Heart Failure with Preserved Ejection Fraction
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CLINICAL_TRIALS trial_result · 2021-02-08Clinical Trial Update: A Randomized, Double-blind Controlled Study Comparing LCZ696 to Medical Therapy for Comorbidities in HFpEF Patients [Phase 3]
Phase 3 randomized trial comparing LCZ696 (sacubitril/valsartan) to standard medical therapy in patients with heart failure with preserved e…
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CLINICAL_TRIALS trial_result · 2021-02-04Clinical Trial Update: Effects of SGLT2 Inhibition on the Mechanisms of Cardiac Damage in the Diabetic Patient With HFpEF [Phase 4]
Phase 4 trial evaluating the effects of SGLT2 inhibition on mechanisms of cardiac damage in patients with type 2 diabetes and heart failure …
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CLINICAL_TRIALS trial_result · 2021-02-02Clinical Trial Update: Myocardial Perfusion, Oxidative Metabolism, and Fibrosis in HFpEF [Phase 4]
Phase 4 clinical trial update assessing myocardial perfusion, oxidative metabolism, and fibrosis in heart failure with preserved ejection fr…
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CLINICAL_TRIALS trial_result · 2020-12-08Clinical Trial Update: This Study Tests Empagliflozin in Patients With Chronic Heart Failure With Preserved Ejection Fraction (HFpEF). The Study Looks at How Far Patients Can Walk in 6 Minutes and at Their Heart Failure Symptoms. [Phase 3]
A Phase 3 trial evaluated empagliflozin in chronic heart failure with preserved ejection fraction (HFpEF), focusing on 6-minute walk test di…
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CLINICAL_TRIALS trial_result · 2020-12-04Clinical Trial Update: An Open-label Extension Study Evaluating Safety and Tolerability of LCZ696 in Subjects Who Completed PARAGON-HF in Japan. [Phase 3]
A Phase 3 open-label extension study evaluating safety and tolerability of LCZ696 (sacubitril/valsartan) in Japanese patients who completed …
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CLINICAL_TRIALS trial_result · 2020-12-03Clinical Trial Update: Patient-reported Outcomes in Vericiguat-treated Patients With HFpEF [Phase 2]
Phase 2 trial evaluating patient-reported outcomes in vericiguat-treated patients with heart failure with preserved ejection fraction (HFpEF…
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CLINICAL_TRIALS trial_result · 2020-11-04Clinical Trial Update: Pharmacodynamic Effects of Riociguat in Pulmonary Hypertension and Heart Failure With Preserved Ejection Fraction [Phase 2]
Phase 2 study evaluating pharmacodynamic effects of riociguat in pulmonary hypertension and heart failure with preserved ejection fraction (…
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CLINICAL_TRIALS trial_result · 2020-10-22Clinical Trial Update: Oral Treprostinil in Subjects With Pulmonary Hypertension Associated With Heart Failure With Preserved Ejection Fraction [Phase 3]
Phase 3 trial of oral treprostinil in pulmonary hypertension due to heart failure with preserved ejection fraction was terminated; results p…
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CLINICAL_TRIALS trial_result · 2020-09-29Clinical Trial Update: Efficacy and Safety of LCZ696 Compared to Valsartan, on Morbidity and Mortality in Heart Failure Patients With Preserved Ejection Fraction [Phase 3]
Phase 3 trial evaluating LCZ696 (sacubitril/valsartan) versus valsartan in heart failure with preserved ejection fraction; results completed…
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CLINICAL_TRIALS trial_result · 2020-09-22Clinical Trial Update: Stratified Treatment to Ameliorate Diastolic Left Ventricular Stiffness in Heart Failure With Preserved Ejection Fraction [Phase 2]
Phase 2 trial update exploring stratified treatment to improve diastolic left ventricular stiffness in heart failure with preserved ejection…
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CLINICAL_TRIALS trial_result · 2020-08-07Clinical Trial Update: The Effect of Exercise and Alagebrium on the Diastolic Function of the Heart [Phase 2]
A phase 2 randomized trial examining the effects of exercise and alagebrium on diastolic function of the heart has completed.
