Critical Limb Ischemia
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS trial_result · 2020-08-12Clinical Trial Update: Lutonix DCB Versus Standard Balloon Angioplasty for Treatment of Below-The-Knee (BTK) Arteries [NA]
A completed clinical trial comparing Lutonix drug-coated balloon to standard balloon angioplasty for treatment of below-the-knee arteries in…
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CLINICAL_TRIALS trial_result · 2020-05-20Clinical Trial Update: Use of Ixmyelocel-T (Formerly Vascular Repair Cells [VRC]) in Patients With Peripheral Arterial Disease to Treat Critical Limb Ischemia [Phase 2]
Phase 2 clinical trial update evaluating Ixmyelocel-T for treating critical limb ischemia in peripheral arterial disease.
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CLINICAL_TRIALS trial_result · 2020-04-14Clinical Trial Update: A Safety and Tolerability Study of RJX Drug Product in Healthy Participants [Phase 1]
Phase 1 safety and tolerability trial of RJX Drug Product in healthy participants has completed; results posted.
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CLINICAL_TRIALS trial_result · 2020-03-20Clinical Trial Update: Alprostadil as an Adjuvant Therapy With Indirect Angiosomal Revascularization in Critical Limb Ischemia. [Phase 4]
Trial update for alprostadil as an adjuvant therapy in critical limb ischemia (Phase 4).
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CLINICAL_TRIALS trial_result · 2020-03-13Clinical Trial Update: Effect of Evolocumab in Patients With Critical Limb Ischemia (Evol-CLI) [Phase 4]
Phase 4 clinical trial update evaluating evolocumab in patients with critical limb ischemia.
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CLINICAL_TRIALS trial_result · 2020-01-22Clinical Trial Update: Evaluation of the Use of ACOTEC Drug-Eluting Balloon Litos ® in Below-The-Knee Arteries to Treat Critical Limb Ischemia [Phase 4]
Phase 4 clinical trial update evaluating ACOTEC Drug-Eluting Balloon Litos in below-the-knee arteries for critical limb ischemia.
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CLINICAL_TRIALS trial_result · 2019-11-22Clinical Trial Update: Pilot Study to Examine the Use of Rivaroxaban After Angioplasty for Critical Limb Ischemia [Phase 2]
A Phase 2 pilot trial investigated rivaroxaban after angioplasty for critical limb ischemia; results have been posted after completion.
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CLINICAL_TRIALS trial_result · 2019-08-13Clinical Trial Update: Efficacy and Safety of AMG0001 in Subjects With Critical Limb Ischemia [Phase 3]
Phase 3 trial of AMG0001 in critical limb ischemia was terminated; results have been posted.
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CLINICAL_TRIALS trial_result · 2019-06-28Clinical Trial Update: Aspirin and Clopidogrel Reactivity in Patients With Critical Limb Ischemia (CLI)
Clinical trial evaluating aspirin and clopidogrel reactivity in patients with critical limb ischemia has completed with posted results.
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CLINICAL_TRIALS trial_result · 2019-06-21Clinical Trial Update: Cell Therapy in Critical Limb Ischemia [Phase 2]
Phase 2 clinical trial update for a cell therapy in critical limb ischemia, status not reported.
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CLINICAL_TRIALS trial_result · 2019-06-19Clinical Trial Update: Switch to Ticagrelor in Critical Limb Ischemia Anti-platelet Study [Phase 1, Phase 2]
A phase 1/2 trial investigating switching to ticagrelor for patients with Critical Limb Ischemia has completed with results posted.
