Dedifferentiated Liposarcoma

• CLINICAL_TRIALS research · 2026-04-22
  Clinical Trial Update: Measuring if Immunotherapy Plus Chemotherapy is Better Than Chemotherapy Alone for Patients With Aggressive Poorly Differentiated Sarcomas [Phase 3]

  This Phase 3 trial is evaluating whether adding immunotherapy to chemotherapy improves outcomes versus chemotherapy alone in patients with a…

• CLINICAL_TRIALS other · 2026-04-21
  Clinical Trial Update: STC-15 as a Part of Combination Therapy With Toripalimab in Selected Advanced Cancers and as Monotherapy in Participants With Selected Sarcomas [Phase 1, Phase 2]

  This clinical trial update notes recruitment for STC-15 in combination with toripalimab for selected advanced cancers and as monotherapy in …

• CLINICAL_TRIALS trial_result · 2026-04-15
  Clinical Trial Update: Oleclumab and Durvalumab for the Treatment of Recurrent, Refractory, or Metastatic Sarcoma [Phase 2]

  Phase 2 clinical trial update of the combination of oleclumab and durvalumab for recurrent, refractory, or metastatic sarcoma, including ang…

• CLINICAL_TRIALS research · 2026-04-13
  Clinical Trial Update: Testing the Addition of an Anti-cancer Drug, Abemaciclib, to the Usual Chemotherapy Treatment (Gemcitabine) for Soft Tissue Sarcoma [Phase 1, Phase 2]

  A Phase 1/2 clinical trial is evaluating adding abemaciclib to gemcitabine for soft tissue sarcoma; recruitment is ongoing.

• CLINICAL_TRIALS trial_result · 2026-04-13
  Clinical Trial Update: Testing Low-Dose Common Chemotherapy (Liposomal Doxorubicin) in Combination With an Anti-Cancer Drug, Peposertib, in Advanced Sarcoma [Phase 1]

  Phase 1 trial evaluating the safety of low-dose pegylated liposomal doxorubicin in combination with peposertib for advanced sarcoma; current…

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• CLINICAL_TRIALS research · 2026-03-13
  Clinical Trial Update: A Study of Mirdametinib in Combination With Palbociclib in People With Liposarcoma [Phase 1, Phase 2]

  This update reports on a Phase 1/2 clinical trial evaluating the MEK inhibitor mirdametinib in combination with palbociclib for liposarcoma,…

• CLINICAL_TRIALS trial_result · 2026-03-05
  Clinical Trial Update: Nivolumab With and Without Ipilimumab and Radiation Therapy in Treating Patients With Recurrent or Resectable Undifferentiated Pleomorphic Sarcoma or Dedifferentiated Liposarcoma Before Surgery [Phase 2]

  This is a Phase 2 clinical trial evaluating nivolumab with or without ipilimumab, plus radiation therapy, in patients with recurrent or rese…

• CLINICAL_TRIALS research · 2026-02-25
  Clinical Trial Update: Precision Medicine Approaches for Neoadjuvant Therapy in High-risk Sarcoma Patients

  Clinical trial update describing precision medicine approaches for neoadjuvant therapy in high‑risk sarcoma patients; currently recruiting.

• CLINICAL_TRIALS trial_result · 2026-02-18
  Clinical Trial Update: Study on Trabectedin in Combination With Pioglitazone in Patients Myxoid Liposarcomas With Stable Disease After T Alone. [Phase 2]

  A Phase 2 trial evaluating the combination of trabectedin and pioglitazone in myxoid liposarcoma has completed.

• CLINICAL_TRIALS research · 2026-02-04
  Clinical Trial Update: A Study of LN-144 or LN-145 in People With Advanced Uveal Melanoma, Undifferentiated Pleomorphic Sarcoma, or Dedifferentiated Liposarcoma [Phase 1]

  This Phase 1 study evaluates LN-144 or LN-145 in people with advanced uveal melanoma, undifferentiated pleomorphic sarcoma, dedifferentiated…

• CLINICAL_TRIALS research · 2026-01-26
  Clinical Trial Update: Testing the Addition of Cemiplimab to Palbociclib for the Treatment of Advanced Dedifferentiated Liposarcoma [Phase 2]

  Phase 2 study evaluating cemiplimab in combination with palbociclib for advanced or unresectable dedifferentiated liposarcoma; the trial is …

• CLINICAL_TRIALS trial_result · 2026-01-09
  Clinical Trial Update: Brightline-4: A Study to Test How Well Brigimadlin is Tolerated by People With a Type of Cancer Called Dedifferentiated Liposarcoma [Phase 3]

  Phase 3 Brightline-4 trial evaluating brigimadlin tolerability in patients with dedifferentiated liposarcoma has completed.

