Heart Failure with Reduced Ejection Fraction
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CLINICAL_TRIALS research · 2025-09-04Clinical Trial Update: A Multicenter Pragmatic Implementation Study of ECG-AI-Based Clinical Decision Support Software to Identify Low LVEF [NA]
Terminated multicenter pragmatic study evaluating an ECG-AI-based clinical decision support software to identify low left ventricular ejecti…
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CLINICAL_TRIALS trial_result · 2025-09-04Clinical Trial Update: Effects of 2-week Ketosis on the Heart's Ketone Body Consumption, Utilization, and Energetic Efficiency in Patients With Chronic Heart Failure [NA]
This completed clinical trial evaluated whether two weeks of ketosis influences heart ketone uptake, utilization, and energetic efficiency i…
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CLINICAL_TRIALS research · 2025-08-22Clinical Trial Update: Study of JK07 in Patients With Chronic Heart Failure [Phase 2]
Phase 2 study update for JK07 in chronic heart failure; the trial (NCT06369298) is currently recruiting in patients with heart failure with …
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CLINICAL_TRIALS withdrawal · 2025-08-17Clinical Trial Update: Evaluation of the HekaHeart Platform in Medication Management for Heart Failure Patients
This clinical trial registry entry indicates that Yale University's study evaluating the HekaHeart Platform for medication management in hea…
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CLINICAL_TRIALS research · 2025-08-13Clinical Trial Update: Developing a Digital Aid to Improve ICD Decisions [NA]
A Stanford-sponsored clinical trial update describes developing a digital decision aid to guide implantable cardioverter-defibrillator use i…
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CLINICAL_TRIALS other · 2025-08-12Clinical Trial Update: Resistance Exercise With Blood Flow Restriction by Vascular Occlusion on Myocardial Function in Heart Failure With Reduced Ejection Fraction [NA]
This update describes a clinical trial investigating resistance exercise with blood flow restriction by vascular occlusion to assess its eff…
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CLINICAL_TRIALS withdrawal · 2025-08-11Clinical Trial Update: Evaluation of Left Bundle Branch Area Pacing As A Rescue Strategy for Cardiac Resynchronization Therapy Non-Response [NA]
A clinical trial evaluating left bundle branch area pacing as a rescue strategy for patients with heart failure who do not respond to cardia…
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CLINICAL_TRIALS research · 2025-08-08Clinical Trial Update: Flow Regulation by Opening the SepTum in Patients With Heart Failure; a Prospective, Randomized, Sham-controlled, Double-blind, Global Multicenter Study [NA]
A prospective randomized, sham-controlled global trial sponsored by Occlutech International AB is evaluating flow regulation by opening the …
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CLINICAL_TRIALS trial_result · 2025-08-07Clinical Trial Update: Hemodynamic-GUIDEd Management of Heart Failure [NA]
Abbott Medical Devices completed a trial on hemodynamic-guided management of heart failure; results were posted on 2025-08-07.
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CLINICAL_TRIALS trial_result · 2025-08-07Clinical Trial Update: Improving CRT Outcome With Non-Invasive Cardiac Mapping [NA]
This clinical trial update describes ongoing evaluation of non-invasive cardiac mapping to improve outcomes in cardiac resynchronization the…
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CLINICAL_TRIALS trial_result · 2025-08-06Clinical Trial Update: Exercise and NO in HFrEF [EARLY_Phase 1]
This is an update on a completed EARLY_PHASE1 clinical trial examining exercise and nitric oxide in patients with heart failure with reduced…
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CLINICAL_TRIALS research · 2025-08-05Clinical Trial Update: Vietnamese Rapid Acceleration Protocol for Intensifying Drug Therapy in Heart Failure With Reduced Ejection Fraction [NA]
This clinical trial update describes a Vietnamese Rapid Acceleration Protocol aimed at intensifying drug therapy in acute heart failure with…
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CLINICAL_TRIALS trial_result · 2025-08-03Clinical Trial Update: Effect of Dietary Nitrate Ingestion in Heart Failure [Phase 2]
The Phase 2 dietary nitrate trial in heart failure was terminated; the update does not include trial results.
