Choroidal Neovascularization
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CLINICAL_TRIALS research · 2025-04-25Clinical Trial Update: Biomarkers and Choroidal Neovascularization
This entry describes an INSERM-led clinical trial in France investigating biomarkers for Choroidal Neovascularization and Mineralocorticoid …
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EMA withdrawal · 2025-04-14EMA Application withdrawn: Skojoy (aflibercept) — Amgen Technology (Ireland) UC
EMA has withdrawn the marketing authorization application for Skojoy (aflibercept) submitted by Amgen Technology (Ireland) UC. The applicati…
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CLINICAL_TRIALS research · 2025-04-09Clinical Trial Update: An Interpretable Fundus Diseases Report Generating System Based On Weakly Labelings
A protocol for an interpretable fundus disease report generator using weakly labeled data, sponsored by Zhongshan Ophthalmic Center, Sun Yat…
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CLINICAL_TRIALS trial_result · 2024-10-31Clinical Trial Update: Efficacy and Safety of Intravitreal Bevacizumab in the Treatment of Choroidal Neovascular Membranes Associated to High Myopia [Phase 3]
A Phase 3 trial evaluating intravitreal bevacizumab for choroidal neovascular membranes associated with high myopia has completed, reporting…
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CLINICAL_TRIALS trial_result · 2024-06-03Clinical Trial Update: Multifocal Electrophysiologic Findings After Intravitreal Bevacizumab(Avastin)Treatment [Phase 2, Phase 3]
Phase 2/3 clinical trial evaluating intravitreal bevacizumab (Avastin) for diabetic retinopathy and retinal vein occlusion; the study was te…
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CLINICAL_TRIALS trial_result · 2024-06-03Clinical Trial Update: Efficacy of Retreatments With Intravitreal Bevacizumab [Phase 3]
Phase 3 trial evaluating retreatments with intravitreal bevacizumab for age-related macular degeneration has been terminated; no final effic…
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CLINICAL_TRIALS withdrawal · 2024-06-03Clinical Trial Update: Use of Intravitreal Bevacizumab in Eyes With Choroidal Neovascularization Secondary to Angioid Streaks [Phase 3]
A Phase 3 trial evaluating intravitreal bevacizumab for choroidal neovascularization associated with angioid streaks was terminated.
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CLINICAL_TRIALS trial_result · 2024-05-22Clinical Trial Update: Deep Learning Optical Coherence Tomography (OCT) and OCT Angiography (OCTA) in NVC
The study evaluating deep learning analysis of OCT and OCTA for neovascularization in age-related macular degeneration has completed. It dis…
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CLINICAL_TRIALS trial_result · 2021-03-15Clinical Trial Update: Open-Label Study of Intravitreal ICON-1 in Patients With Choroidal Neovascularization Secondary to Age-related Macular Degeneration (AMD) [Phase 2]
Phase 2 open-label study of intravitreal ICON-1 in choroidal neovascularization due to age-related macular degeneration has been terminated …
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CLINICAL_TRIALS trial_result · 2020-10-09Clinical Trial Update: A Proof-of-Concept Study of Faricimab (RO6867461) in Participants With Choroidal Neovascularization (CNV) Secondary to Age-Related Macular Degeneration (AMD) [Phase 2]
Phase 2 proof-of-concept trial of faricimab in choroidal neovascularization due to age-related macular degeneration has completed with resul…
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CLINICAL_TRIALS trial_result · 2020-09-24Clinical Trial Update: Study Evaluating Intravitreal hI-con1™ in Patients With Choroidal Neovascularization Secondary to Age-related Macular Degeneration [Phase 2]
Phase 2 trial evaluating intravitreal hI-con1 for choroidal neovascularization due to age-related macular degeneration has completed with po…
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CLINICAL_TRIALS trial_result · 2019-10-31Clinical Trial Update: Efficacy and Safety of RTH258 Versus Aflibercept - Study 1 [Phase 3]
Completed Phase 3 trial (Study 1) comparing RTH258 (brolucizumab) with aflibercept in neovascular age-related macular degeneration, with eff…
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CLINICAL_TRIALS trial_result · 2019-10-31Clinical Trial Update: Efficacy and Safety of RTH258 Versus Aflibercept - Study 2 [Phase 3]
A Phase 3 study comparing RTH258 (brolucizumab) to aflibercept in neovascular age-related macular degeneration focuses on efficacy and safet…
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CLINICAL_TRIALS trial_result · 2019-08-12Clinical Trial Update: An Open-label Extended Clinical Protocol of Ranibizumab to Evaluate Safety and Efficacy in Rare VEGF Driven Ocular Diseases. [Phase 3]
A completed Phase 3 open-label extended protocol evaluating the safety and efficacy of ranibizumab in rare VEGF-driven ocular diseases.
