Blastic Plasmacytoid Dendritic Cell Neoplasm
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CLINICAL_TRIALS trial_result · 2026-07-06Clinical Trial Results: First-in-human Study of SAR443579 Infusion in Male and Female Children and Adult Participants With Relapsed or Refractory Acute Myeloid Leukemia (R/R AML), B-cell Acute Lymphoblastic Leukemia (B-ALL), High Risk-myelodysplasia (HR-MDS), or Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN) [Phase 1, Phase 2]
First-in-human study results for SAR443579 in relapsed or refractory acute leukemias and BPDCN across Phase 1/2 cohorts; the study was termi…
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CLINICAL_TRIALS research · 2026-04-14Clinical Trial Update: Venetoclax, SL-401, and Chemotherapy for the Treatment of Blastic Plasmacytoid Dendritic Cell Neoplasm [Phase 2]
A Phase 2 clinical trial evaluating venetoclax in combination with SL-401 and chemotherapy for Blastic plasmacytoid dendritic cell neoplasm …
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: Adaptive Dual-Target CAR-T Cells for Relapsed or Refractory Hematologic Malignancies [Phase 1, Phase 2]
Phase 1/Phase 2 clinical trial evaluating adaptive dual-target CAR-T cell therapy for relapsed or refractory hematologic malignancies; recru…
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CLINICAL_TRIALS trial_result · 2026-03-30Clinical Trial Update: CD123-Directed T-Cell Therapy for Acute Myelogenous Leukemia (CATCHAML) [Phase 1]
Phase 1 clinical trial of CD123-directed T-cell therapy for acute myeloid leukemia and related hematologic diseases is currently recruiting …
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CLINICAL_TRIALS research · 2026-02-17Clinical Trial Update: Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN) International Registry
An update on the Blastic plasmacytoid dendritic cell neoplasm (BPDCN) international registry indicating the study is currently recruiting.
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CLINICAL_TRIALS trial_result · 2026-02-02Clinical Trial Update: Study of Venetoclax, a BCL2 Antagonist, for Patients With Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN) [Phase 1]
A Phase 1 study of venetoclax for Blastic Plasmacytoid Dendritic Cell Neoplasm has completed.
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CLINICAL_TRIALS trial_result · 2026-01-28Clinical Trial Update: Flotetuzumab for the Treatment of Relapsed or Refractory Advanced CD123-Positive Hematological Malignancies [Phase 1]
A Phase 1 trial evaluating flotetuzumab for relapsed or refractory CD123-positive hematologic malignancies has completed, providing initial …
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CLINICAL_TRIALS research · 2026-01-22Clinical Trial Update: Cord Blood Transplant, Cyclophosphamide, Fludarabine, and Total-Body Irradiation in Treating Patients With High-Risk Hematologic Diseases [Phase 2]
Phase 2 clinical trial evaluating a cord blood transplant using cyclophosphamide, fludarabine, and total-body irradiation in high-risk hemat…
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CLINICAL_TRIALS research · 2026-01-13Clinical Trial Update: A Study of MGD024 in Patients With Relapsed or Refractory Hematologic Malignancies [Phase 1]
MacroGenics reports a Phase 1 study of MGD024 in relapsed or refractory hematologic malignancies is currently recruiting across multiple dis…
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CLINICAL_TRIALS research · 2026-01-12Clinical Trial Update: CART123 T Cells in Relapsed or Refractory CD123+ Hematologic Malignancies: A Dose Escalation Phase I Trial [EARLY_Phase 1]
This update describes an early-phase dose-escalation trial evaluating CART123 T cells in relapsed or refractory CD123+ hematologic malignanc…
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CLINICAL_TRIALS trial_result · 2025-12-15Clinical Trial Update: First-in-human Study of SAR443579 Infusion in Male and Female Children and Adult Participants With Relapsed or Refractory Acute Myeloid Leukemia (R/R AML), B-cell Acute Lymphoblastic Leukemia (B-ALL), High Risk-myelodysplasia (HR-MDS), or Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN) [Phase 1, Phase 2]
The first-in-human study of SAR443579 in children and adults with relapsed or refractory acute myeloid leukemia, acute lymphoblastic leukemi…
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CLINICAL_TRIALS research · 2025-11-26Clinical Trial Update: Phase II Study Evaluating the Efficacy and Safety of the Combination of Tagraxofusp and Venetoclax in Treatment-naive Blastic Plasmacytoid Dendritic Cell Neoplasm Patients [Phase 2]
Phase II clinical trial evaluating the combination of tagraxofusp and venetoclax in treatment-naive blastic plasmacytoid dendritic cell neop…
