Diffuse Large B-cell Lymphoma
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2026-02-13Clinical Trial Update: A Study of MT-2111 in Patients With Relapsed/Refractory DLBCL [Phase 1, Phase 2]
A Phase 1/2 study of MT-2111 in relapsed or refractory Diffuse Large B-Cell Lymphoma is ongoing, with the trial status shown as active but n…
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CLINICAL_TRIALS research · 2026-02-13Clinical Trial Update: Study of SGR-1505 in Mature B-Cell Neoplasms [Phase 1]
Schrödinger's SGR-1505 is being evaluated in a Phase 1 trial across multiple mature B-cell neoplasms and is currently recruiting. The study …
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CLINICAL_TRIALS research · 2026-02-13Clinical Trial Update: B-Cell Activating Factor Receptor (BAFFR)-Based Chimeric Antigen Receptor T-Cells With Fludarabine and Cyclophosphamide Lymphodepletion for the Treatment of Relapsed or Refractory B-cell Hematologic Malignancies [Phase 1]
Phase 1 clinical trial from Mayo Clinic is evaluating BAFFR-based CAR-T cells with lymphodepletion (fludarabine and cyclophosphamide) for re…
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CLINICAL_TRIALS trial_result · 2026-02-13Clinical Trial Update: A Study to Evaluate Zilovertamab Vedotin (MK-2140) for Relapsed or Refractory Diffuse Large B-Cell Lymphoma (DLBCL) (MK-2140-004) [Phase 2]
This clinical trial update reports on a Phase 2 study evaluating Zilovertamab Vedotin (MK-2140) in relapsed or refractory diffuse large B-ce…
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CLINICAL_TRIALS trial_result · 2026-02-12Clinical Trial Update: Evaluation of Prime-boost Anti-pneumococcal Vaccination in Patients With Diffuse Large B Cell Lymphoma Treated With Rituximab [Phase 3]
A Phase 3 clinical trial evaluating a prime-boost anti-pneumococcal vaccination strategy in patients with diffuse large B-cell lymphoma trea…
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CLINICAL_TRIALS research · 2026-02-12Clinical Trial Update: Study to Evaluate Adverse Events and Change in Disease Activity in Adult Participants With B-Cell Malignancies Receiving Oral ABBV-525 Tablets [Phase 1]
This clinical trial update describes the ongoing Phase 1 study of ABBV-525 tablets in adults with B-cell malignancies. The study evaluates a…
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CLINICAL_TRIALS research · 2026-02-12Clinical Trial Update: Selinexor in Combination With R-CHOP as the First-line Therapy for TP53-mutated DLBCL Patients (Smart Trial) [Phase 2]
Phase 2 trial evaluating selinexor in combination with the R-CHOP regimen as first-line therapy for TP53-mutated diffuse large B-cell lympho…
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CLINICAL_TRIALS research · 2026-02-12Clinical Trial Update: Study to Compare the Effectiveness and Safety of Golcadomide Plus R-CHOP vs Placebo Plus R-CHOP in Participants With Previously Untreated High-risk Large B-cell Lymphoma [Phase 3]
A Phase 3 clinical trial compares golcadomide plus R-CHOP to placebo plus R-CHOP in previously untreated high-risk diffuse large B-cell lymp…
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CLINICAL_TRIALS trial_result · 2026-02-11Clinical Trial Update: A Study of C-CAR066 in Subjects With r/r Diffuse Large B Cell Lymphoma Who Received CD19 CAR-T Therapy [Phase 1]
Phase 1 results are reported for C-CAR066 in patients with relapsed/refractory diffuse large B-cell lymphoma who previously received CD19 CA…
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CLINICAL_TRIALS trial_result · 2026-02-11Clinical Trial Update: Exploratory Study of CD19-targeted Chimeric Antigen Receptor T Cells(BZ019) for Relapsed and Refractory B-cell Lymphoma [Phase 1]
A Phase 1 exploratory study evaluated CD19-targeted CAR T cells (BZ019) in relapsed/refractory B-cell lymphomas, including diffuse large B-c…
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CLINICAL_TRIALS other · 2026-02-11Clinical Trial Update: Evaluation of Human Immune Responses Vaccination in Patients With Lymphoma
An Emory University-sponsored clinical trial is recruiting to evaluate human immune responses to vaccination in patients with lymphoma. The …
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CLINICAL_TRIALS research · 2026-02-10Clinical Trial Update: This is a Phase 1 Study to Evaluate the Safety of LTZ-301 in Patients With Non-Hodgkin Lymphoma [Phase 1]
Phase 1 clinical trial assessing the safety of LTZ-301 in patients with various forms of non-Hodgkin lymphoma, currently recruiting.
