Central Nervous System Neoplasms
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS trial_result · 2026-02-05Clinical Trial Update: B7-H3.CD28Z.CART in CNS Neoplasms [Phase 1]
A Phase 1 clinical trial evaluating B7-H3.CD28Z.CART for central nervous system neoplasms is currently not yet recruiting.
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CLINICAL_TRIALS trial_result · 2025-12-02Clinical Trial Update: Larotrectinib in Treating Patients With Previously Untreated TRK Fusion Solid Tumors and TRK Fusion Relapsed Acute Leukemia [Phase 2]
Phase 2 trial evaluating larotrectinib for TRK fusion cancers across solid tumors and TRK fusion relapsed acute leukemia in pediatric patien…
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CLINICAL_TRIALS trial_result · 2025-11-10Clinical Trial Update: Neurobehavioral Functioning in Pediatric Brain Tumor Patients After Proton Beam Radiation Treatment
A completed clinical trial assessed neurobehavioral functioning in pediatric brain tumor patients following proton beam radiation therapy.
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CLINICAL_TRIALS trial_result · 2025-10-02Clinical Trial Update: Pharmacoscopy for Patients With Refractory Primary Brain Tumors [Phase 2]
Phase 2 clinical trial update for pharmacoscopy in patients with refractory primary brain tumors, currently not yet recruiting.
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CLINICAL_TRIALS trial_result · 2025-05-02Clinical Trial Update: EPO906 Plus Radiation Therapy for the Treatment of Cancer Patients [Phase 1]
Phase 1 trial results for EPO906 in combination with radiation therapy in cancer patients, including central nervous system neoplasms and he…
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CLINICAL_TRIALS trial_result · 2025-05-02Clinical Trial Update: A Trial Using Velcade Plus Chemoradiation for Central Nervous System, Head and Neck, and Cervical Cancer Patients [Phase 1]
A Phase 1 trial evaluating Velcade (bortezomib) with chemoradiation in patients with brain/CNS neoplasms and head-and-neck/cervical cancers …
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CLINICAL_TRIALS trial_result · 2024-11-21Clinical Trial Update: Memantine for the Reduction of Cognitive Impairment After Radiation Therapy in Pediatric Patients With Central Nervous System Tumors [EARLY_Phase 1]
Completed EARLY Phase 1 clinical trial evaluating memantine to reduce cognitive impairment after radiation therapy in pediatric central nerv…
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CLINICAL_TRIALS trial_result · 2024-10-31Clinical Trial Update: RRx-001 Given With Irinotecan and Temozolomide for Pediatric Patients With Recurrent or Progressive Malignant Solid and Central Nervous System Tumors [Phase 1]
This Phase 1 trial update indicates termination of the pediatric study evaluating RRx-001 with irinotecan and temozolomide for recurrent or …
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CLINICAL_TRIALS trial_result · 2024-09-27Clinical Trial Update: Blood Brain Barrier Differences in Patients with Brain Tumors Undergoing Surgery
This completed clinical trial examined differences in the blood-brain barrier in patients with brain tumors undergoing surgical resection.
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CLINICAL_TRIALS trial_result · 2024-05-10Clinical Trial Update: Cognitive Function After Treatment of Primary CNS Malignancy
A completed Mayo Clinic clinical trial evaluating cognitive function after treatment for primary central nervous system tumors.