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CLINICAL_TRIALS trial_result · 2019-03-11Clinical Trial Update: Dosing Strategy of Intravitreal Ranibizumab for Pathological Myopia Choroidal Neovascularization [Phase 4]
Phase 4 trial update on dosing strategy for intravitreal ranibizumab in choroidal neovascularization associated with pathological myopia.
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CLINICAL_TRIALS trial_result · 2019-03-08Clinical Trial Update: Efficacy of Aflibercept (Eylea®) on Choroidal Neovascularization (Type 3) [Phase 4]
Phase 4 trial update evaluating aflibercept (Eylea) for efficacy in Type 3 choroidal neovascularization has been completed.
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CLINICAL_TRIALS trial_result · 2019-02-05Clinical Trial Update: Enhancing the Lucentis (Ranibizumab) Management of Choroidal Neovascular Membranes With Hyperspectral Imaging
A clinical trial evaluating hyperspectral imaging to enhance management of choroidal neovascular membranes in age-related macular degenerati…
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CLINICAL_TRIALS trial_result · 2018-09-17Clinical Trial Update: Safety and Preliminary Efficacy Study of WST11 (Stakel®)-Mediated VTP Therapy in Subjects With CNV Associated With AMD [Phase 2]
Phase 2 safety and preliminary efficacy study of WST11-mediated VTP therapy in CNV associated with AMD was terminated; results posted in 201…
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CLINICAL_TRIALS trial_result · 2018-08-29Clinical Trial Update: Ziv-aflibercept in Ocular Disease Requiring Anti-VEGF Injection [Phase 2]
Phase 2 trial update for Ziv-aflibercept in ocular diseases requiring anti-VEGF injections.
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CLINICAL_TRIALS trial_result · 2018-02-26Clinical Trial Update: Evaluating RXI-109 to Reduce the Progression of Subretinal Fibrosis in Subjects With NVAMD [Phase 1, Phase 2]
This clinical trial update describes a Phase 1/2 study evaluating RXI-109 to reduce progression of subretinal fibrosis in neovascular age-re…
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CLINICAL_TRIALS trial_result · 2018-02-01Clinical Trial Update: SD-OCT-guided Intravitreal Ranibizumab Treatment in Choroidal Neovascularization Due to Myopia [Phase 4]
Phase 4 trial updating SD-OCT-guided intravitreal ranibizumab treatment for choroidal neovascularization due to myopia and age-related macul…
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CLINICAL_TRIALS trial_result · 2018-01-08Clinical Trial Update: Time Course of Activity Signs at SD-OCT High Frequency Intravitreal Ranibizumab Treatment in CNV Due to AMD [Phase 4]
Phase 4 trial update evaluating time course of activity signs at high-frequency intravitreal ranibizumab for CNV due to age-related macular …
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CLINICAL_TRIALS trial_result · 2017-12-06Clinical Trial Update: Combretastatin A4 Phosphate in Patients With Neovascular Age-Related Macular Degeneration [Phase 1, Phase 2]
This clinical trial update notes the completion of Phase 1/2 studies evaluating Combretastatin A4 Phosphate in patients with neovascular age…
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CLINICAL_TRIALS trial_result · 2017-10-30Clinical Trial Update: Use of Spectral OCT in Combination Therapy
This entry reports the completion of a clinical trial evaluating the use of Spectral OCT in combination therapy for choroidal neovasculariza…
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CLINICAL_TRIALS trial_result · 2017-05-25Clinical Trial Update: Comparison of Ranibizumab Monotherapy and Ranibizumab Combination Therapies in Recurrent or Persistent Choroidal Neovascularization Secondary to Age-related Macular Degeneration [Phase 2]
Phase 2 clinical trial comparing ranibizumab monotherapy with ranibizumab in combination therapies for recurrent or persistent choroidal neo…