Diffuse Large B-cell Lymphoma
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2025-11-06Clinical Trial Update: Rituximab (Rtx) + Tafasitamab in Combination With Allogeneic NK Cells for Treatment of Relapsed/Refractory (r/r) B-cell Non-Hodgkin Lymphoma (NHL) [Phase 1]
Phase 1 clinical trial evaluating the combination of Rituximab and Tafasitamab with allogeneic NK cells in relapsed/refractory B-cell non-Ho…
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CLINICAL_TRIALS research · 2025-11-04Clinical Trial Update: Hyperfractionated Dual Equivalent Fractionated Radiation Therapy [NA]
A clinical trial at Yale University is evaluating a hyperfractionated dual equivalent fractionated radiation therapy approach for Diffuse La…
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CLINICAL_TRIALS research · 2025-10-23Clinical Trial Update: Adding Pirtobrutinib to the Usual Treatment for People With Newly Diagnosed Richter Transformation, The PIRAMID Trial [Phase 3]
Phase 3 PIRAMID trial evaluating adding pirtobrutinib to standard therapy for newly diagnosed Richter transformation (transformed CLL/SLL to…
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CLINICAL_TRIALS research · 2025-10-20Clinical Trial Update: Study Adding Drugs to Usual Treatment for Large B-Cell Lymphoma That Returned or Did Not Respond to Treatment [Phase 2]
This SWOG Cancer Research Network Phase 2 trial is evaluating adding drugs to standard therapy for large B-cell lymphoma that has returned o…
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CLINICAL_TRIALS research · 2025-10-20Clinical Trial Update: A Phase Ib Study of VK-2019 in Patients With Relapsed or Refractory EBV+ Diffuse Large B-cell Lymphomas (DLBCL) [Phase 1]
Phase Ib study of VK-2019 in patients with EBV-positive diffuse large B-cell lymphoma (EBV+ DLBCL). The trial is currently recruiting.
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CLINICAL_TRIALS research · 2025-10-20Clinical Trial Update: A Study to Evaluate the Impact of Mosunetuzumab Consolidation for Older Patients With Diffuse Large B-cell Lymphoma (DLBCL) Who Have Detectable Amounts of ctDNA (Circulating Tumor DNA) at the End of Treatment With Pola-R-mini-CHP [Phase 2]
This is a Phase 2 clinical trial investigating mosunetuzumab consolidation for older patients with diffuse large B-cell lymphoma who have de…
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CLINICAL_TRIALS research · 2025-10-16Clinical Trial Update: Study of the Monoclonal Antibody IMT-009 in Patients With Advanced Solid Tumors or Lymphomas [Phase 1, Phase 2]
Clinical trial update describing a Phase 1/2 study of the monoclonal antibody IMT-009 in various advanced solid tumors and lymphomas, with t…
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CLINICAL_TRIALS research · 2025-10-16Clinical Trial Update: Loncastuximab Tesirine for the Treatment of Relapsed or Refractory B-Cell Malignancies [Phase 2]
This update reports a Phase 2 trial of loncastuximab tesirine for relapsed or refractory B-cell malignancies that is currently recruiting, i…
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CLINICAL_TRIALS research · 2025-10-09Clinical Trial Update: Study of a Communication Training Intervention for Large B-Cell Lymphoma Providers [NA]
Memorial Sloan Kettering Cancer Center reports an ongoing trial evaluating a communication training intervention for clinicians treating lar…
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CLINICAL_TRIALS research · 2025-10-06Clinical Trial Update: Genetically Modified T-cell Infusion Following Peripheral Blood Stem Cell Transplant in Treating Patients With Recurrent or High-Risk Non-Hodgkin Lymphoma [Phase 1]
This update outlines a Phase 1 study of genetically modified T-cell infusions following peripheral blood stem cell transplant for patients w…
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CLINICAL_TRIALS research · 2025-10-03Clinical Trial Update: A Study of Rituximab-Gemcitabine-Dexamethasone-Platinum (R-GDP) With or Without Selinexor in Patients With Relapsed/Refractory Diffuse Large B-cell Lymphoma [Phase 2, Phase 3]
A Phase 2/3 clinical trial is evaluating the addition of selinexor to the Rituximab-Gemcitabine-Dexamethasone-Platinum regimen for relapsed/…
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CLINICAL_TRIALS research · 2025-10-03Clinical Trial Update: Bio-CAR-T BS Study
A clinical trial update indicates the Bio-CAR-T BS study is currently recruiting for diffuse large B-cell lymphoma, primary mediastinal B-ce…
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CLINICAL_TRIALS research · 2025-10-01Clinical Trial Update: Selinexor (KPT-330) in Patients With Relapsed/Refractory Diffuse Large B-Cell Lymphoma (DLBCL) [Phase 2]
