Diffuse Large B-cell Lymphoma
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2026-03-31Clinical Trial Update: A Combination of Acalabrutinib With R-CHOP in Subjects With Previously Untreated Non-GCB DLBCL (ACE-LY-312) [Phase 3]
This clinical trial update describes ACE-LY-312, a Phase 3 study evaluating acalabrutinib in combination with R-CHOP for previously untreate…
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CLINICAL_TRIALS research · 2026-03-31Clinical Trial Update: TPG: Tafasitamab, Polatuzumab Vedotin, and Glofitamab as First-line Therapy for Diffuse Large B-cell Lymphoma and High-grade B-cell Lymphoma [Phase 2]
Phase 2 trial evaluating first-line Tafasitamab, Polatuzumab Vedotin, and Glofitamab for diffuse large B-cell lymphoma and high-grade B-cell…
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CLINICAL_TRIALS research · 2026-03-30Clinical Trial Update: Genetic Subtype-matched Targeted Therapy for the Treatment of Newly Diagnosed DLBCL With TP53 Mutation [Phase 2]
Phase 2 clinical trial evaluating a genetic subtype-matched targeted therapy for newly diagnosed Diffuse Large B-Cell Lymphoma with TP53 mut…
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CLINICAL_TRIALS research · 2026-03-30Clinical Trial Update: Gene Therapy for CD19-Positive Hematologic Malignancies (SENTRY-CD19) [Phase 1, Phase 2]
A Phase 1/2 clinical trial of SENTRY-CD19, a CD19-targeted gene therapy, in multiple CD19-positive hematologic malignancies is currently rec…
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CLINICAL_TRIALS research · 2026-03-30Clinical Trial Update: NexCAR19 (Talikabtagene Autoleucel) in Relapsed/Refractory B-Cell Malignancies (NexCAR19) [Phase 2, Phase 3]
Clinical trial update for NexCAR19 (Talikabtagene autoleucel), a CAR-T therapy studied in relapsed/refractory B-cell malignancies; the Phase…
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CLINICAL_TRIALS research · 2026-03-27Clinical Trial Update: A Study to Learn About the Effects of Two Study Medicines (Maplirpacept [PF-07901801] And Glofitamab) When Given Together In People With Relapsed Or Refractory Diffuse Large B Cell Lymphoma. [Phase 1, Phase 2]
Clinical trial update on a Phase 1/2 study evaluating Maplirpacept and Glofitamab together in relapsed or refractory diffuse large B-cell ly…
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CLINICAL_TRIALS research · 2026-03-27Clinical Trial Update: Celecoxib Plus R-CHOP vs R-CHOP in Newly Diagnosed Advanced CD5+ DLBCL [Phase 2]
This entry describes a Phase 2 trial comparing celecoxib added to R-CHOP versus R-CHOP alone in newly diagnosed CD5-positive diffuse large B…
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CLINICAL_TRIALS research · 2026-03-27Clinical Trial Update: Study of Bcl-2 Inhibitor Sonrotoclax (BGB-11417) in Participants With Mature B-Cell Malignancies [Phase 1]
Phase 1 clinical trial evaluating Sonrotoclax (BGB-11417), a Bcl-2 inhibitor, in participants with mature B-cell malignancies. The study is …
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CLINICAL_TRIALS research · 2026-03-27Clinical Trial Update: Glofitamab in Chinese Patients With R/R DLBCL
Clinical trial update for glofitamab in Chinese patients with relapsed/refractory diffuse large B-cell lymphoma; the study is currently recr…
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CLINICAL_TRIALS research · 2026-03-27Clinical Trial Update: Gut Microbiome in DLBCL Treated With Glofitamab
Clinical trial update examining the gut microbiome in patients with diffuse large B-cell lymphoma treated with glofitamab; the study status …
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CLINICAL_TRIALS research · 2026-03-25Clinical Trial Update: Chidamide Combination With R-mini CHOP Followed by Chidamide+CD20 Maintenance in Elderly Newly Diagnosed MYC/BCL2+ DLBCL [Phase 2]
A Phase 2 trial is evaluating chidamide in combination with R-mini CHOP followed by chidamide plus CD20 maintenance in elderly patients with…
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CLINICAL_TRIALS research · 2026-03-24Clinical Trial Update: Study to Evaluate Loncastuximab Tesirine With Rituximab Versus Immunochemotherapy in Participants With Relapsed or Refractory Diffuse Large B-Cell Lymphoma [Phase 3]
Phase 3 study evaluating loncastuximab tesirine with rituximab versus immunochemotherapy in relapsed or refractory diffuse large B-cell lymp…
