Chronic Lymphocytic Leukemia
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2026-03-23Clinical Trial Update: CLL-IMPACT: A Clinical Nutrition Trial Investigating Immune and Metabolic Changes in Early-Stage CLL [NA]
This entry describes an ongoing clinical nutrition trial (CLL-IMPACT) investigating immune and metabolic changes in early-stage chronic lymp…
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CLINICAL_TRIALS research · 2026-03-20Clinical Trial Update: A Study of NX-2127 in Adults With Relapsed/Refractory B-cell Malignancies [Phase 1]
Phase 1 study evaluating NX-2127 in adults with relapsed or refractory B-cell malignancies; currently recruiting.
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CLINICAL_TRIALS research · 2026-03-20Clinical Trial Update: An Extension Study of Venetoclax for Subjects Who Have Completed a Prior Venetoclax Clinical Trial [Phase 3]
This entry details a Phase 3 extension study of Venetoclax for patients who completed prior Venetoclax trials. The study is currently active…
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CLINICAL_TRIALS trial_result · 2026-03-20Clinical Trial Update: Zanubrutinib and Rituximab for the Treatment of Previously Untreated Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma [Phase 2]
A Phase 2 trial evaluating the combination of zanubrutinib and rituximab for previously untreated chronic lymphocytic leukemia or small lymp…
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CLINICAL_TRIALS other · 2026-03-19Clinical Trial Update: FT819 in Subjects With B-cell Malignancies [Phase 1]
This ClinicalTrials.gov entry provides a Phase 1 trial status update for FT819 in B-cell malignancies, indicating the study is ACTIVE_NOT_RE…
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CLINICAL_TRIALS research · 2026-03-18Clinical Trial Update: Study of Iopofosine I-131 (CLR 131) in Select B-Cell Malignancies (CLOVER-1) With Expansion in Waldenstrom [Phase 2]
Phase 2 clinical trial update for CLR-131 in select B-cell malignancies, with expansion into Waldenström macroglobulinemia. The study status…
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CLINICAL_TRIALS trial_result · 2026-03-18Clinical Trial Update: HLA-Mismatched Unrelated Donor Hematopoietic Cell Transplantation With Post-Transplantation Cyclophosphamide [Phase 2]
Phase 2 trial evaluating HLA-mismatched unrelated donor hematopoietic cell transplantation with post-transplantation cyclophosphamide is act…
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EMA approval · 2026-03-17EMA Authorised: Gazyvaro (obinutuzumab) — Roche Registration GmbH
EMA authorised Gazyvaro (obinutuzumab) by Roche Registration GmbH for chronic lymphocytic leukemia (a B-cell leukemia).
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CLINICAL_TRIALS research · 2026-03-17Clinical Trial Update: A Platform Protocol to Investigate Post-Transplant Cyclophosphamide-Based Graft-Versus-Host Disease Prophylaxis in Patients With Hematologic Malignancies Undergoing Mismatched Unrelated Donor Peripheral Blood Stem Cell Transplantation [Phase 2]
This Phase 2 clinical trial protocol investigates a post-transplant cyclophosphamide–based graft-versus-host disease prophylaxis approach in…
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CLINICAL_TRIALS research · 2026-03-17Clinical Trial Update: Front-line VenObi Combination Followed by Ven or VenZan Combination in Patients With Residual Disease: a MRD Tailored Treatment for Young Patients With High-risk CLL [Phase 2]
This Phase 2 trial evaluates frontline venetoclax-based therapy with obinutuzumab (VenObi) followed by venetoclax alone or with zanubrutinib…
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CLINICAL_TRIALS trial_result · 2026-03-17Clinical Trial Update: A Study of Voruciclib Alone or in Combination With Venetoclax in Subjects With B-Cell Malignancies or AML [Phase 1]
Phase 1 trial update for voruciclib alone or with venetoclax in various B-cell malignancies and acute myeloid leukemia; the study has been t…
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CLINICAL_TRIALS research · 2026-03-17Clinical Trial Update: A Study to Evaluate MTM-H-001 Injection in Adult Participants With Relapsed or Refractory B-cell Malignancies [NA]
This clinical trial update describes an evaluation of MTM-H-001 injection in adults with relapsed or refractory B-cell lymphomas, with the s…
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CLINICAL_TRIALS research · 2026-03-16Clinical Trial Update: Long-Term Follow-Up of AvenCell Sponsored CAR-T Cell Clinical Trials
Long-term follow-up update on AvenCell-sponsored CAR-T cell trials for B-cell lymphoma and chronic lymphocytic leukemia with ongoing enrollm…
