Heart Failure with Reduced Ejection Fraction
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CLINICAL_TRIALS research · 2026-03-09Clinical Trial Update: Prospective Evaluation of AI-ECG for SHD Detection
Imperial College London is conducting a prospective study to evaluate an AI-enabled ECG for detecting structural heart disease; the trial is…
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CLINICAL_TRIALS research · 2026-03-05Clinical Trial Update: Real-Time Monitoring of Heart Failure Across the Yale New Haven Health System
A real-time heart failure monitoring clinical trial across Yale New Haven Health System is currently recruiting participants, focusing on he…
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CLINICAL_TRIALS research · 2026-02-27Clinical Trial Update: Exercise Rehabilitation for Cardiorenal Syndrome in HFrEF Patients [NA]
ClinicalTrials.gov entry notes an ongoing trial examining exercise rehabilitation for patients with cardiorenal syndrome in the setting of h…
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CLINICAL_TRIALS research · 2026-02-27Clinical Trial Update: Digital Support Program for Patients With Heart Failure - a Cluster-Randomized Hybrid Type 2 Study [NA]
A cluster-randomized hybrid Type 2 study is evaluating a digital support program for patients with heart failure with reduced ejection fract…
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CLINICAL_TRIALS research · 2026-02-24Clinical Trial Update: Comparing Three Types of Specialist Pacemakers to Improve Heart Function and Reduce Rhythm Problems in Heart Failure [NA]
A clinical trial comparing three types of specialist pacemakers to improve heart function and reduce rhythm problems in people with heart fa…
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CLINICAL_TRIALS research · 2026-02-24Clinical Trial Update: Swedish Cardiac And Renal Failure Study-1 [Phase 2]
A Phase 2 clinical trial named Swedish Cardiac And Renal Failure Study-1 is currently recruiting, studying treatments for heart failure with…
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CLINICAL_TRIALS research · 2026-02-23Clinical Trial Update: London Valvular Heart Disease and Reduced Ejection Fraction Detection in a Multi-ethnic Community Using Cardiac Ultrasound
This recruiting study, led by Queen Mary University of London, aims to detect heart valve disease and reduced ejection fraction in a multi-e…
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CLINICAL_TRIALS research · 2026-02-19Clinical Trial Update: Pilot Study of StudyU for N-of-1 Trials in HFrEF Patients (N-of-1 App) [Phase 4]
A Phase 4 pilot study evaluating the StudyU app for conducting N-of-1 trials in patients with heart failure with reduced ejection fraction. …
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CLINICAL_TRIALS research · 2026-02-18Clinical Trial Update: Real-world Comparative Effectiveness and Safety of Jardiance in Chinese Patients With Heart Failure of Reduced Ejection Fraction
This clinical trial update describes a real-world comparative effectiveness and safety study of Jardiance (empagliflozin) in Chinese patient…
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CLINICAL_TRIALS research · 2026-02-17Clinical Trial Update: Study With Omecamtiv Mecarbil (CK-1827452) to Treat Chronic Heart Failure With Severely Reduced Ejection Fraction [Phase 3]
This clinical trial update indicates that a Phase 3 study of omecamtiv mecarbil (CK-1827452) for chronic heart failure with severely reduced…
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CLINICAL_TRIALS research · 2026-02-17Clinical Trial Update: Evaluation of the HeartLogic Diagnostic in Optimizing Guideline-directed Medical Therapy in Patients With Congestive Heart Failure and Chronically Low Ejection Fractions (EFs) [NA]
A clinical trial evaluating the HeartLogic diagnostic to optimize guideline-directed medical therapy in patients with congestive heart failu…
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CLINICAL_TRIALS research · 2026-02-13Clinical Trial Update: Wearable Device-Assisted Remote Management in Atrial Fibrillation Complicated by Heart Failure: WARM-HF Trial [NA]
A protocol for the WARM-HF trial evaluating wearable device-assisted remote management in patients with heart failure with reduced ejection …
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CLINICAL_TRIALS research · 2026-02-12Clinical Trial Update: Vericiguat and Reverse Remodeling Indices in Heart Failure [Phase 4]
