Heart Failure with Preserved Ejection Fraction
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CLINICAL_TRIALS research · 2026-02-18Clinical Trial Update: LEVosimendan to Improve Exercise Limitation in Patients With PH-HFpEF [Phase 3]
Phase 3 trial of levosimendan to improve exercise limitation in patients with pulmonary hypertension due to heart failure with preserved eje…
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CLINICAL_TRIALS research · 2026-02-18Clinical Trial Update: The Effect of Sacubitril and Valsartan on Heart Function in Chronic Hemodialysis Patients With HFpEF [Phase 4]
A Phase 4 clinical trial is evaluating the effect of sacubitril/valsartan on heart function in chronic hemodialysis patients with heart fail…
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CLINICAL_TRIALS research · 2026-02-18Clinical Trial Update: Can Tiny Bubbles Offer an Alternative to Catheters for Assessing Pressures Inside the Heart? Investigating Ultrasound Contrast Agents as Pressure Sensors Against Gold Standard Catheter Pressures in Cardiac Catheterisation Patients. [NA]
This clinical trial is investigating ultrasound contrast agents as noninvasive pressure sensors to estimate cardiac pressures, validated aga…
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CLINICAL_TRIALS research · 2026-02-17Clinical Trial Update: Treating Atrial Fibrillation in Heart Failure With Preserved Ejection Fraction: Ablation or Medication [NA]
This clinical trial update reports a study recruiting patients to compare ablation versus medical therapy for treating atrial fibrillation i…
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CLINICAL_TRIALS research · 2026-02-13Clinical Trial Update: Real-world Study to Describe the Effectiveness and Safety Outcomes of Jardiance in Chinese Patients With Heart Failure and Preserved Ejection Fraction
This clinical trial update outlines a real-world study to evaluate the effectiveness and safety of Jardiance (empagliflozin) in Chinese pati…
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CLINICAL_TRIALS research · 2026-02-11Clinical Trial Update: Transitions of Care Clinic (TOCC) [NA]
Clinical trial update for the Transitions of Care Clinic (TOCC) indicates the study is currently recruiting. It targets heart failure with p…
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CLINICAL_TRIALS research · 2026-02-10Clinical Trial Update: Heart Failure With Preserved Ejection Fraction in Patients With Сhronic Obstructive Pulmonary Disease: Clinical Course and Prognosis
A recruiting clinical trial studying the clinical course and prognosis of heart failure with preserved ejection fraction in patients with ch…
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CLINICAL_TRIALS research · 2026-02-04Clinical Trial Update: Electroporation Treatment for Early AF Management in Heart Failure With Preserved Ejection Fraction (HFpEF) Pilot Study [NA]
A pilot clinical trial update evaluating electroporation treatment for early atrial fibrillation management in patients with heart failure w…
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CLINICAL_TRIALS research · 2026-01-30Clinical Trial Update: Emulation of the STEP-HFpEF DM Heart Failure Trial in Healthcare Claims Data
A study update describing emulation of the STEP-HFpEF trial in healthcare claims data for patients with type 2 diabetes mellitus and heart f…
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CLINICAL_TRIALS research · 2026-01-27Clinical Trial Update: Fast Induced Remodeling in Heart Failure With Preserved Ejection Fraction [NA]
Medtronic is conducting a study on fast induced remodeling in heart failure with preserved ejection fraction and concentric hypertrophy. The…
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CLINICAL_TRIALS research · 2026-01-23Clinical Trial Update: Hospital Register of Decompensated Heart Failure With Preserved Ejection Fraction
This is an update on a hospital registry trial examining decompensated heart failure with preserved ejection fraction, including patients wi…
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CLINICAL_TRIALS research · 2026-01-22Clinical Trial Update: Allopurinol Improves Heart Function in African Americans With Resistant Hypertension [Phase 2]
Phase 2 clinical trial evaluating allopurinol to improve heart function in African Americans with resistant hypertension and heart failure w…
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CLINICAL_TRIALS research · 2026-01-21Clinical Trial Update: Precision Subtyping and Prognostic Study of Heart Failure Based on Multi-Omics Integration and Clinical Indicators: A Prospective Single-Center Cohort Study
