Desmoid-type Fibromatosis
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2026-04-17Clinical Trial Update: A Study of Nirogacestat in Japanese Adults With Desmoid Tumors/Aggressive Fibromatosis (DT/AF) [Phase 2]
This document provides an update on a Phase 2 clinical trial of nirogacestat in Japanese adults with desmoid tumors/aggressive fibromatosis.
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CLINICAL_TRIALS research · 2026-04-06Clinical Trial Update: Nirogacestat in Premenopausal Females With Desmoid Tumor/Aggressive Fibromatosis (DT/AF) [Phase 4]
A Phase 4 clinical trial evaluating Nirogacestat in premenopausal females with desmoid-type fibromatosis is currently recruiting. The study …
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EMA approval · 2026-03-31EMA Authorised: Ogsiveo (nirogacestat hydrobromide) — SpringWorks Therapeutics Ireland Limited
EMA authorised Ogsiveo (nirogacestat hydrobromide) for desmoid tumors, designated as an orphan medicine in the EU.
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CLINICAL_TRIALS research · 2026-03-27Clinical Trial Update: Immunological Phenotype of Desmoid-fibromatosis-affected Patients.
A clinical trial investigating the immunological phenotype of patients with desmoid-type fibromatosis, currently recruiting participants.
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CLINICAL_TRIALS research · 2026-03-10Clinical Trial Update: Familial Adenomatous Poliposys Italian Network (Rete Italiana Poliposi Adenomatosa Familiare)
Clinical trial update shows the Italian Network for Familial Adenomatous Polyposis study is active but not recruiting, covering FAP, AFAP an…
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CLINICAL_TRIALS research · 2026-02-24Clinical Trial Update: Tegavivint for the Treatment of Recurrent or Refractory Solid Tumors, Including Lymphomas and Desmoid Tumors [Phase 1, Phase 2]
A Phase 1/2 clinical trial update for tegavivint in recurrent or refractory solid tumors, including lymphomas and desmoid tumors, currently …
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CLINICAL_TRIALS trial_result · 2026-02-05Clinical Trial Update: A Study of AL102 in Patients With Progressing Desmoid Tumors [Phase 2, Phase 3]
A Phase 2/Phase 3 clinical trial evaluating AL102 in patients with progressing desmoid-type fibromatosis (desmoid tumors) is ongoing and cur…
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CLINICAL_TRIALS research · 2026-02-04Clinical Trial Update: HIFU Ablation of Soft Tissue Sarcoma [NA]
This clinical trial update reports ongoing recruitment for high-intensity focused ultrasound (HIFU) ablation in soft tissue sarcoma and desm…
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CLINICAL_TRIALS research · 2025-12-23Clinical Trial Update: Electrochemotherapy for Desmoid Tumors
ClinicalTrials.gov reports an ongoing study on electrochemotherapy for desmoid-type fibromatosis that is currently recruiting.
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CLINICAL_TRIALS trial_result · 2025-12-23Clinical Trial Update: Endoxifen in Adults With Hormone Receptor Positive Solid Tumors [Phase 1]
Phase 1 clinical trial update of endoxifen in adults with hormone receptor-positive solid tumors; the study is reported as completed.
