Diffuse Large B-cell Lymphoma
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS trial_result · 2026-02-20Clinical Trial Update: Pembrolizumab for Patients With PD-L1 Diffuse Large B Cell Lymphoma (DLBCL) [Phase 2]
A Phase 2 trial of pembrolizumab in PD-L1–expressing Diffuse Large B-Cell Lymphoma was terminated, and results were posted on February 20, 2…
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CLINICAL_TRIALS trial_result · 2026-02-17Clinical Trial Update: Pilot Study of Anti-CD19 Chimeric Antigen Receptor T Cells (CAR-T Cells) for the Treatment of Relapsed/Refractory CD19+ Malignancies [Phase 1]
Phase 1 pilot study evaluating anti-CD19 CAR-T cells for relapsed/refractory CD19+ malignancies; the trial is currently recruiting at the Un…
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CLINICAL_TRIALS trial_result · 2026-02-13Clinical Trial Update: A Study to Evaluate Zilovertamab Vedotin (MK-2140) for Relapsed or Refractory Diffuse Large B-Cell Lymphoma (DLBCL) (MK-2140-004) [Phase 2]
This clinical trial update reports on a Phase 2 study evaluating Zilovertamab Vedotin (MK-2140) in relapsed or refractory diffuse large B-ce…
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CLINICAL_TRIALS trial_result · 2026-02-12Clinical Trial Update: Evaluation of Prime-boost Anti-pneumococcal Vaccination in Patients With Diffuse Large B Cell Lymphoma Treated With Rituximab [Phase 3]
A Phase 3 clinical trial evaluating a prime-boost anti-pneumococcal vaccination strategy in patients with diffuse large B-cell lymphoma trea…
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CLINICAL_TRIALS trial_result · 2026-02-11Clinical Trial Update: A Study of C-CAR066 in Subjects With r/r Diffuse Large B Cell Lymphoma Who Received CD19 CAR-T Therapy [Phase 1]
Phase 1 results are reported for C-CAR066 in patients with relapsed/refractory diffuse large B-cell lymphoma who previously received CD19 CA…
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CLINICAL_TRIALS trial_result · 2026-02-11Clinical Trial Update: Exploratory Study of CD19-targeted Chimeric Antigen Receptor T Cells(BZ019) for Relapsed and Refractory B-cell Lymphoma [Phase 1]
A Phase 1 exploratory study evaluated CD19-targeted CAR T cells (BZ019) in relapsed/refractory B-cell lymphomas, including diffuse large B-c…
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CLINICAL_TRIALS trial_result · 2026-02-09Clinical Trial Update: A Study of PET Adapted Therapy and Non-invasive Monitoring for Previously Untreated Limited Stage Diffuse Large B Cell Lymphoma [Phase 2]
This is a Phase 2 clinical trial evaluating PET-adapted therapy and non-invasive monitoring for previously untreated limited-stage diffuse l…
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CLINICAL_TRIALS trial_result · 2026-02-06Clinical Trial Update: Dose Escalation/Dose Expansion Study of PRGN-3007 UltraCAR-T Cells in Patients With Advanced Hematologic and Solid Tumor Malignancies [Phase 1]
Phase 1 dose-escalation and expansion study of PRGN-3007 UltraCAR-T cells in patients with advanced hematologic and solid tumors has complet…
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CLINICAL_TRIALS trial_result · 2026-02-06Clinical Trial Update: Zanubrutinib in Combination With R-PolaCHP (ZaR-PolaCHP) for Newly Diagnosed Diffuse Large B-Cell Lymphoma [Phase 1]
A Phase 1 trial of zanubrutinib in combination with R-PolaCHP for newly diagnosed diffuse large B-cell lymphoma has been suspended.
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CLINICAL_TRIALS trial_result · 2026-02-06Clinical Trial Update: A Study Comparing the Efficacy and Safety of Polatuzumab Vedotin With Rituximab-Cyclophosphamide, Doxorubicin, and Prednisone (R-CHP) Versus Rituximab-Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone (R-CHOP) in Participants With Diffuse Large B-Cell Lymphoma [Phase 3]
Phase 3 trial comparing polatuzumab vedotin with R-CHP versus R-CHOP in patients with diffuse large B-cell lymphoma; the study is currently …
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CLINICAL_TRIALS trial_result · 2026-02-04Clinical Trial Update: Study of Purinostat Mesylate for Injection in the Treatment of Relapsed or Refractory Diffuse Large B-cell Lymphoma (R/R DLBCL) [Phase 2]
Phase 2 clinical trial update for Purinostat Mesylate in relapsed or refractory diffuse large B-cell lymphoma, with the study currently acti…
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CLINICAL_TRIALS trial_result · 2026-02-02Clinical Trial Update: Study of Axicabtagene Ciloleucel Given With Steroids In Participants With Relapsed Or Refractory Large B-Cell Lymphoma [Phase 2]
Phase 2 study evaluating axicabtagene ciloleucel given with steroids in relapsed or refractory diffuse large B-cell lymphoma has completed.
