Diffuse Large B-cell Lymphoma
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS trial_result · 2025-08-21Clinical Trial Update: Trial of Mosunetuzumab (BTCT4465A) as Consolidation Therapy in Participants With Diffuse Large B-Cell Lymphoma Following First-Line Immunochemotherapy and as Monotherapy or in Combination With Polatuzumab Vedotin in Elderly/Unfit Participants With Previously Untreated Diffuse Large B-Cell Lymphoma [Phase 1, Phase 2]
This clinical trial update covers Roche's Phase 1/2 study of mosunetuzumab as consolidation after first-line immunochemotherapy and as monot…
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CLINICAL_TRIALS research · 2025-08-19Clinical Trial Update: Orelabrutinib Combined With Pola-R-CHP Regimen for the Treatment of Untreated Non-GCB Diffuse Large B-Cell Lymphoma [Phase 2]
Phase 2 trial evaluating Orelabrutinib in combination with the Polatuzumab vedotin-containing Pola-R-CHP regimen for untreated non-GCB diffu…
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CLINICAL_TRIALS research · 2025-08-19Clinical Trial Update: Pola-ZR2P in Previously Untreated DLBCL [Phase 2]
This clinical trial update reports a Phase 2 study of Pola-ZR2P for previously untreated diffuse large B-cell lymphoma, currently recruiting…
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CLINICAL_TRIALS research · 2025-08-19Clinical Trial Update: Epcoritamab for the Treatment of Relapsed or Refractory Post Transplant Lymphoproliferative Disorders [Phase 1]
Phase 1 trial update for Epcoritamab in relapsed or refractory post-transplant lymphoproliferative disorders, including DLBCL-type PTLD and …
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CLINICAL_TRIALS research · 2025-08-17Clinical Trial Update: Response-adaptive to Epcoritamab In First Relapse: Study to Evaluate the Efficacy of Eptoritamab in Patients With Relapse/Refractory Large B Cell Lymphoma [Phase 2]
A Phase 2 trial is evaluating the efficacy of epcoritamab in patients with relapsed or refractory diffuse large B-cell lymphoma, employing a…
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CLINICAL_TRIALS research · 2025-08-15Clinical Trial Update: A Feasibility Trial of Tazemetostat Plus CAR T Cell Therapy in B-cell Lymphomas [Phase 1]
Phase 1 feasibility trial evaluating the combination of tazemetostat with CAR T-cell therapy in B-cell lymphomas, including follicular lymph…
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CLINICAL_TRIALS research · 2025-08-15Clinical Trial Update: A Study of HDM2005 in Combination With Standard of Care in Patients With Diffuse Large B-Cell Lymphoma [Phase 1, Phase 2]
A Phase 1/2 clinical trial evaluating HDM2005 in combination with standard of care for diffuse large B-cell lymphoma is currently recruiting…
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CLINICAL_TRIALS trial_result · 2025-08-14Clinical Trial Update: Pirtobrutinib in Combination With Rituximab, Gemcitabine, Oxaliplatin With or Without Polatuzumab Vedotin in Covalent BTK Inhibitor-Pretreated Relapsed/Refractory Diffuse Large B-Cell Lymphoma [Phase 2]
Phase 2 study evaluating pirtobrutinib in combination with rituximab, gemcitabine, oxaliplatin, with or without polatuzumab vedotin in coval…
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CLINICAL_TRIALS research · 2025-08-14Clinical Trial Update: G-Pola-ZLP in Diffuse Large B-Cell Lymphoma [Phase 2]
A Phase 2 clinical trial update indicates the G-Pola-ZLP regimen for Diffuse Large B-Cell Lymphoma is not yet recruiting.
