Chronic Lymphocytic Leukemia
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2026-03-02Clinical Trial Update: A Master Protocol to Evaluate the Long-Term Safety of (LY3527727) Pirtobrutinib [Phase 4]
This document describes a Phase 4 master protocol studying the long-term safety of Pirtobrutinib (LY3527727). The study is currently recruit…
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CLINICAL_TRIALS research · 2026-03-02Clinical Trial Update: A Study of (LY3527727) Pirtobrutinib in Participants With Previously Treated Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma or Non-Hodgkin Lymphoma [Phase 4]
This clinical trial update reports a Phase 4 study of pirtobrutinib (LY3527727) in previously treated chronic lymphocytic leukemia/small lym…
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CLINICAL_TRIALS research · 2026-02-27Clinical Trial Update: Evaluation of Hypertension Management and Cardiovascular Adverse Event Prevention in Patients With B-cell Malignancies Undergoing Treatment With Bruton Tyrosine Kinase Inhibitors, the HALT Study
A Mayo Clinic-sponsored clinical trial (HALT) is evaluating strategies to manage hypertension and prevent cardiovascular adverse events in p…
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CLINICAL_TRIALS research · 2026-02-25Clinical Trial Update: A Study to Evaluate the Effect of Venetoclax on Participants Receiving a Covalent Bruton's Tyrosine Kinase Inhibitor (cBTKi) for First-line Chronic Lymphocytic Leukemia (1L CLL) to Achieve Deep Durable Remissions to Allow Off-treatment Period [Phase 2]
Phase 2 study assessing venetoclax in combination with a covalent BTK inhibitor for first-line chronic lymphocytic leukemia to achieve deep,…
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CLINICAL_TRIALS research · 2026-02-25Clinical Trial Update: Zanubrutinib and Venetoclax as Initial Therapy for Chronic Lymphocytic Leukemia (CLL) With Response-based Obinutuzumab [Phase 2]
This Phase 2 clinical trial update investigates initial therapy with zanubrutinib and venetoclax, with obinutuzumab added based on response,…
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CLINICAL_TRIALS research · 2026-02-24Clinical Trial Update: A First-in-Human Study of HLA-Partially to Fully Matched Allogenic Cryopreserved Deceased Donor Bone Marrow Transplantation for Patients With Hematologic Malignancies [Phase 1, Phase 2]
A first-in-human study evaluating HLA partially to fully matched allogeneic, cryopreserved deceased donor bone marrow transplantation for va…
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CLINICAL_TRIALS research · 2026-02-24Clinical Trial Update: Time-limited Triplet Combination of Pirtobrutinib, Venetoclax, and Obinutuzumab for Patients With Treatment-naïve Chronic Lymphocytic Leukemia (CLL) or Richter Transformation (RT) [Phase 2]
A Phase 2 clinical trial is evaluating a time-limited triplet therapy of pirtobrutinib, venetoclax, and obinutuzumab for treatment-naïve chr…
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CLINICAL_TRIALS research · 2026-02-24Clinical Trial Update: Early Clonal Dynamics During Venetoclax Treatment for Relapsed or Refractory Chronic Lymphocytic Leukemia (CLL) [Phase 2]
Phase 2 clinical trial of venetoclax for relapsed or refractory chronic lymphocytic leukemia is currently recruiting, with a focus on early …
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CLINICAL_TRIALS research · 2026-02-23Clinical Trial Update: CAR-20/19-T Cells in Patients With Relapsed Refractory B Cell Malignancies [Phase 1, Phase 2]
Phase 1/2 clinical trial evaluating CAR-20/19-T cells in relapsed or refractory B-cell malignancies, including multiple non-Hodgkin lymphoma…
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CLINICAL_TRIALS research · 2026-02-19Clinical Trial Update: Pirtobrutinib (LOXO-305) and Venetoclax for the Treatment of Patients With CLL or SLL Resistant to Covalent BTKi [Phase 2]
This clinical trial update describes a Phase 2 study evaluating pirtobrutinib in combination with venetoclax for patients with chronic lymph…
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CLINICAL_TRIALS research · 2026-02-19Clinical Trial Update: Acalabrutinib in Combination With Venetoclax or Obinutuzumab for the Treatment of Treatment-naive Chronic Lymphocytic Leukemia [Phase 2]
This is a Phase 2 clinical trial update on acalabrutinib combined with venetoclax or obinutuzumab for treatment-naive chronic lymphocytic le…
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CLINICAL_TRIALS research · 2026-02-18Clinical Trial Update: A Study of Acalabrutinib Plus Venetoclax Versus Venetoclax Plus Obinutuzumab in Previously Untreated Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma [Phase 3]
A Phase 3 clinical trial comparing acalabrutinib plus venetoclax versus venetoclax plus obinutuzumab in previously untreated chronic lymphoc…
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CLINICAL_TRIALS research · 2026-02-18Clinical Trial Update: Pharmacokinetic Study of Venetoclax Tablets Crushed and Dissolved Into a Solution
