Gastric Adenocarcinoma

• CLINICAL_TRIALS research · 2025-12-19
  Clinical Trial Update: Aldesleukin With Nivolumab and Standard Chemotherapy for Treatment of Gastric Cancer With Peritoneal Metastasis [Phase 1]

  This is a Phase 1 clinical trial evaluating Aldesleukin in combination with Nivolumab and standard chemotherapy for clinical stage IV gastri…

• CLINICAL_TRIALS research · 2025-12-19
  Clinical Trial Update: A Phase Ib Trial Evaluating the Safety and Activity of Neoadjuvant Combination of Tislelizumab Plus FLOT for Resectable Esophagogastric Adenocarcinoma [Phase 1]

  Phase Ib trial evaluating the safety and activity of neoadjuvant tislelizumab plus the FLOT chemotherapy regimen in patients with resectable…

• CLINICAL_TRIALS research · 2025-12-15
  Clinical Trial Update: A Study of Multiple Immunotherapy-Based Treatment Combinations in Patients With Locally Advanced Unresectable or Metastatic Gastric or Gastroesophageal Junction Cancer (G/GEJ) or Esophageal Cancer (Morpheus-Gastric and Esophageal Cancer) [Phase 1, Phase 2]

  A Roche-sponsored Phase 1/2 clinical trial evaluating multiple immunotherapy-based treatment combinations in patients with locally advanced …

• CLINICAL_TRIALS research · 2025-12-04
  Clinical Trial Update: A Phase II, Multicenter, Randomized, Controlled Clinical Study Comparing the Efficacy and Safety of Sintilimab Plus SOX Versus SOX Alone as Adjuvant Therapy for PD-L1-Positive, Stage pN3 Gastric Cancer [Phase 2]

  A Phase II multicenter randomized trial is evaluating sintilimab plus SOX versus SOX alone as adjuvant therapy for PD-L1-positive, stage pN3…

• CLINICAL_TRIALS research · 2025-12-03
  Clinical Trial Update: Paclitaxel, Pembrolizumab and Olaparib in Previously Treated Advanced Gastric Adenocarcinoma [Phase 2]

  Phase 2 clinical trial evaluating paclitaxel, pembrolizumab, and olaparib in previously treated advanced gastric adenocarcinoma is currently…

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• CLINICAL_TRIALS research · 2025-12-02
  Clinical Trial Update: A Randomized Controlled Study of Serplulimab Combined With Chemotherapy for Locally Advanced Gastric Adenocarcinoma [Phase 2]

  This is a Phase 2 randomized study evaluating serplulimab in combination with chemotherapy for locally advanced gastric cancer (gastric aden…

• CLINICAL_TRIALS research · 2025-11-28
  Clinical Trial Update: Testing Ivonescimab in Combination With Chemotherapy in Advanced or Metastatic Gastric/Gastroesophageal Adenocarcinoma [Phase 2]

  Phase 2 clinical trial evaluating Ivonescimab in combination with chemotherapy for advanced or metastatic gastric/gastroesophageal adenocarc…

• CLINICAL_TRIALS research · 2025-11-19
  Clinical Trial Update: A Phase II Study of Perioperative Paclitaxel in Patients With Gastric Adenocarcinoma and Carcinomatosis or Positive Cytology [Phase 2]

  A Phase II clinical trial evaluating perioperative paclitaxel in patients with gastric adenocarcinoma and peritoneal carcinomatosis or posit…

• CLINICAL_TRIALS research · 2025-11-17
  Clinical Trial Update: A Study of BL-M07D1 Versus Investigator's Choice of Chemotherapy in Patients With HER2-positive Locally Advanced or Metastatic Gastric or Gastro-esophageal Junction Adenocarcinoma [Phase 3]

  This is a Phase 3 clinical trial comparing BL-M07D1 to investigator's choice chemotherapy in HER2-positive locally advanced or metastatic ga…

• CLINICAL_TRIALS research · 2025-11-10
  Clinical Trial Update: Nab-Paclitaxel PIPAC in Combination With Paclitaxel and Ramucirumab for the Treatment of Stomach Cancer With Peritoneal Metastases [Phase 1]

  This is a Phase 1 clinical trial evaluating nab-paclitaxel in combination with paclitaxel and ramucirumab for clinical stage IVB gastric can…

• CLINICAL_TRIALS research · 2025-10-23
  Clinical Trial Update: A Phase III Randomized Study in CLDN18.2-positive Unresectable Locally Advanced Gastric Cancer Patients [Phase 3]

  A Phase III randomized trial targeting CLDN18.2 in patients with unresectable, locally advanced gastric cancer is currently recruiting.

