Hepatitis C
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CLINICAL_TRIALS trial_result · 2018-12-31Clinical Trial Update: Evaluation of MK-1075 in Participants With Hepatitis C Virus (HCV) Infection (MK-1075-002) [Phase 1]
This publication reports results from a Phase 1 study evaluating MK-1075 in participants with hepatitis C virus infection.
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CLINICAL_TRIALS trial_result · 2018-12-28Clinical Trial Update: Efficacy and Safety of Ledipasvir/Sofosbuvir Fixed-Dose Combination in Participants With Chronic Genotype 1 HCV Infection [Phase 3]
Phase 3 trial update showing efficacy and safety of the ledipasvir/sofosbuvir fixed-dose combination in chronic genotype 1 hepatitis C infec…
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CLINICAL_TRIALS trial_result · 2018-12-26Clinical Trial Update: Efficacy and Safety of Uprifosbuvir (MK-3682) + Ruzasvir (MK-8408) in Treating Hepatitis C Virus Infection Genotypes 1-6 (MK-3682-041) [Phase 2]
Phase 2 trial evaluating Uprifosbuvir + Ruzasvir for hepatitis C genotypes 1-6; study terminated with results posted in 2018.
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CLINICAL_TRIALS trial_result · 2018-12-20Clinical Trial Update: Efficacy and Tolerability of Grazoprevir and Elbasvir in Patients With Chronic Genotype 1 HCV and HIV Co-infection [Phase 4]
A Phase 4 trial updated on the efficacy and tolerability of grazoprevir and elbasvir in patients with chronic hepatitis C and HIV co-infecti…
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CLINICAL_TRIALS trial_result · 2018-12-19Clinical Trial Update: Efficacy and Safety of All-Oral Combination of Narlaprevir/Ritonavir and Daclatasvir in Treatment-Naїve Patients With Chronic Hepatitis C Genotype 1b [Phase 2]
Phase 2 clinical trial evaluating an all-oral combination of Narlaprevir/Ritonavir and Daclatasvir for treatment-naïve patients with chronic…
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CLINICAL_TRIALS trial_result · 2018-12-11Clinical Trial Update: Portal-724 MEMS for Medication Adherence Patients Taking HCV Medications
Clinical trial update for Portal-724 MEMS aimed at improving adherence to hepatitis C medications; study completed with results posted in 20…
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CLINICAL_TRIALS trial_result · 2018-11-28Clinical Trial Update: Safety, Pharmacokinetics, and Pharmacodynamics of Ruzasvir (MK-8408) in Participants With Hepatitis C Infection (MK-8408-003) [Phase 1]
Phase 1 clinical trial update on safety, pharmacokinetics, and pharmacodynamics of ruzasvir (MK-8408) in participants with hepatitis C infec…
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CLINICAL_TRIALS trial_result · 2018-11-21Clinical Trial Update: A Study of Pharmacokinetics, Efficacy, Safety, Tolerability, of the Combination of Simeprevir (TMC435), Daclatasvir (BMS-790052), and Ribavirin (RBV) in Patients With Recurrent Chronic Hepatitis C Genotype 1b Infection After Orthotopic Liver Transplantation [Phase 2]
Phase 2 trial assessing pharmacokinetics, efficacy, safety, and tolerability of a combination therapy (simeprevir, daclatasvir, ribavirin) i…
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CLINICAL_TRIALS trial_result · 2018-11-16Clinical Trial Update: Treatment of Egyptian Hepatitis C Genotype 4 Infected Children and Adolescents With Combined Ledipasvir/Sofosbuvir [Phase 4]
Phase 4 study evaluating ledipasvir/sofosbuvir in children and adolescents with Hepatitis C Genotype 4.
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CLINICAL_TRIALS trial_result · 2018-11-13Clinical Trial Update: A Multiple-Dose Study to Evaluate MK-1075 in Hepatitis C Virus (HCV) Infected Participants (MK-1075-004) [Phase 1]
Phase 1 multiple-dose study assessing MK-1075 in participants infected with hepatitis C virus has completed with results posted.
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CLINICAL_TRIALS trial_result · 2018-11-05Clinical Trial Update: Increasing Cure Rate of Hepatitis C Therapy in Obese Hepatitis C Patients [NA]
Clinical trial update on hepatitis C therapy in obese patients; status terminated with results posted in 2018.
