Clostridioides Difficile Infection
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CLINICAL_TRIALS research · 2026-02-10Clinical Trial Update: Fecal Microbiota Transplantation in an Expanded Ulcerative Colitis Population [Phase 1]
Phase 1 trial of fecal microbiota transplantation in an expanded ulcerative colitis population; study is not yet recruiting.
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FDA approval · 2026-02-02FDA Approved: FIDAXOMICIN — Original Application (Apotex Corp.)
FDA approved Apotex Corp.'s original ANDA for fidaxomicin (fidaxomicin) as a generic treatment for Clostridioides difficile infection.
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CLINICAL_TRIALS trial_result · 2026-01-30Clinical Trial Update: Safety and Tolerability of AZD5148 in Japanese Participants [Phase 1]
Phase 1 safety and tolerability study of AZD5148 in Japanese participants has completed.
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CLINICAL_TRIALS trial_result · 2026-01-28Clinical Trial Update: REBYOTA™ Prospective Registry
A prospective registry update for REBYOTA evaluating its use to prevent recurrence of Clostridioides difficile infection has been completed.
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CLINICAL_TRIALS research · 2026-01-28Clinical Trial Update: Clostridioides Difficile: Understanding Responses and Treatment Effects
A clinical trial update from Umeå University investigating responses and treatment effects in Clostridioides difficile infection; the study …
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CLINICAL_TRIALS research · 2026-01-27Clinical Trial Update: To Understand the Safety and Effects of a C. Difficile Vaccine With New Adds-Ons That Will Be Given to Healthy Adults [Phase 1, Phase 2]
Pfizer is conducting Phase 1/2 trials to evaluate the safety and effects of a Clostridioides difficile vaccine in healthy adults; the study …
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FDA approval · 2026-01-27FDA Approved: FIDAXOMICIN — Original Application (Torrent Pharmaceuticals Limited)
The FDA approves the original application (ANDA) for fidaxomicin from Torrent Pharmaceuticals Limited, enabling the generic version to be ma…
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CLINICAL_TRIALS research · 2026-01-21Clinical Trial Update: Fecal Microbiota Transplant National Registry
ClinicalTrials.gov entry for a national registry on fecal microbiota transplant, currently recruiting to study its use in Clostridioides dif…
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CLINICAL_TRIALS research · 2026-01-12Clinical Trial Update: C. Difficile Toxin Levels in Stool From Healthy Individuals Following Standard of Care Antibiotic Treatment for CDI.
Clinical trial update describing a study that measures Clostridioides difficile toxin levels in stool from healthy individuals after standar…
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CLINICAL_TRIALS research · 2026-01-09Clinical Trial Update: Vancomycin Taper to Prevent Recurrent Clostridioides Difficile [Phase 3]
Phase 3 clinical trial evaluating a vancomycin taper strategy to prevent recurrent Clostridioides difficile infection; the study is currentl…
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CLINICAL_TRIALS research · 2026-01-07Clinical Trial Update: Primary Prophylaxis of Clostridioides Difficile Infection With Oral Vancomycin [Phase 2, Phase 3]
This entry describes a Phase 2/Phase 3 clinical trial evaluating oral vancomycin for primary prophylaxis of Clostridioides difficile infecti…
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CLINICAL_TRIALS trial_result · 2025-12-19Clinical Trial Update: Host Immune Response to Clostridium Difficile Infection (ICD) [NA]
A completed clinical trial update from Hospices Civils de Lyon investigates the host immune response to Clostridioides difficile infection.
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CLINICAL_TRIALS trial_result · 2025-12-19Clinical Trial Update: C.Difficile Observational Study
AstraZeneca-sponsored observational study on Clostridioides difficile infection has completed.
