Heart Failure with Reduced Ejection Fraction
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CLINICAL_TRIALS research · 2026-04-24Clinical Trial Update: Digital Remote Management Versus Usual Care for Optimization of Guideline-directed Medical Therapy in Patients With Heart Failure and Reduced Ejection Fraction: a Multicentre, Randomised, Controlled Trial (DigiCare-HFrEF) [NA]
A multicentre randomized trial (DigiCare-HFrEF) evaluating whether digital remote management improves optimization of guideline-directed med…
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CLINICAL_TRIALS research · 2026-04-24Clinical Trial Update: Sacubitril-valsartan in Patients With Heart Failure With Reduced Ejection Fraction From Rural Tanzania [Phase 4]
Phase 4 trial update on sacubitril-valsartan in patients with heart failure with reduced ejection fraction in rural Tanzania; currently not …
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CLINICAL_TRIALS research · 2026-04-23Clinical Trial Update: INitiation and Titration of Guideline Directed Medical TheRApy in HearT Failure Cardiogenic Shock With ImpElla 5.5 for Cardiac Recovery [NA]
This clinical trial update notes initiation and titration of guideline-directed medical therapy in patients with heart failure and cardiogen…
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CLINICAL_TRIALS research · 2026-04-23Clinical Trial Update: A Study of LY3971297 in Participants With Heart Failure [Phase 1]
Phase 1 study of LY3971297 in participants with heart failure (including diastolic and systolic subtypes) is not yet recruiting.
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CLINICAL_TRIALS research · 2026-04-23Clinical Trial Update: Evaluation of Accelerated Bachmann Bundle Area Pacing in Heart Failure With Reduced ejectIon Fraction Who Have electrocarDioGraphic Evidence of Interatrial Block and Indicated for Implantable Cardioverter Defibrillator [NA]
This clinical trial investigates accelerated Bachmann Bundle area pacing in patients with heart failure with reduced ejection fraction who a…
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CLINICAL_TRIALS research · 2026-04-22Clinical Trial Update: Selenium Intervention Registry Randomized Trial in Heart Failure [Phase 3]
A Phase 3 randomized trial evaluating selenium supplementation in patients with various forms of heart failure is currently recruiting.
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CLINICAL_TRIALS research · 2026-04-20Clinical Trial Update: Medication Training Via Ignite Based on Roy Model in Heart Failure: Medication Adherence and Symptom Management [NA]
Clinical trial update describing a medication training program called Ignite based on the Roy model to improve medication adherence and symp…
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CLINICAL_TRIALS research · 2026-04-17Clinical Trial Update: An Observational Study to Learn More About the Use of Vericiguat in Korean People With Chronic Heart Failure With Reduced Ejection Fraction (HFrEF) in Real-world Setting
An observational real-world study in Korea evaluating the use of vericiguat for heart failure with reduced ejection fraction.
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CLINICAL_TRIALS research · 2026-04-14Clinical Trial Update: An Observational Study to Learn More About How Safe Vericiguat is and How Well it Works in Indian People With Chronic Heart Failure With Reduced Ejection Fraction and Worsening Chronic Heart Failure Under Real World Conditions
An observational real-world study in Indian patients is designed to evaluate the safety and effectiveness of vericiguat in chronic heart fai…
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CLINICAL_TRIALS research · 2026-04-14Clinical Trial Update: Mechanistic Clinical Trial Comparing the Pharmacokinetics/Pharmacodynamics of Metoprolol in Heart Failure With Reduced Ejection Fraction Patients With Low vs. High Polygenic Score [Phase 4]
Phase 4 mechanistic trial assessing pharmacokinetics and pharmacodynamics of metoprolol in patients with heart failure with reduced ejection…
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CLINICAL_TRIALS research · 2026-04-14Clinical Trial Update: Secondary Use of PARALLEL-HF Data
A clinical trial update describing the secondary use of PARALLEL-HF data, focusing on chronic heart failure with reduced ejection fraction (…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: Telemedicine-guided Uptitration of Therapy in Chronic Heart Failure [NA]
This clinical trial update reports that a study evaluating telemedicine-guided uptitration of heart failure therapies in patients with heart…
