Crohn Disease
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Sign up freeTop drugs studied for this disease
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FDA approval · 2024-06-28FDA Approved: USTEKINUMAB-TTWE — Original Application (Quallent Pharmaceuticals Health LLC)
FDA approves a new biologic product, ustekinumab-tTWE, from Quallent Pharmaceuticals Health LLC, via an Original Biologics License Applicati…
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CLINICAL_TRIALS trial_result · 2024-06-27Clinical Trial Update: Home basEd faecaL calProtectin Measurements Predicting Adalimumab Induction Destiny [NA]
A completed KU Leuven study evaluated whether home-based fecal calprotectin measurements can predict the induction outcome of adalimumab in …
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CLINICAL_TRIALS trial_result · 2024-06-24Clinical Trial Update: Significance and Outcome of Magnetic Resonance Enterography Revealing Sacroiliitis in Crohn's Disease: A Pilot Study [NA]
A completed pilot study evaluating the significance and outcomes of magnetic resonance enterography-detected sacroiliitis in Crohn's disease…
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CLINICAL_TRIALS trial_result · 2024-06-21Clinical Trial Update: A Safety Extension Study of Ontamalimab in Participants With Moderate to Severe Ulcerative Colitis or Crohn's Disease (AIDA) [Phase 3]
Safety extension results from a Phase 3 trial of ontamalimab in moderate to severe Crohn's disease or ulcerative colitis have been completed…
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CLINICAL_TRIALS research · 2024-06-18Clinical Trial Update: Mitochondrial DAMPs as Mechanistic Biomarkers of Mucosal Inflammation in Crohn's Disease and Ulcerative Colitis
This clinical trial investigates mitochondrial DAMPs as mechanistic biomarkers of mucosal inflammation in Crohn's disease and ulcerative col…
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CLINICAL_TRIALS trial_result · 2024-06-14Clinical Trial Update: Comparative Effectiveness of Biologics or Small Molecule Therapies in Inflammatory Bowel Disease (IBD)
Completed comparative effectiveness trial comparing biologics and small-molecule therapies for Crohn's disease and ulcerative colitis, with …
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CLINICAL_TRIALS research · 2024-06-14Clinical Trial Update: Intraoperative Ultrasound in Crohn's Disease [NA]
A clinical trial is investigating the use of intraoperative ultrasound in Crohn's disease, sponsored by Fondazione Policlinico Universitario…
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CLINICAL_TRIALS trial_result · 2024-06-13Clinical Trial Update: Comparison of Trough Level- and Clinical-based Spacing of Infliximab Infusions in Patients With IBD in Deep Remission [NA]
This update reports a terminated clinical trial comparing trough-level–based spacing to clinically based spacing of infliximab infusions in …
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CLINICAL_TRIALS research · 2024-06-13Clinical Trial Update: Development and Validation of a Nomogram for Predicting Surgery in Newly-diagnosed Crohn's Disease: a Retrospective Cohort Study
A retrospective cohort study that develops and validates a nomogram to predict the need for surgery in patients with newly diagnosed Crohn's…
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CLINICAL_TRIALS research · 2024-06-12Clinical Trial Update: SAPHIR : Assessment of Predictive Factors for Persistence of Treatment After Initiation of Adalimumab With a Biosimilar (Adalimumab Fresenius KaBI or Substitution of Reference Adalimumab With the Fresenius Kabi Adalimumab Biosimilar in Patients With Chronic Inflammatory Diseases
Clinical trial SAPHIR assesses predictive factors for persistence of adalimumab treatment after switching from reference product to Freseniu…
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CLINICAL_TRIALS research · 2024-06-12Clinical Trial Update: Evaluate the Distribution and Dynamic Behavior of TH-SC01 Cells in Vivo in Patients With Perianal Fistula [Phase 1]
This Phase 1 clinical trial is evaluating the in vivo distribution and behavior of TH-SC01 cell therapy in patients with anal fistula, and i…
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CLINICAL_TRIALS research · 2024-06-12Clinical Trial Update: Preliminary Clinical Study on the Effect of L-ornithine on the Efficacy of Ustekinumab in Patients With Crohn's Disease [NA]
A preliminary clinical study is evaluating whether L-ornithine influences the efficacy of ustekinumab in Crohn's disease. The trial is curre…
