Colorectal Cancer

CLINICAL_TRIALS research · 2026-02-19

Clinical Trial Update: Study of AZD5305 as Monotherapy and in Combination With Anti-cancer Agents in Patients With Advanced Solid Malignancies [Phase 1, Phase 2]

AZD5305 is being evaluated as a monotherapy and in combination with anti-cancer agents in a Phase 1/2 trial for multiple advanced solid mali…

CLINICAL_TRIALS research · 2026-02-19

Clinical Trial Update: Phase 1/2 Study Evaluating MCLA-129, a Human Anti-EGFR, Anti-c-MET Bispecific Antibody, in Advanced NSCLC and Other Solid Tumors, Alone and in Combination [Phase 1, Phase 2]

Phase 1/2 trial update evaluating MCLA-129, a bispecific anti-EGFR and anti-c-MET antibody, in advanced non-small cell lung cancer and other…

CLINICAL_TRIALS research · 2026-02-19

Clinical Trial Update: Combination Immunotherapy for the Treatment of Chemotherapy-refractory Metastatic MSS CRC [Phase 1, Phase 2]

Phase 1/2 clinical trial evaluating a combination immunotherapy for metastatic microsatellite-stable colorectal cancer is currently recruiti…

CLINICAL_TRIALS trial_result · 2026-02-19

Clinical Trial Update: A Phase 1 Study of MRTX0902 in Solid Tumors With Mutations in the KRAS MAPK Pathway [Phase 1]

A Phase 1 study evaluating MRTX0902 in solid tumors with KRAS MAPK pathway mutations has been terminated.

CLINICAL_TRIALS research · 2026-02-19

Clinical Trial Update: Connecting Black Families in Houston, Texas to Hereditary Cancer Genetic Counseling, Genetic Testing, and Cascade Testing by Using a Simple Genetic Risk Screening Tool and Telegenetics [NA]

This clinical trial update from MD Anderson Cancer Center describes a study to connect Black families in Houston to hereditary cancer geneti…

CLINICAL_TRIALS research · 2026-02-19

Clinical Trial Update: Neoadjuvant Therapy With Tislelizumab for dMMR/MSI-H Stage II-III Colorectal Cancer

A neoadjuvant trial evaluating tislelizumab for patients with dMMR/MSI-H stage II-III colorectal cancer is currently recruiting.

CLINICAL_TRIALS withdrawal · 2026-02-19

Clinical Trial Update: Immunotherapies in Combination With Stereotactic Body Radiation Radiotherapy in Microsatellite Stable (MSS) Metastatic Colorectal Cancer (mCRC) [Phase 2]

A Phase 2 trial evaluating immunotherapies in combination with stereotactic body radiotherapy for microsatellite stable metastatic colorecta…

CLINICAL_TRIALS research · 2026-02-19

Clinical Trial Update: Utero-ovarian Transposition in Patients With Pelvic Malignancies Undergoing Whole Pelvic Radiotherapy [NA]

This clinical trial evaluates utero-ovarian transposition to preserve fertility in patients with pelvic malignancies undergoing whole pelvic…

CLINICAL_TRIALS research · 2026-02-18

Clinical Trial Update: EBNK-001 Allogeneic NK Cells With Low-Dose IL-15 ± Pembrolizumab in Advanced Solid Tumors [Phase 1, Phase 2]

Clinical Trial Update on an ongoing Phase 1/2 study of allogeneic NK cells (EBNK-001) with low-dose interleukin-15, with or without pembroli…

CLINICAL_TRIALS research · 2026-02-18

Clinical Trial Update: Biomarker-Guided Allogeneic Single-Target or Dual-Target CAR-NK Cell Therapy for Advanced Solid Tumors [Phase 1, Phase 2]

This clinical trial update details a biomarker-guided allogeneic CAR-NK cell therapy using single-target or dual-target constructs for advan…

CLINICAL_TRIALS research · 2026-02-18

Clinical Trial Update: A Study of Single Fraction Stereotactic Body Radiation Therapy (SBRT) Guided by Magnetic Resonance Imaging (MRI) in People With Liver Metastasis From Colorectal Cancer [Phase 2]

Phase 2 clinical trial evaluating single-fraction MRI-guided stereotactic body radiation therapy for liver metastases from colorectal cancer…

CLINICAL_TRIALS research · 2026-02-18

Clinical Trial Update: Study of CP-383 in Patients With Advanced or Metastatic Solid Tumors [Phase 1, Phase 2]

Tasca Therapeutics is testing CP-383 in a Phase 1/2 trial for patients with advanced or metastatic solid tumors, including colorectal cancer…

CLINICAL_TRIALS research · 2026-02-18

Clinical Trial Update: Single-Stapled Technique for Colorectal Anastomosis

Clinical trial update indicates a single-stapled technique for colorectal anastomosis is under investigation and currently recruiting, spons…

CLINICAL_TRIALS trial_result · 2026-02-18

Clinical Trial Update: Study on Aspirin Versus Placebo in Resected Colon Cancer With PI3K Mutation Stage III or II High Risk [Phase 3]

A Phase 3 trial is evaluating aspirin versus placebo in patients with resected colorectal cancer carrying a PI3K mutation and high-risk stag…

CLINICAL_TRIALS trial_result · 2026-02-18

Clinical Trial Update: SafeHeal Diverting Ileostomy Pivotal Study

A clinical trial update indicates SafeHeal's pivotal study for a diverting ileostomy in colorectal cancer is active but not recruiting.

CLINICAL_TRIALS research · 2026-02-18

Clinical Trial Update: SafeHeal Colovac Anastomosis Protection Device Evaluation Pivotal Study [NA]

Clinical trial update on the SafeHeal Colovac Anastomosis Protection Device evaluating its use in colorectal cancer patients undergoing ileo…

CLINICAL_TRIALS trial_result · 2026-02-17

Clinical Trial Update: Combination With Sintilimab and XELOX+Bevacizumab as 1st Line Therapy in RAS-mutant Metastatic Colorectal Cancer [Phase 3]

Phase 3 study evaluating the combination of sintilimab with XELOX and bevacizumab as first-line therapy for RAS-mutant metastatic colorectal…

CLINICAL_TRIALS trial_result · 2026-02-17

Clinical Trial Update: Liver Surgery and Chemotherapy in Treating Patients With Colorectal Cancer With Liver Metastases That Can Be Removed by Surgery and Lung Metastases That Cannot Be Removed by Surgery [Phase 2]

A Phase 2 trial evaluated liver surgery plus chemotherapy for colorectal cancer with resectable liver metastases and unresectable lung metas…