Clostridioides Difficile Infection
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CLINICAL_TRIALS trial_result · 2025-01-31Clinical Trial Update: FQ Restriction for the Prevention of CDI
The clinical trial update notes that a study evaluating fluoroquinolone restriction to prevent Clostridioides difficile infection has comple…
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CLINICAL_TRIALS trial_result · 2025-01-17Clinical Trial Update: ACX-362E [Ibezapolstat] for Oral Treatment of Clostridioides Difficile Infection [Phase 2]
Phase 2 trial results for ACX-362E (Ibezapolstat) in treating Clostridioides difficile infection have been posted.
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CLINICAL_TRIALS trial_result · 2025-01-09Clinical Trial Update: Fecal Microbiota Transplantation for C. Difficile Infection in Solid Organ Transplant Recipients [Phase 2]
Phase 2 clinical trial evaluating fecal microbiota transplantation for recurrent Clostridioides difficile infection in solid organ transplan…
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CLINICAL_TRIALS trial_result · 2024-12-12Clinical Trial Update: Oral Vancomycin Vs Placebo in the Prevention of Recurrence of Clostridioides Difficile's Infection [Phase 3]
A Phase 3 clinical trial comparing oral vancomycin to placebo for preventing recurrence of Clostridioides difficile infection has completed.
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CLINICAL_TRIALS trial_result · 2024-12-11Clinical Trial Update: ICON-2: FMT and Bezlotoxumab Compared to FMT and Placebo for Patients With IBD and CDI [Phase 2]
Phase 2 ICON-2 trial comparing fecal microbiota transplantation plus bezlotoxumab versus fecal microbiota transplantation plus placebo in pa…
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CLINICAL_TRIALS trial_result · 2024-11-07Clinical Trial Update: Novel Biomarkers to Predict Outcome in Clostridium Difficile Infection
The update describes a completed clinical trial evaluating novel biomarkers that may predict outcomes in patients with Clostridioides diffic…
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CLINICAL_TRIALS trial_result · 2024-11-01Clinical Trial Update: Rescue FMT with Bezlotoxumab for Recurrent C. Difficile Infection
A completed trial examined using bezlotoxumab alongside fecal microbiota transplantation for recurrent Clostridioides difficile infection.
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CLINICAL_TRIALS trial_result · 2024-10-31Clinical Trial Update: A Phase IIIB/IV Study to Compare the Efficacy of Vancomycin Therapy to Extended Duration of Fidaxomicin Therapy in the Clinical Cure of Clostridium Difficile Infection (CDI) in an Older Population [Phase 4]
A Phase IIIB/IV trial comparing vancomycin to extended-duration fidaxomicin for clinical cure of Clostridioides difficile infection in older…
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CLINICAL_TRIALS trial_result · 2024-10-31Clinical Trial Update: A Study to Compare Safety and Efficacy of OPT-80(Fidaxomicin) With Vancomycin in Subjects With Clostridium Difficile-associated Diarrhea (CDAD) [Phase 3]
Phase 3 study comparing fidaxomicin (OPT-80) to vancomycin for safety and efficacy in Clostridioides difficile infection has completed.
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CLINICAL_TRIALS trial_result · 2024-10-31Clinical Trial Update: Study to Evaluate the Pharmacokinetics of Fidaxomicin in Inflammatory Bowel Disease (IBD) Subjects With Clostridium Difficile Infection (CDI) [Phase 4]
A Phase 4 pharmacokinetic study evaluated fidaxomicin in patients with inflammatory bowel disease who have Clostridioides difficile infectio…
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CLINICAL_TRIALS trial_result · 2024-09-23Clinical Trial Update: Safety and Immunogenicity Study of GSK's Clostridium Difficile Vaccine 2904545A When Administered in Healthy Adults Aged 18-45 Years and 50-70 Years [Phase 1]
Phase 1 safety and immunogenicity study of GlaxoSmithKline's Clostridioides difficile vaccine (2904545A) in healthy adults aged 18-45 and 50…
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CLINICAL_TRIALS trial_result · 2024-09-23Clinical Trial Update: Lyophilized Fecal Microbiota Transplantation for Recurrent Clostridioides Difficile Infection [NA]
This ClinicalTrials.gov update reports completion of a trial evaluating lyophilized fecal microbiota transplantation for recurrent Clostridi…
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CLINICAL_TRIALS trial_result · 2024-09-19Clinical Trial Update: Fecal Transplantation for Primary Clostridium Difficile Infection [Phase 3]
Phase 3 trial evaluating fecal microbiota transplantation for primary Clostridioides difficile infection has been terminated.
