Chronic Lymphocytic Leukemia
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS trial_result · 2022-10-24Clinical Trial Update: Ublituximab + Ibrutinib in Select B-cell Malignancies [Phase 1, Phase 2]
A phase 1/2 trial evaluating ublituximab in combination with ibrutinib for select B-cell malignancies has completed.
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CLINICAL_TRIALS trial_result · 2022-10-10Clinical Trial Update: Phase II Protocol for CLL With Fludarabine and Cyclophosphamide With Rituximab (FCR) Plus Lenalidomide [Phase 2]
Phase II trial protocol in chronic lymphocytic leukemia evaluates the FCR regimen (fludarabine, cyclophosphamide, rituximab) with lenalidomi…
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CLINICAL_TRIALS trial_result · 2022-09-28Clinical Trial Update: Lenalidomide and Obinutuzumab in Treating Patients With Recurrent or Refractory Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma [Phase 2]
Phase 2 clinical trial of lenalidomide and obinutuzumab in patients with recurrent or refractory chronic lymphocytic leukemia or small lymph…
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CLINICAL_TRIALS trial_result · 2022-09-19Clinical Trial Update: Acalabrutinib in Combination With R-ICE For Relapsed or Refractory Lymphoma [Phase 2]
Phase 2 trial evaluating acalabrutinib in combination with the R-ICE chemotherapy regimen for relapsed or refractory lymphoma; the study was…
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CLINICAL_TRIALS trial_result · 2022-09-16Clinical Trial Update: Protocol GELLC-7: Ibrutinib Followed by Ibrutinib Consolidation in Combination With Ofatumumab [Phase 2]
Phase 2 trial update for GELLC-7 protocol evaluating iBrutinib followed by consolidation with ofatumumab in Chronic Lymphocytic Leukemia.
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CLINICAL_TRIALS trial_result · 2022-09-10Clinical Trial Update: ACP-196 (Acalabrutinib), a Novel Bruton Tyrosine Kinase (BTK) Inhibitor, for Treatment of Chronic Lymphocytic Leukemia, Richter's Syndrome or Prolymphocytic Leukemia [Phase 1, Phase 2]
ACP-196 (acalabrutinib), a BTK inhibitor, is being studied in Phase 1/2 trials for chronic lymphocytic leukemia, Richter's syndrome, small l…
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CLINICAL_TRIALS trial_result · 2022-08-31Clinical Trial Update: Genetically Modified T-Cell Therapy in Treating Patients With Advanced ROR1+ Malignancies [Phase 1]
Phase 1 trial update of a genetically modified T-cell therapy targeting ROR1 in advanced malignancies, with terminated status and posted res…
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CLINICAL_TRIALS trial_result · 2022-08-04Clinical Trial Update: Safety and Efficacy of KRT-232 in Combination With Acalabrutinib in Subjects With R/R DLBCL or R/R CLL [Phase 1, Phase 2]
Phase 1/2 trial evaluating KRT-232 in combination with acalabrutinib for relapsed/refractory DLBCL and CLL; status not disclosed.
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CLINICAL_TRIALS trial_result · 2022-08-02Clinical Trial Update: A Prospective, Multicenter, Phase-II Trial of Ibrutinib Plus Venetoclax in Patients With Creatinine Clearance >= 30 ml/Min Who Have Relapsed or Refractory Chronic Lymphocytic Leukemia (RR-CLL) With or Without TP53 Aberrations [Phase 2]
Phase II multicenter trial evaluating the combination of ibrutinib and venetoclax in relapsed/refractory chronic lymphocytic leukemia with a…
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CLINICAL_TRIALS trial_result · 2022-07-20Clinical Trial Update: Study Examining the Combination of Revlimid (Lenalidomide)and Vidaza (Azacitidine) for Relapsed/Refractory CLL and SLL [Phase 2]
A Phase 2 trial evaluating the combination of lenalidomide and azacitidine for relapsed/refractory chronic lymphocytic leukemia and small ly…
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CLINICAL_TRIALS trial_result · 2022-07-06Clinical Trial Update: A Study to Evaluate ICP-022 in Patients With CLL/ SLL [Phase 1, Phase 2]
Clinical trial update on ICP-022 for chronic lymphocytic leukemia and small lymphocytic lymphoma (early-phase study).
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CLINICAL_TRIALS trial_result · 2022-05-25Clinical Trial Update: Laboratory Treated T Cells in Treating Patients With Relapsed or Refractory Chronic Lymphocytic Leukemia, Non-Hodgkin Lymphoma, or Acute Lymphoblastic Leukemia [Phase 1, Phase 2]
Phase 1/2 trial evaluating laboratory-treated T cells in relapsed or refractory B-cell malignancies and acute lymphoblastic leukemia.
