Colorectal Cancer
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2024-07-11Clinical Trial Update: Prospective Phase II Study on Continuous Circumferential Reinforcement of Laparoscopic Rectal Anastomosis to Prevent Complications [Phase 2]
A Phase II clinical trial evaluating a continuous circumferential reinforcement technique during laparoscopic rectal anastomosis to prevent …
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CLINICAL_TRIALS trial_result · 2024-07-10Clinical Trial Update: Aflibercept +/- LV5FU2 in First Line of Non-resectalbe Metastatic Colorectal Cancers [Phase 2]
Phase 2 trial evaluating aflibercept with or without LV5FU2 as first-line therapy for non-resectable metastatic colorectal cancer has comple…
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CLINICAL_TRIALS trial_result · 2024-07-10Clinical Trial Update: De-escalation Chemotherapies Versus Escalation in Non Pre-treated Unresectable Patients With Metastatic Colorectal Cancer [Phase 2]
Phase 2 trial comparing de-escalation versus escalation chemotherapy in previously untreated unresectable metastatic colorectal cancer was t…
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CLINICAL_TRIALS research · 2024-07-10Clinical Trial Update: Sacituzumab Govitecan in Metastatic Colorectal Cancer [Phase 2, Phase 3]
An ongoing Phase 2/Phase 3 trial of sacituzumab govitecan in metastatic colorectal cancer is currently recruiting.
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CLINICAL_TRIALS trial_result · 2024-07-10Clinical Trial Update: Lonsurf® (Trifluridine/Tipiracil) Plus Chemotherapy in Metastatic Colorectal Cancer Prospective Study in Taiwan [NA]
Prospective study in Taiwan evaluating Lonsurf (trifluridine/tipiracil) in combination with chemotherapy for metastatic colorectal cancer.
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CLINICAL_TRIALS research · 2024-07-09Clinical Trial Update: First-Line Treatment Induced With mFOLFOX6 and HLX04 Regimen, Following Combined With Serplulimab in MSS Initially Unresectable Metastatic Colorectal Cancer [Phase 2]
This document describes a Phase 2 clinical trial evaluating first-line treatment with the mFOLFOX6/HLX04 regimen followed by Serplulimab in …
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CLINICAL_TRIALS research · 2024-07-09Clinical Trial Update: MNK Inhibitor AUM001 in Combination With Either Pembrolizumab or Irinotecan to Treat Metastatic Colorectal Cancer [Phase 2]
A Phase 2 clinical trial is evaluating AUM001 in combination with pembrolizumab or irinotecan for metastatic colorectal cancer.
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CLINICAL_TRIALS guidance · 2024-07-09Clinical Trial Update: Direct Information to At-risk Relatives [NA]
Clinical trial update about providing direct information to at-risk relatives for hereditary cancer syndromes.
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CLINICAL_TRIALS trial_result · 2024-07-09Clinical Trial Update: Study of RO7515629 in Participants With HLA-G Positive Solid Tumors [Phase 1]
This Phase 1 study of RO7515629 in participants with HLA-G positive solid tumors has been terminated. The trial enrolled patients with renal…
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CLINICAL_TRIALS withdrawal · 2024-07-09Clinical Trial Update: Tislelizumab Combined With Fruquintinib for Metastatic pMMR/MSS Colorectal Cancer [Phase 2]
A Phase 2 trial of tislelizumab combined with fruquintinib for metastatic pMMR/MSS colorectal cancer has been withdrawn.
