Diffuse Large B-cell Lymphoma

CLINICAL_TRIALS research · 2026-01-02

Clinical Trial Update: Real-Time Monitoring of Circulating Tumor DNA and Study of Prognostic Factors in Patients Treated With CAR-T Cells [NA]

This update describes an ongoing study that monitors circulating tumor DNA in real time and analyzes prognostic factors in patients with Dif…

CLINICAL_TRIALS research · 2025-12-30

Clinical Trial Update: Assessing a ctDNA and PET-oriented Therapy in Patients With DLBCL A Multicenter, Open-label, Phase II Trial. [Phase 2]

This multicenter Phase II study evaluates a ctDNA- and PET-guided therapy approach in patients with diffuse large B-cell lymphoma. The trial…

CLINICAL_TRIALS research · 2025-12-30

Clinical Trial Update: Pragmatic Geriatric Assessment Before CAR-T or Bispecific Antibody Therapy to Predict Side Effects and Outcomes in Older Patients (GA-ACT Trial)

A recruiting clinical study evaluating whether a pragmatic geriatric assessment before CAR-T cell therapy or bispecific antibody treatment c…

CLINICAL_TRIALS trial_result · 2025-12-30

Clinical Trial Update: Treatment and Outcomes of DLBCL After Progression on Polatuzumab Vedotin-based Combination Therapy

This clinical trial update discusses treatment approaches and outcomes for patients with diffuse large B-cell lymphoma who progressed after …

CLINICAL_TRIALS research · 2025-12-30

Clinical Trial Update: Cholecalciferol in Improving Survival in Patients With Newly Diagnosed Cancer With Vitamin D Insufficiency [NA]

A Mayo Clinic-sponsored clinical trial evaluates cholecalciferol (vitamin D3) for improving survival in patients with newly diagnosed cancer…

CLINICAL_TRIALS research · 2025-12-30

Clinical Trial Update: Copanlisib and Nivolumab in Treating Patients With Richter's Transformation or Transformed Indolent Non-Hodgkin Lymphoma [Phase 1]

A Phase 1 trial is evaluating the combination of copanlisib and nivolumab in patients with Richter's transformation or transformed indolent …

CLINICAL_TRIALS research · 2025-12-29

Clinical Trial Update: Exploring the Clinical Impact of MYC Aberrations and Their Relationship With Microenvironment in Diffuse Large B Cell Lymphoma and High-Grade B Cell Lymphoma

A recruiting clinical trial investigating how MYC aberrations and the tumor microenvironment affect diffuse large B-cell lymphoma and high-g…

CLINICAL_TRIALS research · 2025-12-26

Clinical Trial Update: Reduced-Dose Apixaban and Rivaroxaban Versus Low-Molecular-Weight Heparin in Patients With Hematologic Malignancies [NA]

This clinical trial compares reduced-dose apixaban and rivaroxaban against low-molecular-weight heparin for venous thromboembolism managemen…

CLINICAL_TRIALS research · 2025-12-26

Clinical Trial Update: Randomised Controlled Trial of Artificial Intelligence-assisted Health Education [NA]

A randomized controlled trial to assess the effectiveness of artificial intelligence–assisted health education, sponsored by Zhongnan Hospit…

CLINICAL_TRIALS trial_result · 2025-12-24

Clinical Trial Update: Efficacy and Safety of MB-CART2019.1 vs. SoC in Lymphoma Patients [Phase 2]

A Phase 2 clinical trial comparing MB-CART2019.1 CAR-T therapy to standard of care in patients with Diffuse Large B-cell Lymphoma to assess …

CLINICAL_TRIALS research · 2025-12-24

Clinical Trial Update: Ibrutinib + R-CHOP Followed by Ibrutinib Maintenance [Phase 2]

Clinical trial update describing a Phase 2 study of combining ibrutinib with R-CHOP followed by ibrutinib maintenance for diffuse large B-ce…

CLINICAL_TRIALS research · 2025-12-24

Clinical Trial Update: A Dose Escalation and Dose Expansion Study of Intratumoral ONM-501 Alone and in Combination With Cemiplimab in Patients With Advanced Solid Tumors and Lymphomas. [Phase 1]

This is a Phase 1 dose-escalation and expansion study evaluating intratumoral ONM-501 alone and in combination with cemiplimab in patients w…

CLINICAL_TRIALS trial_result · 2025-12-23

Clinical Trial Update: A Compassionate Use (CU) Program of Odronextamab

Compassionate-use program update for odronextamab in relapsed or refractory B-cell lymphomas, including follicular lymphoma and diffuse larg…

CLINICAL_TRIALS trial_result · 2025-12-22

Clinical Trial Update: A Study to Evaluate the Safety and Efficacy of Polatuzumab Vedotin in Combination With Rituximab, Gemcitabine and Oxaliplatin Compared to Rituximab, Gemcitabine and Oxaliplatin Alone in Participants With Relapsed or Refractory Diffuse Large B-Cell Lymphoma [Phase 3]

A Phase 3 trial evaluating polatuzumab vedotin in combination with rituximab, gemcitabine and oxaliplatin versus rituximab, gemcitabine and …

CLINICAL_TRIALS research · 2025-12-22

Clinical Trial Update: Study of Acalabrutinib and Rituximab in Untreated Elderly and/or Frail Patients With DLBCL [Phase 2]

Phase 2 study evaluating acalabrutinib in combination with rituximab for untreated, elderly and/or frail patients with diffuse large B-cell …

CLINICAL_TRIALS trial_result · 2025-12-22

Clinical Trial Update: GEN3014 Trial in Relapsed or Refractory Hematologic Malignancies [Phase 1, Phase 2]

Genmab's GEN3014 trial in relapsed or refractory hematologic malignancies (relapsed/refractory multiple myeloma, diffuse large B cell lympho…

CLINICAL_TRIALS research · 2025-12-22

Clinical Trial Update: A Study to Evaluate the Safety and Clinical Activity of GF- CART01 (CD20/19 CAR T Cell) in Subjects With Relapsed or Refractory B-Cell Hematological Malignancies [Phase 1]

This clinical trial update describes a Phase 1 study of GF-CART01, a CD20/CD19 CAR T cell therapy, evaluating safety and early activity in a…

CLINICAL_TRIALS other · 2025-12-22

Clinical Trial Update: Single-Cell Map of Immune and Lymphoma Cells in B-cell Non-Hodgkin's Lymphoma [NA]

ClinicalTrials.gov reports a completed study investigating a single-cell map of immune and lymphoma cells in Diffuse large B-cell lymphoma. …

EMA approval · 2025-12-18

EMA Authorised: Breyanzi (lisocabtagene maraleucel) — Bristol-Myers Squibb Pharma EEIG

The EMA authorised Breyanzi (lisocabtagene maraleucel) for additional lymphomas, including diffuse large B-cell lymphoma and follicular lymp…