Heart Failure with Reduced Ejection Fraction
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CLINICAL_TRIALS trial_result · 2024-11-04Clinical Trial Update: Heart Failure Therapy and Outcomes in Patients With Heart Failure With Mildly Reduced or Preserved Ejection Fraction
Novartis reports completion of a clinical trial evaluating heart failure therapy and patient outcomes in individuals with mildly reduced or …
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CLINICAL_TRIALS trial_result · 2024-10-18Clinical Trial Update: Uncertainty in HFrEF Patients
A completed clinical trial (NCT05632198) investigating heart failure with reduced ejection fraction has finished; the report notes uncertain…
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CLINICAL_TRIALS trial_result · 2024-10-17Clinical Trial Update: Effective Study of ARNI on Ventricular Arrhythmia in HFrEF Patients With ICD or CRT-D (RHYTHM) [Phase 4]
A Phase 4 trial evaluating the effect of sacubitril/valsartan (an ARNI) on ventricular arrhythmias in patients with heart failure and reduce…
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CLINICAL_TRIALS trial_result · 2024-10-09Clinical Trial Update: Benefits of Empagliflozin in Patients With Heart Failure and Reduced Ejection Fraction Without Diabetes Mellitus [Phase 4]
Phase 4 clinical trial evaluating empagliflozin in patients with heart failure with reduced ejection fraction who do not have diabetes has c…
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CLINICAL_TRIALS trial_result · 2024-10-09Clinical Trial Update: Building Electronic Tools To Enhance and Reinforce CArdiovascular REcommendations - Heart Failure (BETTER CARE-HF) [NA]
This trial update notes the completed BETTER CARE-HF study and that results have been posted, focusing on electronic tools to reinforce card…
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CLINICAL_TRIALS trial_result · 2024-10-08Clinical Trial Update: A Study to Learn How Well the Drug Vericiguat Works and How Safe it is Under Real World Conditions in Indian Participants After Worsening of a Long-term Heart Condition in Which the Left Side of the Heart Does Not Pump Blood as Well as it Should (Chronic Heart Failure With Reduced Ejection Fraction) [Phase 4]
Phase 4 real-world study to evaluate the effectiveness and safety of vericiguat in Indian participants with chronic heart failure with reduc…
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CLINICAL_TRIALS trial_result · 2024-10-08Clinical Trial Update: Oxygen Therapy in Patients With Chronic Heart Failure With Reduced Ejection Fraction [NA]
Clinical trial update indicating termination of a study evaluating oxygen therapy in patients with heart failure with reduced ejection fract…
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CLINICAL_TRIALS trial_result · 2024-08-23Clinical Trial Update: Pragmatic Trial Of Alerts for Use of Mineralocorticoid Receptor Antagonists [NA]
A pragmatic trial evaluating alerts for the use of mineralocorticoid receptor antagonists in patients with heart failure with reduced ejecti…
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CLINICAL_TRIALS trial_result · 2024-08-01Clinical Trial Update: Strategy, Efficacy and Safety of Medication Usage in Heart Failure Patients Who Were Intolerable to GDMT
This completed clinical trial evaluates strategies for medication use in patients with heart failure with reduced ejection fraction who are …
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CLINICAL_TRIALS trial_result · 2024-07-05Clinical Trial Update: Left Bundle Branch Area Pacing in Patients With Heart Failure [NA]
The document reports the status of an ongoing clinical trial evaluating left bundle branch area pacing in patients with heart failure with r…
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CLINICAL_TRIALS trial_result · 2024-07-03Clinical Trial Update: An Observational Study to Learn More About Vericiguat Treatment Patterns and Its Safety in People With Chronic Heart Failure With Reduced Ejection Fraction in Routine Medical Care in the United States
This completed observational study evaluates real-world use and safety of vericiguat in US patients with chronic heart failure with reduced …
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CLINICAL_TRIALS trial_result · 2024-07-01Clinical Trial Update: The Effect of Oxygen Supplementation in Training in Heart Failure Patients on Aerobic Performance and Quality of Life [NA]
A completed clinical trial evaluating whether oxygen supplementation during training improves aerobic performance and quality of life in pat…
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CLINICAL_TRIALS trial_result · 2024-06-27Clinical Trial Update: Precision of AI-Based Cardiac Ultrasound for LVEF in the Elderly
A completed clinical trial evaluating the precision of an AI-based ultrasound method for measuring left ventricular ejection fraction in eld…
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CLINICAL_TRIALS trial_result · 2024-05-30Clinical Trial Update: A Study of LY3461767 in Participants With Chronic Heart Failure With Reduced Ejection Fraction [Phase 1]
Phase 1 trial of LY3461767 in patients with heart failure with reduced ejection fraction has completed.