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CLINICAL_TRIALS research · 2025-08-12Clinical Trial Update: A Study of GFH009 in Combination With Zanubrutinib in Subjects With Relapsed or Refractory DLBCL [Phase 1, Phase 2]
A phase 1/2 study evaluating GFH009 in combination with zanubrutinib for relapsed or refractory diffuse large B-cell lymphoma is currently r…
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CLINICAL_TRIALS research · 2025-08-12Clinical Trial Update: A Study of Brentuximab Vedotin, Rituximab, and Dose Attenuated CHP in Elderly Patients With Diffuse Large B-Cell Lymphoma (DLBCL) [Phase 2]
A Phase 2 clinical trial evaluating Brentuximab Vedotin plus Rituximab with dose-attenuated CHP in elderly patients with diffuse large B-cel…
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CLINICAL_TRIALS trial_result · 2025-08-11Clinical Trial Update: Safety and Efficacy of MAK683 in Adult Patients With Advanced Malignancies [Phase 1]
This update reports a Phase 1 trial of MAK683 in adults with advanced malignancies, including diffuse large B-cell lymphoma, focusing on saf…
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CLINICAL_TRIALS trial_result · 2025-08-11Clinical Trial Update: ACE1831 in Adult Subjects With Relapsed/ Refractory CD20-expressing B-cell Malignancies [Phase 1]
Acepodia Biotech's Phase 1 trial of ACE1831 in adults with relapsed/refractory CD20-expressing B-cell malignancies is currently recruiting a…
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CLINICAL_TRIALS research · 2025-08-08Clinical Trial Update: Obinutuzumab and ICE Chemotherapy in Refractory/Recurrent CD20+ Mature NHL [Phase 2]
Phase 2 clinical trial evaluating obinutuzumab plus ICE chemotherapy for refractory or recurrent CD20-positive mature non-Hodgkin lymphoma i…
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CLINICAL_TRIALS trial_result · 2025-08-08Clinical Trial Update: Copanlisib With Rituximab-Bendamustine in Patients With Relapsed-Refractory Diffuse Large B-cell Lymphoma [Phase 2]
This clinical trial update notes the termination of a Phase 2 study evaluating copanlisib in combination with rituximab-bendamustine for rel…
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CLINICAL_TRIALS trial_result · 2025-08-07Clinical Trial Update: Long-term Follow-up of Patients Treated With Genetically Modified Autologous T Cells [Phase 2]
This clinical trial update reports long-term follow-up data from patients treated with Autolus' autologous CAR T cell therapy in multiple my…
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CLINICAL_TRIALS research · 2025-08-06Clinical Trial Update: Fourth-gen CAR T Cells Targeting CD19/CD22 for Highly Resistant B-cell Lymphoma/Leukemia (PMBCL/CNS-BCL). [Phase 1, Phase 2]
This Clinical Trial Update describes a fourth-generation CD19/CD22 dual-targeting CAR T-cell therapy being evaluated in Phase 1/2 for highly…
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CLINICAL_TRIALS research · 2025-08-06Clinical Trial Update: Acalabrutinib in Combination With R-CHOP for Previously Untreated Diffuse Large B-cell Lymphoma (DLBCL) [Phase 2]
A Phase 2 clinical trial is evaluating acalabrutinib in combination with R-CHOP for previously untreated diffuse large B-cell lymphoma and i…
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CLINICAL_TRIALS trial_result · 2025-08-05Clinical Trial Update: A Study to Evaluate the Therapeutic Benefit of Tisagenlecleucel Compared to Existing Standard of Care in German Adult Patients With Relapsed or Refractory Diffuse Large B-cell Lymphoma
A completed study evaluating tisagenlecleucel versus standard of care in German adults with relapsed or refractory Diffuse large B-cell lymp…
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CLINICAL_TRIALS research · 2025-08-05Clinical Trial Update: Loncastuximab and Roflumilast Added to R-CHOP (Lo-(Rituximab and Roflumilast) RR-CHOP) for Naïve High-Risk Diffuse Large B-cell Lymphoma (DLBCL) [Phase 1]
A Phase 1 trial is evaluating adding loncastuximab and roflumilast to the Rituximab-CHOP regimen for adults with naïve high-risk Diffuse Lar…
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CLINICAL_TRIALS trial_result · 2025-08-03Clinical Trial Update: Genetically Engineered Cells (EGFRt/19-28z/IL-12 CAR T Cells) for the Treatment of Relapsed or Refractory CD19+ Hematologic Malignancies [Phase 1]
Phase 1 clinical trial update on genetically engineered CAR T cells (EGFRt/19-28z/IL-12) for relapsed or refractory CD19+ hematologic malign…
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CLINICAL_TRIALS trial_result · 2025-08-01Clinical Trial Update: A Trial Comparing the Two High-dose Chemotherapies BeEAM and BEAM Given Before Autologous Stem Cell Transplantation (ASCT) in Lymphoma Patients (BEB-trial) [Phase 2]
Phase 2 trial comparing BeEAM and BEAM high-dose chemotherapy regimens before autologous stem cell transplantation in lymphoma patients; the…
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CLINICAL_TRIALS research · 2025-07-31Clinical Trial Update: Prospective Observational Study of Diffuse Large-cell B Lymphoma
This is an ongoing prospective observational study of diffuse large B-cell lymphoma that is currently recruiting. The sponsor is Grand Hôpit…
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CLINICAL_TRIALS research · 2025-07-28Clinical Trial Update: A Phase I/II Trial of ALETA-001 for the Treatment of Participants With B-cell Malignancies [Phase 1, Phase 2]
This document outlines a Phase I/II clinical trial of ALETA-001 for various B-cell lymphomas, with recruitment ongoing and sponsored by Canc…
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CLINICAL_TRIALS trial_result · 2025-07-28Clinical Trial Update: Safety and Pharmacokinetics Study of a Modified Tafasitamab IV Dosing Regimen Combined With Lenalidomide in R-R DLBCL Patients [Phase 1, Phase 2]
This clinical trial update reports safety and pharmacokinetic data for a modified tafasitamab intravenous dosing regimen in combination with…