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CLINICAL_TRIALS research · 2026-04-01Clinical Trial Update: Visualization of the Effects of Guideline-directed Medical Therapy (GDMT) on Improving Adherence and Quality of Life in Heart Failure With Reduced Ejection Fraction (HFrEF) [EARLY_Phase 1]
This clinical trial update describes a Phase 1 study that visualizes the effects of guideline-directed medical therapy (GDMT) on adherence a…
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CLINICAL_TRIALS research · 2026-03-31Clinical Trial Update: Heart Failure Management for Patient With CIED Remotely Monitored [NA]
A clinical trial update indicates a study on heart failure management for patients with remotely monitored cardiac implanted electronic devi…
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CLINICAL_TRIALS research · 2026-03-31Clinical Trial Update: Synchronized Diaphragmatic Stimulation in Symptomatic Heart Failure [NA]
A clinical trial evaluating synchronized diaphragmatic stimulation for heart failure with reduced ejection fraction is currently recruiting.…
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CLINICAL_TRIALS research · 2026-03-30Clinical Trial Update: Pharmacological Optimization in Prevention in Heart Failure: A Sex-gap? [Phase 4]
An update on a Phase 4 trial evaluating pharmacological optimization to prevent heart failure, including consideration of sex differences; r…
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CLINICAL_TRIALS research · 2026-03-24Clinical Trial Update: Propensity-Matched Study of Cardiac Contractility Modulation Therapy in Heart Failure
A clinical trial update describes a propensity-matched analysis of cardiac contractility modulation therapy in patients with heart failure w…
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CLINICAL_TRIALS research · 2026-03-16Clinical Trial Update: Effectiveness of Video Monitoring and Care Transition for Heart Failure Patients (EVIT-HF): Randomized Clinical Trial [NA]
This document describes a randomized clinical trial (EVIT-HF) evaluating video monitoring and care transition for patients with heart failur…
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CLINICAL_TRIALS research · 2026-03-13Clinical Trial Update: Ketones in Heart Failure With Reduced Ejection Fraction [Phase 2]
Phase 2 clinical trial evaluating ketone-based therapy for heart failure with reduced ejection fraction; enrollment is currently by invitati…
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CLINICAL_TRIALS research · 2026-03-13Clinical Trial Update: THE RELATIONSHIP BETWEEN CARDIAC RESYNCHRONİZATION THERAPY RESPONSE IN HEART FAILURE PATIENTS AND YKL-40 LEVELS
This clinical trial update from Trakya University describes an ongoing study investigating the relationship between response to cardiac resy…
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CLINICAL_TRIALS research · 2026-03-12Clinical Trial Update: A Real-world Study of Clinical Treatment Guidelines for Patients With Heart Failure With Reduced Ejection Fraction Treated With Sacubitril/Valsartan
A real-world study evaluating how current clinical treatment guidelines guide the use of sacubitril/valsartan in patients with heart failure…
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CLINICAL_TRIALS research · 2026-03-12Clinical Trial Update: A Randomized Placebo-procedure Controlled Trial of the Enhancor System (PULmonary Artery Denervation) to Evaluate Safety and Efficacy in Patients With Combined Pre- and Post-capillary Pulmonary Hypertension Associated With Left Heart Disease [NA]
Clinical trial update for a randomized study evaluating the Enhancor System, a pulmonary artery denervation device, in patients with combine…
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CLINICAL_TRIALS research · 2026-03-12Clinical Trial Update: Evaluation of the Effects of Sauna Therapy on Congestion and Loop Diuretic Use in Patients With Heart Failure With Reduced or Moderately Reduced Ejection Fraction [NA]
Registry entry for a clinical trial evaluating sauna therapy to reduce congestion and loop diuretic use in patients with heart failure with …
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CLINICAL_TRIALS research · 2026-03-12Clinical Trial Update: Infusing Needed Iron to Target Insufficiency in Adults Treated for Evidence of Heart Failure [NA]
This Kaiser Permanente trial tests intravenous iron to treat iron deficiency in adults with evidence of heart failure and its subtypes; the …
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CLINICAL_TRIALS research · 2026-03-11Clinical Trial Update: AI-Based Monitoring System for Chronic Heart Failure With Advanced Wearable and Mini-Invasive Devices
A clinical trial is evaluating an AI-based monitoring system for chronic heart failure using wearable and mini-invasive devices. The study i…