Chronic Lymphocytic Leukemia
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CLINICAL_TRIALS research · 2025-01-07Clinical Trial Update: Phase I/II Open-label Study Evaluating The Safety And Efficacy of Concomitant Administration of Anti-CD19 CAR T-cell Therapy and Lenalidomide in Refractory/Relapsed Chronic Lymphocytic Leukemia Patients. [Phase 1, Phase 2]
A Phase 1/2 open-label trial evaluating the safety and efficacy of concomitant administration of anti-CD19 CAR T-cell therapy and Lenalidomi…
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CLINICAL_TRIALS research · 2024-12-31Clinical Trial Update: Ibrutinib Monotherapy Versus Fixed-duration Venetoclax Plus Obinutuzumab Versus Fixed-duration Ibrutinib Plus Venetoclax in Patients with Previously Untreated Chronic Lymphocytic Leukaemia (CLL) [Phase 3]
A Phase 3 clinical trial compares three treatment strategies in previously untreated chronic lymphocytic leukemia: ibrutinib monotherapy, fi…
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CLINICAL_TRIALS research · 2024-12-27Clinical Trial Update: Study of Acalabrutinib (ACP-196) in Combination With Venetoclax (ABT-199), With and Without Obinutuzumab (GA101) Versus Chemoimmunotherapy for Previously Untreated CLL [Phase 3]
Phase 3 study evaluating acalabrutinib (ACP-196) with venetoclax, with and without obinutuzumab (GA101), versus chemoimmunotherapy in previo…
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CLINICAL_TRIALS research · 2024-12-09Clinical Trial Update: Belimumab in Patients with Chronic Lymphocytic Leukemia [Phase 2]
Belimumab is being evaluated in a Phase 2 trial for relapsed chronic lymphocytic leukemia conducted by University Hospital Tuebingen; the st…
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CLINICAL_TRIALS research · 2024-11-19Clinical Trial Update: Study to Evaluate the Safety and Preliminary Efficacy of Ibrutinib and Pembrolizumab in Patients With Chronic Lymphocytic Leukemia (CLL) or Mantle Cell Lymphoma (MCL) [Phase 1, Phase 2]
Early-phase study evaluating the safety and preliminary efficacy of combining ibrutinib with pembrolizumab in chronic lymphocytic leukemia o…
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CLINICAL_TRIALS research · 2024-10-24Clinical Trial Update: Zanubrutinib With Obinutuzumab in Untreated Patients With Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma [Phase 2]
A Phase 2 clinical trial evaluating zanubrutinib in combination with obinutuzumab in untreated chronic lymphocytic leukemia or small lymphoc…
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CLINICAL_TRIALS research · 2024-10-01Clinical Trial Update: Safety and Efficacy of KLS-1 Monotherapy in Malignant Neoplasms [Phase 1, Phase 2]
A Phase 1/Phase 2 trial evaluating KLS-1 as a monotherapy for malignant neoplasms, including chronic lymphocytic leukemia and solid tumors; …
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CLINICAL_TRIALS research · 2024-08-21Clinical Trial Update: The Real World Study of BTK Inhibitor in the Treatment of Chronic Lymphocytic Leukemia in China
A real-world study evaluating a BTK inhibitor for chronic lymphocytic leukemia in China; the trial status is not yet recruiting.
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CLINICAL_TRIALS research · 2024-08-13Clinical Trial Update: A Study of FCN-338 in Patients With Chronic CLL/SLL [Phase 1]
FCN-338 is being evaluated in a Phase 1 trial for chronic lymphocytic leukemia and small lymphocytic lymphoma, with the study currently acti…
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CLINICAL_TRIALS research · 2024-08-09Clinical Trial Update: Zanubrutinib, Obinutuzumab and Lenalidomide in Newly Diagnosed Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL) [Phase 1]
Phase 1 trial evaluating a triple combination of zanubrutinib, obinutuzumab, and lenalidomide in newly diagnosed chronic lymphocytic leukemi…
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CLINICAL_TRIALS research · 2024-07-29Clinical Trial Update: Treatment of Patients With Relapsed or Refractory CD19+ Lymphoid Disease With T Cells Expressing a Third-generation CAR [Phase 1, Phase 2]
A Phase 1/2 clinical trial at University Hospital Heidelberg is evaluating third-generation CD19-directed CAR T cells in relapsed or refract…
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CLINICAL_TRIALS research · 2024-07-18Clinical Trial Update: Current Status of BTKi Treatment for CLL/SLL in China
An update on a Bruton tyrosine kinase inhibitor (BTKi) trial for chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) in China,…
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CLINICAL_TRIALS research · 2024-07-18Clinical Trial Update: A Study to Investigate the Efficacy and Safety of MS-553 in CLL/SLL [Phase 1, Phase 2]
A Phase 1/2 study evaluating MS-553 for chronic lymphocytic leukemia and small lymphocytic lymphoma was terminated.