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CLINICAL_TRIALS research · 2026-03-24Clinical Trial Update: Enhancing CAR-T Cell Therapy Efficacy in B-cell Lymphoma Via Chidamide and PD-1 Inhibitor Combination. [Phase 2]
A Phase 2 clinical trial is evaluating whether combining chidamide and a PD-1 inhibitor can improve the efficacy of CAR-T cell therapy in re…
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CLINICAL_TRIALS research · 2026-03-24Clinical Trial Update: Nemtabrutinib and Pembrolizumab for the Treatment of Richter Transformation, Diffuse Large B-cell Lymphoma Subtype [Phase 2]
Phase 2 study evaluating nemtabrutinib combined with pembrolizumab for Richter transformation and Diffuse Large B-Cell Lymphoma in patients …
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CLINICAL_TRIALS research · 2026-03-24Clinical Trial Update: A Study of Ultra-fraction Radiotherapy Bridging CART in R/R DLBCL [NA]
Clinical trial update for a study evaluating ultra-fraction radiotherapy as bridging therapy before CAR-T in relapsed/refractory diffuse lar…
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CLINICAL_TRIALS research · 2026-03-23Clinical Trial Update: Rituxan/Bendamustine/PCI-32765 in Relapsed DLBCL, MCL, or Indolent Non-Hodgkin's Lymphoma [Phase 1]
Phase 1 clinical trial evaluating Rituximab plus Bendamustine and ibrutinib (PCI-32765) in relapsed DLBCL, mantle cell lymphoma, and various…
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CLINICAL_TRIALS research · 2026-03-20Clinical Trial Update: A Study of NX-2127 in Adults With Relapsed/Refractory B-cell Malignancies [Phase 1]
Phase 1 study evaluating NX-2127 in adults with relapsed or refractory B-cell malignancies; currently recruiting.
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CLINICAL_TRIALS research · 2026-03-20Clinical Trial Update: NKTR-255 in Combination With CAR-T Cell Therapy for the Treatment of Relapsed or Refractory Large B-cell Lymphoma [Phase 1]
This clinical trial update describes a Phase 1 study of NKTR-255 in combination with CAR-T cell therapy for relapsed or refractory large B-c…
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CLINICAL_TRIALS research · 2026-03-18Clinical Trial Update: Study of Iopofosine I-131 (CLR 131) in Select B-Cell Malignancies (CLOVER-1) With Expansion in Waldenstrom [Phase 2]
Phase 2 clinical trial update for CLR-131 in select B-cell malignancies, with expansion into Waldenström macroglobulinemia. The study status…
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CLINICAL_TRIALS research · 2026-03-18Clinical Trial Update: CAR-T Followed by Bispecific Antibodies [Phase 2]
Phase 2 clinical trial evaluating sequencing of CAR-T therapy followed by bispecific antibodies in diffuse large B-cell lymphoma; currently …
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CLINICAL_TRIALS research · 2026-03-18Clinical Trial Update: A Study of AZD0486 in Subjects With B-Cell Non-Hodgkin Lymphoma [Phase 1]
AstraZeneca reports a Phase 1 clinical trial of AZD0486 in B-cell non-Hodgkin lymphomas, including diffuse large B-cell lymphoma, high-grade…
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CLINICAL_TRIALS research · 2026-03-18Clinical Trial Update: Radiation, Oral Vancomycin, and CAR-T for B-Cell Lymphomas [Phase 1]
Phase 1 clinical trial update evaluating radiation therapy, oral vancomycin, and CAR-T cell therapy for large B-cell/Non-Hodgkin lymphoma, c…
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CLINICAL_TRIALS research · 2026-03-17Clinical Trial Update: A Study to Evaluate MTM-H-001 Injection in Adult Participants With Relapsed or Refractory B-cell Malignancies [NA]
This clinical trial update describes an evaluation of MTM-H-001 injection in adults with relapsed or refractory B-cell lymphomas, with the s…
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CLINICAL_TRIALS research · 2026-03-16Clinical Trial Update: CD79b-19 CAR T Cells in Non-Hodgkin Lymphoma [Phase 1]
A Phase 1 clinical trial evaluating CD79b-19 CAR T cells for relapsed or refractory non-Hodgkin lymphoma, including several subtypes, is cur…
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CLINICAL_TRIALS research · 2026-03-16Clinical Trial Update: Study of Safety and Efficacy of TC011 in the Relapsed/Refractory Large B Cell Non-Hodgkin Lymphoma Patients [Phase 1, Phase 2]
This clinical trial update describes a Phase 1/2 study of TC011 for relapsed/refractory large B-cell non-Hodgkin lymphoma, assessing safety …