Heart Failure with Reduced Ejection Fraction
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CLINICAL_TRIALS trial_result · 2021-02-16Clinical Trial Update: Prospective Comparison of Metolazone Versus Chlorothiazide for Acute Decompensated Heart Failure With Diuretic Resistance [Phase 4]
Phase 4 trial comparing metolazone to chlorothiazide for acute decompensated heart failure with diuretic resistance; study terminated.
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CLINICAL_TRIALS trial_result · 2021-01-26Clinical Trial Update: An Investigational Study of Continuous 8-Hour Intravenous Administrations of BMS-986231 in Participants With Heart Failure and Reduced Heart Function Given a Standard Dose of Loop Diuretic [Phase 2]
Phase 2 trial update for continuous 8-hour IV administration of BMS-986231 in heart failure patients on loop diuretics; study completed with…
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CLINICAL_TRIALS trial_result · 2021-01-08Clinical Trial Update: Understanding Outcomes With the EMBLEM™ S-ICD in Primary Prevention Patients With Low Ejection Fraction [NA]
Boston Scientific's EMBLEM S-ICD was studied for primary prevention in patients with low ejection fraction, and the trial results were poste…
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CLINICAL_TRIALS trial_result · 2020-11-13Clinical Trial Update: Effects of Furosemide Plus Small HSS in Subjects With Heart Failure With Reduced Ejection Fraction (HFrEF) [Phase 3]
Phase 3 clinical trial update evaluating the effects of furosemide plus small HSS in subjects with heart failure with reduced ejection fract…
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CLINICAL_TRIALS trial_result · 2020-11-04Clinical Trial Update: Differential Vascular and Endocrine Effects of Valsartan/Sacubitril in Heart Failure With Reduced Ejection Fraction [Phase 4]
Phase 4 trial update analyzing differential vascular and endocrine effects of valsartan/sacubitril in heart failure with reduced ejection fr…
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CLINICAL_TRIALS trial_result · 2020-10-22Clinical Trial Update: This Study Tests Empagliflozin in Patients With Chronic Heart Failure With Reduced Ejection Fraction (HFrEF). The Study Looks at How Far Patients Can Walk in 6 Minutes and at Their Heart Failure Symptoms [Phase 3]
Phase 3 trial evaluating empagliflozin in chronic heart failure with reduced ejection fraction, assessing 6-minute walk distance and HF symp…
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CLINICAL_TRIALS trial_result · 2020-10-19Clinical Trial Update: Beta 3 Agonist Treatment in Heart Failure [Phase 2]
Phase 2 clinical trial update for a beta-3 agonist in chronic heart failure with reduced ejection fraction (HFrEF) completed.
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CLINICAL_TRIALS trial_result · 2020-10-09Clinical Trial Update: Exercise Capacity Study of LCZ696 vs. Enalapril in Patients With Chronic Heart Failure and Reduced Ejection Fraction. [Phase 4]
Phase 4 trial comparing LCZ696 (sacubitril/valsartan) to enalapril in chronic heart failure with reduced ejection fraction has completed wit…
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CLINICAL_TRIALS trial_result · 2020-09-30Clinical Trial Update: Dapagliflozin And Pulmonary Artery Hemodynamics in Heart Failure With Reduced Ejection Fraction Patients With CardioMEMS® [Phase 4]
Phase 4 trial update on dapagliflozin for heart failure with reduced ejection fraction evaluating pulmonary artery hemodynamics in patients …
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CLINICAL_TRIALS trial_result · 2020-09-01Clinical Trial Update: Study to Evaluate the Effect of Dapagliflozin on the Incidence of Worsening Heart Failure or Cardiovascular Death in Patients With Chronic Heart Failure [Phase 3]
Phase 3 trial evaluating dapagliflozin for reducing worsening heart failure or cardiovascular death in chronic heart failure with reduced ej…
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CLINICAL_TRIALS trial_result · 2020-08-05Clinical Trial Update: Safety of HMA-CD20 in Patients With HFrEF [Phase 2]
Phase 2 trial update assessing safety of HMA-CD20 in patients with heart failure with reduced ejection fraction.
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CLINICAL_TRIALS trial_result · 2020-06-29Clinical Trial Update: A Study of Vericiguat in Participants With Heart Failure With Reduced Ejection Fraction (HFrEF) (MK-1242-001) [Phase 3]
Phase 3 trial of vericiguat in participants with heart failure with reduced ejection fraction (HFrEF) has completed and results were posted.