A pharmacokinetic study is evaluating how crushing venetoclax tablets and dissolving them in solution affects drug exposure, to assess alter…
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CLINICAL_TRIALS research · 2026-02-17Clinical Trial Update: Epcoritamab in Chronic Lymphocytic Leukemia and Richter Syndrome [Phase 1]
Phase 1 clinical trial update evaluating epcoritamab in chronic lymphocytic leukemia and Richter syndrome. The study is currently active but…
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CLINICAL_TRIALS research · 2026-02-17Clinical Trial Update: This Clinical Trial is a Single-arm, Non-randomized Pilot Trial to Determine the Safety of Administering Autologous Anti-C19 Cells (ARI-0001) and the Feasibility of Local CAR-T Cell Production in Patients Over 18 Years of Age With Relapsed/Refractory (R/R) CD19+ Hematologic Malignancies, Including R [NA]
A single-arm, non-randomized pilot trial to evaluate the safety of autologous anti-CD19 CAR-T cells (ARI-0001) and the feasibility of local …
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CLINICAL_TRIALS research · 2026-02-13Clinical Trial Update: Study of Oral Administration of LP-168 in Patients With Relapsed or Refractory B-cell Malignancies. [Phase 1]
A Phase 1 clinical trial evaluating oral LP-168 in relapsed or refractory B-cell malignancies is recruiting. Target conditions include CLL/S…
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CLINICAL_TRIALS research · 2026-02-13Clinical Trial Update: Study of SGR-1505 in Mature B-Cell Neoplasms [Phase 1]
Schrödinger's SGR-1505 is being evaluated in a Phase 1 trial across multiple mature B-cell neoplasms and is currently recruiting. The study …
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CLINICAL_TRIALS research · 2026-02-13Clinical Trial Update: B-Cell Activating Factor Receptor (BAFFR)-Based Chimeric Antigen Receptor T-Cells With Fludarabine and Cyclophosphamide Lymphodepletion for the Treatment of Relapsed or Refractory B-cell Hematologic Malignancies [Phase 1]
Phase 1 clinical trial from Mayo Clinic is evaluating BAFFR-based CAR-T cells with lymphodepletion (fludarabine and cyclophosphamide) for re…
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CLINICAL_TRIALS research · 2026-02-12Clinical Trial Update: Study to Evaluate Adverse Events and Change in Disease Activity in Adult Participants With B-Cell Malignancies Receiving Oral ABBV-525 Tablets [Phase 1]
This clinical trial update describes the ongoing Phase 1 study of ABBV-525 tablets in adults with B-cell malignancies. The study evaluates a…
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CLINICAL_TRIALS research · 2026-02-12Clinical Trial Update: Pirtobrutinib and Venetoclax With MRD Detection for Previously Untreated Chronic Lymphocytic Leukemia [Phase 2]
Phase 2 clinical trial update examining the combination of pirtobrutinib and venetoclax with measurable residual disease (MRD) detection for…
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CLINICAL_TRIALS research · 2026-02-12Clinical Trial Update: Study of MGUS, Smoldering Myeloma, Early MDS and CLL to Assess Molecular Events of Progression and Clinical Outcome
A Dana-Farber Cancer Institute-led clinical study recruiting to investigate molecular progression and clinical outcomes in MGUS, smoldering …
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CLINICAL_TRIALS research · 2026-02-11Clinical Trial Update: Roginolisib (IOA-244) With Venetoclax and Rituximab for Refractory/Relapsed Chronic Lymphocytic Leukemia (CLL) [Phase 1, Phase 2]
This clinical trial update reports a Phase 1/2 study evaluating roginolisib (IOA-244) in combination with venetoclax and rituximab for patie…
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CLINICAL_TRIALS research · 2026-02-09Clinical Trial Update: Acalabrutinib With or Without Obinutuzumab in Treating Patients With Early-Stage Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma [Phase 2]
This clinical trial update notes a Phase 2 study of acalabrutinib with or without obinutuzumab in patients with early-stage chronic lymphocy…
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CLINICAL_TRIALS research · 2026-02-09Clinical Trial Update: Study to Assess Change in Disease Activity and Adverse Events of Oral Venetoclax With Intravenous (IV) Obinutuzumab in Adult Participants With Recurring Chronic Lymphocytic Leukemia (CLL) [Phase 2]
A Phase 2 clinical trial evaluating the combination of oral venetoclax and intravenous obinutuzumab in adults with recurring chronic lymphoc…
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CLINICAL_TRIALS research · 2026-02-06Clinical Trial Update: CD19 Chimeric Receptor Expressing T Lymphocytes In B-Cell Non Hodgkin's Lymphoma, ALL & CLL [Phase 1]
Phase 1 study evaluating CD19 CAR-T cells in B-cell non-Hodgkin lymphoma, chronic lymphocytic leukemia, and acute lymphoblastic leukemia; th…