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CLINICAL_TRIALS research · 2025-11-04Clinical Trial Update: SL-401 in Combination With Azacitidine or Azacitidine/Venetoclax in Acute Myeloid Leukemia (AML), High-Risk Myelodysplastic Syndrome (MDS) or Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN) [Phase 1]
This is a Phase 1 trial evaluating SL-401 (tagraxofusp) in combination with azacitidine or azacitidine plus venetoclax for acute myeloid leu…
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CLINICAL_TRIALS research · 2025-09-16Clinical Trial Update: Genetically Modified T-cell Immunotherapy in Treating Patients With Relapsed/Refractory Acute Myeloid Leukemia and Persistent/Recurrent Blastic Plasmacytoid Dendritic Cell Neoplasm [Phase 1]
This document describes an ongoing Phase 1 clinical trial evaluating a genetically modified T-cell immunotherapy for adults with relapsed/re…
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CLINICAL_TRIALS trial_result · 2025-06-04Clinical Trial Update: Selective Depletion of CD45RA+ T Cells From Allogeneic Peripheral Blood Stem Cell Grafts From HLA-Matched Related and Unrelated Donors in Preventing GVHD [Phase 2]
Phase 2 clinical trial assessing selective depletion of CD45RA+ T cells from allogeneic stem cell grafts to prevent graft-versus-host diseas…
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CLINICAL_TRIALS research · 2025-05-02Clinical Trial Update: Precision-T: A Study of Orca-T in Recipients Undergoing Allogeneic Transplantation for Hematologic Malignancies [Phase 1]
Phase 1 study update for Orca-T in recipients undergoing allogeneic transplantation for hematologic malignancies; the trial is currently act…
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CLINICAL_TRIALS research · 2024-12-16Clinical Trial Update: Study of IMGN632 in Patients With Untreated BPDCN and Relapsed/Refractory BPDCN [Phase 1, Phase 2]
An ongoing Phase 1/2 trial of IMGN632 for untreated and relapsed/refractory Blastic plasmacytoid dendritic cell neoplasm. The study is curre…
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CLINICAL_TRIALS trial_result · 2024-12-06Clinical Trial Update: Tagraxofusp in Pediatric Patients With Relapsed or Refractory CD123 Expressing Hematologic Malignancies [Phase 1]
Phase 1 clinical trial studying tagraxofusp in pediatric patients with CD123-expressing hematologic malignancies is currently recruiting, sp…
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CLINICAL_TRIALS research · 2024-11-15Clinical Trial Update: Clinical Trial of CD123-targeted CAR-NK Therapy for Relapse/refractory AML or BPDCN [Phase 1]
Phase 1 clinical trial evaluating a CD123-targeted CAR-NK cell therapy for relapsed/refractory acute myeloid leukemia or blastic plasmacytoi…
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CLINICAL_TRIALS trial_result · 2024-08-01Clinical Trial Update: Tagraxofusp in Patients With Blastic Plasmacytoid Dendritic Cell Neoplasm or Acute Myeloid Leukemia [Phase 1, Phase 2]
Phase 1/Phase 2 clinical trial results for Tagraxofusp in Blastic Plasmacytoid Dendritic Cell Neoplasm and Acute Myeloid Leukemia have been …
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CLINICAL_TRIALS withdrawal · 2024-07-22Clinical Trial Update: Trial to Evaluate the Safety and Efficacy of MB-102 in Patients With BPDCN. [Phase 1, Phase 2]
A clinical trial evaluating MB-102 for safety and efficacy in Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN) has been terminated. No f…
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CLINICAL_TRIALS trial_result · 2024-07-22Clinical Trial Update: Long-term Follow-up Study in Patients Previously Treated With a Mustang Bio CAR-T Cell Investigational Product.
A long-term follow-up update on patients previously treated with Mustang Bio's CAR-T cell investigational product; the trial has been termin…
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CLINICAL_TRIALS trial_result · 2024-07-16Clinical Trial Update: Tagraxofusp in Treating Patients With Blastic Plasmacytoid Dendritic Cell Neoplasm After Stem Cell Transplant [Phase 2]
A Phase 2 trial of Tagraxofusp for Blastic Plasmacytoid Dendritic Cell Neoplasm after stem cell transplant was terminated, and results have …
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CLINICAL_TRIALS trial_result · 2024-02-08Clinical Trial Update: Combination Chemotherapy in Patients With Newly Diagnosed BPDCN [Phase 2]
Phase 2 trial evaluating combination chemotherapy in newly diagnosed Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN).
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FDA approval · 2023-07-26FDA Approved: ELZONRIS — Supplemental Application (Stemline Therapeutics, Inc.)
FDA approves a supplemental application for ELZONRIS (tagraxofusp) from Stemline Therapeutics, Inc. The action updates the drug's labeling/i…