• CLINICAL_TRIALS trial_result · 2025-11-21
  Clinical Trial Update: TQB3616 Capsules in the Treatment of Dedifferentiated Liposarcoma [Phase 2]

  A Phase 2 trial of TQB3616 capsules for dedifferentiated liposarcoma has been terminated.

• CLINICAL_TRIALS research · 2025-10-20
  Clinical Trial Update: A Study of Etrumadenant and Zimberelimab in People With Dedifferentiated Liposarcoma [Phase 2]

  A Phase 2 study evaluating the combination of Etrumadenant and Zimberelimab in Dedifferentiated liposarcoma; the trial is currently active b…

• CLINICAL_TRIALS trial_result · 2025-10-14
  Clinical Trial Update: Palbociclib and INCMGA00012 in People With Advanced Liposarcoma [Phase 2]

  Phase 2 clinical trial evaluating the combination of palbociclib and INCMGA00012 in advanced well-differentiated or dedifferentiated liposar…

• CLINICAL_TRIALS research · 2025-09-05
  Clinical Trial Update: A Phase 1, First-in-human Study of OKN4395 and Pembrolizumab in Patients With Solid Tumors [Phase 1]

  Phase 1 first-in-human trial evaluating OKN4395 in combination with pembrolizumab in patients with solid tumors is currently recruiting. The…

• CLINICAL_TRIALS trial_result · 2025-08-28
  Clinical Trial Update: Study of DCC-3014 in Combination With Avelumab in Patients With Advanced or Metastatic Sarcomas [Phase 1]

  Phase 1 study of DCC-3014 in combination with Avelumab in patients with advanced or metastatic sarcoma has completed; no efficacy data is pr…

• CLINICAL_TRIALS research · 2025-08-28
  Clinical Trial Update: A Phase 2, Open Label Study of PEmigatinib and REtifanlimab in Advanced Dedifferentiated LIposarcoma (PERELI) [Phase 2]

  This document reports a Phase 2 open-label trial (PERELI) investigating the combination of pemigatinib and retifanlimab in advanced dediffer…

• CLINICAL_TRIALS trial_result · 2025-07-10
  Clinical Trial Update: Real-world Study of Dedifferentiated Liposarcoma Patients in China

  This entry reports completion and posted results of a real-world observational study of dedifferentiated liposarcoma patients in China spons…

• CLINICAL_TRIALS trial_result · 2025-07-04
  Clinical Trial Update: Brightline-1: A Study to Compare Brigimadlin (BI 907828) With Doxorubicin in People With a Type of Cancer Called Dedifferentiated Liposarcoma [Phase 2, Phase 3]

  A Phase 2/3 trial comparing Brigimadlin (BI 907828) to doxorubicin in patients with dedifferentiated liposarcoma has completed and results h…

• CLINICAL_TRIALS trial_result · 2025-06-05
  Clinical Trial Update: Study of Abemaciclib in Dedifferentiated Liposarcoma [Phase 2]

  Phase 2 study of abemaciclib in dedifferentiated liposarcoma is currently active but not recruiting.

• CLINICAL_TRIALS trial_result · 2025-04-04
  Clinical Trial Update: Phase II Trial of Ribociclib and Everolimus in Advanced Dedifferentiated Liposarcoma (DDL) and Leiomyosarcoma (LMS) [Phase 2]

  Phase II clinical trial evaluating ribociclib in combination with everolimus in advanced dedifferentiated liposarcoma and leiomyosarcoma; th…

• CLINICAL_TRIALS trial_result · 2025-01-14
  Clinical Trial Update: Treatment of Milademetan Versus Trabectedin in Patient With Dedifferentiated Liposarcoma [Phase 3]

  A Phase 3 trial comparing Milademetan to Trabectedin in dedifferentiated liposarcoma was terminated; results have been posted.

• CLINICAL_TRIALS research · 2024-12-06
  Clinical Trial Update: SARC041: Study of Abemaciclib Versus Placebo in Patients with Advanced Dedifferentiated Liposarcoma [Phase 3]

  A Clinical Trial Update for the Phase 3 SARC041 study comparing abemaciclib to placebo in patients with advanced dedifferentiated liposarcom…

• CLINICAL_TRIALS research · 2024-11-19
  Clinical Trial Update: First-line Treatment of Advanced/unresectable DDLPS [Phase 2]

  This clinical trial update outlines a Phase 2 first-line treatment study for advanced or unresectable dedifferentiated liposarcoma (DDLPS) a…