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CLINICAL_TRIALS research · 2024-07-09Clinical Trial Update: PD-1 Inhibitors Combined With VEGF Inhibitors for Locally Advanced dMMR/MSI-H Colorectal Cancer [Phase 2]
A Phase 2 trial evaluating the combination of PD-1 inhibitors with VEGF inhibitors for locally advanced dMMR/MSI-H colorectal cancer; the st…
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CLINICAL_TRIALS research · 2024-07-09Clinical Trial Update: ctDNA-guided Surveillance for Stage III CRC, a Randomized Intervention Trial [NA]
Update on a randomized trial investigating ctDNA-guided surveillance for stage III colorectal cancer; the trial is currently active but not …
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CLINICAL_TRIALS research · 2024-07-08Clinical Trial Update: Randomised Study Evaluating Adjuvant Chemotherapy After Resection of Stage III Colonic Adenocarcinoma in Patients of 70 and Over [Phase 3]
Phase 3 randomized trial evaluating adjuvant chemotherapy after resection of Stage III colonic adenocarcinoma in patients aged 70 and over. …
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CLINICAL_TRIALS research · 2024-07-08Clinical Trial Update: Assessing Frailty and Its Impacts on Patients Facing Major GI Surgery
This clinical trial update describes a study evaluating frailty and its effects on patients undergoing major gastrointestinal surgery for bo…
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CLINICAL_TRIALS trial_result · 2024-07-08Clinical Trial Update: Chemotherapy Plus EGFR Monoclonal Antibody in Patients With Liver Metastases From Colorectal Cancer With ctDNA Superselective Negative Genes [Phase 2]
Phase 2 clinical trial evaluating chemotherapy plus an EGFR monoclonal antibody for colorectal cancer with liver metastases is not yet recru…
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CLINICAL_TRIALS research · 2024-07-05Clinical Trial Update: IX001 TCR-T In the Treatment of Advanced Pancreatic Cancer and Colorectal Cancer Induced by KRAS Mutations [Phase 1]
A Phase 1 clinical trial evaluating IX001 TCR-T therapy for advanced pancreatic cancer and KRAS-mutant colorectal cancer is currently recrui…
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CLINICAL_TRIALS trial_result · 2024-07-05Clinical Trial Update: Effect of Exercise on Bowel Function in Colorectal Cancer Survivors [NA]
A completed clinical trial evaluated whether an exercise program improves bowel function in colorectal cancer survivors, including those wit…
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CLINICAL_TRIALS trial_result · 2024-07-03Clinical Trial Update: EAGLE Trial CADDIE Artificial Intelligence Endoscopy [NA]
The EAGLE trial evaluating the CADDIE AI endoscopy system has completed. The study involves colorectal cancer, colon polyps, and colon adeno…
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CLINICAL_TRIALS trial_result · 2024-07-03Clinical Trial Update: Efficacy and Safety of Trifluridine/Tipiracil Combined With Fufuquitinib for Third-line Treatment of mCRC [Phase 2]
A Phase 2 clinical trial evaluating the efficacy and safety of combining trifluridine/tipiracil with fufuquitinib as third-line therapy for …
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CLINICAL_TRIALS research · 2024-07-03Clinical Trial Update: Irinotecan Plus Anlotinib or Further in Combination With Penpulimab for Second-line Treatment of mCRC [Phase 2]
Phase 2 clinical trial evaluating irinotecan plus anlotinib, with or without penpulimab, as second-line therapy for metastatic colorectal ca…
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CLINICAL_TRIALS research · 2024-07-03Clinical Trial Update: Fruquintinib and Pirfenidone in Combination With Anti-PD-1 Antibody in Advanced or Metastatic pMMR/MSS Colorectal Carcinoma [Phase 1, Phase 2]
This clinical trial update describes an early-phase study evaluating the safety and efficacy of combining Fruquintinib and Pirfenidone with …
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CLINICAL_TRIALS research · 2024-07-01Clinical Trial Update: Randomized Trial Comparing Laparoscopic-assisted Rectosigmoid Resection Versus Laparoscopic Rectosigmoid Resection With Transrectal Specimen Retrieval [Phase 2]
This is a Phase 2 randomized clinical trial comparing laparoscopic-assisted rectosigmoid resection versus laparoscopic rectosigmoid resectio…
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CLINICAL_TRIALS trial_result · 2024-06-28Clinical Trial Update: An Imaging Agent (I-124 M5A) in Detecting CEA-Positive Liver Metastases in Patients With Colorectal Cancer [Phase 1]
Phase 1 clinical trial evaluating the imaging agent I-124 M5A for detecting CEA-positive liver metastases in colorectal cancer has completed…
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CLINICAL_TRIALS trial_result · 2024-06-28Clinical Trial Update: MicroOrganoSphere (MOS) Drug Screen Pilot Trial in Colorectal Cancer
The pilot trial evaluating Xilis' MicroOrganoSphere Drug Screen in colorectal cancer has completed enrollment/status.
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CLINICAL_TRIALS research · 2024-06-27Clinical Trial Update: The Efficacy of Watch and Wait Strategy or Surgery After Neoadjuvant Immunotherapy for Locally Advanced Colorectal Cancer With dMMR/MSI-H Guided by MRD Dynamic Monitoring: A Single-center, Open-label, Prospective, Phase II Clinical Trial.
A single-center, open-label Phase II trial is evaluating whether a watch-and-wait approach or surgical resection after neoadjuvant immunothe…