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CLINICAL_TRIALS research · 2025-12-16Clinical Trial Update: Pilot Trial of Xylitol for C. Difficile De-Colonization in Patients With Inflammatory Bowel Disease [EARLY_Phase 1]
Early-phase pilot trial evaluating xylitol for de-colonization of Clostridioides difficile in patients with inflammatory bowel disease; the …
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CLINICAL_TRIALS trial_result · 2025-12-10Clinical Trial Update: Initial Vancomycin Taper for the Prevention of Recurrent Clostridium Difficile Infection [Phase 3]
A Phase 3 trial evaluating an initial vancomycin taper to prevent recurrent Clostridioides difficile infection has completed.
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CLINICAL_TRIALS research · 2025-12-03Clinical Trial Update: Real-World Study on Fecal Microbiota Transplantation: Long-Term Effectiveness and Safety Statistics
This clinical trial real-world study is assessing the long-term effectiveness and safety of fecal microbiota transplantation across several …
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CLINICAL_TRIALS research · 2025-11-17Clinical Trial Update: Autologous Fecal Microbiota Transplantation (Auto-FMT) for Prophylaxis of Clostridium Difficile Infection in Recipients of Allogeneic Hematopoietic Stem Cell Transplantation [Phase 2]
Phase 2 trial evaluating autologous fecal microbiota transplantation to prevent Clostridioides difficile infection in recipients of allogene…
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CLINICAL_TRIALS trial_result · 2025-11-17Clinical Trial Update: The Clostridioides Difficile Trial of REC-3964 [Phase 2]
A Phase 2 trial of REC-3964 for recurrent Clostridioides difficile infection has been terminated, with results posted.
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CLINICAL_TRIALS trial_result · 2025-11-12Clinical Trial Update: Optimal Treatment for Recurrent Clostridium Difficile [Phase 4]
Phase 4 trial evaluating optimal treatment for recurrent Clostridioides difficile infection has terminated with results posted.
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CLINICAL_TRIALS research · 2025-11-10Clinical Trial Update: Enteral Vancomycin as Primary Prophylaxis Against Clostridioides Difficile Infection in Critically Ill Patients [Phase 2, Phase 3]
Status update for a Phase 2/Phase 3 clinical trial evaluating enteral vancomycin as primary prophylaxis to prevent Clostridioides difficile …
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CLINICAL_TRIALS research · 2025-11-10Clinical Trial Update: MTC Versus FMT in for RCDI [Phase 1]
Phase 1 clinical trial comparing MTC to fecal microbiota transplantation for recurrent Clostridioides difficile infection is currently recru…
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CLINICAL_TRIALS research · 2025-11-03Clinical Trial Update: Use of Fidaxomicin Compared to Vancomycin for Decolonization of C. Difficile in Patients With Inflammatory Bowel Disease [Phase 4]
Phase 4 clinical trial comparing fidaxomicin to vancomycin for decolonization of Clostridioides difficile infection in patients with inflamm…
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CLINICAL_TRIALS trial_result · 2025-10-09Clinical Trial Update: Prevention of Recurrence of Clostridioides Difficile Colitis With Ursodeoxycholic Acid (UCDA) as a Supplement to Standard Therapy [EARLY_Phase 1]
An early-phase 1 trial is examining ursodeoxycholic acid as a supplement to standard therapy to prevent recurrence of Clostridioides diffici…
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CLINICAL_TRIALS trial_result · 2025-09-23Clinical Trial Update: Efficacy and Safety of Teicoplanin in CDAD [Phase 4]
Phase 4 trial evaluating teicoplanin for Clostridioides difficile infection–associated diarrhea and colitis was terminated; no efficacy or s…
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CLINICAL_TRIALS research · 2025-09-22Clinical Trial Update: An Open-Label, Pilot Clinical Trial To Test The Safety And Feasibility Of A Suspension of Freeze-dried Microbiota In Patients Undergoing Colon Resection [Phase 1]
Open-label Phase 1 trial to assess safety and feasibility of a freeze-dried microbiota suspension in patients undergoing colon resection.