Heart Failure with Reduced Ejection Fraction
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CLINICAL_TRIALS trial_result · 2016-10-27Clinical Trial Update: Prognostic Impact of Noncardiac Comorbidities in Heart Failure Patients
This completed clinical trial evaluates the prognostic impact of noncardiac comorbidities on patients with both diastolic (HFpEF) and systol…
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CLINICAL_TRIALS research · 2016-09-14Clinical Trial Update: Blind Assessment of the Concordance Between the Administered Treatment and the Recommendations of a Medical Algorithm Decision Support Software in Systolic Heart Failure
Clinical trial update describing a blinded assessment of the concordance between administered treatment and the recommendations of a medical…
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CLINICAL_TRIALS trial_result · 2016-02-17Clinical Trial Update: Identifying an Ideal Cardiopulmonary Exercise Test Parameter
Completed Imperial College London trial to identify an ideal cardiopulmonary exercise test parameter in patients with heart failure with red…
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CLINICAL_TRIALS trial_result · 2015-12-03Clinical Trial Update: Pacemaker Upgrade to Cardiac Resynchronisation Therapy in Patients With Left Ventricular Dysfunction Dependant Upon Right Ventricular Pacing [NA]
The study reports completion of a trial evaluating upgrading from a standard pacemaker to cardiac resynchronization therapy in patients with…
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CLINICAL_TRIALS trial_result · 2015-12-03Clinical Trial Update: Atrial Fibrillation Ablation Compared to Rate Control Strategy in Patients With Impaired Left Ventricular Function [Phase 4]
This is a Phase 4 clinical trial update comparing atrial fibrillation ablation with a rate-control strategy in patients with persistent atri…
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CLINICAL_TRIALS trial_result · 2015-10-15Clinical Trial Update: Safety and Tolerability of Initiating LCZ696 in Heart Failure Patients [Phase 2]
A Phase 2 trial assessing the safety and tolerability of initiating LCZ696 (sacubitril/valsartan) in patients with heart failure with reduce…
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CLINICAL_TRIALS trial_result · 2015-10-12Clinical Trial Update: Improving Heart Failure Care in Minority Communities [NA]
This clinical trial update notes the completion of a study aimed at improving heart failure care in minority communities.
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CLINICAL_TRIALS trial_result · 2015-10-07Clinical Trial Update: Benefits of CTO-PCI in Selected Cases With HFrEF (CTOHFrEF) [NA]
Completed clinical trial evaluating the benefits of CTO-PCI in selected patients with heart failure with reduced ejection fraction.
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CLINICAL_TRIALS trial_result · 2015-10-07Clinical Trial Update: Association of PICP Serum Marker in Patients With LVSD
The clinical trial examining the association of the PICP serum marker in patients with left ventricular systolic dysfunction was terminated.
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CLINICAL_TRIALS trial_result · 2015-09-07Clinical Trial Update: This Study Will Evaluate the Efficacy and Safety of LCZ696 Compared to Enalapril on Morbidity and Mortality of Patients With Chronic Heart Failure [Phase 3]
Phase 3 study comparing LCZ696 (sacubitril/valsartan) with Enalapril in chronic heart failure with reduced ejection fraction was terminated;…
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FDA approval · 2015-07-07FDA Approved: ENTRESTO — Original Application (Novartis Pharmaceuticals Corporation)
FDA approves ENTRESTO (sacubitril/valsartan) under an original application from Novartis. The drug is indicated for treatment of heart failu…
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CLINICAL_TRIALS trial_result · 2015-06-25Clinical Trial Update: The BEAUTIFUL Study: Effects of Ivabradine in Patients With Stable Coronary Artery Disease and Left Ventricular Systolic Dysfunction [Phase 3]
This entry reports the completion and posting of results for the Phase 3 BEAUTIFUL study evaluating ivabradine in patients with stable coron…
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FDA approval · 2015-04-15FDA Approved: CORLANOR — Original Application (Amgen Inc)
FDA approves CORLANOR (ivabradine) from Amgen in its original NDA for chronic heart failure with reduced ejection fraction in adults. In add…
