Heart Failure
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CLINICAL_TRIALS research · 2026-04-07Clinical Trial Update: Prospective Multicentric Study Comparing the Acute Hemodynamic Effect of Three Modes of Stimulation in Cardiac Resynchronization Therapy Recipients [NA]
A multicenter prospective study evaluating three stimulation modes in cardiac resynchronization therapy recipients was terminated.
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CLINICAL_TRIALS research · 2026-04-07Clinical Trial Update: The Assessment of Partial Guideline-Directed Medical Therapy Down Titration in Heart Failure in Remission. [Phase 4]
This clinical trial update concerns a Phase 4 study examining down-titration of guideline-directed medical therapy in heart failure patients…
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CLINICAL_TRIALS research · 2026-04-07Clinical Trial Update: Pulmonary Artery Sensor System Pressure Monitoring to Improve Heart Failure (HF) Outcomes [NA]
This clinical trial update notes that a Pulmonary Artery Sensor System for pressure monitoring in heart failure is currently active but not …
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CLINICAL_TRIALS research · 2026-04-07Clinical Trial Update: Safety and Efficacy of Second Infusion of FAP iCDC in End-stage Dilated Cardiomyopathy [Phase 1]
A Phase 1 clinical trial evaluating a second infusion of FAP iCDC for end-stage dilated cardiomyopathy, currently not recruiting.
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CLINICAL_TRIALS research · 2026-04-07Clinical Trial Update: Multimodal Phenotyping In Patients Referred With Acute Cardiac faiLurE
A clinical trial at University Heart Center Freiburg - Bad Krozingen is studying multimodal phenotyping in patients referred for acute cardi…
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CLINICAL_TRIALS research · 2026-04-07Clinical Trial Update: A Research Study Looking Into How Ziltivekimab Works Compared to Placebo in Participants With Heart Failure and Inflammation [Phase 3]
Phase 3 clinical trial evaluating ziltivekimab versus placebo in participants with heart failure and systemic inflammation; the study is cur…
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CLINICAL_TRIALS research · 2026-04-06Clinical Trial Update: Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS)
Duke University-sponsored trial evaluating pharmacokinetics, pharmacodynamics, and safety of understudied drugs given to children as part of…
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CLINICAL_TRIALS research · 2026-04-06Clinical Trial Update: Sotagliflozin in Patients With Heart Failure Symptoms and Type 1 Diabetes [Phase 2]
A Phase 2 clinical trial evaluating sotagliflozin in patients with Type 1 diabetes mellitus and heart failure symptoms is currently recruiti…
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CLINICAL_TRIALS research · 2026-04-06Clinical Trial Update: Impact of Yoga on Cognitive Function [NA]
This entry reports an ongoing clinical trial evaluating the impact of yoga on cognitive function in individuals with heart failure and mild …
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CLINICAL_TRIALS research · 2026-04-06Clinical Trial Update: Randomized Clinical Trial to Improve Mobility After Hospitalization [NA]
Clinical trial update for an active-but-not-recruiting randomized study aiming to improve mobility after hospitalization, sponsored by the U…
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CLINICAL_TRIALS research · 2026-04-06Clinical Trial Update: Effect and Cost Effectiveness of a Dyadic Empowerment-based Heart Failure Management Program for Self-care [NA]
A clinical trial evaluating the effectiveness and cost-effectiveness of a dyadic, empowerment-based heart failure self-care management progr…
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CLINICAL_TRIALS research · 2026-04-03Clinical Trial Update: Efficacy and Safety of Human Induced Pluripotent Stem Cell-Derived Cardiomyocyte Injection (HiCM-188) in Advanced Heart Failure (NYHA Class III-IV) [Phase 3]
Update on an ongoing Phase 3 trial evaluating HiCM-188, an induced pluripotent stem cell-derived cardiomyocyte injection, for advanced heart…
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CLINICAL_TRIALS research · 2026-04-03Clinical Trial Update: Non-interventional Study on Guideline Directed Medical Therapy for Patients With Heart Failure (HF) in Germany