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CLINICAL_TRIALS research · 2026-02-10Clinical Trial Update: Lisatoclax Plus R-CHOP or Pola-R-CHP in Untreated DLBCL: A Phase Ib/II Study [Phase 1, Phase 2]
A Phase Ib/II study evaluating lisatoclax in combination with standard regimens R-CHOP or Pola-R-CHP for untreated diffuse large B-cell lymp…
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CLINICAL_TRIALS trial_result · 2026-02-09Clinical Trial Update: A Study of PET Adapted Therapy and Non-invasive Monitoring for Previously Untreated Limited Stage Diffuse Large B Cell Lymphoma [Phase 2]
This is a Phase 2 clinical trial evaluating PET-adapted therapy and non-invasive monitoring for previously untreated limited-stage diffuse l…
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CLINICAL_TRIALS research · 2026-02-09Clinical Trial Update: CRP Regimen in Treating Elderly Patients With Previously Untreated Double-Positive DLBCL [Phase 2]
A Phase 2 clinical trial is evaluating a CRP regimen for elderly patients with previously untreated double-positive diffuse large B-cell lym…
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EMA approval · 2026-02-06EMA Authorised: Tepkinly (epcoritamab) — AbbVie Deutschland GmbH & Co. KG
The EMA authorised Tepkinly (epcoritamab) from AbbVie Deutschland for diffuse large B-cell lymphoma, with conditional approval.
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CLINICAL_TRIALS trial_result · 2026-02-06Clinical Trial Update: Dose Escalation/Dose Expansion Study of PRGN-3007 UltraCAR-T Cells in Patients With Advanced Hematologic and Solid Tumor Malignancies [Phase 1]
Phase 1 dose-escalation and expansion study of PRGN-3007 UltraCAR-T cells in patients with advanced hematologic and solid tumors has complet…
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CLINICAL_TRIALS trial_result · 2026-02-06Clinical Trial Update: Zanubrutinib in Combination With R-PolaCHP (ZaR-PolaCHP) for Newly Diagnosed Diffuse Large B-Cell Lymphoma [Phase 1]
A Phase 1 trial of zanubrutinib in combination with R-PolaCHP for newly diagnosed diffuse large B-cell lymphoma has been suspended.
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CLINICAL_TRIALS research · 2026-02-06Clinical Trial Update: Italian Real-World Study of Epcoritamab in Relapsed or Refractory DLBCL
The document provides details of an Italian real-world study evaluating epcoritamab in relapsed or refractory diffuse large B-cell lymphoma.
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CLINICAL_TRIALS trial_result · 2026-02-06Clinical Trial Update: A Study Comparing the Efficacy and Safety of Polatuzumab Vedotin With Rituximab-Cyclophosphamide, Doxorubicin, and Prednisone (R-CHP) Versus Rituximab-Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone (R-CHOP) in Participants With Diffuse Large B-Cell Lymphoma [Phase 3]
Phase 3 trial comparing polatuzumab vedotin with R-CHP versus R-CHOP in patients with diffuse large B-cell lymphoma; the study is currently …
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CLINICAL_TRIALS research · 2026-02-06Clinical Trial Update: Nivolumab With DA-REPOCH Chemotherapy Regimen in Treating Patients With Aggressive B-Cell Non-Hodgkin's Lymphoma [Phase 2]
Ongoing Phase 2 trial evaluating nivolumab in combination with DA-REPOCH chemotherapy for aggressive B-cell non-Hodgkin lymphomas, including…
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CLINICAL_TRIALS research · 2026-02-05Clinical Trial Update: Modified R-MINE Regimen vs. R-GemOx Regimens on the Treatment of Late Relapsed DLBCL [NA]
A clinical trial comparing modified R-MINE versus R-GemOx regimens for late-relapsed diffuse large B-cell lymphoma; the study is not yet rec…
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CLINICAL_TRIALS other · 2026-02-05Clinical Trial Update: A Study to Compare How Well Odronextamab Combined With Chemotherapy Works and How Safe it is Against Rituximab Combined With Chemotherapy, in Adult Patients With Previously Untreated Diffuse Large B-cell Lymphoma [Phase 3]
A Phase 3 trial comparing odronextamab plus chemotherapy with rituximab plus chemotherapy in adults with previously untreated diffuse large …
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CLINICAL_TRIALS research · 2026-02-04Clinical Trial Update: Evaluation of Bridging Radiation Therapy Before CAR T-Cell Infusion for the Treatment of Relapsed or Refractory Large B-Cell Lymphoma [EARLY_Phase 1]
This clinical trial update notes a Phase 1 study evaluating bridging radiation therapy before CAR T-cell infusion for relapsed or refractory…
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CLINICAL_TRIALS research · 2026-02-04Clinical Trial Update: Glofitamab as a Bridge to and/or Consolidation Post Autologous Stem Cell Transplant in Patients With Relapsed B Cell Lymphomas [Phase 2]
Phase 2 clinical trial evaluating glofitamab as a bridge to and/or consolidation after autologous stem cell transplant in patients with rela…