• CLINICAL_TRIALS research · 2025-10-16
  Clinical Trial Update: Tadalafil Effect + Chemotherapy in Resectable Gastric/GEJ Cancer [Phase 2]

  Phase 2 trial evaluating tadalafil in combination with chemotherapy for resectable gastric or gastroesophageal junction adenocarcinoma; curr…

• CLINICAL_TRIALS research · 2025-09-17
  Clinical Trial Update: Gender Differences in Gastric Cancer Care and Its Adherence to Guidelines in Germany

  An observational clinical trial in Germany assessing gender differences in the management of gastric adenocarcinoma and adherence to clinica…

• CLINICAL_TRIALS research · 2025-09-10
  Clinical Trial Update: Early Access Program for Zolbetuximab

  It provides an update on the Early Access Program for zolbetuximab in patients with locally advanced unresectable or metastatic gastric or g…

• CLINICAL_TRIALS research · 2025-09-05
  Clinical Trial Update: Conversion Therapy Plus Surgery and Radiotherapy for Retroperitoneal Nodal Metastases in Gastric Cancer [Phase 2]

  A Phase 2 clinical trial investigating conversion therapy plus surgery and radiotherapy for gastric cancer with retroperitoneal nodal metast…

• CLINICAL_TRIALS research · 2025-08-27
  Clinical Trial Update: [18F]F-FAPI PET/CT and Laparoscopy in Staging Advanced Gastric Cancer [Phase 2, Phase 3]

  This Phase 2/Phase 3 trial from Leiden University Medical Center is evaluating [18F]F-FAPI PET/CT with laparoscopy for staging locally advan…

• CLINICAL_TRIALS research · 2025-08-22
  Clinical Trial Update: A Vaccine (Ad5.F35-hGCC-PADRE) for the Treatment of Gastrointestinal Adenocarcinoma [Phase 2]

  Phase 2 clinical trial update on the Ad5.F35-hGCC-PADRE cancer vaccine for pancreatic, colorectal, gastric, and esophageal adenocarcinomas; …

• CLINICAL_TRIALS research · 2025-08-07
  Clinical Trial Update: A Study of Evorpacept (ALX148) in Patients With Advanced HER2+ Gastric Cancer (ASPEN-06) [Phase 2, Phase 3]

  Clinical trial update on evorpacept (ALX148) for advanced HER2-positive gastric cancer (ASPEN-06) noting that Phase 2 and Phase 3 cohorts ar…

• CLINICAL_TRIALS research · 2025-08-03
  Clinical Trial Update: A Study of TRK-950 When Used in Combination With Ramucirumab and Paclitaxel in Patients With Gastric Cancer [Phase 2]

  Phase 2 clinical trial evaluating TRK-950 in combination with ramucirumab and paclitaxel for gastric cancer in recruiting status.

• CLINICAL_TRIALS research · 2025-08-03
  Clinical Trial Update: Expanded Access Use of DKN-01 for the Treatment of Advanced Solid Tumors

  Expanded-access update for Leap Therapeutics' DKN-01 in advanced solid tumors, noting the program is no longer available and targeting multi…

• CLINICAL_TRIALS research · 2025-08-01
  Clinical Trial Update: Shenqi Fuwei Mixture Combined With Chemotherapy Neoadjuvant Therapy for Locally Advanced Gastric Cancer [NA]

  A clinical trial (NCT07098026) is evaluating Shenqi Fuwei Mixture combined with chemotherapy as neoadjuvant therapy for locally advanced gas…

• CLINICAL_TRIALS research · 2025-07-29
  Clinical Trial Update: Efficacy and Safety of AK112 Combined Chemotherapy as Neoadjuvant Treatment for Signet Ring Cell-containing G/GEJ Adenocarcinoma [Phase 2]

  A Phase 2 trial is evaluating AK112 in combination with chemotherapy as neoadjuvant therapy for signet ring cell-containing gastric or gastr…

• CLINICAL_TRIALS research · 2025-06-10
  Clinical Trial Update: Planning Treatment for Oesophago-gastric Cancer: a Maintenance Therapy Trial [Phase 2]

  A Phase 2 maintenance therapy trial for oesophago-gastric cancer is active but not recruiting, focusing on esophageal, gastroesophageal junc…

• CLINICAL_TRIALS research · 2025-06-05
  Clinical Trial Update: Study to Evaluate the Efficacy, Safety and Pharmacokinetics of CT041 Autologous CAR T-cell Injection [Phase 1, Phase 2]

  This update describes an ongoing Phase 1/2 clinical trial evaluating CT041 autologous CAR T-cell therapy for gastric adenocarcinoma, gastroe…

• CLINICAL_TRIALS research · 2025-06-02
  Clinical Trial Update: Timing of Minimally Invasive Local Treatment After First-Line Systemic Therapy in Oligometastatic Esophageal or Gastric Adenocarcinoma [Phase 2, Phase 3]

  This clinical trial update outlines a Phase 2/Phase 3 study evaluating the timing of minimally invasive local treatment following first-line…