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CLINICAL_TRIALS trial_result · 2019-02-22Clinical Trial Update: Study to Assess Efficacy and Safety of Bone Marrow Derived Stem Cells in Patients With Critical Limb Ischemia [Phase 2]
The study assessed the efficacy and safety of bone marrow–derived stem cells in patients with critical limb ischemia. The Phase 2 trial has …
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CLINICAL_TRIALS trial_result · 2019-01-24Clinical Trial Update: Complete Lesion Assessment With ffR and IVUS TechnologY [NA]
A completed clinical trial evaluating imaging and assessment technology (ffR and IVUS) for peripheral artery disease and critical limb ische…
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CLINICAL_TRIALS trial_result · 2019-01-14Clinical Trial Update: Comparison of Cilostazol-based Triple Antiplatelet Therapy Versus Dual Antiplatelet Therapy for Outcomes of below-the Knee Endovascular Intervention in Patients With Critical Limb Ischemia (TAP CLI Study) [Phase 4]
Clinical trial update comparing cilostazol-based triple antiplatelet therapy to dual antiplatelet therapy for below-the-knee endovascular in…
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CLINICAL_TRIALS trial_result · 2018-08-17Clinical Trial Update: Treatment of Chronic Critical Limb Ischemia With G-CSF-mobilized Autologous Peripheral Blood Mononuclear Cells [Phase 3]
Phase 3 trial evaluating G-CSF-mobilized autologous peripheral blood mononuclear cells for treatment of chronic critical limb ischemia has c…
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CLINICAL_TRIALS trial_result · 2018-08-09Clinical Trial Update: Revascularization of Stenosed Vessels Using Optimized Treatment of Rejuveinix for Reversing Endothelial Dysfunction [Phase 1, Phase 2]
A phase 1/2 trial update on revascularization using Rejuveinix aiming to reverse endothelial dysfunction in critical limb ischemia and perip…
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CLINICAL_TRIALS trial_result · 2018-07-09Clinical Trial Update: Application of Cell Regeneration Therapy With Mesenchymal Stem Cells From Adipose Tissue in Critical Chronic Ischemic Syndrome of Lower Limbs (CLI) in Nondiabetic Patients. [Phase 2]
Phase 2 trial evaluating adipose-derived mesenchymal stem cells for critical limb ischemia in non-diabetic patients has completed.
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CLINICAL_TRIALS trial_result · 2018-06-15Clinical Trial Update: Randomized Study of Pregabalin for Pain Reduction in Patients With Rest Pain and Lower Limb Ischemia [Phase 4]
Phase 4 randomized trial of pregabalin for pain reduction in patients with rest pain and lower limb ischemia sponsored by Karolinska Institu…
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CLINICAL_TRIALS trial_result · 2018-05-18Clinical Trial Update: An Efficacy and Safety Study to Evaluate Ranger DEB for BTK Angioplasty in Patients With CLI (RANGER-BTK) [Phase 2, Phase 3]
A Phase 2/3 clinical trial evaluating Ranger DEB for below-the-knee angioplasty in patients with critical limb ischemia and peripheral arter…
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CLINICAL_TRIALS trial_result · 2017-10-12Clinical Trial Update: BOLD MRI as a Surrogate of Improved Muscle Oxygenation Following Endovascular Therapy for the Treatment of CLI [NA]
This update reports on a completed clinical trial evaluating BOLD MRI as a surrogate for improved muscle oxygenation following endovascular …
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CLINICAL_TRIALS trial_result · 2017-05-09Clinical Trial Update: Monocentric Trial: Stem Cell Emergency Life Threatening Limbs Arteriopathy (SCELTA) [Phase 2, Phase 3]
The SCELTA trial, a monocentric Phase 2/3 study of stem cell therapy for critical limb ischemia, has completed.
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CLINICAL_TRIALS trial_result · 2017-05-04Clinical Trial Update: Treatment of PAD by Platelet Lysate for Therapeutic Angiogenesis [Phase 1, Phase 2]
This update reports the completion of a Phase 1/2 trial evaluating platelet lysate therapy for therapeutic angiogenesis in patients with cri…
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CLINICAL_TRIALS trial_result · 2017-02-27Clinical Trial Update: The COPPER-B Trial [NA]
The COPPER-B trial has completed enrollment/status, but this update provides no results.
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CLINICAL_TRIALS trial_result · 2017-02-23Clinical Trial Update: Evaluation of Diagnostic Criteria for Chronic Critical Limb Ischemia
A completed clinical study evaluating diagnostic criteria for chronic limb-threatening ischemia, with stroke listed among the conditions.
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CLINICAL_TRIALS trial_result · 2017-01-24Clinical Trial Update: Safety Study of Bone Marrow Cell Concentrate Prepared Using the Magellan System to Treat Critical Limb Ischemia (CLI) [Phase 1]
A completed Phase 1 safety study evaluating autologous bone marrow cell concentrate prepared with the Magellan System for treating critical …