Chronic Lymphocytic Leukemia

• CLINICAL_TRIALS trial_result · 2020-08-12
  Clinical Trial Update: IL-15 Super Agonist ALT-803 to Treat Relapse Of Hematologic Malignancy After Allogeneic SCT [Phase 1, Phase 2]

  Clinical trial update on an IL-15 super agonist ALT-803 for relapse of hematologic malignancies after allogeneic stem cell transplant, compl…

• CLINICAL_TRIALS trial_result · 2020-07-24
  Clinical Trial Update: Intravenous BI 836826 in Combination With Ibrutinib in Relapsed/Refractory CLL Patients Who Have Been Pre-treated With at Least One Prior Line of Systemic Therapy, and Who Are Eligible for Treatment With Ibrutinib [Phase 1]

  Phase 1 trial evaluating intravenous BI 836826 in combination with ibrutinib in relapsed/refractory chronic lymphocytic leukemia after prior…

• CLINICAL_TRIALS trial_result · 2020-07-01
  Clinical Trial Update: Study to Evaluate the Safety and Efficacy of the Combination of Tirabrutinib and Idelalisib With and Without Obinutuzumab in Adults With Relapsed or Refractory Chronic Lymphocytic Leukemia (CLL) [Phase 2]

  Phase 2 trial evaluating tirabrutinib and idelalisib with/without obinutuzumab in relapsed/refractory chronic lymphocytic leukemia has compl…

• CLINICAL_TRIALS trial_result · 2020-06-23
  Clinical Trial Update: Imprime PGG, Alemtuzumab, and Rituximab in Treating Patients With High Risk Chronic Lymphocytic Leukemia [Phase 1, Phase 2]

  Phase 1/2 clinical trial evaluating Imprime PGG with Alemtuzumab and Rituximab in high-risk chronic lymphocytic leukemia has completed with …

• CLINICAL_TRIALS trial_result · 2020-06-23
  Clinical Trial Update: A Phase I/Ib Safety and Efficacy Study of the PI3K-delta Inhibitor TGR-1202 and Ibrutinib in Patients With CLL or MCL [Phase 1]

  This report summarizes results from a Phase I/Ib safety and preliminary efficacy study of the PI3K-delta inhibitor TGR-1202 in combination w…

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• CLINICAL_TRIALS trial_result · 2020-06-16
  Clinical Trial Update: Lenalidomide and AT-101 in Treating Patients With Relapsed B-Cell Chronic Lymphocytic Leukemia [Phase 1, Phase 2]

  Clinical trial update for lenalidomide and AT-101 in relapsed B-cell chronic lymphocytic leukemia (Phase 1/2) has terminated; results posted…

• CLINICAL_TRIALS trial_result · 2020-06-11
  Clinical Trial Update: Sequential Regimen of Bendamustin-Debulking Followed by Ofatumumab and Ibrutinib in CLL Patients (CLL2-BIO) [Phase 2]

  Phase 2 clinical trial update evaluating a sequential regimen of bendamustine debulking followed by ofatumumab and ibrutinib in chronic lymp…

• CLINICAL_TRIALS trial_result · 2020-06-02
  Clinical Trial Update: Entospletinib in Combination With Idelalisib in Adults With Relapsed or Refractory Hematologic Malignancies [Phase 2]

  Phase 2 trial of Entospletinib plus Idelalisib in adults with relapsed or refractory hematologic malignancies was terminated; results posted…

• CLINICAL_TRIALS trial_result · 2020-05-26
  Clinical Trial Update: Lirilumab With Rituximab for Relapsed, Refractory or High-risk Untreated Chronic Lymphocytic Leukemia (CLL) Patients [Phase 2]

  Phase 2 clinical trial evaluating lirilumab in combination with rituximab for relapsed/refractory or high-risk untreated chronic lymphocytic…

• CLINICAL_TRIALS trial_result · 2020-05-15
  Clinical Trial Update: A Phase II Study of Ibrutinib Plus FCR in Previously Untreated, Younger Patients With Chronic Lymphocytic Leukemia [Phase 2]

  Phase II study evaluating ibrutinib in combination with FCR (fludarabine, cyclophosphamide, rituximab) in previously untreated, younger pati…

• CLINICAL_TRIALS trial_result · 2020-05-04
  Clinical Trial Update: A Study to Evaluate the Efficacy of Venetoclax Monotherapy in Relapsed/Refractory Participants With Chronic Lymphocytic Leukemia (CLL) [Phase 3]

  A Phase 3 trial evaluating venetoclax monotherapy in relapsed/refractory chronic lymphocytic leukemia has completed with results posted in 2…

• CLINICAL_TRIALS trial_result · 2020-04-13
  Clinical Trial Update: Study of ADCT-402 in Patients With Relapsed or Refractory B-cell Lineage Non Hodgkin Lymphoma (B-NHL) [Phase 1]

  Phase 1 study of ADCT-402 in relapsed or refractory B-cell lineage non-Hodgkin lymphoma completed; results posted in 2020.

