Heart Failure
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS approval · 2013-11-27Clinical Trial Update: Clinical Evaluation of Cardiac Resynchronization Therapy (CRT) Using the Ovatio CRT Implantable Cardioverter-defibrillator (ICD) System
The Ovatio CRT Implantable Cardioverter-defibrillator System received marketing approval for use in congestive heart failure, according to t…
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CLINICAL_TRIALS trial_result · 2013-11-27Clinical Trial Update: Terminal Graft Failure
The clinical trial involving orthotopic heart transplantation and graft failure was terminated, ending the study.
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CLINICAL_TRIALS trial_result · 2013-11-15Clinical Trial Update: Study of Blood Concentrations and Physiologic Effects of Levosimendan Given During Heart Surgery [Phase 3]
Phase 3 trial of levosimendan given during heart surgery was terminated; the update discusses blood concentrations and physiologic effects i…
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CLINICAL_TRIALS trial_result · 2013-11-13Clinical Trial Update: 0.5M Na Lactate Solution in Acute Heart Failure (AHF) [Phase 2]
A Phase 2 trial evaluating 0.5 M sodium lactate solution in acute heart failure has completed. The update does not include results in the sn…
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CLINICAL_TRIALS trial_result · 2013-11-11Clinical Trial Update: Efficacy Study of Digoxin & Ivabradine to Treat Heart Failure [Phase 4]
A Phase 4 clinical trial evaluating the efficacy of digoxin and ivabradine for treating heart failure has completed.
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CLINICAL_TRIALS research · 2013-11-08Clinical Trial Update: Development and Prevention of Severe Heart Disease in Systemic Sclerosis
This clinical trial update outlines ongoing efforts to prevent and manage severe heart disease in systemic sclerosis, including cardiac bloc…
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CLINICAL_TRIALS research · 2013-11-08Clinical Trial Update: Validation of the "ApneaScan" Algorithm for the Detection of Sleep Disordered Breathing in Chronic Heart Failure
This entry reports a clinical trial validating the ApneaScan algorithm for detecting sleep-disordered breathing in patients with chronic hea…
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CLINICAL_TRIALS trial_result · 2013-11-07Clinical Trial Update: Sildenafil Impact on Ventricular Function in Patients With Heart Failure [Phase 2, Phase 3]
This clinical trial update reports completion of Phase 2 and Phase 3 studies evaluating sildenafil's effect on ventricular function in patie…
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CLINICAL_TRIALS trial_result · 2013-11-07Clinical Trial Update: Right Ventricular (RV) Pacing in Early Post-operative Continuous Flow Left Ventricular Assist Device (LVAD) [Phase 4]
Phase 4 trial evaluating right ventricular pacing early after LVAD implantation in patients with heart failure was terminated; results were …
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CLINICAL_TRIALS research · 2013-11-06Clinical Trial Update: Nutritional Evaluation of Patients With Congestive Heart Failure
This document reports a clinical trial investigating the nutritional evaluation of patients with congestive heart failure (NCT01977404).
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FDA label_change · 2013-11-05FDA Approved: ZESTRIL — Supplemental Application (Upsher-Smith Laboratories, LLC)
FDA approved a supplemental application for ZESTRIL (lisinopril) submitted by Upsher-Smith Laboratories, LLC.
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CLINICAL_TRIALS trial_result · 2013-11-05Clinical Trial Update: A Thyroid Hormone Analog to Fight Heart Failure: Phase II Trial (DITPA) [Phase 2]
Phase II study of DITPA, a thyroid hormone analog, for congestive heart failure has been terminated.
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CLINICAL_TRIALS trial_result · 2013-10-29Clinical Trial Update: Thoratec HeartMate II Left Ventricular Assist System (LVAS) for Destination Therapy [NA]
A completed clinical trial update for the Thoratec HeartMate II LVAD used for destination therapy in heart failure patients; results were po…
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FDA approval · 2013-10-29FDA Approved: LISINOPRIL — Original Application (Exelan Pharmaceuticals Inc.)
FDA approved Exelan Pharmaceuticals’ Original Application for lisinopril, a generic ACE inhibitor, marking the availability of a generic lis…
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CLINICAL_TRIALS trial_result · 2013-10-28Clinical Trial Update: Estimated Physical Activity of Congestive Heart Failure Patients by a Physical Activity Questionnaire [NA]
A completed clinical trial explored how well a physical activity questionnaire estimates activity levels in patients with congestive heart f…
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CLINICAL_TRIALS trial_result · 2013-10-21Clinical Trial Update: Comparison of a MAGNET Protocol Versus "off-on" Protocol for Patients With Implantable Cardioverter Defibrillators
A completed clinical trial comparing the MAGNET protocol to an off-on protocol in patients with implantable cardioverter-defibrillators.
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FDA approval · 2013-10-18FDA Approved: DIOVAN — Supplemental Application (Novartis Pharmaceuticals Corporation)
FDA approved a supplemental application for Diovan (valsartan) submitted by Novartis Pharmaceuticals Corporation.
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CLINICAL_TRIALS trial_result · 2013-10-10Clinical Trial Update: Traditional Chinese Medicine for Treatment of Chronic Heart Failure [Phase 2]
Phase 2 trial evaluating traditional Chinese medicine for chronic heart failure has completed.
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CLINICAL_TRIALS trial_result · 2013-10-10Clinical Trial Update: Six Months Efficacy and Safety of Aliskiren Therapy on Top of Standard Therapy, on Morbidity and Mortality in Patients With Acute Decompensated Heart Failure [Phase 3]
A Phase 3 trial tested six months of aliskiren added to standard therapy in patients with acute decompensated heart failure and reported on …
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CLINICAL_TRIALS withdrawal · 2013-10-10Clinical Trial Update: Nebulized Albuterol for Congestive Heart Failure Exacerbation [Phase 2, Phase 3]
A Phase 2/Phase 3 trial evaluating nebulized albuterol for congestive heart failure exacerbation has been withdrawn.
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CLINICAL_TRIALS trial_result · 2013-10-08Clinical Trial Update: Nesiritide in Chronic Heart Failure [Phase 2]
Phase 2 trial update for Nesiritide in chronic heart failure; the study was terminated.
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CLINICAL_TRIALS trial_result · 2013-09-27Clinical Trial Update: Jarvik 2000 Heart as a Bridge to Cardiac Transplantation - Pivotal Trial [Phase 2, Phase 3]
A pivotal Phase 2/3 trial evaluating the Jarvik 2000 Heart LVAD as a bridge to heart transplantation for heart failure has completed.
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FDA label_change · 2013-09-27FDA Approved: SAMSCA — Supplemental Application (Otsuka America Pharmaceutical, Inc.)
FDA supplemental application for SAMSCA (tolvaptan) submitted by Otsuka America Pharmaceutical, Inc., for a labeling change. The filing indi…
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CLINICAL_TRIALS trial_result · 2013-09-24Clinical Trial Update: Valsalva Manœuvre in the Diagnosis of Left Ventricular Failure in Chronic Obstructive Pulmonary Disease Exacerbation [NA]
Completed clinical trial update evaluating the use of the Valsalva maneuver to diagnose left ventricular failure during COPD exacerbation.
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CLINICAL_TRIALS research · 2013-09-23Clinical Trial Update: DECIDE-HF: Heart Rate Variability in Heart Failure Patients
A clinical trial update for DECIDE-HF evaluating heart rate variability in patients with heart failure; the current status is not disclosed.