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CLINICAL_TRIALS trial_result · 2024-05-03Clinical Trial Update: Effects of a Single Oral Dose of KETone Ester ON Exercise Performance in Patients With Chronic Heart Failure [NA]
A completed clinical trial evaluated whether a single oral dose of a ketone ester affects exercise performance in patients with chronic hear…
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CLINICAL_TRIALS trial_result · 2024-04-30Clinical Trial Update: SGLT2 Inhibitors and Treatment of Heart Failure in Severe Renal Insufficiency [Phase 4]
A Phase 4 trial evaluating SGLT2 inhibitors for heart failure with reduced ejection fraction in patients with chronic kidney disease has bee…
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CLINICAL_TRIALS trial_result · 2024-02-28Clinical Trial Update: Clinical Outcomes of Dapagliflozin in Acute Heart Failure With Reduced Ejection Fraction (CODA-HFrEF) [Phase 4]
Phase 4 trial update on dapagliflozin in acute heart failure with reduced ejection fraction assessing clinical outcomes.
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CLINICAL_TRIALS trial_result · 2024-01-18Clinical Trial Update: Determination of Drug Levels for Pharmacotherapy of Heart Failure [Phase 4]
A Phase 4 trial update focusing on determining drug levels for pharmacotherapy in heart failure with reduced ejection fraction.
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CLINICAL_TRIALS trial_result · 2023-12-20Clinical Trial Update: Pulse Reduction On Beta-blocker and Ivabradine Therapy [Phase 4]
A Phase 4 clinical trial update evaluating pulse reduction on beta-blocker and ivabradine therapy in patients with dilated cardiomyopathy an…
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CLINICAL_TRIALS trial_result · 2023-12-12Clinical Trial Update: Effect of Dapagliflozin on Submaximal Exercise Tolerance in Heart Failure [Phase 2]
Phase 2 trial assessing dapagliflozin effect on submaximal exercise tolerance in heart failure with reduced ejection fraction (HFrEF) has co…
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CLINICAL_TRIALS trial_result · 2023-12-08Clinical Trial Update: Study of Efficacy and Safety of LCZ696 in Japanese Patients With Chronic Heart Failure and Reduced Ejection Fraction [Phase 3]
Phase 3 trial update for LCZ696 in Japanese patients with chronic heart failure with reduced ejection fraction (HF-rEF) has completed with r…
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CLINICAL_TRIALS trial_result · 2023-12-07Clinical Trial Update: Multi-intravenous Infusion of Umbilical Cord Mesenchymal Stem Cells in Heart Failure With Reduced Ejection Fraction（PRIME-HFrEF Study） [Phase 1, Phase 2]
Phase 1/2 trial investigating multi-intravenous infusion of umbilical cord mesenchymal stem cells in heart failure with reduced ejection fra…
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CLINICAL_TRIALS trial_result · 2023-11-13Clinical Trial Update: Role of Glutamine as Myocardial Protector in Elective On-Pump CABG Surgery With Low EF [Phase 3]
A Phase 3 trial evaluated glutamine as a myocardial protector in elective on-pump CABG surgery for patients with low ejection fraction; the …
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CLINICAL_TRIALS trial_result · 2023-11-09Clinical Trial Update: A Study to Assess the Hemodynamic Effects, Safety, Tolerability, and Pharmacokinetics of Intravenous APD418 in Adult Participants With Heart Failure With Reduced Ejection Fraction [Phase 2]
Phase 2 trial evaluating intravenous APD418 for hemodynamic effects, safety, tolerability, and pharmacokinetics in adults with heart failure…
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CLINICAL_TRIALS trial_result · 2023-10-13Clinical Trial Update: ERTU-SODIUM: Study on the Effects of Ertugliflozin on Sodium Storage, Interstitial Volume, and Plasma Volume in HFrEF [Phase 4]
A Phase 4 clinical trial assessing the effects of ertugliflozin (ERTU-SODIUM) on sodium storage, interstitial volume, and plasma volume in h…