Chronic Lymphocytic Leukemia
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2025-11-21Clinical Trial Update: Venetoclax With Ibrutinib or Acalabrutinib in Pts. With High-risk CLL [Phase 2]
Phase 2 clinical trial evaluating venetoclax with either ibrutinib or acalabrutinib in high-risk chronic lymphocytic leukemia is currently r…
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CLINICAL_TRIALS research · 2025-11-21Clinical Trial Update: Watch and Wait or Worry and Wait in Indolent Lymphoma
An ongoing clinical trial at Seoul National University Hospital is evaluating watchful waiting versus proactive worry-and-wait strategies in…
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CLINICAL_TRIALS research · 2025-11-21Clinical Trial Update: ICP-248 in Combination With Orelabrutinib in Treatment-naïve Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (APEX-03) [Phase 2, Phase 3]
APEX-03 is a Phase 2/3 clinical trial evaluating ICP-248 in combination with orelabrutinib for treatment-naïve chronic lymphocytic leukemia …
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CLINICAL_TRIALS research · 2025-11-19Clinical Trial Update: Acalabrutinib in Combination With Venetoclax for the Treatment of Refractory or Recurrent Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma, The AVENUE-2 Trial [Phase 2]
The AVENUE-2 Phase 2 trial investigates acalabrutinib in combination with venetoclax for patients with refractory or recurrent chronic lymph…
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CLINICAL_TRIALS research · 2025-11-14Clinical Trial Update: A Safety and Efficacy Study Evaluating CTX112 in Subjects With Relapsed or Refractory B-Cell Malignancies [Phase 1, Phase 2]
A phase 1/2 clinical trial evaluating CTX112 in relapsed or refractory B-cell malignancies is currently recruiting.
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CLINICAL_TRIALS research · 2025-11-10Clinical Trial Update: huCART19-IL18 in CD19+ Cancers [Phase 1]
Phase 1 clinical trial of huCART19-IL18 for CD19+ cancers is currently ACTIVE_NOT_RECRUITING, sponsored by the University of Pennsylvania, i…
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CLINICAL_TRIALS research · 2025-11-10Clinical Trial Update: Long-term Follow-up Study of Patients Receiving CAR-T Cells
This clinical trial update outlines a long-term follow-up study of patients who received CAR-T cell therapy. Sponsored by the Medical Colleg…
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CLINICAL_TRIALS research · 2025-11-06Clinical Trial Update: Ibrutinib With or Without Rituximab in Treating Patients With Relapsed Chronic Lymphocytic Leukemia [Phase 2]
A Phase 2 trial is evaluating ibrutinib with or without rituximab in patients with relapsed chronic lymphocytic leukemia and related lymphop…
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CLINICAL_TRIALS research · 2025-11-06Clinical Trial Update: Tafasitamab, Acalabrutinib, and Obinutuzumab for the Treatment of Previously Untreated Chronic Lymphocytic Leukemia and Small Lymphocytic Lymphoma [Phase 1]
Phase 1 clinical trial evaluating a triplet regimen of tafasitamab, acalabrutinib, and obinutuzumab for previously untreated chronic lymphoc…
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CLINICAL_TRIALS research · 2025-11-04Clinical Trial Update: Tafasitamab and Zanubrutinib for the Treatment of Patients With Newly Diagnosed Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma, TaZA CLL Study [Phase 2]
Phase 2 TaZA CLL study evaluating the combination of tafasitamab and zanubrutinib for newly diagnosed chronic lymphocytic leukemia or small …
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CLINICAL_TRIALS research · 2025-10-30Clinical Trial Update: Two Step Haplo With Radiation Conditioning [Phase 2]
Phase 2 clinical trial update describing two-step haploidentical transplantation with radiation conditioning for hematologic diseases, curre…
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CLINICAL_TRIALS research · 2025-10-23Clinical Trial Update: Adding Pirtobrutinib to the Usual Treatment for People With Newly Diagnosed Richter Transformation, The PIRAMID Trial [Phase 3]
Phase 3 PIRAMID trial evaluating adding pirtobrutinib to standard therapy for newly diagnosed Richter transformation (transformed CLL/SLL to…
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CLINICAL_TRIALS research · 2025-10-21Clinical Trial Update: Kappa-CD28 T Lymphocytes, Chronic Lymphocytic Leukemia, B-cell Lymphoma or Multiple Myeloma, CHARKALL [Phase 1]
Phase 1 clinical trial update for Kappa-CD28 T lymphocytes in chronic lymphocytic leukemia, B-cell lymphoma, and multiple myeloma. The study…
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CLINICAL_TRIALS research · 2025-10-14Clinical Trial Update: Family Study of Lymphoproliferative Disorders
A Mayo Clinic-led clinical trial is a family study investigating lymphoproliferative disorders, currently in the recruitment phase.