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CLINICAL_TRIALS trial_result · 2022-05-20Clinical Trial Update: Ublituximab in Combination With Ibrutinib Versus Ibrutinib Alone in Participants With Previously Treated High-Risk Chronic Lymphocytic Leukemia (CLL) [Phase 3]
Phase 3 trial comparing ublituximab plus ibrutinib versus ibrutinib alone in previously treated high-risk chronic lymphocytic leukemia has c…
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CLINICAL_TRIALS trial_result · 2022-05-10Clinical Trial Update: Study to Evaluate the Safety and Tolerability of Brexucabtagene Autoleucel (KTE-X19) in People With Relapsed/Refractory Chronic Lymphocytic Leukemia and Small Lymphocytic Lymphoma [Phase 1]
Phase 1 trial evaluating safety and tolerability of brexucabtagene autoleucel (KTE-X19) in relapsed/refractory chronic lymphocytic leukemia …
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CLINICAL_TRIALS trial_result · 2022-05-06Clinical Trial Update: Ofatumumab as Part of Reduced Intensity Conditioning (RIC) Regimen for Patients With High Risk Chronic Lymphocytic Leukemia (CLL) Undergoing Allogeneic Hematopoietic Cell Transplantation [Phase 2]
Phase 2 clinical trial evaluating adding ofatumumab to reduced intensity conditioning for high-risk chronic lymphocytic leukemia patients un…
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CLINICAL_TRIALS trial_result · 2022-05-06Clinical Trial Update: ACP-196 (Acalabrutinib) in Combination With Pembrolizumab, for Treatment of Hematologic Malignancies [Phase 1, Phase 2]
Phase 1/2 trial of acalabrutinib (ACP-196) in combination with pembrolizumab in hematologic malignancies has completed with results posted i…
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CLINICAL_TRIALS trial_result · 2022-04-19Clinical Trial Update: Orelabrutinib and Obinutuzumab Plus FC Regimen in Treating Newly Diagnosed CLL/SLL [Phase 2]
Phase 2 trial update evaluating orelabrutinib with obinutuzumab plus FC in newly diagnosed CLL/SLL.
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CLINICAL_TRIALS trial_result · 2022-04-11Clinical Trial Update: Bendamustine and Rituximab in Combination With Copanlisib for the Treatment of Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma [Phase 2]
Phase 2 trial investigating bendamustine and rituximab in combination with copanlisib for chronic lymphocytic leukemia or small lymphocytic …
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CLINICAL_TRIALS trial_result · 2022-04-05Clinical Trial Update: Phase 1/2a Dose Escalation Study in Participants With CLL, SLL, or NHL [Phase 1, Phase 2]
Phase 1/2a dose-escalation study in CLL/SLL and various NHL subtypes completed with results posted.
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CLINICAL_TRIALS trial_result · 2022-03-31Clinical Trial Update: Zanubrutinib Followed Zanubrutinib Plus FCR / BR in Newly Diagnosed Symptomatic CLL/SLL [Phase 2]
Phase 2 trial evaluating zanubrutinib followed by zanubrutinib plus FCR/BR in newly diagnosed symptomatic CLL/SLL.
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CLINICAL_TRIALS trial_result · 2022-03-28Clinical Trial Update: A Study of the Combination of Ibrutinib Plus Venetoclax Versus Chlorambucil Plus Obinutuzumab for the First-line Treatment of Participants With Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL) [Phase 3]
This Phase 3 clinical trial update reports results for frontline therapy in chronic lymphocytic leukemia/small lymphocytic lymphoma comparin…
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CLINICAL_TRIALS trial_result · 2022-03-28Clinical Trial Update: A Study of the Combination of Ibrutinib Plus Venetoclax Versus Chlorambucil Plus Obinutuzumab for the First-line Treatment of Participants With Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL) [Phase 3]
Phase 3 trial evaluating ibrutinib plus venetoclax versus chlorambucil plus obinutuzumab as first-line therapy in chronic lymphocytic leukem…
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CLINICAL_TRIALS trial_result · 2022-03-10Clinical Trial Update: Human IL-15 (rhIL-15) and Obinutuzumab for Relapsed and Refractory Chronic Lymphocyte Leukemia [Phase 1]
Phase 1 trial evaluating human IL-15 and obinutuzumab in relapsed/refractory chronic lymphocytic leukemia was terminated with posted results…
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CLINICAL_TRIALS trial_result · 2022-03-09Clinical Trial Update: Duvelisib for Ibrutinib-Resistant Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma [Phase 2]
Phase 2 trial of duvelisib in ibrutinib-resistant CLL/SLL was terminated; results posted in 2022.
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CLINICAL_TRIALS trial_result · 2022-03-03Clinical Trial Update: Bendamustine Combined With Alemtuzumab in Pretreated Chronic Lymphocytic Leukemia (CLL) [Phase 1, Phase 2]
Phase 1/2 trial evaluating bendamustine in combination with alemtuzumab in patients with pretreated chronic lymphocytic leukemia (CLL) has c…