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CLINICAL_TRIALS trial_result · 2025-09-11Clinical Trial Update: Tailored Beta-catenin Mutational Approach in Extra-abdominal Sporadic Desmoids Tumor Patients
The clinical trial evaluating a tailored beta-catenin mutational approach for extra-abdominal sporadic desmoid-type fibromatosis has complet…
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CLINICAL_TRIALS research · 2025-05-16Clinical Trial Update: Observing People With Desmoid-Type Fibromatosis
This clinical trial update notes the recruitment status for an observational study of desmoid-type fibromatosis at Memorial Sloan Kettering …
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CLINICAL_TRIALS research · 2025-04-02Clinical Trial Update: Arterial Chemoembolization for the Treatment of Desmoid Fibromatosis
This clinical trial update indicates that a study evaluating arterial chemoembolization for desmoid-type fibromatosis is currently recruitin…
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CLINICAL_TRIALS withdrawal · 2024-12-09Clinical Trial Update: Vactosertib and Imatinib Combination in Patients with Advanced Desmoid Tumor/aggressive Fibromatosis (DT/AF) [Phase 2]
A Phase 2 trial evaluating the combination of Vactosertib and Imatinib for advanced Desmoid Tumor / Aggressive Fibromatosis has been withdra…
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CLINICAL_TRIALS trial_result · 2024-06-12Clinical Trial Update: Nirogacestat for Adults With Desmoid Tumor/Aggressive Fibromatosis (DT/AF) [Phase 3]
Phase 3 trial results for nirogacestat in adults with desmoid-type fibromatosis have been completed and results posted.
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FDA approval · 2024-04-04FDA Approved: OGSIVEO — Supplemental Application (SpringWorks Therapeutics, Inc.)
The FDA approved a supplemental application for OGSIVEO (nirogacestat) from SpringWorks Therapeutics, expanding the drug's approved use.
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FDA approval · 2023-11-27FDA Approved: OGSIVEO — Original Application (SpringWorks Therapeutics, Inc.)
FDA approved OGSIVEO (nirogacestat) through an original NDA submitted by SpringWorks Therapeutics, Inc. for the treatment of desmoid tumors.
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CLINICAL_TRIALS trial_result · 2021-03-05Clinical Trial Update: PAZOPANIB Efficacy and Tolerance in Desmoids Tumors [Phase 2]
Phase 2 trial evaluating pazopanib for progressive desmoid-type fibromatosis reports efficacy and tolerability results. The study is complet…
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CLINICAL_TRIALS research · 2019-02-01Clinical Trial Update: Compassionate Use Protocol for PF-03084014 in Patients With Advanced Solid Tumor Malignancies
This update notes that the compassionate-use protocol for PF-03084014 in patients with advanced solid tumors, including desmoid tumors, is n…
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CLINICAL_TRIALS trial_result · 2017-05-03Clinical Trial Update: Study to Evaluate Imatinib in Desmoid Tumors [Phase 2]
A Phase 2 study evaluating imatinib in desmoid tumors has completed.
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CLINICAL_TRIALS withdrawal · 2017-04-20Clinical Trial Update: Effect of Hydroxyurea as Treatment for Primary Desmoid Tumors [Phase 2]
Phase 2 trial evaluating hydroxyurea for primary desmoid tumors has been withdrawn. The study examined hydroxyurea as a treatment for desmoi…
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CLINICAL_TRIALS trial_result · 2016-08-30Clinical Trial Update: Imatinib Mesylate in Treating Patients With Recurrent or Refractory Fibromatosis [Phase 1, Phase 2]
Imatinib mesylate was evaluated in a Phase 1/2 study for desmoid-type fibromatosis, and the trial has completed.
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CLINICAL_TRIALS trial_result · 2016-01-20Clinical Trial Update: Sunitinib in Treating Patients With Metastatic, Locally Advanced, or Locally Recurrent Sarcomas [Phase 2]
Phase 2 trial of sunitinib in metastatic, locally advanced, or locally recurrent sarcomas completed; results posted in 2016 and include desm…
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CLINICAL_TRIALS research · 2015-02-02Clinical Trial Update: Toremifene in Desmoid Tumor: Prospective Clinical Trial and Identification of Potential Molecular Targets [Phase 2]
Prospective Phase 2 clinical trial evaluating toremifene for desmoid-type fibromatosis. The study includes exploratory identification of pot…
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CLINICAL_TRIALS trial_result · 2014-07-25Clinical Trial Update: Vinblastine and Methotrexate in Treating Children With Desmoid Tumors [Phase 2]
A completed Phase 2 trial evaluating the combination of vinblastine and methotrexate for treating desmoid tumors in children.