Chronic Myeloid Leukemia
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS trial_result · 2025-08-22Clinical Trial Update: Ropeginterferon for Treatment Free Remission [Phase 4]
Phase 4 trial evaluating Ropeginterferon alfa-2b for treatment-free remission in chronic myeloid leukemia has completed.
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CLINICAL_TRIALS trial_result · 2025-08-19Clinical Trial Update: Phase 1-2 MAHCT w/ TCell Depleted Graft w/ Simultaneous Infusion Conventional and Regulatory T Cell [Phase 1, Phase 2]
A completed Phase 1/2 study from Stanford evaluated a haploidentical hematopoietic cell transplantation approach using a T-cell depleted gra…
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CLINICAL_TRIALS trial_result · 2025-07-29Clinical Trial Update: Retro-prospective Observational Study on Risk of Progression in CP-CML Patients Eligible for TKI Discontinuation
This update notes the completion of a retro-prospective observational study assessing the risk of disease progression in chronic myeloid leu…
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CLINICAL_TRIALS trial_result · 2025-07-11Clinical Trial Update: CASPALLO: Allodepleted T Cells Transduced With Inducible Caspase 9 Suicide Gene [Phase 1]
Phase 1 clinical trial of CASPALLO allodepleted T cells engineered with an inducible caspase-9 suicide gene; the study is currently active b…
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CLINICAL_TRIALS trial_result · 2025-07-04Clinical Trial Update: UCB Transplant for Hematological Diseases Using a Non Myeloablative Prep [Phase 2]
Phase 2 clinical trial evaluating non-myeloablative preparative regimens followed by umbilical cord blood transplantation for various hemato…
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CLINICAL_TRIALS trial_result · 2025-06-15Clinical Trial Update: Alpha/Beta T Cell and CD19+ B Cell Depletion in Allogeneic Stem Cell Transplantation in Patients With Malignant Diseases [Phase 2]
A Phase 2 clinical trial is testing alpha/beta T cell and CD19+ B cell depletion in allogeneic stem cell transplantation for malignant disea…
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CLINICAL_TRIALS trial_result · 2025-06-08Clinical Trial Update: Long-acting Low Dose Ropeginterferon for Chronic Myeloid Leukemia Treated With Bosutinib From Diagnosis [Phase 2]
A Phase 2 trial evaluated long-acting low-dose ropeginterferon in patients with chronic myeloid leukemia who are treated with bosutinib from…
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CLINICAL_TRIALS trial_result · 2025-06-05Clinical Trial Update: TyrosIne Kinase Inhibitors in Chronic Myeloid Leukemia: Efficacy and Tolerability. The TIKlet Study
The TIKlet Study evaluated tyrosine kinase inhibitors for chronic myeloid leukemia and has completed, reporting data on efficacy and tolerab…
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CLINICAL_TRIALS trial_result · 2025-06-03Clinical Trial Update: Ruxolitinib in Treating Participants With Chronic Myeloid Leukemia With Minimal Residual Disease While on Therapy With Tyrosine Kinase Inhibitors [Phase 1]
Phase 1 trial evaluating ruxolitinib in chronic myeloid leukemia patients with minimal residual disease on tyrosine kinase inhibitors was te…
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CLINICAL_TRIALS trial_result · 2025-05-25Clinical Trial Update: Blinded Cross-Over Bioequivalence (BE) Trial of Luitpold Azacitidine vs Vidaza [Phase 1]
Phase 1 blinded cross-over bioequivalence trial comparing Luitpold azacitidine with Vidaza has completed, with results posted.
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CLINICAL_TRIALS trial_result · 2025-05-25Clinical Trial Update: Study of Predictive Immunological Parameters of Molecular Complete Remission in Patients With Chronic Myelogenous Leukemia in Chronic Phase and Treated With Tyrosine Kinase Inhibitor [NA]
This completed clinical trial update evaluates predictive immunological parameters of molecular complete remission in chronic myeloid leukem…
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CLINICAL_TRIALS trial_result · 2025-05-16Clinical Trial Update: TGRX-678 Phase I Oral Pharmacokinetic Study [Phase 1]
A Phase I oral pharmacokinetic study of TGRX-678 for chronic myeloid leukemia has completed.
