Heart Failure with Reduced Ejection Fraction
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CLINICAL_TRIALS trial_result · 2026-07-17Clinical Trial Results: Novel Respiratory Training as Part of Palliative Care for Older Adults With Heart Failure [NA]
Trial results report on novel respiratory training as part of palliative care for older adults with heart failure, focusing on aging and fra…
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CLINICAL_TRIALS trial_result · 2026-04-27Clinical Trial Update: Lokelma for RAAS Maximisation in CKD & Heart Failure. [Phase 3]
Phase 3 trial update for Lokelma evaluating potassium management to maximize RAAS inhibition in chronic kidney disease and heart failure wit…
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CLINICAL_TRIALS trial_result · 2026-04-27Clinical Trial Update: Lokelma for RAAS Maximisation in CKD & Heart Failure. [Phase 3]
Phase 3 trial update for Lokelma aimed at maximizing RAAS inhibition in CKD and heart failure with reduced ejection fraction; study complete…
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CLINICAL_TRIALS trial_result · 2026-04-24Clinical Trial Update: Administration of the SGLT-2 Inhibitor Dapagliflozin in the Patients With Amyloid Cardiomyopathy [NA]
A completed clinical trial evaluating the SGLT-2 inhibitor dapagliflozin in patients with amyloid cardiomyopathy across heart failure phenot…
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CLINICAL_TRIALS trial_result · 2026-04-21Clinical Trial Update: Study to Assess Efficacy and Safety of CDR132L in Patients With Reduced Left Ventricular Ejection Fraction After Myocardial Infarction [Phase 2]
The update covers the Phase 2 study of CDR132L for patients with reduced left ventricular ejection fraction after acute myocardial infarctio…
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CLINICAL_TRIALS trial_result · 2026-04-15Clinical Trial Update: A Safety and Tolerability Study of HJB647 in Heart Failure Participants With Reduced Ejection Fraction [Phase 1]
This clinical trial update describes a Phase 1 safety and tolerability study of HJB647 in patients with heart failure with reduced ejection …
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CLINICAL_TRIALS trial_result · 2026-04-13Clinical Trial Update: Cardiac Left Atrial Evaluation and Response in HFrEF With Sacubitril/Valsartan
This clinical trial update reports the completion of a study evaluating left atrial evaluation and response in heart failure with reduced ej…
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CLINICAL_TRIALS trial_result · 2026-04-09Clinical Trial Update: AI-ECG for Time-Resolved Prediction of HFrEF
A clinical trial evaluating an AI-enabled ECG for time-resolved prediction of heart failure with reduced ejection fraction has completed.
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CLINICAL_TRIALS trial_result · 2026-04-08Clinical Trial Update: Hemodynamic Effects of ARNI on Noninvasive Pressure-volume Analysis in Patients With Chronic Heart Failure
A completed clinical trial evaluating the hemodynamic effects of an ARNI regimen on noninvasive pressure-volume measurements in patients wit…
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CLINICAL_TRIALS trial_result · 2026-04-02Clinical Trial Update: Metabolomic Profiling in Ischemic and Non-Ischemic Cardiomyopathy Patients With Ventricular Arrhythmias
This clinical trial update reports completion of a metabolomic profiling study in patients with ischemic and non-ischemic cardiomyopathy who…
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CLINICAL_TRIALS trial_result · 2026-04-01Clinical Trial Update: Neuromodulation of Inflammation and Vascular Function in Systolic Heart Failure [NA]
ClinicalTrials.gov update shows termination of a study investigating neuromodulation effects on inflammation and vascular function in heart …
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CLINICAL_TRIALS trial_result · 2026-03-27Clinical Trial Update: Efficacy and Safety of Sacubitril/Valsartan in African American Patients With Heart Failure With Reduced Ejection Fraction
A completed clinical trial assessed the efficacy and safety of sacubitril/valsartan in African American patients with heart failure with red…
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CLINICAL_TRIALS trial_result · 2026-03-25Clinical Trial Update: Sodium-Glucose Cotransporter 2 Inhibitor Use in a National Heart Failure Telemonitoring Program
This clinical trial update reports the completion of a national telemonitoring program evaluating the use of SGLT2 inhibitors in heart failu…