A prospective, single-center cohort study aiming to subtype heart failure patients using multi-omics data and clinical indicators to refine …
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CLINICAL_TRIALS research · 2026-01-20Clinical Trial Update: Study of JK07 in Patients With Heart Failure and WHO Group 2 Combined Post- and Pre-Capillary Pulmonary Hypertension [Phase 2]
Phase 2 clinical trial of JK07 for heart failure (reduced and preserved ejection fraction) with Group 2 pulmonary hypertension is currently …
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CLINICAL_TRIALS research · 2026-01-16Clinical Trial Update: HEART Camp Connect -Promoting Exercise in Adults With Heart Failure With Preserved Ejection Fraction [NA]
A clinical trial update for HEART Camp Connect evaluating a structured exercise program for adults with heart failure with preserved ejectio…
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CLINICAL_TRIALS research · 2026-01-15Clinical Trial Update: Assessment of CCM in HF With Higher Ejection Fraction [NA]
Clinical trial update on Cardiac Contractility Modulation (CCM) for heart failure across multiple ejection fraction subtypes; the study is c…
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CLINICAL_TRIALS research · 2026-01-12Clinical Trial Update: AMBER-HFpEF: Assessment of CK-4021586 in a Multi-Center, Blinded Evaluation of Safety and Tolerability Results in HFpEF [Phase 2]
This clinical trial update describes a Phase 2 study evaluating CK-4021586 in heart failure with preserved ejection fraction to assess safet…
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CLINICAL_TRIALS research · 2026-01-09Clinical Trial Update: Pulmonary Artery Denervation for Heart Failure With Preserved Left Ventricular Ejection Fraction [NA]
Clinical trial evaluating pulmonary artery denervation for heart failure with preserved ejection fraction (HFpEF); the study is not yet recr…
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CLINICAL_TRIALS research · 2026-01-08Clinical Trial Update: Accelerated Pacing and Cardiac Filling Pressures During Exercise in Patients With Heart Failure With Preserved Ejection Fraction [NA]
This clinical trial update describes an ongoing study investigating accelerated pacing and its effects on cardiac filling pressures during e…
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CLINICAL_TRIALS research · 2026-01-06Clinical Trial Update: Descriptive Study of Circulating Gene or Protein Inflammatory Biomarkers and Bioimpedance Parameters in a Population of Patients Hospitalized for Decompensated Heart Failure With Preserved or Mildly Reduced Cardiac Function
Describes a descriptive clinical trial evaluating circulating inflammatory biomarkers and bioimpedance parameters in patients hospitalized f…
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CLINICAL_TRIALS research · 2026-01-06Clinical Trial Update: The Relationship Between Epicardial Fat Tissue and Cardiac Function in HFpEF Patients
A completed clinical trial investigating the relationship between epicardial fat tissue and cardiac function in patients with Heart Failure …
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CLINICAL_TRIALS research · 2026-01-06Clinical Trial Update: Metformin for Older Patients With Heart Failure With Preserved Ejection Fraction [Phase 2]
Phase 2 clinical trial update on using metformin in older patients with heart failure with preserved ejection fraction; the study is current…
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CLINICAL_TRIALS research · 2025-12-29Clinical Trial Update: Study on the Efficacy and Safety of HRS-7535 in Patients With Mild Decrease in Ejection Fraction/Preserved Ejection Fraction Heart Failure and Obesity [Phase 2]
A Phase 2 clinical trial evaluating the efficacy and safety of HRS-7535 in adults with heart failure with reduced or preserved ejection frac…
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CLINICAL_TRIALS research · 2025-12-26Clinical Trial Update: AlEX-DHF: Ablation and Exercise in Diastolic Heart Failure [NA]
AlEX-DHF is a clinical trial evaluating ablation and exercise as treatments for diastolic heart failure in patients with preserved ejection …
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CLINICAL_TRIALS research · 2025-12-24Clinical Trial Update: Associations Between the Microbiome, Skeletal Muscle Perfusion, and Fitness Status
A clinical trial is examining links between the gut microbiome, skeletal muscle perfusion, and fitness status. The study includes participan…