Crohn Disease
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Sign up freeTop drugs studied for this disease
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EMA guidance · 2016-02-12Updated recommendations to minimise the risk of the rare brain infection PML with Tysabri
The EMA published updated recommendations to minimize the risk of progressive multifocal leukoencephalopathy (PML) associated with Tysabri (…
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CLINICAL_TRIALS research · 2016-01-28Clinical Trial Update: Predictors of Non-response and Loss of Response in IBD Patients Treated With Anti-TNF
This clinical trial update examines factors that predict non-response and loss of response to anti-TNF therapy in patients with inflammatory…
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CLINICAL_TRIALS trial_result · 2016-01-27Clinical Trial Update: Evaluation of Urinary Isoprostanes in the Assessment of Children With Inflammatory Bowel Disease
This completed clinical trial evaluates urinary isoprostanes as a biomarker for disease assessment in children with inflammatory bowel disea…
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CLINICAL_TRIALS research · 2016-01-26Clinical Trial Update: Contrast Enhanced Ultrasonography (CEUS) of Patients With Crohn's Disease
A clinical trial evaluating contrast-enhanced ultrasonography in Crohn's disease was terminated.
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CLINICAL_TRIALS trial_result · 2016-01-22Clinical Trial Update: Evaluation of a New Oral Contrast Agent for MR Enterography in the Assessment of Crohn Disease in the Small Bowel
A completed clinical trial evaluating a new oral contrast agent for MR enterography to assess Crohn disease in the small bowel.
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CLINICAL_TRIALS trial_result · 2016-01-21Clinical Trial Update: A Study To Assess The Efficacy And Safety Of PF-04236921 In Subjects With Crohn's Disease Who Failed Anti-TNF Therapy [Phase 2]
A Phase 2 trial evaluating PF-04236921 for efficacy and safety in Crohn's disease patients who failed anti-TNF therapy has completed and res…
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CLINICAL_TRIALS trial_result · 2016-01-21Clinical Trial Update: A Study to Evaluate Safety of Long Term Therapy of Certolizumab Pegol Patients With Crohn's Disease [Phase 3]
Phase 3 trial evaluating long-term safety of Certolizumab Pegol in Crohn's disease completed; results posted.
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CLINICAL_TRIALS research · 2016-01-20Clinical Trial Update: Registry of Pediatric Patients Diagnosed With Crohn's Disease in Belgium
A completed registry of pediatric Crohn's disease patients in Belgium. It describes disease course, phenotypes, medications used, safety obs…
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CLINICAL_TRIALS research · 2016-01-14Clinical Trial Update: Multi Modal Imaging: An MRI Study to Investigate Differences in the Structure and the Function of the Brain at Rest.
This completed UCLA-sponsored study used multimodal MRI to examine differences in brain structure and resting-state function.
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CLINICAL_TRIALS trial_result · 2016-01-11Clinical Trial Update: NIH Substudy of AIN457 (Anti-IL-17 Monoclonal Antibody) for Treatment of Moderate to Severe Crohn's Disease [NA]
The NIH substudy of the anti-IL-17 monoclonal antibody AIN457 for moderate-to-severe Crohn's disease was terminated, and its results were po…
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CLINICAL_TRIALS trial_result · 2015-12-29Clinical Trial Update: Infliximab to Treat Crohn'S-like Inflammatory Bowel Disease in Chronic Granulomatous Disease [Phase 1, Phase 2]
Infliximab was studied in a Phase 1/2 trial for Crohn's-like inflammatory bowel disease in patients with chronic granulomatous disease. The …
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CLINICAL_TRIALS trial_result · 2015-12-22Clinical Trial Update: Comparison of 2 Immunomodulator Withdrawal Schemes for Infliximab Monotherapy in Active Pediatric Crohn's Disease After Thiopurine Failure [Phase 4]
Phase 4 pediatric Crohn's disease trial evaluating two immunomodulator withdrawal schemes in infliximab monotherapy has been terminated.