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CLINICAL_TRIALS trial_result · 2024-01-02Clinical Trial Update: Selinexor in Treating Younger Patients With Recurrent or Refractory Solid Tumors or High-Grade Gliomas [Phase 1]
A pediatric Phase 1 trial evaluating selinexor in children with recurrent or refractory solid tumors and high-grade gliomas has completed. R…
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CLINICAL_TRIALS trial_result · 2022-12-13Clinical Trial Update: Selumetinib Sulfate in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With Activating MAPK Pathway Mutations (A Pediatric MATCH Treatment Trial) [Phase 2]
A Phase 2 pediatric MATCH trial evaluating selumetinib sulfate in relapsed or refractory advanced solid tumors, non-Hodgkin lymphoma, and hi…
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CLINICAL_TRIALS trial_result · 2022-09-23Clinical Trial Update: Pevonedistat, Irinotecan, and Temozolomide in Treating Patients With Recurrent or Refractory Solid Tumors or Lymphoma [Phase 1]
This Phase 1 study evaluated pevonedistat in combination with irinotecan and temozolomide in patients with recurrent or refractory solid tum…
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CLINICAL_TRIALS trial_result · 2020-09-18Clinical Trial Update: Oral Pazopanib Plus Oral Topotecan Metronomic Antiangiogenic Therapy for Recurrent Glioblastoma Multiforme (A) Without Prior Bevacizumab Exposure and (B) After Failing Prior Bevacizumab [Phase 2]
Phase 2 clinical trial evaluating oral pazopanib plus oral topotecan given in a metronomic antiangiogenic regimen for recurrent glioblastoma…
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CLINICAL_TRIALS trial_result · 2019-12-10Clinical Trial Update: A Study of Pomalidomide Monotherapy for Children and Young Adults With Recurrent or Progressive Primary Brain Tumors [Phase 2]
Phase 2 trial evaluating pomalidomide monotherapy in children and young adults with recurrent or progressive primary brain tumors, including…
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CLINICAL_TRIALS trial_result · 2019-06-05Clinical Trial Update: Phase I/II Bevacizumab Versus Bevacizumab Plus TPI 287 for Recurrent Glioblastoma [Phase 1, Phase 2]
Phase I/II trial comparing bevacizumab alone versus bevacizumab plus TPI-287 for recurrent glioblastoma; trial terminated with results poste…
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CLINICAL_TRIALS trial_result · 2018-07-05Clinical Trial Update: High-Dose Trivalent Influenza Vaccine in Inducing Immune Response Patients With Central Nervous System Tumors [Phase 1]
Phase 1 trial evaluating whether a high-dose trivalent influenza vaccine can induce an immune response in patients with central nervous syst…
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CLINICAL_TRIALS trial_result · 2018-07-03Clinical Trial Update: Trivalent Influenza Vaccine in Preventing Flu in Patients With Central Nervous System Tumors
Completed clinical trial evaluating whether a trivalent influenza vaccine prevents influenza in patients with central nervous system neoplas…
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CLINICAL_TRIALS trial_result · 2018-06-26Clinical Trial Update: Gefitinib in Treating Patients With Recurrent or Progressive CNS Tumors [Phase 2]
Phase 2 results update on Gefitinib for patients with recurrent or progressive brain and central nervous system tumors. The trial status is …
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CLINICAL_TRIALS trial_result · 2018-04-20Clinical Trial Update: Radiation Therapy or Combination Chemotherapy in Treating Patients With Clinically or Radiologically Progressive Low-Grade Gliomas [NA]
A completed clinical trial evaluating radiation therapy or combination chemotherapy for progressive low-grade gliomas in patients, as report…
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CLINICAL_TRIALS trial_result · 2018-04-05Clinical Trial Update: Interdisciplinary Rehabilitation of Patients With Glioma During Anti-cancer Treatment [NA]
A completed clinical trial assessing interdisciplinary rehabilitation for glioma patients during anti-cancer treatment.
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CLINICAL_TRIALS trial_result · 2017-03-14Clinical Trial Update: Assessing the Suitability of an Imaging Probe for Use in Clinical Cell and Gene Therapy Trials in Cancer and Rheumatoid Arthritis [Phase 1]
Phase 1 clinical trial update on an imaging probe for use in cell and gene therapy trials targeting brain neoplasms and rheumatoid arthritis…
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CLINICAL_TRIALS trial_result · 2016-02-02Clinical Trial Update: Phase I Study of 5-Fluorouracil in Children and Young Adults With Recurrent Ependymoma [Phase 1]
This clinical trial update reports the completion of a Phase I study evaluating 5-fluorouracil in children and young adults with recurrent e…
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CLINICAL_TRIALS trial_result · 2015-10-14Clinical Trial Update: A Trial of Everolimus and Bevacizumab in Children With Recurrent Solid Tumors [Phase 1]
A Phase 1 clinical trial assessing the combination of everolimus and bevacizumab in pediatric patients with recurrent solid tumors and CNS m…
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CLINICAL_TRIALS trial_result · 2015-03-25Clinical Trial Update: Combination Chemotherapy Plus Gene Therapy in Treating Patients With CNS Tumors [Phase 1]
This document reports the completion of a Phase 1 trial evaluating combination chemotherapy plus gene therapy in patients with brain neoplas…