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CLINICAL_TRIALS trial_result · 2015-01-21Clinical Trial Update: Optimal Coronary Sinus Lead Implantation Using Intracardiac Impedography and Magnetic Resonance Imaging [NA]
This clinical trial update reports on a completed study evaluating optimal coronary sinus lead implantation using intracardiac impedography …
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CLINICAL_TRIALS research · 2014-12-03Clinical Trial Update: Reasons for Variations in Health Related Quality of Life and Symptom Burden in Patients With Atrial Fibrillation
This clinical trial update discusses the factors contributing to variations in health-related quality of life and symptom burden among patie…
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CLINICAL_TRIALS trial_result · 2014-08-22Clinical Trial Update: Effect of Nitrate-rich Beetroot Juice on Exercise Performance in Heart Failure Patients [NA]
A completed clinical trial evaluated whether nitrate-rich beetroot juice improves exercise performance in patients with systolic heart failu…
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CLINICAL_TRIALS trial_result · 2014-02-14Clinical Trial Update: A Prospective, Open-labeled, Multi-centric Trial in Subjects With Systolic Heart Failure to Evaluate Bisoprolol Treatment for the Effects on Surrogate Markers of Heart Failure in Korea [Phase 4]
A prospective open-label Phase 4 trial in Korea assessed bisoprolol's effects on surrogate markers of heart failure in patients with systoli…
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CLINICAL_TRIALS research · 2014-01-27Clinical Trial Update: Digoxin Versus Ivabradine in Heart Failure With Reduced Ejection Fraction [Phase 4]
A Phase 4 clinical trial update comparing digoxin with ivabradine in heart failure with reduced ejection fraction; the current status is unk…
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CLINICAL_TRIALS trial_result · 2013-12-25Clinical Trial Update: A Study to Test the Effects of Riociguat in Patients With Pulmonary Hypertension Associated With Left Ventricular Systolic Dysfunction [Phase 2]
A Phase 2 trial evaluating riociguat for pulmonary hypertension associated with left ventricular systolic dysfunction has completed, with re…
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CLINICAL_TRIALS research · 2013-12-23Clinical Trial Update: Predictives Factors of Cardiac Resynchronization Therapy: a Multimodal Analysis Using 2D Speckle Tracking Echocardiography Coupled With MIBG Myocardial Scintigraphy and Heart Failure Biomarkers
A clinical trial evaluating predictive factors for response to cardiac resynchronization therapy using multimodal imaging (2D speckle tracki…
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CLINICAL_TRIALS trial_result · 2013-08-14Clinical Trial Update: EP-Catheter Guided CS-Lead Implantation
Update on a completed clinical trial evaluating EP-Catheter Guided CS-Lead implantation in patients with heart failure with reduced ejection…
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CLINICAL_TRIALS trial_result · 2013-05-14Clinical Trial Update: Warfarin Versus Aspirin in Reduced Cardiac Ejection Fraction (WARCEF) Trial [Phase 3]
Phase 3 WARCEF trial comparing warfarin with aspirin in patients with reduced left ventricular ejection fraction found no significant reduct…
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CLINICAL_TRIALS trial_result · 2013-03-01Clinical Trial Update: Effect of Post Discharge Follow-up on Readmission Rates for Congestive Heart Failure Patients
This completed clinical trial assessed whether enhanced post-discharge follow-up reduces hospital readmission rates for patients with conges…
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FDA approval · 2012-06-22FDA Approved: EPLERENONE — Supplemental Application (Mylan Pharmaceuticals Inc.)
The FDA approved a supplemental application for eplerenone filed by Mylan Pharmaceuticals Inc. This action updates regulatory aspects of the…
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CLINICAL_TRIALS trial_result · 2011-05-20Clinical Trial Update: DMP115 in Patients With an Ejection Fraction Between 25%-40% to Evaluate the Use of Contrast Echocardiography to Assess Heart Function [Phase 4]
A Phase 4 clinical trial evaluating DMP115 as a contrast echocardiography agent to assess heart function in patients with reduced ejection f…