Chronic Obstructive Pulmonary Disease

CLINICAL_TRIALS trial_result · 2017-06-27

Clinical Trial Update: Safety, Tolerability, Pharmacokinetic and Pharmacodynamic Effects of GSK573719 (LAMA) and GW642444 (LABA)Administered Individually and Concurrently in Healthy Japanese Subjects [Phase 1]

This Phase 1 trial evaluated the safety, tolerability, and pharmacokinetic/pharmacodynamic effects of GSK573719 (LAMA) and GW642444 (LABA) w…

CLINICAL_TRIALS research · 2017-06-27

Clinical Trial Update: A Safety and Feasibility Study of Re-treating Patients With Severe Emphysema With the RePneu LVRC System. [NA]

This update covers a completed safety and feasibility study evaluating re-treatment with the RePneu LVRC System in patients with severe emph…

CLINICAL_TRIALS trial_result · 2017-06-27

Clinical Trial Update: Helium-3 MRI Imaging Study in COPD [Phase 1]

Phase 1 trial evaluating helium-3 MRI imaging for assessing lung ventilation in chronic obstructive pulmonary disease has completed. Sponsor…

CLINICAL_TRIALS research · 2017-06-27

Clinical Trial Update: A Study to Determine the Excretion Balance and Pharmacokinetics of 14C-GSK573719 [Phase 1]

Phase 1 study to determine excretion balance and pharmacokinetics of 14C-labeled GSK573719 in chronic obstructive pulmonary disease; the tri…

CLINICAL_TRIALS trial_result · 2017-06-27

Clinical Trial Update: GSK573719 IV Enabling Study [Phase 1]

Phase 1 enabling study of GSK573719 IV in chronic obstructive pulmonary disease has completed.

CLINICAL_TRIALS trial_result · 2017-06-23

Clinical Trial Update: Lung Deposition of Beclometasone Dipropionate/Formoterol Fumarate/Glycopyrronium Bromide Administered Via pMDI in Healthy, Asthmatic and COPD Patients [Phase 1]

Phase 1 study evaluating lung deposition of a triple inhaled therapy (beclometasone dipropionate/formoterol fumarate/glycopyrronium bromide)…

CLINICAL_TRIALS trial_result · 2017-06-23

Clinical Trial Update: Sustained Effects of Hypertonic Saline on Mucociliary Clearance in Subjects With Chronic Bronchitis [NA]

A completed clinical trial evaluated the sustained effects of inhaled hypertonic saline on mucociliary clearance in people with chronic bron…

CLINICAL_TRIALS research · 2017-06-23

Clinical Trial Update: Patient Registry of Roflumilast In Real Life

A real-world patient registry study assessing roflumilast in chronic obstructive pulmonary disease has completed.

CLINICAL_TRIALS withdrawal · 2017-06-23

Clinical Trial Update: Novel Therapies for Muco-Obstructive Lung Diseases: Testing the Transnasal Pulmonary Delivery Device in COPD/CB Subjects [NA]

A clinical trial testing a transnasal pulmonary delivery device for COPD and chronic bronchitis has been withdrawn.

CLINICAL_TRIALS trial_result · 2017-06-22

Clinical Trial Update: Post Marketing Surveillance of Roflumilast in Korea

Completed post-marketing surveillance study of roflumilast in Korea for chronic obstructive pulmonary disease.

CLINICAL_TRIALS trial_result · 2017-06-22

Clinical Trial Update: Preference Attributes of ELLIPTA Dry Powder Inhaler (DPI) and HANDIHALER DPI in Subjects With Chronic Obstructive Pulmonary Disease (COPD) [Phase 4]

Phase 4 trial updating preference attributes of ELLIPTA and HANDIHALER dry powder inhalers in COPD patients; results completed with posted r…

CLINICAL_TRIALS research · 2017-06-22

Clinical Trial Update: Characterisation of Healthy Volunteers, Asthma and Chronic Obstructive Pulmonary Disease Patients for Inhalation Profile, Pharyngometry, Spirometric Indices and Lung Morphometry [Phase 1]

Phase 1 study characterising inhalation profiles, pharyngometry, spirometry indices and lung morphometry in healthy volunteers and patients …

CLINICAL_TRIALS trial_result · 2017-06-20

Clinical Trial Update: A Single Dose Study to Determine the Excretion, Balance and Metabolic Disposition of Radiolabelled GW642444. [Phase 1]

Phase 1 trial evaluating excretion, balance, and metabolic disposition of radiolabeled GW642444 after a single dose in chronic obstructive p…

CLINICAL_TRIALS trial_result · 2017-06-20

Clinical Trial Update: Assessment of Lung Function After Single Inhalations of a Bronchodilator From 2 Configurations a Dry Powder Inhaler. [Phase 1]

Phase 1 study assessing acute lung function after single inhalations of a bronchodilator delivered via two dry powder inhaler configurations…

CLINICAL_TRIALS trial_result · 2017-06-15

Clinical Trial Update: A Study to Assess the Bioavailability and to Compare the Pharmacokinetics of AZD7594 Inhaled Via Monodose Inhaler and Multiple-dose Dry Powder Inhalers (DPI) or Pressurized Metered-dose Inhaler (pMDI) in Healthy Male Subjects [Phase 1]

Phase 1 study evaluating bioavailability and pharmacokinetics of AZD7594 inhaled via different devices in healthy male subjects; results pos…

CLINICAL_TRIALS trial_result · 2017-06-14

Clinical Trial Update: Changes in Cardiac Function in COPD Patients After Administration of Budesonide/Formoterol (Symbicort®) Versus Placebo [Phase 4]

Phase 4 trial evaluating cardiac function in COPD patients treated with budesonide/formoterol (Symbicort) versus placebo. The study was term…

CLINICAL_TRIALS trial_result · 2017-06-14

Clinical Trial Update: Pharmacokinetic and Safety of GSK573719 and GW642444 Administered Individually and Concurrently, With Verapamilin in Healthy Subjects [Phase 1]

Phase 1 pharmacokinetic and safety study of GSK573719 and GW642444 administered alone and with verapamil in healthy subjects.

CLINICAL_TRIALS trial_result · 2017-06-14

Clinical Trial Update: The Safety and Efficiency of Sildenafil in the Treatment of Severe Post-capillary Pulmonary Hypertension Caused by COPD [NA]

This document is a clinical trial update examining the safety and efficacy of sildenafil for severe post-capillary pulmonary hypertension ca…