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CLINICAL_TRIALS trial_result · 2020-07-02Clinical Trial Update: The Efficacy and Safety of Pirfenidone in Patients With Heart Failure and Preserved Left Ventricular Ejection Fraction [Phase 2]
Phase 2 clinical trial update evaluating the efficacy and safety of pirfenidone in patients with heart failure with preserved ejection fract…
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CLINICAL_TRIALS trial_result · 2020-05-28Clinical Trial Update: Pressure Assessment to Improve Outcomes After TAVR: a Registry [EARLY_Phase 1]
Early-phase registry trial assessing pressure measurement after TAVR to improve outcomes has completed with posted results.
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CLINICAL_TRIALS trial_result · 2020-03-23Clinical Trial Update: The Efficacy and Safety of Zhigancao Tang Granule for HFpEF of Qi-Yin Dificiency [Phase 2]
Phase 2 trial update evaluating the efficacy and safety of Zhigancao Tang Granule for heart failure with preserved ejection fraction due to …
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CLINICAL_TRIALS trial_result · 2020-01-22Clinical Trial Update: Oral Nitrite for Older Heart Failure With Preserved Ejection Fraction [Phase 2]
Phase 2 trial update on oral nitrite for older adults with heart failure with preserved ejection fraction has completed with results posted.
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CLINICAL_TRIALS trial_result · 2020-01-18Clinical Trial Update: The Effects of Ranolazine on Exercise Capacity in Patients With Heart Failure With Preserved Ejection Fraction [NA]
A completed clinical trial evaluating the effects of ranolazine on exercise capacity in patients with heart failure with preserved ejection …
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CLINICAL_TRIALS trial_result · 2019-08-14Clinical Trial Update: Inhaled Iloprost and Exercise Hemodynamics and Ventricular Performance in Heart Failure With Preserved Ejection Fraction [Phase 4]
Phase 4 trial update investigating inhaled iloprost effects on exercise hemodynamics and ventricular performance in heart failure with prese…
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CLINICAL_TRIALS trial_result · 2019-07-23Clinical Trial Update: A Trial to Study Neladenoson Bialanate Over 20 Weeks in Patients With Chronic Heart Failure With Preserved Ejection Fraction [Phase 2]
Phase 2 trial update evaluating neladenoson bialanate in chronic heart failure with preserved ejection fraction has completed with results p…
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CLINICAL_TRIALS trial_result · 2019-06-11Clinical Trial Update: Noninvasive Neuromodulation to Reserve Diastolic Dysfunction [NA]
A completed clinical trial investigating noninvasive neuromodulation to reserve diastolic dysfunction in heart failure patients; results pos…
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CLINICAL_TRIALS trial_result · 2019-05-22Clinical Trial Update: Safety and Efficacy Trial to Treat Diastolic Heart Failure Using Ambrisentan [Phase 4]
Phase 4 trial evaluating safety and efficacy of ambrisentan for diastolic heart failure (heart failure with preserved ejection fraction) in …
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CLINICAL_TRIALS trial_result · 2019-05-21Clinical Trial Update: Carvedilol SR Study for Biomarkers From Blood and Urine and Safety of in Patients With Heart Failure With Preserved Ejection Fraction [Phase 4]
Phase 4 trial update evaluating carvedilol extended-release for biomarkers in blood and urine and safety in patients with heart failure with…
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CLINICAL_TRIALS trial_result · 2019-04-23Clinical Trial Update: Chronotropic Incompetence in Patients With HFpEF [NA]
Clinical trial update regarding chronotropic incompetence in patients with heart failure with preserved ejection fraction (HFpEF) has comple…
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CLINICAL_TRIALS trial_result · 2019-03-21Clinical Trial Update: Metoprolol XR in Heart Failure With Normal Ejection Fraction [Phase 2]
Phase 2 trial update on Metoprolol XR for heart failure with preserved ejection fraction (diastolic heart failure).
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CLINICAL_TRIALS trial_result · 2019-03-13Clinical Trial Update: Inorganic Nitrite Delivery to Improve Exercise Capacity in HFpEF [Phase 2]
A Phase 2 trial evaluating inorganic nitrite delivery to improve exercise capacity in heart failure with preserved ejection fraction has com…
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CLINICAL_TRIALS trial_result · 2019-02-05Clinical Trial Update: Inhaled Beta-adrenergic Agonists to Treat Pulmonary Vascular Disease in Heart Failure With Preserved EF (BEAT HFpEF): A Randomized Controlled Trial [Phase 3]
Phase 3 randomized trial BEAT HFpEF evaluating inhaled beta-adrenergic agonists for pulmonary vascular disease in heart failure with preserv…