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CLINICAL_TRIALS research · 2025-07-31Clinical Trial Update: Assessment of Combined CCM and ICD Device in HFrEF [NA]
A clinical trial update for a combined cardiac contractility modulation (CCM) and implantable defibrillator (ICD) device in heart failure wi…
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CLINICAL_TRIALS research · 2025-07-30Clinical Trial Update: Telemonitoring to Optimize Medication Titration for Heart Failure: a Feasibility Study [NA]
This document reports a feasibility study from the Chinese University of Hong Kong evaluating telemonitoring to optimize medication titratio…
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CLINICAL_TRIALS research · 2025-07-28Clinical Trial Update: Deep Learning Detection of Pulmonary Hypertension and Low Ejection Fraction Via Digital Stethoscope and 3-Lead ECG
A clinical trial by Eko Devices is evaluating deep learning detection of pulmonary hypertension and reduced ejection fraction using a digita…
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CLINICAL_TRIALS trial_result · 2025-07-25Clinical Trial Update: Cryoballoon Ablation Versus Medical Therapy in Patients With Heart Failure and Atrial Fibrillation [NA]
The Maastricht University trial evaluating cryoballoon ablation versus medical therapy in patients with atrial fibrillation and heart failur…
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CLINICAL_TRIALS trial_result · 2025-07-23Clinical Trial Update: Virtual Care to Improve Heart Failure Outcomes (VITAL-HF) [NA]
Clinical trial VITAL-HF completed evaluating virtual care to improve outcomes in heart failure with reduced ejection fraction.
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CLINICAL_TRIALS research · 2025-07-22Clinical Trial Update: Respiratory Sinus Arrhythmia Pacing Post-CABG Surgery in Patients With HFrEF [NA]
Clinical trial update on respiratory sinus arrhythmia pacing for patients with heart failure with reduced ejection fraction undergoing CABG …
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CLINICAL_TRIALS research · 2025-07-17Clinical Trial Update: The Left Bundle Cardiac Resynchronization Therapy Trial [NA]
Clinical trial status update for The Left Bundle Cardiac Resynchronization Therapy Trial shows the study is active but not recruiting.
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FDA approval · 2025-07-16FDA Approved: SACUBITRIL AND VALSARTAN — Original Application (Novadoz Pharmaceuticals LLC)
FDA approved the original application (ANDA213748) for a generic sacubitril/valsartan combination from Novadoz Pharmaceuticals LLC.
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CLINICAL_TRIALS research · 2025-07-10Clinical Trial Update: Conduction System Pacing vs Biventricular Resynchronization Therapy in Systolic Dysfunction and Wide QRS: CONSYST-CRT. [NA]
The CONSYST-CRT trial comparing conduction system pacing versus biventricular resynchronization therapy in patients with systolic dysfunctio…
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CLINICAL_TRIALS trial_result · 2025-07-09Clinical Trial Update: Study to Assess Efficacy and Safety of SZC for the Management of High Potassium in Patients With Symptomatic HFrEF Receiving Spironolactone [Phase 4]
Phase 4 study update shows completion and posted results for the efficacy and safety of Sodium Zirconium Cyclosilicate (SZC) in managing hyp…
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CLINICAL_TRIALS trial_result · 2025-07-09Clinical Trial Update: Study of JK07 in Subjects With Heart Failure With Reduced Ejection Fraction (HFrEF) [Phase 1]
A Phase 1 trial of JK07 in heart failure with reduced ejection fraction has completed enrollment and posted results.
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CLINICAL_TRIALS research · 2025-07-08Clinical Trial Update: IRONICA: IRON Repletion In Heart Failure - A Comparison of Oral and IV Approaches [Phase 4]
This Phase 4 trial update outlines IRONICA, a study comparing oral and IV iron repletion in patients with heart failure and iron deficiency/…