Chronic Lymphocytic Leukemia
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CLINICAL_TRIALS research · 2026-04-16Clinical Trial Update: Treatment of Relapsed or Chemotherapy Refractory Chronic Lymphocytic Leukemia or Indolent B Cell Lymphoma Using Autologous T Cells Genetically Targeted to the B Cell Specific Antigen CD19 [Phase 1, Phase 2]
Clinical trial evaluating autologous CD19-targeted T cells (CAR-T) for relapsed or chemotherapy-refractory chronic lymphocytic leukemia and …
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CLINICAL_TRIALS research · 2026-04-16Clinical Trial Update: AQUALIS:QoL of CLL Patients Treated With Acalabrutinib in France, Retrospective Study Based on Data From PLATON Database
This entry describes a retrospective study (AQUALIS) to evaluate quality of life in Chronic Lymphocytic Leukemia patients treated with acala…
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CLINICAL_TRIALS research · 2026-04-16Clinical Trial Update: Ruxolitinib Phosphate in Reducing Fatigue in Patients With Chronic Lymphocytic Leukemia [Phase 2]
A Phase 2 clinical trial is evaluating ruxolitinib phosphate to reduce fatigue in patients with chronic lymphocytic leukemia, and the study …
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CLINICAL_TRIALS research · 2026-04-15Clinical Trial Update: Acalabrutinib Monotherapy vs Investigator's Choice of Treatment in Patients With CL Leukaemia and Heart Failure [Phase 4]
This is a Phase 4 clinical trial comparing acalabrutinib monotherapy to investigator's choice of treatment in patients with chronic lymphocy…
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CLINICAL_TRIALS research · 2026-04-15Clinical Trial Update: Anti-CD19/20/22 Chimeric Antigen Receptor T Cells (TriCAR19.20.22 T Cells) for the Treatment of Relapsed or Refractory Non-Hodgkin Lymphoma, Acute Lymphoblastic Leukemia, and Chronic Lymphocytic Leukemia [Phase 1]
Phase 1 trial evaluating TriCAR19.20.22 T cells, a CD19/20/22-targeting CAR-T therapy, for relapsed or refractory non-Hodgkin lymphoma, acut…
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CLINICAL_TRIALS research · 2026-04-14Clinical Trial Update: A Study of NX-5948 in Adults With CLL/SLL Previously Treated With a Bruton's Tyrosine Kinase Inhibitor and a B-cell Lymphoma-2 Inhibitor (DAYBreak CLL-201) [Phase 2]
A Phase 2 clinical trial (DAYBreak CLL-201) evaluating NX-5948 in adults with chronic lymphocytic leukemia or small lymphocytic lymphoma who…
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CLINICAL_TRIALS research · 2026-04-14Clinical Trial Update: Acalabrutinib and Venetoclax With or Without Early Obinutuzumab for the Treatment of High Risk, Recurrent, or Refractory Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma [Phase 2]
Phase 2 clinical trial evaluating acalabrutinib and venetoclax with or without early obinutuzumab for high-risk, recurrent, or refractory ch…
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CLINICAL_TRIALS research · 2026-04-14Clinical Trial Update: Natural History Study of Monoclonal B Cell Lymphocytosis (MBL), Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL), Lymphoplasmacytic Lymphoma (LPL)/Waldenstrom Macroglobulinemia (WM), and Splenic Marginal Zone Lymphoma (SMZL)
This clinical trial status update indicates an ongoing natural history study of Monoclonal B-Cell Lymphocytosis, chronic lymphocytic leukemi…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: Assessing the Ability of Combination Treatment With Venetoclax to Permit Time Limited Therapy in Chronic Lymphocytic Leukemia [Phase 3]
This clinical trial update describes a Phase 3 study evaluating whether combining venetoclax with other therapy can enable time-limited trea…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: Safety and Efficacy Study of Epcoritamab in Subjects With Relapsed/Refractory Chronic Lymphocytic Leukemia and Richter's Syndrome [Phase 1, Phase 2]
A Phase 1/2 clinical trial evaluating the safety and efficacy of epcoritamab in subjects with relapsed/refractory chronic lymphocytic leukem…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: variaTIon in Referral Thresholds in the Chronic Lymphocytic LeukaEmia Pathway
Clinical trial update on variation in referral thresholds within the Chronic Lymphocytic Leukemia pathway; the study is not yet recruiting.