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CLINICAL_TRIALS research · 2024-06-11Clinical Trial Update: Neurophenotype Predicts CD Disease Progression
A clinical trial is currently recruiting to test whether neurophenotypes can predict Crohn's disease progression. The study uses radiomics a…
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CLINICAL_TRIALS trial_result · 2024-06-10Clinical Trial Update: Efficacy and Safety Comparison of Upadacitinib and Vedolizumab in Second-line Treatment for Crohn's Disease
A completed clinical trial comparing upadacitinib versus vedolizumab for second-line Crohn's disease to assess their efficacy and safety, as…
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CLINICAL_TRIALS trial_result · 2024-06-07Clinical Trial Update: Real-life Use of the Crohn's Disease Exclusion Diet (CDED) in Adult Patients With Crohn's Disease [NA]
This completed clinical trial evaluates the real-world use of the Crohn's Disease Exclusion Diet (CDED) in adults with Crohn's disease. The …
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CLINICAL_TRIALS research · 2024-06-07Clinical Trial Update: Research on the Mechanisms of Treatment Non-response in Inflammatory Bowel Disease Based on Multi-omics Technology
A clinical trial studying the mechanisms of non-response to treatment in inflammatory bowel disease using multi-omics approaches; the study …
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CLINICAL_TRIALS research · 2024-06-06Clinical Trial Update: Semiflex Assisted Vacuum Therapy for Perianal Abscesses/Sinuses and Fistula: a Pilot Study [NA]
A clinical trial update indicates a pilot study evaluating Semiflex Assisted Vacuum Therapy for perianal abscesses and fistulas is currently…
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CLINICAL_TRIALS research · 2024-06-06Clinical Trial Update: The ADDapt Diet in Reducing Crohn's Disease Inflammation [NA]
Clinical trial update for the ADDapt Diet in Crohn's disease and inflammatory bowel disease; no results or phase information are provided.
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CLINICAL_TRIALS research · 2024-06-04Clinical Trial Update: Surgical Closure vs Anti-TNF in the Treatment of Perianal Fistulas in Crohn's Disease (PISA-II): a Comprehensive Cohort Design [Phase 3]
Phase 3 study (PISA-II) comparing surgical closure versus Anti-TNF therapy for perianal fistulas in Crohn's disease; the design is a compreh…
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CLINICAL_TRIALS trial_result · 2024-06-03Clinical Trial Update: Intra-erythrocyte Dexamethasone Versus Placebo in Patients With Steroid-dependent Crohn's Disease [Phase 3]
A Phase 3 trial comparing intra-erythrocyte dexamethasone to placebo in steroid-dependent Crohn's disease was terminated, with results poste…
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CLINICAL_TRIALS trial_result · 2024-06-03Clinical Trial Update: CD INFORM: Investigating Natalizumab Through Further Observational Research and Monitoring
The CD INFORM observational study of natalizumab for Crohn's disease has been terminated, ending further observational research and monitori…
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CLINICAL_TRIALS research · 2024-05-31Clinical Trial Update: Obsessive-compulsive Disorder, Depression and Anxiety Among Patients With Crohn's Disease
A completed clinical trial investigating obsessive-compulsive disorder, depression, and anxiety among patients with Crohn's disease.
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CLINICAL_TRIALS trial_result · 2024-05-30Clinical Trial Update: A Study to Observe Vedolizumab and Anti-tumour Necrosis Factors (Anti-TNFs) Outcomes in Real-world Biologic Ulcerative Colitis (UC) and Crohn's Disease (CD) Participants
A completed real-world observational study evaluating vedolizumab and anti-TNF therapies in patients with ulcerative colitis or Crohn's dise…
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CLINICAL_TRIALS trial_result · 2024-05-30Clinical Trial Update: Evaluation of the Response of Itraconazole and Terbinafine Therapy in Subjects With Crohn's Disease [Phase 2]
A Phase 2 trial evaluating itraconazole and terbinafine for Crohn's disease has been terminated. The update notes the study status but does …
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CLINICAL_TRIALS trial_result · 2024-05-20Clinical Trial Update: The PRognostic Effect of Environmental Factors in Crohn's and Colitis
This clinical trial evaluated the prognostic impact of environmental factors on inflammatory bowel diseases, specifically Crohn's disease an…