Hepatic Insufficiency
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CLINICAL_TRIALS trial_result · 2026-04-21Clinical Trial Update: Hepato Biliary Scintigraphy to Assess the Risk of Postoperative Liver Failure Hepatectomies [NA]
This entry reports the completion status of a clinical trial evaluating hepatobiliary scintigraphy to assess the risk of postoperative liver…
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CLINICAL_TRIALS research · 2026-03-20Clinical Trial Update: A Study of Eloralintide (LY3841136) in Participants With Different Levels of Liver Damage and in Participants With Healthy Livers. [Phase 1]
This is a Phase 1 clinical trial evaluating Eloralintide (LY3841136) in participants with varying levels of liver function, including health…
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CLINICAL_TRIALS trial_result · 2026-02-25Clinical Trial Update: A Study of Bomedemstat (MK-3543) in Participants With Mild or Moderate Hepatic Impairment (MK-3543-023) [Phase 1]
A Phase 1 study assessing the pharmacokinetics of Bomedemstat (MK-3543) in participants with mild or moderate hepatic impairment has complet…
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CLINICAL_TRIALS trial_result · 2025-11-28Clinical Trial Update: A Study to Test How BI 1015550 is Taken up in the Blood of People With and Without Liver Problems [Phase 1]
A Phase 1 pharmacokinetics study evaluating how BI 1015550 is absorbed into the bloodstream in people with and without hepatic impairment, w…
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CLINICAL_TRIALS trial_result · 2025-11-12Clinical Trial Update: A Study of Imlunestrant (LY3484356) in Female Participants With Impaired Liver Function [Phase 1]
Phase 1 study evaluating Imlunestrant (LY3484356) in female participants with hepatic insufficiency, with results posted after completion.
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CLINICAL_TRIALS trial_result · 2025-01-23Clinical Trial Update: Study to Determine the Pharmacokinetics on TPV/r in Subjects With Mild and Moderate Hepatic Insufficiency [Phase 1]
A Phase 1 pharmacokinetic study evaluating TPV/r (tipranavir/ritonavir) in subjects with mild to moderate hepatic impairment to assess how l…
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CLINICAL_TRIALS trial_result · 2025-01-09Clinical Trial Update: Study of Pirtobrutinib (LOXO-305) in Participants With Impaired Liver Function and Healthy Participants [Phase 1]
Phase 1 study of Pirtobrutinib in healthy participants and those with hepatic impairment completed, with results posted; the data inform pha…
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CLINICAL_TRIALS trial_result · 2025-01-07Clinical Trial Update: A Pharmacokinetic Study of Simufilam in Subjects With Impaired Hepatic Function [Phase 1]
A Phase 1 pharmacokinetic study evaluating simufilam in subjects with hepatic impairment has been completed.
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CLINICAL_TRIALS trial_result · 2024-11-12Clinical Trial Update: Clinical Trial of FCN-437c Capsule in Patients With Hepatic Insufficiency [Phase 1]
A Phase 1 trial of FCN-437c Capsule in patients with hepatic insufficiency has completed, according to the update from Ahon Pharmaceutical; …
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CLINICAL_TRIALS trial_result · 2024-08-02Clinical Trial Update: A Study to Investigate the Effect of Impaired Hepatic Function on the Pharmacokinetics of Entrectinib in Volunteers With Different Levels of Hepatic Function [Phase 1]
This Phase 1 study evaluated how hepatic impairment affects the pharmacokinetics of entrectinib in volunteers with varying liver function, a…
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CLINICAL_TRIALS trial_result · 2023-03-24Clinical Trial Update: A Study of Tirzepatide in Participants With Impaired Liver Function [Phase 1]
A Phase 1 trial evaluating tirzepatide in participants with impaired liver function has completed and posted results.
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CLINICAL_TRIALS trial_result · 2021-09-22Clinical Trial Update: A Study of LY2140023 in Hepatically-Impaired Participants [Phase 1]
Phase 1 trial update of LY2140023 in participants with hepatic impairment has completed with results posted.
