadjuvant HAIC and PD-1 Plus Adjuvant PD-1 for High-risk Recurrent HCC [Phase 2]
Clinical trial update for a Phase 2 neoadjuvant hepatic arterial infusion chemotherapy with PD-1 inhibitor and adjuvant PD-1 in high-risk re…
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CLINICAL_TRIALS research · 2025-09-29Clinical Trial Update: Neoadjuvant IMRT Combined With Camrelizumab and Apatinib for Resectable HCC With PVTT [Phase 2]
A Phase 2 neoadjuvant trial is evaluating camrelizumab plus apatinib with intensity-modulated radiotherapy for resectable hepatocellular car…
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CLINICAL_TRIALS research · 2025-09-29Clinical Trial Update: Phase I Clinical Trial of CT0180 Cells in the Treatment of Hepatocellular Carcinoma [Phase 1]
Phase I trial update for CT0180 cells in advanced hepatocellular carcinoma; the study is active but not recruiting.
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CLINICAL_TRIALS research · 2025-09-26Clinical Trial Update: Value of [68Ga]Ga-PSMA-11 PET/MRI in the Assessment of Liver Cirrhosis
Clinical trial evaluating the utility of [68Ga]Ga-PSMA-11 PET/MRI for assessing liver cirrhosis and related conditions is currently recruiti…
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CLINICAL_TRIALS research · 2025-09-25Clinical Trial Update: Systemic Chemotherapy With FOLFOX Plus Atezolizumab & Bevacizumab for Patients With Advanced HCC Who Previously Received Atezolizumab & Bevacizumab [Phase 2]
Phase 2 trial evaluating FOLFOX chemotherapy with atezolizumab and bevacizumab in patients with advanced hepatocellular carcinoma who previo…
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CLINICAL_TRIALS research · 2025-09-24Clinical Trial Update: Real-world Elecsys® GAAD Implementation and Validation to Improve Surveillance and Early Detection of HCC [NA]
This clinical trial update describes the real-world implementation and validation of the Elecsys GAAD assay to improve surveillance and earl…
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CLINICAL_TRIALS research · 2025-09-23Clinical Trial Update: Phase I Study of RNA Oligonucleotide, MTL-CEBPA, Atezolizumab and Bevacizumab in Patients With Advanced Hepatocellular Carcinoma. [Phase 1]
Phase I trial evaluating the RNA oligonucleotide MTL-CEBPA in combination with atezolizumab and bevacizumab for advanced hepatocellular carc…
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CLINICAL_TRIALS research · 2025-09-23Clinical Trial Update: Single-arm Clinical Trial of TACE in Combination With Icaritin as Adjuvant Therapy After Surgery in Patients With Hepatocellular Carcinoma at High Risk of Recurrence [Phase 2, Phase 3]
A single-arm Phase 2/3 clinical trial in hepatocellular carcinoma evaluating adjuvant therapy with Icaritin in combination with transarteria…
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CLINICAL_TRIALS research · 2025-09-23Clinical Trial Update: Safety and Efficacy of Atorvastatin v. Placebo on HCC Risk [Phase 2]
Phase 2 clinical trial evaluating whether atorvastatin reduces hepatocellular carcinoma risk compared with placebo in patients with liver fi…
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CLINICAL_TRIALS research · 2025-09-23Clinical Trial Update: Neoantigen Dendritic Cell Vaccine and Nivolumab in HCC and Liver Metastases From CRC [Phase 2]
Phase 2 clinical trial evaluating a neoantigen dendritic cell vaccine in combination with nivolumab for hepatocellular carcinoma and colorec…
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CLINICAL_TRIALS research · 2025-09-23Clinical Trial Update: 68Ga-PSMA-11 PET-directed Radioligand Therapy in Metastatic Hepatocellular Carcinoma (HCC) [Phase 2]
This clinical trial update concerns a Phase 2 study evaluating 68Ga-PSMA-11 PET-directed radioligand therapy in metastatic hepatocellular ca…
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CLINICAL_TRIALS research · 2025-09-22Clinical Trial Update: EDN Combined With TACE/HAIC and Second-Line Immune-Targeted Treatment Versus TACE/HAIC Alone in Locally Advanced HCC With Portal Vein Tumor Thrombosis After First-Line Therapy Failure: A Prospective, Multicenter, Randomized Controlled Trial [Phase 1, Phase 2]
A multicenter, randomized Phase 1/2 trial evaluating EDN in combination with TACE/HAIC and a second-line immune-targeted therapy versus TACE…
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CLINICAL_TRIALS research · 2025-09-22Clinical Trial Update: Immunogenomic Dynamics and Biomarkers in Patients With Hepatocellular Carcinoma Receiving Immunotherapy
Clinical trial update exploring immunogenomic dynamics and biomarkers in hepatocellular carcinoma patients receiving immunotherapy. The stud…
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CLINICAL_TRIALS research · 2025-09-22Clinical Trial Update: Abbreviated Magnetic Resonance Imaging vs Ultrasound Surveillance for Liver Cancer dETection in People at High Risk of Developing Liver Cancer
A clinical trial update indicates recruitment is ongoing for a study comparing abbreviated MRI to ultrasound surveillance for detecting live…
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CLINICAL_TRIALS research · 2025-09-19Clinical Trial Update: A Phase I, First in Human Study of CBA-1205, Anti-DLK1 Monoclonal Antibody in Patients With Advanced Solid Tumors, Hepatocellular Carcinoma (HCC), Melanoma, and Pediatric Cancer [Phase 1]
Chiome Bioscience's CBA-1205, an anti-DLK1 monoclonal antibody, is in a Phase I first-in-human trial for advanced solid tumors including hep…
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CLINICAL_TRIALS research · 2025-09-19Clinical Trial Update: BI-1910 as a Single Agent and in Combination With Pembrolizumab for the Treatment of Advanced Solid Tumors [Phase 1, Phase 2]
Clinical trial update for BI-1910 as a single agent and in combination with pembrolizumab in advanced solid tumors, including non-small cell…
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CLINICAL_TRIALS research · 2025-09-19Clinical Trial Update: CT Volume Measurement of Hepatocellular Carcinoma
This document provides a clinical trial update on using CT-based volume measurement for hepatocellular carcinoma. The study is currently not…