Diffuse Large B-cell Lymphoma
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS trial_result · 2021-10-13Clinical Trial Update: Trial of Idelalisib in Patients With Relapsed Diffuse Large B-cell Lymphoma [Phase 2]
Phase 2 trial update for idelalisib in relapsed diffuse large B-cell lymphoma has completed enrollment.
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CLINICAL_TRIALS trial_result · 2021-10-08Clinical Trial Update: Impact of an APA Program on EFS in Patients With Diffuse Large-cell B Lymphoma Treated in 1st Line [Phase 3]
Phase 3 trial update evaluating an APA program's impact on event-free survival in first-line diffuse large B-cell lymphoma.
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CLINICAL_TRIALS trial_result · 2021-09-23Clinical Trial Update: Intermediate Dose of IV MTX as CNS Prophylaxis for High Risk DLBCL [Phase 3]
A Phase 3 trial evaluates intermediate-dose intravenous methotrexate as central nervous system prophylaxis for high-risk diffuse large B-cel…
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CLINICAL_TRIALS trial_result · 2021-09-20Clinical Trial Update: Phase II Trial of Tirelizumab Combined With R2-ICE Regimen in the Treatment of rrDLBCL/HGBL [Phase 2]
Phase II trial update examining tirelizumab with the R2-ICE regimen for relapsed/refractory diffuse large B-cell lymphoma and high-grade B-c…
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CLINICAL_TRIALS trial_result · 2021-09-10Clinical Trial Update: A Study Comparing the Efficacy and Safety Between H-CHOP and R-CHOP in Untreated CD20-Positive Diffuse Large B-cell Lymphoma Patients [Phase 3]
Phase 3 trial comparing H-CHOP versus R-CHOP in untreated CD20-positive diffuse large B-cell lymphoma; status and full results not yet avail…
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CLINICAL_TRIALS trial_result · 2021-08-20Clinical Trial Update: Carfilzomib, Rituximab, Ifosfamide, Carboplatin, and Etoposide in Treating Patients With Relapsed or Refractory Stage I-IV Diffuse Large B-cell Lymphoma [Phase 1]
Phase 1 study evaluating a combination of carfilzomib, rituximab, ifosfamide, carboplatin, and etoposide in relapsed or refractory stage I-I…
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CLINICAL_TRIALS trial_result · 2021-08-18Clinical Trial Update: A Study of TQ-B3525 in Subjects With Relapse/Refractory Diffuse Large B-cell Lymphoma （DLBCL） [Phase 2]
Phase 2 clinical trial update for TQ-B3525 in relapsed/refractory diffuse large B-cell lymphoma.
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CLINICAL_TRIALS trial_result · 2021-08-06Clinical Trial Update: Ibrutinib Combined With Rituximab for Treatment of Relapsed Refractory MYD88 and CD79A/B (or CD79B Alone) DLBCL Who Have Received at Least Two Prior Therapies [Phase 2]
Phase 2 trial evaluating the combination of ibrutinib with rituximab for relapsed/refractory DLBCL with MYD88 and CD79A/B mutations after at…
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CLINICAL_TRIALS trial_result · 2021-07-29Clinical Trial Update: Study to Evaluate the Efficacy and Safety of Loncastuximab Tesirine in Patients With Relapsed or Refractory Diffuse Large B-Cell Lymphoma [Phase 2]
Phase 2 trial evaluating loncastuximab tesirine for relapsed or refractory diffuse large B-cell lymphoma has completed with results posted.
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CLINICAL_TRIALS trial_result · 2021-07-27Clinical Trial Update: A Study of Obinutuzumab in Combination With Idasanutlin and Venetoclax in Participants With Relapsed or Refractory (R/R) Follicular Lymphoma (FL) or Rituximab in Combination With Idasanutlin and Venetoclax in Participants With R/R Diffuse Large B-Cell Lymphoma (DLBCL) [Phase 1, Phase 2]
A phase 1/2 trial investigating obinutuzumab with idasanutlin and venetoclax in relapsed/refractory follicular lymphoma and rituximab with i…
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CLINICAL_TRIALS trial_result · 2021-07-26Clinical Trial Update: Study of Lenalidomide Maintenance Versus Placebo in Responding Elderly Patients With DLBCL and Treated With R-CHOP [Phase 3]
Phase 3 trial comparing lenalidomide maintenance to placebo in responding elderly patients with diffuse large B-cell lymphoma treated with R…
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CLINICAL_TRIALS research · 2021-07-22Clinical Trial Update: Tailoring Treatment for B Cell Non-hodgkin's Lymphoma Based on PET Scan Results Mid Treatment [Phase 2]
A Phase 2 clinical trial exploring tailoring treatment for advanced diffuse large B-cell non-Hodgkin lymphoma based on mid-treatment PET sca…
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CLINICAL_TRIALS trial_result · 2021-07-12Clinical Trial Update: A Trial of Pembrolizumab (MK-3475) in Participants With Blood Cancers (MK-3475-013/KEYNOTE-013) [Phase 1]
Phase 1 trial evaluating pembrolizumab (MK-3475) in blood cancers has completed with results posted.