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CLINICAL_TRIALS trial_result · 2019-11-13Clinical Trial Update: Single-Dose Pharmacokinetics of MK-3866 in Participants With Hepatic Impairment (MK-3866-006) [Phase 1]
Phase 1 pharmacokinetic study evaluating single-dose MK-3866 in participants with hepatic impairment; the trial is terminated with results p…
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CLINICAL_TRIALS trial_result · 2019-01-22Clinical Trial Update: A Study of Abemaciclib in Participants With Varying Degrees of Liver Impairment [Phase 1]
Phase 1 study evaluating abemaciclib in participants with varying degrees of liver impairment has completed; results posted in 2019.
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CLINICAL_TRIALS trial_result · 2018-10-19Clinical Trial Update: A Single Dose Study of LY2605541 in Participants With Liver Impairment [Phase 1]
Phase 1 single-dose study of LY2605541 in participants with hepatic impairment completed; results posted in 2018.
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CLINICAL_TRIALS trial_result · 2018-10-12Clinical Trial Update: A Study of Evacetrapib (LY2484595) in Participants With Hepatic (Liver) Impairment [Phase 1]
Phase 1 trial update assessing Evacetrapib in participants with hepatic impairment has completed and results posted.
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CLINICAL_TRIALS research · 2018-04-03Clinical Trial Update: Preoperative Glucose Infusion: a Novel Strategy to Improve Liver Function After Liver Resection [NA]
An update on a clinical trial evaluating preoperative glucose infusion as a strategy to improve liver function after liver resection.
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CLINICAL_TRIALS trial_result · 2018-01-24Clinical Trial Update: A Study To Describe The Effect Of Impaired Hepatic Function Of The Pharmacokinetics Of Palbociclib [Phase 1]
A Phase 1 study describing the effect of impaired hepatic function on the pharmacokinetics of palbociclib.
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CLINICAL_TRIALS trial_result · 2017-10-27Clinical Trial Update: Assessment of Pharmacokinetics of Single Dose Odanacatib (MK-0822) in Participants With Moderate Hepatic Insufficiency (MK-0822-070) [Phase 1]
Phase 1 pharmacokinetics study assessing single-dose exposure of odanacatib in participants with moderate hepatic insufficiency.
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CLINICAL_TRIALS trial_result · 2017-04-21Clinical Trial Update: A Pharmacokinetic Study of Baricitinib in Participants With Liver Disease [Phase 1]
This Phase 1 pharmacokinetic study evaluated how baricitinib behaves in participants with liver disease and hepatic impairment; results were…
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CLINICAL_TRIALS trial_result · 2016-11-18Clinical Trial Update: The Influence of Hepatic Insufficiency on the Pharmacokinetics of Elbasvir (MK-8742) (MK-8742-009) [Phase 1]
A Phase 1 trial assessing how hepatic insufficiency affects the pharmacokinetics of elbasvir (MK-8742).
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CLINICAL_TRIALS trial_result · 2016-06-15Clinical Trial Update: Prognostic Impact of Organ Damage in STEMI Patients
Completed study evaluating how organ damage during ST-elevation myocardial infarction affects prognosis, with emphasis on kidney and liver d…
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CLINICAL_TRIALS trial_result · 2014-10-16Clinical Trial Update: Pharmacokinetics, Safety and Tolerability of BIIL 284 BS in Patients With Hepatic Impairment in Comparison to Healthy Volunteers [Phase 1]
Phase 1 pharmacokinetics, safety and tolerability study of BIIL 284 BS in patients with hepatic insufficiency compared to healthy volunteers…
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CLINICAL_TRIALS trial_result · 2014-08-29Clinical Trial Update: Pharmacokinetics of Suvorexant in Participants With Hepatic Insufficiency (MK-4305-017) [Phase 1]
Phase 1 pharmacokinetics study of suvorexant in participants with hepatic insufficiency completed; assesses how liver impairment affects dru…
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CLINICAL_TRIALS trial_result · 2014-06-13Clinical Trial Update: Pharmacokinetics of Empagliflozin (BI 10773) in Patients With Impaired Liver Function [Phase 1]
A Phase 1 pharmacokinetic study examined empagliflozin in individuals with impaired liver function to assess how hepatic impairment affects …