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CLINICAL_TRIALS research · 2025-10-14Clinical Trial Update: A Randomized Phase II Study Of Bruton Tyrosine Kinase Inhibitor With Or Without Venetoclax In Veterans With Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL) [Phase 2]
A Phase II randomized trial evaluating a Bruton tyrosine kinase inhibitor with or without venetoclax in veterans with chronic lymphocytic le…
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CLINICAL_TRIALS research · 2025-10-10Clinical Trial Update: A Study of JNJ-75348780 in Participants With Non-Hodgkin Lymphoma (NHL) and Chronic Lymphocytic Leukemia (CLL) [Phase 1]
This clinical trial update reports the Phase 1 study of JNJ-75348780 in participants with Non-Hodgkin lymphoma and chronic lymphocytic leuke…
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CLINICAL_TRIALS research · 2025-10-10Clinical Trial Update: Q702 for the Treatment of Patients With Hematologic Malignancies [Phase 1]
This entry notes a Phase 1 clinical trial (Q702) for hematologic malignancies led by Mayo Clinic, currently recruiting and including histioc…
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CLINICAL_TRIALS research · 2025-10-09Clinical Trial Update: A Phase 1 Study of Acalabrutinib in Japanese Adult Patients With Advanced B-cell Malignancies [Phase 1]
Phase 1 clinical trial update of acalabrutinib in Japanese adults with advanced B-cell malignancies, including relapsed/refractory CLL and m…
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CLINICAL_TRIALS research · 2025-10-07Clinical Trial Update: Polatuzumab Vedotin in Combination With Chemotherapy in Subjects With Richter's Transformation [Phase 2]
Phase 2 clinical trial evaluating polatuzumab vedotin in combination with chemotherapy for Richter syndrome and chronic lymphocytic leukemia…
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CLINICAL_TRIALS research · 2025-10-03Clinical Trial Update: Bringing Optimised COVID-19 Vaccine Schedules To ImmunoCompromised Populations (BOOST-IC): an Adaptive Randomised Controlled Clinical Trial [Phase 3]
Adaptive Phase 3 trial assessing optimized COVID-19 vaccination schedules for immunocompromised individuals, including patients with HIV and…
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CLINICAL_TRIALS research · 2025-09-30Clinical Trial Update: Immune Adverse Events Registry in Onco-Hematologic Patients Treated With Immunotherapy
A registry study tracking immune-related adverse events in cancer patients receiving immunotherapy. The study is not yet recruiting and is s…
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CLINICAL_TRIALS research · 2025-09-29Clinical Trial Update: A Phase Ib Study of the Selective PKC-β Inhibitor MS-553 in Patients With Refractory or Relapsed CLL/SLL [Phase 1, Phase 2]
A Phase Ib study of the selective PKC-β inhibitor MS-553 in patients with refractory or relapsed chronic lymphocytic leukemia or small lymph…
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CLINICAL_TRIALS research · 2025-09-26Clinical Trial Update: A Study of GNC-035 in Relapsed or Refractory Chronic Lymphocytic Leukemia and Other Hematological Malignancies [Phase 1, Phase 2]
An ongoing Phase 1/2 clinical trial of GNC-035 for relapsed/refractory chronic lymphocytic leukemia (and other hematological malignancies) i…
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CLINICAL_TRIALS research · 2025-09-25Clinical Trial Update: Biomarker for Infection Risk in CLL and MM
This update describes a biomarker study to assess infection risk in patients with multiple myeloma and chronic lymphocytic leukemia. The tri…
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CLINICAL_TRIALS research · 2025-09-25Clinical Trial Update: Clinical Trial Using CAR- T Cells for Treatment of Patients With Refractory or Relapsed CD19-positive B Lymphoid Malignancies [Phase 1]
A Phase 1 clinical trial update for CD19-directed CAR-T cell therapy in patients with refractory or relapsed B lymphoid malignancies is curr…