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CLINICAL_TRIALS trial_result · 2024-08-15Clinical Trial Update: Effects of Gastric Acid on Colonic Microbiome [Phase 4]
This Phase 4 trial examined how gastric acid influences the colonic microbiome in Clostridioides difficile infection. Results have been post…
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CLINICAL_TRIALS trial_result · 2024-08-13Clinical Trial Update: Screening to Prophylax Against Clostridium Difficile Infection - [Phase 4]
A Phase 4 clinical trial evaluating screening-based prophylaxis to prevent Clostridioides difficile infection has completed, with results po…
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CLINICAL_TRIALS trial_result · 2024-08-07Clinical Trial Update: Microbiota Restoration Therapy for Recurrent Clostridium Difficile Infection (PUNCH CD3-OLS) [Phase 3]
Phase 3 trial results for RBX2660, a microbiota restoration therapy, in recurrent Clostridioides difficile infection have been posted.
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CLINICAL_TRIALS trial_result · 2024-06-04Clinical Trial Update: Multicentre Blinded Comparison of Lyophilized Sterile Fecal Filtrate to Lyophilized Fecal Microbiota Transplant in Recurrent Clostridioides Difficile Infection [Phase 2]
Phase 2 multicenter trial comparing lyophilized sterile fecal filtrate to lyophilized fecal microbiota transplant for recurrent Clostridioid…
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CLINICAL_TRIALS trial_result · 2023-11-28Clinical Trial Update: Oral Vancomycin to Prevent Recurrent C Difficile Infection With Antibiotics [Phase 4]
Phase 4 trial updating oral vancomycin use to prevent recurrent Clostridioides difficile infection in patients on antibiotics.
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CLINICAL_TRIALS trial_result · 2023-11-13Clinical Trial Update: A Trial of CP101 for the Prevention of Recurrent CDI (PRISM4) [Phase 3]
Phase 3 trial (PRISM4) of CP101 for prevention of recurrent Clostridioides difficile infection has been terminated, with results posted.
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CLINICAL_TRIALS trial_result · 2023-11-01Clinical Trial Update: Penn Microbiome Therapy for Recurrent Clostridium Difficile Infection [Phase 2]
Phase 2 trial update for Penn microbiome therapy targeting recurrent Clostridioides difficile infection; study terminated with results poste…
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CLINICAL_TRIALS trial_result · 2023-08-21Clinical Trial Update: Safety, Tolerability and the Pharmacokinetics of Ridinilazole in Adolescent Subjects [Phase 3]
Phase 3 safety and pharmacokinetics update for ridinilazole in adolescents; trial terminated with posted results.
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CLINICAL_TRIALS trial_result · 2023-08-14Clinical Trial Update: Microbiota Restoration Therapy for Recurrent Clostridium Difficile Infection (PUNCHCD3) [Phase 3]
Phase 3 trial of Microbiota Restoration Therapy for recurrent Clostridioides difficile infection has completed, with results posted in Augus…
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CLINICAL_TRIALS trial_result · 2023-07-03Clinical Trial Update: Phase 2 Study of VE303 for Prevention of Recurrent Clostridioides Difficile Infection [Phase 2]
Phase 2 trial of VE303 for prevention of recurrent Clostridioides difficile infection has completed; results were posted in 2023.
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CLINICAL_TRIALS trial_result · 2023-05-19Clinical Trial Update: Fecal Filtrate as a Treatment Option of Multiple Recurrent Clostridioides Difficile Infection [Phase 3]
Phase 3 clinical trial evaluating fecal filtrate as a treatment for recurrent Clostridioides difficile infection is ongoing or not yet repor…
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CLINICAL_TRIALS trial_result · 2023-03-31Clinical Trial Update: ECOSPOR IV: An Open-Label Study Evaluating SER-109 in Recurrent Clostridioides Difficile Infection [Phase 3]
Phase 3 open-label trial of SER-109 for recurrent Clostridioides difficile infection has completed with results posted.