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CLINICAL_TRIALS trial_result · 2026-03-16Clinical Trial Update: Effect of Vericiguat on cardiAc Remodeling in Patients With Heart faiLure and Reduced Ejection fractioN (HFrEF): A Prospective sTudy usIng NOvel Echocardiographic Imaging Techniques (VALENTINO)
This completed clinical trial evaluates the effect of vericiguat on cardiac remodeling in patients with heart failure with reduced ejection …
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CLINICAL_TRIALS trial_result · 2026-03-13Clinical Trial Update: BIOmarker Based Diagnostic TOOLkit to Personalize Pharmacological Approaches in Congestive Heart Failure
A completed clinical trial evaluating a biomarker-based diagnostic toolkit to personalize pharmacological therapy for heart failure, includi…
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CLINICAL_TRIALS trial_result · 2026-02-13Clinical Trial Update: Pulsed Field or Cryoballoon Pulmonary Vein Isolation for Atrial Fibrillation in Heart Failure
The trial investigating pulsed field or cryoballoon pulmonary vein isolation for atrial fibrillation in patients with heart failure with red…
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CLINICAL_TRIALS trial_result · 2026-02-12Clinical Trial Update: Direct HIS/LBB Pacing as an Alternative to Biventricular Pacing in Patients With HFrEF and a Typical LBBB. [NA]
The clinical trial evaluates direct His bundle/left bundle-branch pacing as an alternative to biventricular pacing in heart failure with red…
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CLINICAL_TRIALS trial_result · 2026-02-04Clinical Trial Update: A Real-world Study to Compare the Effectiveness of Sacubitril/Valsartan Versus ACEi/ARB in HFrEF Patients
A completed real-world study comparing the effectiveness of sacubitril/valsartan versus ACE inhibitors/ARBs in patients with heart failure w…
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CLINICAL_TRIALS trial_result · 2026-01-30Clinical Trial Update: An Observational Study, Called VERI-China, to Learn More About How Well Vericiguat Works and How Safe it is in Real-world Setting in People With Chronic Heart Failure With Reduced Ejection Fraction (HFrEF) in China
This entry notes the VERI-China observational study assessing vericiguat in real-world patients with chronic heart failure with reduced ejec…
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CLINICAL_TRIALS trial_result · 2026-01-27Clinical Trial Update: Predicting Heart Failure Outcomes With Biomarkers and Imaging
A completed clinical trial evaluating whether circulating biomarkers and imaging findings can predict outcomes across different forms of hea…
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CLINICAL_TRIALS trial_result · 2026-01-16Clinical Trial Update: The Impact of an Adaptive Patient-centered Web Application on Medication Optimization in HFrEF Patients [Phase 3]
Phase 3 trial completed evaluating an adaptive patient-centered web application to optimize heart failure medications in patients with reduc…
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CLINICAL_TRIALS trial_result · 2026-01-14Clinical Trial Update: REGN5381 in Adult Participants With Heart Failure With Reduced Ejection Fraction [Phase 2]
Regeneron reports termination of the Phase 2 trial of REGN5381 in adults with heart failure with reduced ejection fraction.
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CLINICAL_TRIALS trial_result · 2025-12-31Clinical Trial Update: Heart Failure Polypill at a Safety Net Hospital [Phase 2]
A Phase 2 clinical trial evaluating a Heart Failure Polypill at a safety-net hospital for patients with heart failure with reduced ejection …
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CLINICAL_TRIALS trial_result · 2025-12-26Clinical Trial Update: PRIMA-HF: Predicting Myocardial Recovery in Heart Failure Using Cardiac Imaging HAI-HF: High Dosing vs. Standard Dosing Adenosine During Myocardial Perfusion in Heart Failure [Phase 4]
This update reports ongoing Phase 4 trials PRIMA-HF and HAI-HF studying myocardial recovery imaging and high-dose versus standard-dose adeno…
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CLINICAL_TRIALS trial_result · 2025-12-24Clinical Trial Update: Effect of Vericiguat on Acute Coronary Syndrome( ACS）Patients With Ejection Fraction <45%
The clinical trial evaluating vericiguat in acute coronary syndrome patients with ejection fraction below 45% has completed.