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CLINICAL_TRIALS withdrawal · 2015-12-03Clinical Trial Update: Improving Treatment of Inflammatory Bowel Diseases Through Better Understanding Infliximab Drug and Antibody Levels
A clinical trial investigating infliximab levels and anti-drug antibodies in Crohn's disease and ulcerative colitis has been withdrawn.
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FDA approval · 2015-11-30FDA Approved: BUDESONIDE — Supplemental Application (Chartwell RX, LLC)
The FDA approved a supplemental application for Budesonide from Chartwell RX, LLC, authorizing a change to an existing generic product.
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CLINICAL_TRIALS trial_result · 2015-11-26Clinical Trial Update: High Dose Vitamin D3 in Crohn's Disease [NA]
A completed clinical trial evaluating high-dose vitamin D3 (cholecalciferol) in Crohn's disease.
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FDA approval · 2015-11-23FDA Approved: HUMIRA — Supplemental Application (Cordavis Limited)
The FDA approved a supplemental application for Humira (adalimumab) filed by Cordavis Limited, indicating regulatory action on a Humira supp…
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FDA approval · 2015-11-20FDA Approved: BUDESONIDE — Supplemental Application (Rite Aid Corporation)
FDA approved a supplemental application for Budesonide filed by Rite Aid Corporation (ANDA078949), confirming an updated approval for this g…
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CLINICAL_TRIALS trial_result · 2015-11-10Clinical Trial Update: Immune Modulation by Parenteral Fish Oil in Patients With Crohn's Disease [Phase 4]
A Phase 4 trial evaluated immune modulation by parenteral fish oil in Crohn's disease and the study has completed.
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CLINICAL_TRIALS trial_result · 2015-11-10Clinical Trial Update: Certolizumab Pegol for the Treatment of Patients With Active Rheumatoid Arthritis (RA) and Crohn's Disease (CD)
This update indicates that the clinical trial evaluating Certolizumab Pegol for active Rheumatoid arthritis and Crohn's disease has been ter…
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CLINICAL_TRIALS research · 2015-11-05Clinical Trial Update: Does Clinical Response Correlate With Serum Certolizumab Levels? [Phase 4]
This Phase 4 clinical trial update explores whether clinical response in Crohn's disease correlates with serum certolizumab pegol levels.
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CLINICAL_TRIALS withdrawal · 2015-11-05Clinical Trial Update: A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of 3 Subcutaneous and 1 Intravenous Dose of E6011 in Subjects With Active Crohn's Disease [Phase 1]
A Phase 1 study evaluating E6011 in active Crohn's disease has been withdrawn.
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CLINICAL_TRIALS trial_result · 2015-11-03Clinical Trial Update: Bioavailability of Vitamin D in Children and Adolescents With Crohn's Disease [Phase 2]
A Phase 2 clinical trial evaluating the bioavailability of vitamin D in children and adolescents with Crohn's disease has completed.
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CLINICAL_TRIALS trial_result · 2015-11-02Clinical Trial Update: Study of Anti-glycan Antibodies Stability in Saint-Etienne IBD Cohort
This clinical trial studied the stability of anti-glycan antibodies in a Saint-Etienne inflammatory bowel disease cohort and has completed.
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CLINICAL_TRIALS research · 2015-10-19Clinical Trial Update: The Diagnostic Methods of Early Postoperative Flare-up of Crohn's Disease
This clinical trial update discusses diagnostic methods for early postoperative flare-ups in Crohn's disease. The sponsor is Jinling Hospita…
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CLINICAL_TRIALS research · 2015-10-14Clinical Trial Update: Efficacy of Fecal Microbiota Transplantation for Inflammatory Bowel Disease [Phase 3]
A Phase 3 trial is evaluating the efficacy of fecal microbiota transplantation for inflammatory bowel disease. The study includes ulcerative…