A Phase 2 trial of Selinexor (KPT-330) for relapsed or refractory diffuse large B-cell lymphoma is currently recruiting. No trial results ar…
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CLINICAL_TRIALS research · 2025-09-30Clinical Trial Update: Polatuzumab Vedotin Plus Rituximab, Ifosfamide, Carboplatin and Etoposide (Pola-R-ICE) Versus R-ICE Alone in Second Line Treatment of Diffuse Large B-cell Lymphoma (DLBCL) [Phase 3]
Phase 3 trial Pola-R-ICE vs R-ICE in second-line Diffuse Large B-Cell Lymphoma is currently active but not recruiting. The study evaluates a…
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CLINICAL_TRIALS research · 2025-09-30Clinical Trial Update: Is Trogocytosis a Predictive Marker of CAR-T Cell Response in Diffuse Large B-cell Lymphoma? [NA]
This clinical trial investigates whether trogocytosis can serve as a predictive biomarker for CAR-T cell response in patients with diffuse l…
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CLINICAL_TRIALS research · 2025-09-30Clinical Trial Update: Brentuximab Vedotin Combined With R-CHP in Newly Diagnosed EBV+ DLBCL-NOS [Phase 2]
Phase 2 trial update evaluating Brentuximab Vedotin with R-CHP in newly diagnosed EBV-positive diffuse large B-cell lymphoma, NOS; the study…
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CLINICAL_TRIALS research · 2025-09-29Clinical Trial Update: Epcoritamab Plus Standard of Care Platinum-Based Chemotherapy and Autologous Hematopoietic Cell Transplant for the Treatment of Relapsed or Refractory Large B-cell Lymphoma [Phase 2]
A Phase 2 trial evaluating epcoritamab in combination with standard platinum-based chemotherapy and autologous hematopoietic cell transplant…
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CLINICAL_TRIALS research · 2025-09-29Clinical Trial Update: Selinexor Plus Combination Chemotherapy in Treating Patients With Advanced B Cell Non-Hodgkin Lymphoma [Phase 1, Phase 2]
Clinical trial update describes an ongoing Phase 1/2 study of selinexor in combination chemotherapy for advanced B-cell non-Hodgkin lymphoma…
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CLINICAL_TRIALS research · 2025-09-29Clinical Trial Update: Odronextamab for the Treatment of Relapsed and Refractory Diffuse Large B-cell Lymphoma Before and After Chimeric Antigen Receptor T-cell Therapy [Phase 2]
A Phase 2 clinical trial evaluating odronextamab for relapsed or refractory diffuse large B-cell lymphoma before and after CAR T-cell therap…
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CLINICAL_TRIALS research · 2025-09-29Clinical Trial Update: Nivolumab and Lenalidomide in Treating Patients With Relapsed or Refractory Non-Hodgkin or Hodgkin Lymphoma [Phase 1, Phase 2]
Phase 1/2 clinical trial update evaluating the combination of nivolumab and lenalidomide in relapsed or refractory lymphomas (non-Hodgkin an…
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CLINICAL_TRIALS research · 2025-09-26Clinical Trial Update: A Study of GNC-038, a Tetra-specific Antibody, in Participants With R/R Diffuse Large B-cell Lymphoma (DLBCL) [Phase 1, Phase 2]
A clinical trial update for GNC-038, a tetra-specific antibody, in relapsed/refractory diffuse large B-cell lymphoma (DLBCL) in Phase 1/2, c…
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CLINICAL_TRIALS research · 2025-09-25Clinical Trial Update: Low Dose Radiation as Bridging Therapy in Relapsed B-Cell Non-Hodgkin Lymphoma [Phase 1]
This Phase 1 trial evaluates low-dose radiation as bridging therapy for relapsed or refractory B-cell non-Hodgkin lymphomas, including DLBCL…
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CLINICAL_TRIALS research · 2025-09-23Clinical Trial Update: Evaluate Safety of Axicabtagene Ciloleucel Reinfusion (Axi-Cel-2) in Patients With Relapsed and/or Refractory Second Line High-Risk Non-Hodgkin Lymphoma After Standard of Care Axi-Cel [Phase 1]
Phase 1 clinical trial evaluating the safety of reinfusing axicabtagene ciloleucel (Axi-Cel-2) in patients with relapsed/refractory second-l…
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CLINICAL_TRIALS research · 2025-09-22Clinical Trial Update: Dose-Reduced Consolidation Radiation Therapy in Patients With Diffuse Large B-cell Lymphoma [NA]
Clinical trial update on dose-reduced consolidation radiation therapy for patients with diffuse large B-cell lymphoma; the study is currentl…
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CLINICAL_TRIALS research · 2025-09-19Clinical Trial Update: A Phase III Clinical Study of Purinostat Mesylate for Injection in Patients With Diffuse Large B-cell Lymphoma [Phase 3]
A Phase III clinical trial is evaluating Purinostat Mesylate for injection in patients with recurrent or refractory diffuse large B-cell lym…