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CLINICAL_TRIALS trial_result · 2020-04-22Clinical Trial Update: Effect of Elamipretide on Left Ventricular Function in Subjects With Stable Heart Failure With Reduced Ejection Fraction [Phase 2]
Phase 2 trial investigating elamipretide to improve left ventricular function in adults with heart failure with reduced ejection fraction ha…
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CLINICAL_TRIALS trial_result · 2020-03-19Clinical Trial Update: Study of Effects of Sacubitril/Valsartan vs. Enalapril on Aortic Stiffness in Patients With Mild to Moderate HF With Reduced Ejection Fraction [Phase 4]
Phase 4 clinical trial comparing sacubitril/valsartan to enalapril examines effects on aortic stiffness in patients with heart failure with …
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CLINICAL_TRIALS trial_result · 2020-03-13Clinical Trial Update: Efficacy of Ivabradine in Patient With Both Persistent Atrial Fibrillation and Heart Failure With Reduce Ejection Fraction [Phase 3]
A Phase 3 clinical trial update evaluating the efficacy of ivabradine in patients with persistent atrial fibrillation and heart failure with…
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CLINICAL_TRIALS trial_result · 2020-03-11Clinical Trial Update: Value of SGLT2 Inhibitor (Dapagliflozin) as an Added Therapy in Diabetic Patients With Heart Failure With Reduced Ejection Fraction; Randomized Controlled Clinical Trial [Phase 2]
Phase 2 randomized trial evaluating add-on dapagliflozin for patients with type 2 diabetes and heart failure with reduced ejection fraction …
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CLINICAL_TRIALS trial_result · 2020-02-05Clinical Trial Update: Empagliflozin in Heart Failure Patients With Reduced Ejection Fraction [Phase 2]
Phase 2 clinical trial update for empagliflozin in patients with heart failure with reduced ejection fraction has completed enrollment/statu…
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CLINICAL_TRIALS trial_result · 2020-01-31Clinical Trial Update: Safety, PK, and Efficacy of Omecamtiv Mecarbil in Japanese Subjects With Heart Failure With Reduced Ejection Fraction [Phase 2]
Phase 2 study evaluating safety, pharmacokinetics, and efficacy of omecamtiv mecarbil in Japanese patients with heart failure with reduced e…
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CLINICAL_TRIALS trial_result · 2019-09-16Clinical Trial Update: randOmized stUdy Using acceleromeTry to Compare Sacubitril/valsarTan and Enalapril in Patients With Heart Failure [Phase 3]
A Phase 3 randomized trial comparing sacubitril/valsartan vs enalapril in chronic heart failure with reduced ejection fraction has completed…
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CLINICAL_TRIALS trial_result · 2019-08-29Clinical Trial Update: Pharmacodynamic Effects of Sacubitril/Valsartan on Natriuretic Peptides, Angiotensin and Neprilysin [Phase 4]
Phase 4 trial update evaluating pharmacodynamic effects of sacubitril/valsartan on natriuretic peptides, angiotensin, and neprilysin in hear…
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CLINICAL_TRIALS trial_result · 2019-06-07Clinical Trial Update: Description of Tolerability of LCZ696 (Sacubitril / Valsartan) in Heart Failure With Reduced Ejection Fraction (HFrEF) Treated in Real Life Setting [Phase 4]
Phase 4 trial update describing tolerability of LCZ696 (sacubitril/valsartan) in real-world heart failure with reduced ejection fraction pat…
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CLINICAL_TRIALS trial_result · 2019-04-23Clinical Trial Update: A Trial to Study Neladenoson Bialanate Over 20 Weeks in Patients With Chronic Heart Failure With Reduced Ejection Fraction [Phase 2]
Phase 2 trial evaluating neladenoson bialanate in chronic heart failure with reduced ejection fraction has completed; results posted in 2019…
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CLINICAL_TRIALS trial_result · 2019-04-08Clinical Trial Update: Study on the Effects of Sacubitril/Valsartan on Physical Activity and Sleep in Heart Failure With Reduced Ejection Fraction Patients. [Phase 4]
Phase 4 trial assessing the effects of sacubitril/valsartan on physical activity and sleep in patients with heart failure with reduced eject…
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CLINICAL_TRIALS trial_result · 2019-03-28Clinical Trial Update: Effect of Melatonin on Cardiovascular and Muscle Mass and Function in Patients With Heart Failure [Phase 2]
Phase 2 clinical trial investigating the effect of melatonin on cardiovascular outcomes and muscle mass/function in patients with heart fail…
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CLINICAL_TRIALS trial_result · 2019-02-20Clinical Trial Update: Safety and Tolerability During Open-label Treatment With LCZ696 in Patients With CHF and Reduced Ejection Fraction [Phase 3]
Phase 3 open-label trial evaluating safety and tolerability of LCZ696 (sacubitril/valsartan) in patients with heart failure with reduced eje…