Diffuse Large B-cell Lymphoma
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2026-04-20Clinical Trial Update: Phase I Clinical Study on the Safety and Efficacy of CY-219 CAR-T Cell Injection in the Treatment of Relapsed/Refractory B-Cell Lymphoma [Phase 1]
Phase I clinical trial evaluating CY-219 CAR-T cell therapy for relapsed/refractory B-cell lymphoma; not yet recruiting.
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CLINICAL_TRIALS research · 2026-04-20Clinical Trial Update: Leukapheresis for CAR or Adoptive Cell Therapy Manufacturing
A clinical trial update describing leukapheresis collection for manufacturing CAR or adoptive cell therapies, with enrollment by invitation …
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CLINICAL_TRIALS research · 2026-04-17Clinical Trial Update: A Study of LY4584180 in Adult Participants With Previously Treated Blood Cancers [Phase 1]
This is a Phase 1 clinical trial update for LY4584180 in adults with previously treated blood cancers, including Non-Hodgkin lymphoma, diffu…
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CLINICAL_TRIALS research · 2026-04-17Clinical Trial Update: Study of CTO1681 for the Prevention and Treatment of CRS in DLBCL Patients Receiving CAR T-Cell Therapy [Phase 1, Phase 2]
A clinical trial update indicates CTO1681 is being studied in Phase 1/2 to prevent or treat cytokine release syndrome in patients with diffu…
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CLINICAL_TRIALS research · 2026-04-17Clinical Trial Update: Study of Rondecabtagene Autoleucel in Aggressive Large B-Cell Lymphoma [Phase 1, Phase 2]
A Phase 1/2 study evaluating Rondecabtagene Autoleucel for aggressive large B-cell lymphoma in patients with relapsed or refractory Non-Hodg…
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CLINICAL_TRIALS research · 2026-04-16Clinical Trial Update: Ascorbic Acid and Chemotherapy for the Treatment of Relapsed or Refractory Lymphoma, CCUS, and Chronic Myelomonocytic Leukemia [Phase 2]
A Phase 2 clinical trial evaluating ascorbic acid with chemotherapy for relapsed/refractory lymphoma, clonal cytopenia of undetermined signi…
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CLINICAL_TRIALS research · 2026-04-16Clinical Trial Update: IOMAB-CAR-T Followed by CAR-T Cell Therapy in R/R DLBCL [Phase 1, Phase 2]
This clinical trial update describes sequential IOMAB-CAR-T followed by CAR-T cell therapy for relapsed/refractory diffuse large B-cell lymp…
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CLINICAL_TRIALS research · 2026-04-15Clinical Trial Update: Rituximab, Lenalidomide, Acalabrutinib, Tafasitamab Alone and With Combination Chemotherapy for the Treatment of Newly Diagnosed Non-germinal Center Diffuse Large B-Cell Lymphoma, Smart Stop Study [Phase 2]
Phase 2 clinical trial evaluating rituximab, lenalidomide, acalabrutinib, and tafasitamab (alone and with chemotherapy) for newly diagnosed …
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CLINICAL_TRIALS research · 2026-04-15Clinical Trial Update: Pomalidomide, Anti-PD-1 Antibody Combined With Selinexor (PPS) in Relapsed/Refractory Primary Central Nervous System Diffuse Large B-Cell Lymphoma [Phase 2]
A Phase 2 clinical trial evaluating pomalidomide combined with an anti-PD-1 antibody and selinexor (PPS) in relapsed/refractory primary cent…
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CLINICAL_TRIALS research · 2026-04-15Clinical Trial Update: Autologous Stem Cell Transplant Followed by Polatuzumab Vedotin in Patients With B-cell Non-Hodgkin and Hodgkin Lymphoma [Phase 1, Phase 2]
A Phase 1/2 clinical trial update describes autologous stem cell transplant followed by polatuzumab vedotin for patients with various B-cell…
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CLINICAL_TRIALS research · 2026-04-15Clinical Trial Update: Study to Compare Axicabtagene Ciloleucel With Standard of Care Therapy as First-line Treatment in Participants With High-risk Large B-cell Lymphoma [Phase 3]
A Phase 3 trial is evaluating axicabtagene ciloleucel versus standard-of-care therapy as first-line treatment for high-risk diffuse large B-…
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CLINICAL_TRIALS research · 2026-04-15Clinical Trial Update: Geriatric-guided Care Versus Conventional Care in Elderly Unfit/Frail Patients With Diffuse Large B-cell Lymphoma in First Line Treatment [NA]
Clinical trial comparing geriatric-guided care versus conventional care in elderly unfit/frail patients with Diffuse Large B-Cell Lymphoma a…