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CLINICAL_TRIALS trial_result · 2018-10-30Clinical Trial Update: Efficacy and Safety of Sofosbuvir/Velpatasvir Fixed-Dose Combination (FDC) and Sofosbuvir/Velpatasvir FDC and Ribavirin in Participants With Chronic Genotype 3 HCV Infection and Cirrhosis [Phase 2]
Phase 2 clinical trial evaluating the efficacy and safety of Sofosbuvir/Velpatasvir fixed-dose combination with and without Ribavirin in adu…
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CLINICAL_TRIALS trial_result · 2018-10-30Clinical Trial Update: Chronic Hepatitis C Treatment in Egyptian Children With Gaucher Disease. [Phase 4]
A Phase 4 clinical trial evaluating chronic hepatitis C treatment in Egyptian children with Gaucher disease is ongoing, with status currentl…
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CLINICAL_TRIALS trial_result · 2018-10-26Clinical Trial Update: Efficacy and Safety of MP-424, Interferon Beta (IFN Beta), and Ribavirin(RBV) in Treatment-Naïve or Having Received Interferon Based Therapy With Chronic Hepatitis C (CHC) [Phase 3]
Phase 3 trial evaluating the efficacy and safety of MP-424 combined with Interferon Beta and Ribavirin in treatment-naïve or interferon-expe…
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CLINICAL_TRIALS trial_result · 2018-10-25Clinical Trial Update: Effects of Harvoni in Patients With Decompensated Cirrhosis Due to Hepatitis C Genotype 1 Infection [Phase 3]
Phase 3 trial update evaluating Harvoni in patients with decompensated cirrhosis due to Hepatitis C genotype 1; study completed.
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CLINICAL_TRIALS trial_result · 2018-10-23Clinical Trial Update: A Study Evaluating Slow Response/Non-Rapid Response in Patients With Chronic Hepatitis C, Genotype 1, 2, 3 & 4 Treated With Pegasys (Peginterferon Alfa-2a) and Copegus (Ribavirin) [Phase 4]
Phase 4 trial assessing slow or non-rapid response in chronic hepatitis C patients treated with pegylated interferon alfa-2a and ribavirin; …
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CLINICAL_TRIALS trial_result · 2018-10-18Clinical Trial Update: A Study to Investigate HCV Response Rates in Real World Patients: HEARTLAND Study [Phase 4]
Phase 4 study update evaluating hepatitis C response rates in real-world patients.
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CLINICAL_TRIALS trial_result · 2018-10-17Clinical Trial Update: Real World Evidence of the Effectiveness of Paritaprevir/Ritonavir, Ombitasvir, ± Dasabuvir, ± Ribavirin in Patients With Chronic Hepatitis C
A real-world evidence study evaluating the effectiveness of Paritaprevir/Ritonavir, Ombitasvir, with or without Dasabuvir and Ribavirin in c…
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CLINICAL_TRIALS trial_result · 2018-10-12Clinical Trial Update: Evaluate the Efficacy and Safety of TG-2349 in Subjects With Hepatitis C Infection [Phase 2]
Phase 2 clinical trial evaluating the efficacy and safety of TG-2349 in adults with chronic hepatitis C has completed with posted results.
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CLINICAL_TRIALS trial_result · 2018-10-11Clinical Trial Update: Sofosbuvir/Ledipasvir for Hepatitis C Genotype 1-6 in Patients With Transfusion-Dependent Thalassemia: An Open Label Trial [Phase 4]
Phase 4 open-label trial assessing Sofosbuvir/Ledipasvir for Hepatitis C in patients with transfusion-dependent thalassemia has completed.
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CLINICAL_TRIALS trial_result · 2018-10-09Clinical Trial Update: Efficacy, Safety, and Tolerability of Ledipasvir/Sofosbuvir (LDV/SOF) Treatment for HIV/HCV Co-infected Participants Who Switch to Elvitegravir/Cobicistat/Emtricitabine/Tenofovir Alafenamide (E/C/F/TAF) or Emtricitabine/Rilpivirine/Tenofovir Alafenamide (F/R/TAF) Prior to LDV/SOF HCV Treatment [Phase 3]
Phase 3 trial update evaluating the efficacy, safety, and tolerability of LDV/SOF treatment for HIV/HCV co-infected participants who switch …
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CLINICAL_TRIALS trial_result · 2018-10-09Clinical Trial Update: ABT-450/Ritonavir/ ABT-267 (ABT-450/r/ABT-267) and ABT-333 Co-Administered With Ribavirin (RBV) in Treatment Naïve and Treatment Experienced Asian Adults With Genotype 1b Chronic Hepatitis C Virus (HCV) Infection and Compensated Cirrhosis [Phase 3]
Phase 3 trial update of ABT-450/r/ABT-267 plus ABT-333 with ribavirin in treatment-naïve and experienced Asian adults with genotype 1b chron…
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CLINICAL_TRIALS trial_result · 2018-09-27Clinical Trial Update: Evaluation of Unipeg® for Response and Ongoing Safety in Pakistani Population [Phase 4]
Phase 4 trial evaluating Unipeg® for response and ongoing safety in the Pakistani population with hepatitis C completed; results posted in 2…
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CLINICAL_TRIALS trial_result · 2018-09-21Clinical Trial Update: DAA-based Therapy for Recently Acquired Hepatitis C II (DAA = Directly Acting Antiviral) [Phase 4]
Phase 4 trial update on direct-acting antiviral therapy for recently acquired hepatitis C; study completed.
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CLINICAL_TRIALS trial_result · 2018-09-20Clinical Trial Update: Statins in Chronic Hepatitis C Patients Receiving Sofosbuvir/Daclatasvir Combination [Phase 2, Phase 3]
A study evaluating the safety and efficacy of statins in patients with chronic hepatitis C undergoing sofosbuvir/daclatasvir therapy, comple…