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: A Study of JNJ-80948543, a T-cell Redirecting CD79b x CD20 x CD3 Trispecific Antibody, in Participants With Non-Hodgkin Lymphoma (NHL) and Chronic Lymphocytic Leukemia (CLL) [Phase 1]
A Phase 1 study of JNJ-80948543, a T-cell redirecting trispecific antibody, in Non-Hodgkin lymphoma and chronic lymphocytic leukemia, is cur…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: Efficacy and Safety of Nemtabrutinib (MK-1026) in Participants With Hematologic Malignancies (MK-1026-003) [Phase 2]
Phase 2 trial update on the efficacy and safety of Nemtabrutinib (MK-1026) in hematologic malignancies, including Waldenström macroglobuline…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: Venetoclax-Obinutuzumab +/- Acalabrutinib in R/R CLL [Phase 2]
A Phase 2 clinical trial at Massachusetts General Hospital is evaluating venetoclax and obinutuzumab with or without acalabrutinib in relaps…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: Lenalidomide, Ibrutinib, and Rituximab in Treating Patients With Relapsed or Refractory Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma That Is Metastatic or Cannot Be Removed by Surgery [Phase 1]
A Phase 1 clinical trial update investigating a combination of lenalidomide, ibrutinib, and rituximab for relapsed or refractory chronic lym…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: A Study of AZD0486 Monotherapy or in Combination With Other Anti-Cancer Agents for Mature B-Cell Malignancies [Phase 1, Phase 2]
AstraZeneca is evaluating AZD0486 as a monotherapy or in combination with other anticancer agents for mature B-cell malignancies in Phase 1/…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: Study on Treatment Outcome Patterns for Patients With CLL After Discontinuation of BTK Inhibitors [Phase 2]
A Phase 2 clinical trial update examining treatment outcome patterns for patients with chronic lymphocytic leukemia or small lymphocytic lym…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: A Long-term Extension Study of PCI-32765 (Ibrutinib) [Phase 3]
Phase 3 long-term extension study of ibrutinib (PCI-32765) in chronic lymphocytic leukemia/small lymphocytic lymphoma and other B-cell malig…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: Study of NX-5948 in Combination With Other Agents in Adults With B-cell Malignancies [Phase 1, Phase 2]
This document provides an update on a Phase 1/2 study of NX-5948 in combination with other agents for adults with B-cell malignancies. The t…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: A Study to Assess Change in Functioning and Health Related Quality of Life in Adult Participants With Chronic Lymphocytic Leukemia (CLL) Receiving Oral Treatments in Routine Clinical Practice in Spain
This is a clinical trial update announcing a study to assess changes in functioning and health-related quality of life in adults with chroni…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: Testing the Effectiveness of the Anti-cancer Drug, Mirdametinib, in Treating Relapsed, Refractory Chronic Lymphocytic Leukemia [Phase 2]
A Phase 2 clinical trial is evaluating the effectiveness of Mirdametinib in relapsed/refractory chronic lymphocytic leukemia and small lymph…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: The Prospective Collection, Storage and Reporting of Data on Patients Undergoing Hematopoietic Stem Cell Transplantation Utilizing a Standard Preparative Regimen
Prospective collection, storage, and reporting of data on patients undergoing hematopoietic stem cell transplantation using a standard prepa…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: Benefits of Individual Physical Activity Intervention on Health-related Quality of Life in Participants With Chronic Lymphocytic Leukemia
A recruiting clinical trial sponsored by Janssen Cilag S.A.S. is evaluating whether an individual physical activity intervention improves he…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: A Study of Nemtabrutinib (MK-1026) Versus Comparator (Investigator's Choice of Ibrutinib or Acalabrutinib) in First Line (1L) Chronic Lymphocytic Leukemia (CLL)/ Small Lymphocytic Lymphoma (SLL) (MK-1026-011/BELLWAVE-011) [Phase 3]
Phase 3 trial evaluating Nemtabrutinib (MK-1026) versus investigator's choice of ibrutinib or acalabrutinib in first-line chronic lymphocyti…
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CLINICAL_TRIALS research · 2026-04-09Clinical Trial Update: A Study to Evaluate the Risk of Tumor Lysis Syndrome (TLS) in Adult Participants Receiving Oral Venetoclax in Combination With Intravenously Infused Obinutuzumab or Oral Acalabrutinib for Previously Untreated Chronic Lymphocytic Leukemia (CLL) [Phase 3]
A Phase 3 clinical trial update evaluating the risk of tumor lysis syndrome in adults with previously untreated chronic lymphocytic leukemia…