Non-interventional study in Germany evaluating guideline-directed medical therapy for patients with heart failure, sponsored by AstraZeneca …
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CLINICAL_TRIALS research · 2026-04-03Clinical Trial Update: Safety and Effectiveness of Left Bundle Branch Area Pacing Versus Conventional Cardiac Resynchronization Therapy in Heart Failure [NA]
A clinical trial is evaluating the safety and effectiveness of Left Bundle Branch Area Pacing versus conventional Cardiac Resynchronization …
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CLINICAL_TRIALS research · 2026-04-03Clinical Trial Update: Conduction System Pacing vs Biventricular Pacing in Systolic Dysfunction and Wide QRS: Mortality, Heart Failure Hospitalization or Cardiac Transplant [NA]
This clinical trial compares conduction system pacing to biventricular pacing in patients with systolic dysfunction and wide QRS. The study …
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CLINICAL_TRIALS research · 2026-04-03Clinical Trial Update: Phase III Study Investigating Heart Failure and Cardiovascular Death With Baxdrostat in Combination With Dapagliflozin [Phase 3]
A Phase 3 trial is evaluating Baxdrostat in combination with dapagliflozin for heart failure and cardiovascular death, and the study is curr…
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CLINICAL_TRIALS research · 2026-04-03Clinical Trial Update: Pulmonary Embolism in Patients With Acute Heart Failure (PEHF Study) [NA]
A clinical trial update for the PEHF Study evaluating pulmonary embolism in patients with acute heart failure; the trial status is not yet r…
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CLINICAL_TRIALS research · 2026-04-03Clinical Trial Update: CardioMEMS HF System Coverage With Evidence Development Study
The update indicates the CardioMEMS HF System Coverage With Evidence Development Study is currently recruiting for heart failure.
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CLINICAL_TRIALS research · 2026-04-02Clinical Trial Update: Safety and Efficacy of Low-dose Anticoagulation With Argatroban and Enoxaparin on ECMO [Phase 2]
Phase 2 clinical trial evaluating low-dose anticoagulation with Argatroban and Enoxaparin during ECMO for pneumonia or heart failure; the st…
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CLINICAL_TRIALS research · 2026-04-02Clinical Trial Update: Characterisation of phenotYpes in aCute Heart faiLure patiEnts
An ongoing study at Universitätsklinikum Hamburg-Eppendorf is characterising phenotypes in acute heart failure patients, including those wit…
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CLINICAL_TRIALS research · 2026-04-02Clinical Trial Update: Ultrastructural Characteristics of Mitochondria in Cardiomyocytes in Heart Failure
A clinical trial update from Tomsk National Research Medical Center is investigating ultrastructural characteristics of mitochondria in card…
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CLINICAL_TRIALS research · 2026-04-02Clinical Trial Update: European Study of the BrioVAD Heart Pump for Advanced Heart Failure [NA]
An upcoming European study of the BrioVAD Heart Pump for advanced heart failure is listed as NOT_YET_RECRUITING. The sponsor is BrioHealth B…
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CLINICAL_TRIALS research · 2026-04-01Clinical Trial Update: Paced Heart Rate Acceleration for Cardiac Conditioning [NA]
A new clinical trial is testing paced heart rate acceleration as a conditioning strategy for systolic heart failure and is currently recruit…
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CLINICAL_TRIALS research · 2026-04-01Clinical Trial Update: PACEVALUE: Development of a Risk Score to Predict Pacing-Induced Cardiomyopathy in Patients Undergoing Pacemaker or ICD Implantation and Evaluation of Patient Outcomes and Cost-Effectiveness Across Different Healthcare Systems
The PACEVALUE study is investigating a risk score to predict pacing-induced cardiomyopathy in patients with pacemakers or ICDs and evaluatin…
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CLINICAL_TRIALS research · 2026-04-01Clinical Trial Update: Investigation of the BrioVAD System for the Treatment of Left Ventricular Heart Failure [NA]
A clinical trial evaluating the BrioVAD System for left ventricular heart failure is currently in the recruiting phase.