Cachexia
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CLINICAL_TRIALS trial_result · 2018-07-11Clinical Trial Update: Non-invasive Assessment of Skeletal Muscle Loss in Cancer Patients
This entry reports the completion of a clinical trial investigating non-invasive assessment methods for skeletal muscle loss in cancer patie…
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CLINICAL_TRIALS trial_result · 2018-03-12Clinical Trial Update: Testosterone for Treating Cachexia in Patients With Squamous Cell Carcinoma [Phase 1]
Phase 1 clinical trial evaluating testosterone for treating cachexia in patients with squamous cell carcinoma; the study was completed and r…
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CLINICAL_TRIALS trial_result · 2017-10-26Clinical Trial Update: Mitochondrial Respiratory Function in Mammalian Skeletal Muscle
UTMB Galveston sponsored a study on mitochondrial respiratory function in mammalian skeletal muscle investigating cancer and cachexia. The t…
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CLINICAL_TRIALS trial_result · 2017-08-01Clinical Trial Update: Individual Dose-escalated Bi-daily Subcutaneously (sc) Ghrelin in Cancer Cachexia: a Phase I/II Study [Phase 1, Phase 2]
Phase I/II clinical trial evaluating dose-escalated subcutaneous ghrelin for cancer cachexia has completed. The study enrolled patients with…
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CLINICAL_TRIALS trial_result · 2017-07-21Clinical Trial Update: Skeletal Muscle Response to Amino Acids and Load Carriage Exercise [NA]
Completed clinical trial evaluating how amino acids and load carriage exercise affect skeletal muscle; no regulatory action reported.
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CLINICAL_TRIALS trial_result · 2017-07-11Clinical Trial Update: Safety and Efficacy of Anamorelin HCl in Patients With Non-Small Cell Lung Cancer-Cachexia (ROMANA 1) [Phase 3]
ROMANA 1 is a Phase 3 trial evaluating the safety and efficacy of anamorelin HCl in patients with non-small cell lung cancer-associated cach…
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CLINICAL_TRIALS trial_result · 2017-07-11Clinical Trial Update: Anamorelin HCl in the Treatment of Non-Small Cell Lung Cancer-Cachexia (NSCLC-C): An Extension Study (ROMANA 3) [Phase 3]
Phase 3 extension study ROMANA 3 evaluated anamorelin HCl for NSCLC-associated cachexia; results completed and posted in 2017.
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CLINICAL_TRIALS trial_result · 2017-06-22Clinical Trial Update: Effectiveness of Nutritional Counselling and "Improved Atta" Supplementation in Cachexic Adult Indian Cancer Patients [NA]
A completed clinical trial in Indian cancer patients assessed the effectiveness of nutritional counselling combined with the 'Improved Atta'…
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CLINICAL_TRIALS trial_result · 2017-06-07Clinical Trial Update: A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of GSK2849466 in Healthy Male Subjects [Phase 1]
A Phase 1 study in healthy male volunteers evaluated the safety, tolerability, pharmacokinetics, and pharmacodynamics of GSK2849466 and has …
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CLINICAL_TRIALS trial_result · 2017-05-22Clinical Trial Update: Role of Myostatin, Activin A and Follistatin Cachexia of ENT Cancers
A completed clinical trial update examining the roles of myostatin, activin A, and follistatin in cachexia associated with head and neck can…
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CLINICAL_TRIALS trial_result · 2017-05-09Clinical Trial Update: A Study to Evaluate a Skeletal-muscle Microbiopsy Technique With Dynamic Proteomic Measurement in Healthy Male Volunteers [Phase 1]
Phase 1 trial update on evaluating a skeletal-muscle microbiopsy technique with dynamic proteomic measurement in healthy volunteers has comp…
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CLINICAL_TRIALS trial_result · 2017-03-06Clinical Trial Update: Safety, Tolerability, Pharmacokinetic (PK), and Pharmacodynamic Study of GSK2881078 and Study to Evaluate the Effect of CYP3A4 Inhibition on PK of GSK2881078 [Phase 1]
This Phase 1 study evaluated safety, tolerability, pharmacokinetics, and pharmacodynamics of GSK2881078 and investigated the impact of CYP3A…
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CLINICAL_TRIALS trial_result · 2017-01-31Clinical Trial Update: Safety, Tolerance and Efficacy of an Oral Nutritional Supplement in Chronic Heart Failure and Chronic Obstructive Pulmonary Disease Patients [NA]
The document reports the completed clinical trial evaluating the safety, tolerability, and efficacy of an oral nutritional supplement in pat…
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CLINICAL_TRIALS trial_result · 2017-01-18Clinical Trial Update: Computerized Questionnaires in Assessing Symptoms, Pain, Depression, and Physical Function in Patients With Metastatic and/or Advanced Locoregional Cancer
This completed clinical trial evaluated the use of computerized questionnaires to assess symptoms, pain, depression, and physical function i…
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CLINICAL_TRIALS trial_result · 2016-12-08Clinical Trial Update: Comparison of Nutritional Supplements in Preventing Weight Loss in Patients With Cancer [Phase 3]
Phase 3 trial comparing nutritional supplements to prevent weight loss in cancer patients has completed.