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CLINICAL_TRIALS trial_result · 2021-06-30Clinical Trial Update: S1001 PET-Directed Therapy in Treating Patients With Limited-Stage Diffuse Large B-Cell Lymphoma [Phase 2]
Phase 2 trial evaluating S1001 PET-directed therapy for limited-stage diffuse large B-cell lymphoma has completed; results have been posted.
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CLINICAL_TRIALS trial_result · 2021-06-25Clinical Trial Update: 18F-FDG PET Radiomics of Diffuse Large B-cell Lymphoma
A completed clinical trial investigating 18F-FDG PET radiomics in diffuse large B-cell lymphoma, with results posted in 2021.
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CLINICAL_TRIALS trial_result · 2021-06-24Clinical Trial Update: Ruxolitinib Phosphate to Treat Diffuse Large B-Cell or Peripheral T-Cell Non-Hodgkin Lymphoma After Stem Cell Transplant [Phase 2]
Phase 2 trial of ruxolitinib phosphate for recurrent/ refractory diffuse large B-cell lymphoma and mature T-/NK-cell non-Hodgkin lymphoma af…
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CLINICAL_TRIALS trial_result · 2021-06-07Clinical Trial Update: Safety and Efficacy of Bendamustine, Gemcitabine, Rituximab, Nivolumab (BeGeRN) in Patients With r/r DLBCL [Phase 1, Phase 2]
Phase 1/2 trial assessing safety and efficacy of Bendamustine, Gemcitabine, Rituximab, and Nivolumab (BeGeRN) in relapsed/refractory diffuse…
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CLINICAL_TRIALS trial_result · 2021-06-03Clinical Trial Update: Rituximab and Combination Chemotherapy With or Without Lenalidomide in Treating Patients With Newly Diagnosed Stage II-IV Diffuse Large B Cell Lymphoma [Phase 2]
A Phase 2 trial evaluating rituximab with standard chemotherapy, with or without lenalidomide, in adults with newly diagnosed Stage II-IV di…
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FDA approval · 2021-06-02FDA Approved: MONJUVI — Supplemental Application (Incyte Corporation)
The FDA approved a supplemental application for MONJUVI (tafasitamab-cxix) from Incyte Corporation. The action updates the product under its…
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CLINICAL_TRIALS trial_result · 2021-05-25Clinical Trial Update: High-Dose Y-90-Ibritumomab Tiuxetan Added to Reduced-Intensity Allogeneic Stem Cell Transplant Regimen for Relapsed or Refractory Aggressive B-Cell Lymphoma [Phase 2]
Phase 2 trial evaluating high-dose Y-90 ibritumomab tiuxetan added to reduced-intensity allogeneic stem cell transplant for relapsed or refr…
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CLINICAL_TRIALS research · 2021-05-18Clinical Trial Update: Detection and Quant of Differences in Hodgkin Lymphoma and Diffuse Large B-cell Lymphoma Using Positron Emission Tomography/Computed Tomography (PET/CT) [NA]
A completed clinical trial evaluating detection and quantification of differences in Hodgkin lymphoma and diffuse large B-cell lymphoma usin…
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FDA approval · 2021-04-23FDA Approved: ZYNLONTA — Original Application (ADC Therapeutics America, Inc.)
The FDA granted original approval for ZYNLONTA (loncastuximab tesirine) from ADC Therapeutics America, Inc. for adults with relapsed or refr…
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CLINICAL_TRIALS trial_result · 2021-04-19Clinical Trial Update: PDR001 Plus LAG525 for Patients With Advanced Solid and Hematologic Malignancies [Phase 2]
Phase 2 trial update evaluating PDR001 plus LAG525 in patients with advanced solid and hematologic malignancies; results posted with complet…
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CLINICAL_TRIALS trial_result · 2021-04-19Clinical Trial Update: Open-Label, Multicenter, Two-Part, Phase 1 Study to Characterize Effects of a Moderate CYP3A Inhibitor on PK of Tazemetostat, Effects of Tazemetostat on PK of CYP2C8 and CYP2C19 Substrates, and Effect of Increased Gastric pH on PK of Tazemetostat in B-cell Lymphoma or Advanced Solid Tumor Patients [Phase 1]
Phase 1/open-label pharmacokinetic study assessing interactions between tazemetostat and CYP enzymes and gastric pH in patients with B-cell …
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CLINICAL_TRIALS trial_result · 2021-04-13Clinical Trial Update: Efficacy of Lenalidomide in Combination With Subcutaneous Rituximab + miniCHOP in DLBCL Patients of 80 y/o or+ [Phase 3]
Phase 3 trial evaluating lenalidomide with subcutaneous rituximab plus miniCHOP in elderly patients with Diffuse Large B-Cell Lymphoma has c…