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CLINICAL_TRIALS research · 2026-03-16Clinical Trial Update: A Study of Nemtabrutinib vs Chemoimmunotherapy for Participants With Previously Untreated Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL) Without TP53 Aberrations (MK-1026-008, BELLWAVE-008) [Phase 3]
Phase 3 study MK-1026-008/BELLWAVE-008 is evaluating nemtabrutinib against chemoimmunotherapy in previously untreated chronic lymphocytic le…
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CLINICAL_TRIALS research · 2026-03-13Clinical Trial Update: Venetoclax and Obinutuzumab Followed by Epcoritamab for the Treatment of Untreated Chronic Lymphocytic Leukemia and Small Lymphocytic Lymphoma, LonGEVity Trial [Phase 2]
Phase 2 LonGEVity trial evaluating a sequence of venetoclax and obinutuzumab followed by epcoritamab for untreated chronic lymphocytic leuke…
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CLINICAL_TRIALS research · 2026-03-13Clinical Trial Update: A Study of Nemtabrutinib Plus Venetoclax vs Venetoclax + Rituximab (VR) in Second-line (2L) + Relapsed/Refractory (R/R) Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL) (MK-1026-010/BELLWAVE-010). [Phase 3]
This Phase 3 clinical trial compares Nemtabrutinib plus Venetoclax versus Venetoclax plus Rituximab in second-line or relapsed/refractory ch…
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CLINICAL_TRIALS research · 2026-03-13Clinical Trial Update: Immune Profiling of CLL/SLL Treated With First-Line Pirtobrutinib [EARLY_Phase 1]
An early-phase trial evaluating immune profiling of first-line pirtobrutinib in chronic lymphocytic leukemia and small lymphocytic lymphoma …
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CLINICAL_TRIALS research · 2026-03-12Clinical Trial Update: A Study of BGB-21447, a Bcl-2 Inhibitor, in Mature B-Cell Malignancies [Phase 1]
Phase 1 clinical trial update of BGB-21447, a Bcl-2 inhibitor developed by BeOne Medicines, evaluating safety and preliminary activity in mu…
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CLINICAL_TRIALS research · 2026-03-12Clinical Trial Update: A Study of Zilovertamab Vedotin (MK-2140) as Monotherapy and in Combination in Participants With Aggressive and Indolent B-cell Malignancies (MK-2140-006) [Phase 2]
This clinical trial update reports on a Phase 2 study of Zilovertamab Vedotin (MK-2140) as monotherapy and in combination for aggressive and…
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CLINICAL_TRIALS research · 2026-03-12Clinical Trial Update: Umbilical Cord Blood Transplantation Using a Myeloablative Preparative Regimen for Hematological Diseases [NA]
This entry reports an ongoing clinical trial evaluating myeloablative preparative regimens for umbilical cord blood transplantation across s…
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CLINICAL_TRIALS trial_result · 2026-03-11Clinical Trial Update: Lenalidomide and Combination Chemotherapy (DA-EPOCH-R) in Treating Patients With MYC-Associated B-Cell Lymphomas [Phase 1, Phase 2]
Phase 1/2 study evaluating the combination of lenalidomide with DA-EPOCH-R in MYC-associated B-cell lymphomas has completed, and results hav…
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CLINICAL_TRIALS research · 2026-03-11Clinical Trial Update: Economic Analysis of Early vs Delayed Therapy in Newly Diagnosed Asymptomatic High-Risk Patients With Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma:
A clinical trial update describes an economic analysis comparing early versus delayed therapy in newly diagnosed asymptomatic high-risk chro…
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CLINICAL_TRIALS research · 2026-03-10Clinical Trial Update: CMV-MVA Triplex Vaccination in HLA-Matched Related Stem Cell Donors for the Prevention of CMV Infection in Patients Undergoing Hematopoietic Stem Cell Transplant [Phase 2]
Phase 2 clinical trial evaluating CMV-MVA Triplex vaccination in HLA-matched related stem cell donors to prevent cytomegalovirus infection i…
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CLINICAL_TRIALS research · 2026-03-10Clinical Trial Update: PICAROS - Acalabrutinib RWE on 1L CLL in Spain
The PICAROS study evaluating acalabrutinib for first-line chronic lymphocytic leukemia in Spain is currently active but not recruiting.
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CLINICAL_TRIALS research · 2026-03-09Clinical Trial Update: Energy Balance Interventions in Increasing Physical Activity in Breast Cancer Gene Positive Patients, Lynch Syndrome-Positive Patients, CLL Survivors or High-Risk Family Members [NA]
Clinical trial evaluating energy balance interventions to increase physical activity in BRCA mutation carriers, Lynch syndrome patients, CLL…