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CLINICAL_TRIALS trial_result · 2016-09-02Clinical Trial Update: Efficacy of Serum Bovine Immunoglobulin in Improving Nutritional Status in Advanced COPD [NA]
A completed clinical trial evaluated whether serum bovine immunoglobulin improves nutritional status in patients with advanced COPD and cach…
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CLINICAL_TRIALS trial_result · 2016-05-03Clinical Trial Update: BYM338 in Chronic Obstructive Pulmonary Disease (COPD) Patients With Cachexia [Phase 2]
Phase 2 trial of BYM338 in patients with chronic obstructive pulmonary disease and cachexia completed; results were posted in 2016.
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CLINICAL_TRIALS trial_result · 2016-05-02Clinical Trial Update: Treatment of Cancer-associated Anorexia Using Megestrol Acetate Concentrated Suspension [Phase 3]
Phase 3 trial of Megestrol Acetate Concentrated Suspension for cancer-associated anorexia was terminated, with results posted in 2016.
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CLINICAL_TRIALS trial_result · 2016-04-20Clinical Trial Update: Evaluate Weight Gain Using 2 Different Formulations of Megestrol Acetate Oral Suspension for AIDS-related Weight Loss [Phase 2]
Phase 2 trial evaluating two formulations of megestrol acetate oral suspension for AIDS-related weight loss completed; results posted in 201…
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CLINICAL_TRIALS trial_result · 2016-02-26Clinical Trial Update: Metabolism of Lipids in Advanced Cancer
A clinical trial studying lipid metabolism in advanced cancer, focusing on lung cancer and cancer cachexia, has been terminated.
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CLINICAL_TRIALS trial_result · 2015-07-02Clinical Trial Update: Non-Invasive Assessment of Skeletal Muscle Loss in Cancer Patients - Phase II
Phase II study evaluating non-invasive methods to assess skeletal muscle loss in cancer patients with cachexia. The trial has completed.
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CLINICAL_TRIALS trial_result · 2015-03-25Clinical Trial Update: Phase II Randomized Study of Physiologic Testosterone Replacement in Premenopausal, HIV-Positive Women [Phase 2]
Phase II randomized study of physiologic testosterone replacement in premenopausal HIV-positive women has completed. The trial investigates …
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CLINICAL_TRIALS trial_result · 2013-09-27Clinical Trial Update: Maternal Determinants of HIV-exposed and HIV-unexposed Fetal Growth, Birth Outcomes and Early Infant Growth
This clinical trial update reports on a completed study examining maternal determinants of fetal growth and birth outcomes in HIV-exposed ve…
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CLINICAL_TRIALS trial_result · 2013-02-21Clinical Trial Update: Study of GTx-024 on Muscle Wasting (Cachexia) Cancer. [Phase 2]
Phase 2 study of GTx-024 in cancer-related cachexia has completed and results were posted in 2013.
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CLINICAL_TRIALS trial_result · 2013-01-30Clinical Trial Update: Regimen for the Treatment of Cachexia in Subjects With NSCLC [Phase 2]
Phase 2 clinical trial evaluating a regimen for treating cachexia in subjects with non-small cell lung cancer; results were posted in 2013 a…