Critical Illness
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2025-12-26Clinical Trial Update: Role of End-Tidal CO2 During Passive Leg Raising to Predict Fluid Responsiveness in ICU
A clinical trial evaluating whether end-tidal CO2 changes during a passive leg-raising maneuver can predict fluid responsiveness in ICU pati…
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CLINICAL_TRIALS research · 2025-12-24Clinical Trial Update: Population Pharmacokinetics of Remifentanil in Low-Weight Critically Ill Patients
A population pharmacokinetics study of remifentanil in low-weight critically ill patients is currently recruiting to improve dosing guidance…
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CLINICAL_TRIALS research · 2025-12-24Clinical Trial Update: Prevalence of Sarcopenia in Patients Admitted to ICU and Its Progression During Hospitalization.
Clinical trial update indicates that the study examining the prevalence of sarcopenia in ICU patients and its progression during hospitaliza…
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CLINICAL_TRIALS research · 2025-12-23Clinical Trial Update: Intraabdominal Hypertension and Occurrence of Microaspiration in Cirrhotics Under Mechanical Ventilation
Clinical trial investigating intraabdominal hypertension and microaspiration in cirrhotic patients on mechanical ventilation is currently re…
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CLINICAL_TRIALS research · 2025-12-22Clinical Trial Update: PICU Up!: A Pilot Stepped-wedge Trial of a Multicomponent Early Mobility Intervention for Critically Ill Children [NA]
Status update for the PICU Up! trial—a pilot stepped-wedge study evaluating an early mobility intervention in critically ill children. The c…
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CLINICAL_TRIALS research · 2025-12-18Clinical Trial Update: Point-of-Care AI Assistance and Critical Care Outcomes: A Randomized Trial [Phase 1, Phase 2]
This clinical trial update describes a Phase 1/Phase 2 randomized study evaluating point-of-care AI assistance to improve outcomes in critic…
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CLINICAL_TRIALS research · 2025-12-18Clinical Trial Update: Crystalloid Fluid Choice and Neurological Outcome in Patients After Subarachnoid Haemorrhage [NA]
An ongoing clinical trial is evaluating crystalloid fluid choice and neurological outcomes in patients after subarachnoid hemorrhage, and is…
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CLINICAL_TRIALS research · 2025-12-17Clinical Trial Update: Factor Associated With Mortality in the ICU
A clinical trial from Hospital Departamental de Villavicencio is examining factors associated with mortality in critically ill ICU patients …
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CLINICAL_TRIALS research · 2025-12-17Clinical Trial Update: Azithromycin for Critical Asthma - Pediatrics [Phase 2, Phase 3]
A pediatric trial update indicates ongoing Phase 2 and Phase 3 studies evaluating azithromycin for pediatric asthma with critical illness; r…
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CLINICAL_TRIALS research · 2025-12-10Clinical Trial Update: Enhanced Protein Intake to Support Muscle Protein Synthesis in ICU [NA]
A Maastricht University Medical Center trial is investigating whether enhanced protein intake supports muscle protein synthesis in criticall…
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CLINICAL_TRIALS research · 2025-12-10Clinical Trial Update: Measuring Total Energy Expenditure in Critically Ill Patients Using the Doubly Labelled Water Method [NA]
This clinical trial update describes a study to measure total energy expenditure in critically ill patients using the doubly labeled water m…
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CLINICAL_TRIALS research · 2025-12-09Clinical Trial Update: NIBP Validation Study
An update on an ongoing NIBP validation study sponsored by Philips, currently recruiting for critical illness patients.
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CLINICAL_TRIALS research · 2025-12-08Clinical Trial Update: Optimizing Enteral Nutrition Regimen for Critically Ill Patients [NA]
This clinical trial update describes a study on optimizing enteral nutrition regimens for critically ill patients that is not yet recruiting…
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CLINICAL_TRIALS research · 2025-12-04Clinical Trial Update: Remimazolam vs Midazolam to Reduce Delirium in Adults ≥65 Undergoing CPB Valve Surgery [Phase 4]
A Phase 4 clinical trial compares remimazolam with midazolam to reduce delirium in adults aged 65 and older undergoing cardiopulmonary bypas…
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CLINICAL_TRIALS research · 2025-12-03Clinical Trial Update: Practice of Fluid Therapy in Critically Ill Invasively Ventilated Patients
The clinical trial NCT05968066 evaluating fluid therapy and vasopressor use in critically ill, invasively ventilated patients has completed.
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CLINICAL_TRIALS research · 2025-12-03Clinical Trial Update: Identifying Diabetes and Impaired Glucose Tolerance in ICU Patients
A recruiting clinical trial aims to identify diabetes and impaired glucose tolerance among ICU patients.
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CLINICAL_TRIALS research · 2025-11-28Clinical Trial Update: ICU Combined Assessment of Cardio-Respiratory Exercise
Clinical trial update for ICU Combined Assessment of Cardio-Respiratory Exercise. The study is currently recruiting and focuses on ICU-acqui…
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CLINICAL_TRIALS research · 2025-11-26Clinical Trial Update: Surface Electrical Myography, Oxygen Consumption, Effort, and Weaning in the Mechanically Ventilated Patient in the Intensive Care Unit
A clinical trial at Leiden University Medical Center is evaluating surface electrical myography, oxygen consumption, effort, and weaning out…
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CLINICAL_TRIALS research · 2025-11-21Clinical Trial Update: The VITDALIZE Study: Effect of High-dose Vitamin D3 on 28-day Mortality in Adult Critically Ill Patients [Phase 3]
A Phase 3 trial is evaluating whether high-dose vitamin D3 can reduce 28-day mortality in adults who are critically ill and vitamin D defici…
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CLINICAL_TRIALS research · 2025-11-21Clinical Trial Update: General Surgery Patients at the Intensive Care Unit
Clinical trial update indicates a study on general surgery patients in the intensive care unit is not yet recruiting, sponsored by Hospital …
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CLINICAL_TRIALS research · 2025-11-14Clinical Trial Update: Opportunistic PK/PD Trial in Critically Ill Children (OPTIC)
Duke University is conducting the OPTIC opportunistic PK/PD trial in critically ill children that is currently recruiting. The study involve…
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CLINICAL_TRIALS research · 2025-11-12Clinical Trial Update: Pivotal Evaluation of Abdominal Neuromuscular Electrical Stimulation (VentFree) for Weaning From Mechanical Ventilation [NA]
Clinical trial update evaluating abdominal neuromuscular electrical stimulation (VentFree) for facilitating weaning from mechanical ventilat…
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CLINICAL_TRIALS research · 2025-11-05Clinical Trial Update: Reestablishing Sleep and Circadian Alignment in Medical Intensive Care Unit (MICU) Patients Via a Mechanistic RCT of an Sleep Chronobundle [NA]
An ongoing randomized controlled trial at Yale is evaluating a sleep chronobundle to reestablish sleep and circadian alignment in critically…
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CLINICAL_TRIALS research · 2025-10-24Clinical Trial Update: Safety and Feasibility of a Self-Balancing Exoskeleton for Rehabilitation in the Thoracic Surgical Intensive Care Unit: a Pilot Trial [Phase 1, Phase 2]
This Phase 1/2 pilot trial evaluates the safety and feasibility of a self-balancing exoskeleton for rehabilitation in the thoracic surgical …
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CLINICAL_TRIALS research · 2025-10-22Clinical Trial Update: Establishing Normative Data for Pupillometer Assessments in Neuro-Intensive Care
This clinical trial update describes efforts to establish normative pupillometer data for neuro-intensive care by collecting pupil response …