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CLINICAL_TRIALS research · 2024-07-05Clinical Trial Update: The Real World Study of Zanubrutinib in the Treatment of Chronic Lymphocytic Leukemia in China
Real-world study evaluating zanubrutinib for chronic lymphocytic leukemia in China; currently not recruiting.
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CLINICAL_TRIALS research · 2024-07-01Clinical Trial Update: Genomic Analysis of Patients With Chronic Lymphocytic Leukemia
This clinical trial update describes ongoing genomic analysis in patients with Chronic Lymphocytic Leukemia. The study status is active but …
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CLINICAL_TRIALS research · 2024-06-27Clinical Trial Update: A Practical Clinical Study Comparing the Fixed-cycle Regimen Containing Orelabrutinib With BTKi Monotherapy [Phase 2]
This update outlines a Phase 2 clinical trial comparing a fixed-cycle regimen including orelabrutinib with BTK inhibitor monotherapy for chr…
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CLINICAL_TRIALS research · 2024-06-26Clinical Trial Update: Description of the Immune Deficiency in Patients With Untreated Chronic Lymphocytic Leukemia and Search for Predictive Factors of Infectious Risk [NA]
This clinical trial update outlines a study of immune deficiency in untreated chronic lymphocytic leukemia patients, and a search for factor…
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CLINICAL_TRIALS research · 2024-06-20Clinical Trial Update: Polymorphism of ITGA4 Gene in Chronic Lymphocytic Leukemia
A clinical trial from Sohag University investigates polymorphism of the ITGA4 gene in Chronic Lymphocytic Leukemia; the study is currently N…
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CLINICAL_TRIALS research · 2024-05-28Clinical Trial Update: ObinutuzuMab AtezOlizumab and VenetocLax in RichTer transfOrmation [Phase 2]
Phase 2 trial evaluating a triple therapy of obinutuzumab, atezolizumab, and venetoclax for Richter transformation in chronic lymphocytic le…
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CLINICAL_TRIALS research · 2024-05-16Clinical Trial Update: Risk and Clinical Consequences of Low Count Monoclonal B-cell Lymphocytosis (LC MBL)
This clinical trial update from the University of Haifa examines the risks and clinical consequences of low-count monoclonal B-cell lymphocy…
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CLINICAL_TRIALS research · 2024-05-09Clinical Trial Update: A Single Arm Study of Acalabrutinib Conbimed With Obinutuzumab in Chinese Patients With Previously Untreated CLL [NA]
A single-arm clinical trial is evaluating acalabrutinib in combination with obinutuzumab in Chinese patients with previously untreated chron…
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CLINICAL_TRIALS research · 2024-05-08Clinical Trial Update: Familial B-cell Lymphoproliferative Disorders
Clinical trial update from the University of Haifa on familial B-cell lymphoproliferative disorders, including monoclonal B-cell lymphocytos…
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CLINICAL_TRIALS research · 2024-05-03Clinical Trial Update: Allogeneic CARCIK-CD19 in Adults/Pediatric B-cell NHL or Chronic Lymphocytic Leukemia [Phase 1, Phase 2]
Clinical trial update for allogeneic CARCIK-CD19 in adults and children with B-cell non-Hodgkin lymphoma or chronic lymphocytic leukemia; Ph…
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CLINICAL_TRIALS research · 2022-12-01Clinical Trial Update: Pyrimethamine for the Treatment of Relapsed Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma [Phase 1, Phase 2]
A completed Phase 1/Phase 2 clinical trial evaluating pyrimethamine for relapsed chronic lymphocytic leukemia/small lymphocytic lymphoma; re…
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CLINICAL_TRIALS research · 2019-09-06Clinical Trial Update: Electrophysiological Biomarkers of Chemotherapy-related Cognitive Impairment and Recovery
Clinical trial assessing electrophysiological biomarkers of chemotherapy-related cognitive impairment and recovery; study completed with pos…