• CLINICAL_TRIALS trial_result · 2020-04-06
  Clinical Trial Update: Early or Delayed Fludarabine and Rituximab in Treating Patients With Previously Untreated Chronic Lymphocytic Leukemia [Phase 3]

  Phase 3 trial evaluating early versus delayed fludarabine and rituximab in previously untreated chronic lymphocytic leukemia; study terminat…

• CLINICAL_TRIALS trial_result · 2020-04-06
  Clinical Trial Update: Fludarabine in Treating Patients With Chronic Lymphocytic Leukemia [Phase 2]

  Phase 2 clinical trial update of fludarabine in treating chronic lymphocytic leukemia.

• CLINICAL_TRIALS trial_result · 2020-03-18
  Clinical Trial Update: A Study to Determine Dose, Safety, and Efficacy of Durvalumab as Monotherapy and in Combination Therapy in Subjects With Lymphoma or Chronic Lymphocytic Leukemia [Phase 1, Phase 2]

  A Phase 1/2 clinical trial evaluated durvalumab as monotherapy and in combination therapy for lymphoma and chronic lymphocytic leukemia, and…

• CLINICAL_TRIALS trial_result · 2020-03-03
  Clinical Trial Update: A Study of Ibrutinib in Combination With Bendamustine and Rituximab in Patients With Relapsed or Refractory Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma [Phase 3]

  Phase 3 trial evaluating ibrutinib with bendamustine and rituximab in relapsed/refractory CLL or SLL has completed with results posted.

• CLINICAL_TRIALS trial_result · 2020-02-28
  Clinical Trial Update: Safety and Efficacy of the Combination of Tirabrutinib and Entospletinib With and Without Obinutuzumab in Adults With Chronic Lymphocytic Leukemia (CLL) [Phase 2]

  Phase 2 trial evaluating tirabrutinib plus entospletinib with or without obinutuzumab in adults with chronic lymphocytic leukemia; results p…

• CLINICAL_TRIALS trial_result · 2020-02-27
  Clinical Trial Update: A Study of Different Doses of Ibrutinib in Participants With Chronic Lymphocytic Leukemia (CLL) [Phase 2, Phase 3]

  A clinical trial evaluating different doses of ibrutinib in chronic lymphocytic leukemia has completed Phase 2 and Phase 3 arms with results…

• CLINICAL_TRIALS trial_result · 2020-02-24
  Clinical Trial Update: Pilot Study to Determine Effects of the Btk Inhibitor PCI-32765 on Leukemia Cell Kinetics and Trafficking, Using Heavy Water Labeling in Subjects With CLL and SLL [Phase 1, Phase 2]

  A pilot study evaluating the Btk inhibitor PCI-32765 (ibrutinib) effects on leukemia cell kinetics and trafficking in CLL/SLL using heavy wa…

• CLINICAL_TRIALS trial_result · 2020-02-20
  Clinical Trial Update: Fludarabine or Observation in Treating Patients With Stage 0, Stage I, or Stage II Chronic Lymphocytic Leukemia [Phase 3]

  Phase 3 trial evaluating fludarabine versus observation in early-stage chronic lymphocytic leukemia has completed.

• CLINICAL_TRIALS trial_result · 2020-02-10
  Clinical Trial Update: Lenalidomide in Chronic Lymphocytic Leukemia (CLL) Patients With Residual Disease [Phase 2]

  Phase 2 clinical trial update of lenalidomide in chronic lymphocytic leukemia patients with residual disease has completed results and poste…

• CLINICAL_TRIALS trial_result · 2020-02-10
  Clinical Trial Update: Allogeneic Stem Cell Transplant for CLL [Phase 1, Phase 2]

  A phase 1/2 clinical trial evaluating allogeneic hematopoietic stem cell transplantation for chronic lymphocytic leukemia and related diseas…

• CLINICAL_TRIALS trial_result · 2020-01-30
  Clinical Trial Update: Study to Evaluate Safety and Preliminary Efficacy of Tafasitamab With Idelalisib or Venetoclax in R/R CLL/SLL Patients Pretreated With BTKi [Phase 2]

  Phase 2 study evaluating safety and preliminary efficacy of tafasitamab with idelalisib or venetoclax in relapsed/refractory CLL/SLL patient…

• CLINICAL_TRIALS trial_result · 2020-01-27
  Clinical Trial Update: Nonmyeloablative Stem Cell Transplantation for Chronic Lymphocytic Leukemia (CLL) [Phase 2]

  A Phase 2 trial on nonmyeloablative stem cell transplantation for chronic lymphocytic leukemia has been terminated with results posted.

• CLINICAL_TRIALS trial_result · 2020-01-09
  Clinical Trial Update: Rituximab Versus Observation as Maintenance Therapy in Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia) [Phase 3]

  Phase 3 trial comparing rituximab maintenance therapy to observation in chronic lymphocytic leukemia has completed.