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CLINICAL_TRIALS research · 2026-04-14Clinical Trial Update: Immune Cell Therapy (CAR-T) for the Treatment of Patients With HIV and B-Cell Non-Hodgkin Lymphoma [Phase 1]
Phase 1 clinical trial evaluating CAR-T cell therapy for HIV-infected individuals with AIDS-related and other B-cell non-Hodgkin lymphomas; …
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: Constitutive IL7R (C7R) Modified Banked Allogeneic CD30.CAR EBVSTS for CD30-Positive Lymphomas [Phase 1]
Phase 1 clinical trial update for constitutive IL7R (C7R) modified banked allogeneic CD30.CAR EBVSTs in CD30-positive lymphomas, currently r…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: A Study of JNJ-90014496 in Participants With B-Cell Non-Hodgkin Lymphoma [Phase 1, Phase 2]
This document provides a status update on a Phase 1/2 clinical trial evaluating JNJ-90014496 in participants with B-cell non-Hodgkin lymphom…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: Testing the Combination of Nivolumab and ASTX727 for Relapsed or Refractory B-Cell Lymphoma [Phase 1]
A Phase 1 clinical trial is evaluating the combination of nivolumab with ASTX727 (decitabine/cedazuridine) in relapsed or refractory B-cell …
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: Testing the Addition of an Immunotherapy Agent, Atezolizumab, When Given With the Usual Chemo-Immunotherapy Drug Combination (Rituximab Plus Gemcitabine and Oxaliplatin) for Relapsed/Refractory (That Has Come Back or Not Responded to Treatment) Transformed Diffuse Large B-Cell Lymphoma [Phase 1]
A Phase 1 trial is evaluating the addition of the immunotherapy atezolizumab to a Rituximab-Gemcitabine-Oxaliplatin regimen for relapsed/ref…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: A Study of AZD0486 Monotherapy or in Combination With Other Anti-Cancer Agents for Mature B-Cell Malignancies [Phase 1, Phase 2]
AstraZeneca is evaluating AZD0486 as a monotherapy or in combination with other anticancer agents for mature B-cell malignancies in Phase 1/…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: A Long-term Extension Study of PCI-32765 (Ibrutinib) [Phase 3]
Phase 3 long-term extension study of ibrutinib (PCI-32765) in chronic lymphocytic leukemia/small lymphocytic lymphoma and other B-cell malig…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: KSV01 Injection for the Treatment of Relapsed/Refractory Diffuse Large B-Cell Lymphoma [Phase 1]
Phase 1 clinical trial update for KSV01 injection in relapsed/refractory diffuse large B-cell lymphoma (DLBCL) and non-Hodgkin lymphoma; tri…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: Real World Practice With Academic Anti CD19 CAR-T Cell Therapy in Relapse/Refractory B-cell Lymphoma
This clinical trial explores real-world use of an academic anti-CD19 CAR-T cell therapy for relapse/refractory diffuse large B-cell lymphoma…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: Testing the Addition of a New Anti-cancer Drug, Venetoclax, to Usual Chemotherapy for High Grade B-cell Lymphomas [Phase 2, Phase 3]
A Phase 2/Phase 3 trial is evaluating adding venetoclax to standard chemotherapy for high-grade B-cell lymphomas, including diffuse large B-…
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CLINICAL_TRIALS research · 2026-04-09Clinical Trial Update: NT-I7 (Efineptakin Alfa), a Long-acting Human IL-7, Post-Axicabtagene Ciloleucel or Post-Lisocabtagene Maraleucel in Subjects With Relapsed/Refractory Large B-cell Lymphoma [Phase 1]
Phase 1 trial evaluating NT-I7 (efineptakin alfa), a long-acting IL-7, in patients with relapsed/refractory diffuse large B-cell lymphoma af…
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CLINICAL_TRIALS research · 2026-04-09Clinical Trial Update: A Clinical Study of MK-1045 in People With Non-Hodgkin Lymphoma (MK-1045-008) [Phase 1, Phase 2]
This is a Phase 1/2 clinical study of MK-1045 for non-Hodgkin lymphoma, including follicular lymphoma and diffuse large B-cell lymphoma, wit…
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CLINICAL_TRIALS research · 2026-04-08Clinical Trial Update: A Sub-study Trial of Epcoritamab vs Investigator's Choice Chemotherapy in Relapsed/Refractory Diffuse Large B-cell Lymphoma (R/R DLBCL) in China [Phase 3]
A Phase 3 sub-study comparing epcoritamab to investigator's choice chemotherapy in relapsed/refractory diffuse large B-cell lymphoma in Chin…