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CLINICAL_TRIALS trial_result · 2025-05-08Clinical Trial Update: Venetoclax, Ponatinib, and Dexamethasone in Participants With Philadelphia Chromosome or BCR-ABL Positive Relapsed or Refractory Acute Lymphoblastic Leukemia or Chronic Myelogenous Leukemia [Phase 1, Phase 2]
A Phase 1/2 study evaluating venetoclax, ponatinib, and dexamethasone in patients with BCR-ABL1 positive Philadelphia chromosome positive re…
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CLINICAL_TRIALS trial_result · 2025-04-25Clinical Trial Update: Genomics Study in CML Patients With Ponatinib Treatment
A genomics-focused study evaluating ponatinib in patients with chronic myeloid leukemia (BCR-ABL1 positive) has completed.
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CLINICAL_TRIALS trial_result · 2025-04-18Clinical Trial Update: Study of Efficacy and Safety of CML-CP Patients Treated With Asciminib Versus Best Available Therapy, Previously Treated With 2 or More Tyrosine Kinase Inhibitors [Phase 2]
A Phase 2 trial evaluating asciminib versus best available therapy in chronic myeloid leukemia in chronic phase patients previously treated …
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CLINICAL_TRIALS trial_result · 2025-04-18Clinical Trial Update: Front-line Nilotinib Treatment of BCR-ABL+ Chronic Myeloid Leukaemia in Chronic Phase
This clinical trial update reports on front-line nilotinib treatment for patients with chronic phase BCR-ABL positive chronic myeloid leukem…
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CLINICAL_TRIALS trial_result · 2025-04-06Clinical Trial Update: Donor Stem Cell Transplantation Using α/β+ T-lymphocyte Depleted Grafts From HLA Mismatched Donors [Phase 2]
A Phase 2 trial evaluating α/β+-T lymphocyte-depleted donor grafts from HLA-mismatched donors in multiple hematologic malignancies was termi…
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CLINICAL_TRIALS trial_result · 2025-03-30Clinical Trial Update: Study of Imatinib Discontinuation in Chronic Myeloid Leukemia With Deep Molecular Response [Phase 2]
Phase 2 trial evaluating discontinuation of imatinib in chronic myeloid leukemia patients with deep molecular response; the study has comple…
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CLINICAL_TRIALS trial_result · 2025-03-27Clinical Trial Update: Asciminib Treatment Optimization in ≥ 3rd Line CML-CP [Phase 3]
A Phase 3 trial evaluating asciminib for treatment optimization in patients with chronic myeloid leukemia in chronic phase who are on ≥ thir…
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CLINICAL_TRIALS trial_result · 2025-03-17Clinical Trial Update: Evaluation of a Cardiovascular Active Prevention in Chronic Myeloid Leukemia on the Cardiovascular Morbi-mortality [Phase 3]
A Phase 3 trial evaluating a cardiovascular preventive strategy in chronic myeloid leukemia has been terminated.
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CLINICAL_TRIALS trial_result · 2025-03-14Clinical Trial Update: De- Escalation and Stopping Treatment of Imatinib, Nilotinib or sprYcel in Chronic Myeloid Leukaemia [Phase 2]
This Phase 2 trial examines de-escalation and stopping treatment with imatinib, nilotinib, or dasatinib (Sprycel) in chronic myeloid leukemi…
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CLINICAL_TRIALS trial_result · 2025-03-10Clinical Trial Update: A Study of Oral Asciminib Versus Other TKIs in Adult Patients With Newly Diagnosed Ph+ CML-CP [Phase 3]
Phase 3 clinical trial update comparing oral asciminib with other tyrosine kinase inhibitors in adults with newly diagnosed Philadelphia chr…
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CLINICAL_TRIALS trial_result · 2025-03-10Clinical Trial Update: A Study of Oral Asciminib Versus Other TKIs in Adult Patients With Newly Diagnosed Ph+ CML-CP [Phase 3]
Phase 3 trial comparing oral asciminib to other TKIs in adults with newly diagnosed Philadelphia chromosome-positive chronic myeloid leukemi…
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CLINICAL_TRIALS trial_result · 2025-03-07Clinical Trial Update: Reduced Intensity Flu/Mel/TBI Conditioning for HAPLO HCT Patients With Hematologic Malignancies [Phase 2]
Phase 2 trial evaluating reduced-intensity conditioning with fludarabine and melphalan plus total body irradiation for haploidentical stem c…
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CLINICAL_TRIALS trial_result · 2025-03-07Clinical Trial Update: Myeloablative Hematopoietic Progenitor Cell Transplantation (HPCT) for Pediatric Malignancies
This completed clinical trial evaluated myeloablative hematopoietic progenitor cell transplantation in pediatric patients with chronic myelo…