This Phase 4 trial evaluates vericiguat and reverse remodeling indices in heart failure with reduced ejection fraction and is currently recr…
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CLINICAL_TRIALS research · 2026-02-11Clinical Trial Update: Endovascular Ablation of the Right Greater Splanchnic Nerve in Subjects With Reduced Ejection Fraction [NA]
A clinical trial is planned to evaluate endovascular ablation of the right greater splanchnic nerve in patients with heart failure with redu…
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CLINICAL_TRIALS research · 2026-02-10Clinical Trial Update: Optimizing HFrEF Patients Using BaroStim and CardioMems [Phase 2, Phase 3]
Clinical trials update describing Phase 2 and Phase 3 studies evaluating optimization of heart failure with reduced ejection fraction using …
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CLINICAL_TRIALS research · 2026-02-09Clinical Trial Update: Evaluate Efficacy, Safety and Tolerability of JTT-861 in Subjects With Heart Failure With Reduced Ejection Fraction [Phase 2]
A Phase 2 trial update reports ongoing evaluation of JTT-861 for efficacy, safety, and tolerability in patients with heart failure with redu…
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CLINICAL_TRIALS research · 2026-02-05Clinical Trial Update: Ketones, SGLT2, HFrEF [EARLY_Phase 1]
A Phase 1 (early) clinical trial sponsored by The University of Texas Health Science Center at San Antonio is evaluating ketones and SGLT2 i…
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CLINICAL_TRIALS research · 2026-02-02Clinical Trial Update: The Effectiveness and Safety of Artificial Intelligence(AI)-Assisted Medical Treatment Decision Support System Compared to Conventional Care in HFrEF Patients [NA]
A clinical trial update on the effectiveness and safety of an AI-assisted medical treatment decision support system versus conventional care…
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CLINICAL_TRIALS research · 2026-01-21Clinical Trial Update: Precision Subtyping and Prognostic Study of Heart Failure Based on Multi-Omics Integration and Clinical Indicators: A Prospective Single-Center Cohort Study
A prospective, single-center cohort study aiming to subtype heart failure patients using multi-omics data and clinical indicators to refine …
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CLINICAL_TRIALS research · 2026-01-21Clinical Trial Update: The Canadian CABG or PCI in Patients With Ischemic Cardiomyopathy Trial (STICH3C) [NA]
The Canadian STICH3C trial evaluating CABG or PCI in patients with ischemic cardiomyopathy is currently recruiting.
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CLINICAL_TRIALS research · 2026-01-21Clinical Trial Update: Acute and Chronic Effects of Oral Ketones in Subjects With HFrEF and Diabetes [EARLY_Phase 1]
This early Phase 1 trial investigates the acute and chronic effects of oral ketones in adults with heart failure with reduced ejection fract…
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CLINICAL_TRIALS research · 2026-01-20Clinical Trial Update: Study of JK07 in Patients With Heart Failure and WHO Group 2 Combined Post- and Pre-Capillary Pulmonary Hypertension [Phase 2]
Phase 2 clinical trial of JK07 for heart failure (reduced and preserved ejection fraction) with Group 2 pulmonary hypertension is currently …
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CLINICAL_TRIALS research · 2026-01-16Clinical Trial Update: Effect of Pre-Hospital ARNI Therapy on Short-Term Outcomes in HFrEF
A clinical trial is evaluating whether pre-hospital initiation of ARNI therapy (sacubitril/valsartan) improves short-term outcomes in patien…
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CLINICAL_TRIALS research · 2026-01-15Clinical Trial Update: Assessment of CCM in HF With Higher Ejection Fraction [NA]
Clinical trial update on Cardiac Contractility Modulation (CCM) for heart failure across multiple ejection fraction subtypes; the study is c…
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CLINICAL_TRIALS research · 2026-01-13Clinical Trial Update: Impact of Barostimulation on Hemodynamics in Adults With Heart Failure [NA]
This ClinicalTrials.gov entry describes a study assessing barostimulation effects on hemodynamics in adults with heart failure with reduced …