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CLINICAL_TRIALS trial_result · 2026-02-02Clinical Trial Update: Parsaclisib Plus the Standard Drug Therapy in Patients With Newly Diagnosed, High Risk Diffuse Large B-cell Lymphoma [Phase 1]
An early-phase study evaluating the combination of parsaclisib with standard therapy in newly diagnosed, high-risk diffuse large B-cell lymp…
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CLINICAL_TRIALS trial_result · 2026-02-02Clinical Trial Update: Observational Study of People Living With HIV Treated With CD19-directed CAR T Cell
An observational study of people living with HIV treated with CD19-directed CAR T-cell therapy has completed.
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CLINICAL_TRIALS trial_result · 2026-02-02Clinical Trial Update: A Study to Evaluate the Effectiveness and Safety of Polatuzumab in Real World Clinical Practice Among Adult Chinese Participants With Diffuse Large B-Cell Lymphoma
This is a clinical trial update describing a study to evaluate the effectiveness and safety of Polivy (polatuzumab vedotin) in real-world Ch…
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CLINICAL_TRIALS trial_result · 2026-01-29Clinical Trial Update: Acalabrutinib + Liso-Cel In R/R Aggressive B-Cell Lymphomas [Phase 2]
Phase 2 study evaluating acalabrutinib plus lisocabtagene maraleucel (Liso-Cel) in refractory/relapsed aggressive B-cell lymphomas, includin…
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CLINICAL_TRIALS trial_result · 2026-01-29Clinical Trial Update: Split-Dose R-CHOP for Older Adults With DLBCL [Phase 2]
Phase 2 trial update reporting results for split-dose R-CHOP in older adults with Diffuse Large B-Cell Lymphoma; results were posted on 2026…
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CLINICAL_TRIALS trial_result · 2026-01-26Clinical Trial Update: A Study of PRT2527 as Monotherapy and in Combination With Zanubrutinib or Venetoclax in Participants With R/R Hematologic Malignancies [Phase 1]
A Phase 1 clinical trial evaluates PRT2527 as a standalone therapy and in combination with zanubrutinib or venetoclax for relapsed/refractor…
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CLINICAL_TRIALS trial_result · 2026-01-26Clinical Trial Update: A Safety Study of PF-08046045/SGN-35T in Adults With Advanced Cancers [Phase 1]
A Phase 1 safety study of PF-08046045/SGN-35T sponsored by Seagen has been terminated in adults with advanced lymphomas and Hodgkin disease.
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CLINICAL_TRIALS trial_result · 2026-01-23Clinical Trial Update: MT2017-45: CAR-T Cell Therapy for Heme Malignancies [Phase 2]
Phase 2 trial MT2017-45 CAR-T cell therapy for hematologic malignancies has an active-not-recruiting status with results posted as of 2026-0…
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CLINICAL_TRIALS trial_result · 2026-01-08Clinical Trial Update: Glofitamab Combined With CAR-T Therapy in R/R DLBCL [Phase 2]
Phase 2 clinical trial assessing glofitamab in combination with CAR-T therapy for relapsed/refractory diffuse large B-cell lymphoma; the stu…
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CLINICAL_TRIALS trial_result · 2026-01-06Clinical Trial Update: Pharmacogenomics Effects on High-Dose Methotrexate Clearance in Patients With Diffuse Large B-Cell Lymphoma
This trial update reports on pharmacogenomics effects on the clearance of high-dose methotrexate in patients with diffuse large B-cell lymph…
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CLINICAL_TRIALS trial_result · 2026-01-05Clinical Trial Update: Prevention of Anthracycline-Induced Cardiac Dysfunction With Dexrazoxane in Patients With Diffuse Large-B Cell Lymphoma [Phase 3]
This Phase 3 trial is investigating whether dexrazoxane can prevent heart damage caused by anthracycline chemotherapy in patients with Diffu…
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CLINICAL_TRIALS trial_result · 2026-01-02Clinical Trial Update: Kinetics of Circulating Tumor DNA in Lymphoma Treated by Immuno-chemotherapy [NA]
A completed clinical trial studying the kinetics of circulating tumor DNA in patients with Diffuse Large B Cell Lymphoma treated with immuno…
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CLINICAL_TRIALS trial_result · 2025-12-30Clinical Trial Update: Treatment and Outcomes of DLBCL After Progression on Polatuzumab Vedotin-based Combination Therapy
This clinical trial update discusses treatment approaches and outcomes for patients with diffuse large B-cell lymphoma who progressed after …